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The map label for this gene is ctaB1 [H]

Identifier: 75674959

GI number: 75674959

Start: 849000

End: 850061

Strand: Direct

Name: ctaB1 [H]

Synonym: Nwi_0763

Alternate gene names: 75674959

Gene position: 849000-850061 (Clockwise)

Preceding gene: 75674958

Following gene: 75674960

Centisome position: 24.96

GC content: 66.76

Gene sequence:

>1062_bases
ATGGACGCTGTCCTCACCGCCTCCGTTCCACCAGTTCTCCACCCTGCCGAAGGTGCAGTAAGCAGTCATGTGAATGTGCG
CGGCGCGCTCACGCGCCGCGCACCCAACAAAGCGGGTAGTATCGTGTCGGTTGTCGATCAAAAAGCCGTTGAGCTGCCGC
CCCGGATCTCGGAGGCGGGTGTCGCCGATTACTTCGCGCTGCTGAAGCCACGAGTGATGTCGCTCGTGATCTTCACCGCG
CTGGTCGGGCTGATGATTGCGCCGGGCCATATTCACCCGGTGCTGGGCTTCATCGCGATCCTGTGCATCGCGGTCGGAGC
CGGCGCCTCCGGCGCGCTGAACATGGCGCTGGAAGGCGATATCGACGTGCTGATGTCGCGCACGGCCAACCGGCCGATCC
CGCGCGGCCGCATCACCCGCGGCGAGGCGATGGGGTTCGGCCTCACGCTGTCGTTCTTCTCGGTGATGACGCTCGGCGCG
CTGGTCAACTGGTACGCCGGGGGGCTGCTCGCCTTCACGATCTTCTTTTACGTGGTGATCTACACGATGGGGCTGAAGCG
GCGGACCGCGCAGAACATCGTGATCGGCGGCGCCGCCGGCGCGCTGCCGCCGGTGGTGGCGTGGGCGGCCGCGACGGGGT
CGTTGTCGGTTGAGCCGCTGCTTCTGTTCTTGATCATCTTCTTCTGGACGCCGCCGCATTTCTGGGCGCTGGCGCTGTTC
CGCTCCGACGATTACGCCCGCGCCGGGGTGCCGATGCTGCCGGTGGTCGCCGGTCCCGACGCGACGCGGCTGCAGATCCT
GCTCTACACCATCGTGCTGGTGGCGATCGCCGCCGCGCCCTGGCCGCTCGGCTACTTCGACTGGGTCTATGGCGTCACCT
CGCTGATCCTCGGCGCCGGCATGCTGGTGCTCGCGATCGAGGTCTATCGCCACCGGACCGGAAGCCAGGCGCTGCGCGCC
ACGCGGCGGCTGTTCGCCTTCTCGATTCTCTATCTGTTCGCGCTGTTCGCCGTTCTGCTGCTCGATGTGGTCGCGAAGGC
CGTCGCGCCGTTGATCTGGTAG

Upstream 100 bases:

>100_bases
GCTTCGGCGTCATCATCTTCCTCTACGGCCTGGTCGACGCCTTCGCGCGCAAGCAGCAGGCGGCCGACAATCCGTGGGGT
GAAGGCGCGACGACGCTGGA

Downstream 100 bases:

>100_bases
AGGGGCGCATGAACCGATGGACAGCAACGACAAGCCGGCCGGAGACCGGATCGTTCTCACCGAAGCTCAGAAGAAGCGCC
GGCGCGAACGCTCGATCGCG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1 [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MDAVLTASVPPVLHPAEGAVSSHVNVRGALTRRAPNKAGSIVSVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTA
LVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGDIDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGA
LVNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALF
RSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWPLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRA
TRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW

Sequences:

>Translated_353_residues
MDAVLTASVPPVLHPAEGAVSSHVNVRGALTRRAPNKAGSIVSVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTA
LVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGDIDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGA
LVNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALF
RSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWPLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRA
TRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW
>Mature_353_residues
MDAVLTASVPPVLHPAEGAVSSHVNVRGALTRRAPNKAGSIVSVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTA
LVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGDIDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGA
LVNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALF
RSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWPLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRA
TRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=266, Percent_Identity=33.8345864661654, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786631, Length=287, Percent_Identity=28.9198606271777, Blast_Score=101, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71998235, Length=268, Percent_Identity=27.9850746268657, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=319, Percent_Identity=26.3322884012539, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921064, Length=326, Percent_Identity=29.4478527607362, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 37662; Mature: 37662

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVLTASVPPVLHPAEGAVSSHVNVRGALTRRAPNKAGSIVSVVDQKAVELPPRISEAG
CCCEEECCCCCCCCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCH
VADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCC
IDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGALVNWYAGGLLAFTIFFYVVI
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALF
HHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
RSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWPLGYFDWVYGVTSLILGAG
CCCCCHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDAVLTASVPPVLHPAEGAVSSHVNVRGALTRRAPNKAGSIVSVVDQKAVELPPRISEAG
CCCEEECCCCCCCCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCH
VADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCC
IDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGALVNWYAGGLLAFTIFFYVVI
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALF
HHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
RSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWPLGYFDWVYGVTSLILGAG
CCCCCHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA