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The map label for this gene is acdA [H]

Identifier: 75674806

GI number: 75674806

Start: 687977

End: 689191

Strand: Direct

Name: acdA [H]

Synonym: Nwi_0608

Alternate gene names: 75674806

Gene position: 687977-689191 (Clockwise)

Preceding gene: 75674805

Following gene: 75674807

Centisome position: 20.22

GC content: 61.89

Gene sequence:

>1215_bases
ATGAGTGTTCGTCCGCAGAGCAAGGACAAGCCCGCGCCGGTCAGTTTCCAATGGGATGATCCGTTCAGGCTGGACGATCA
GTTGACCGAAGACGAGCGCATGATCCGCGACACCGCGCGGGCCTATGCGCAGGACAAGCTGCTGCCACGCATCGTTAAAG
CCTATCAGGACGAGAAGACCGACCGCGAGATCTTCAATGAGATGGGCGAGCTTGGTCTGAACGGCATCACCCTTCCGCAG
GAGTATGGCTGCGCGGATGCCAGCTACGTCGCTTATGGCCTCGTCGCGCGCGAGATCGAGCGCGTGGACTCCGGTTATCG
CTCGATGAATTCGGTGCAGTCCTCGCTGGTGATGTATCCGATCTATGCCTATGGCGACGAGAATCAGCGCAAGAAGTATC
TTCCCCGGCTCGCGACCGGGGAATGGGTCGGCTGTTTCGGACTGACCGAACCGGACGCCGGTTCTGATCCCGGCGGCATG
AAAAGCCGCGCTGAGAAAGTGTCGGACGGCTATCGGCTGACCGGTTCGAAGACGTGGATCTCCAACGCGCCGATCGCGGA
TTTGTTCGTAGTCTGGGCAAGGTCGGCGGCGCATGACAACCAGATCCGCGGCTTCGTGCTCGAAAAGGGAATGAAGGGCC
TCTCCGCTCCGAAGATCGGCGGCAAGCTCAGCCTGCGGGCGTCGGTCACCGGCGAGATCGTGATGGATGGCGTCGTGGTG
CCGGAGGAGAACCTGCTGCCGAACGTATCCGGACTGAAAGGCCCGTTCGGTTGCCTGAACCGCGCGCGCTACGGCATTTC
GTGGGGCGTGATGGGCGCGGCGGAAGACTGCATGCACCGCGCGCGGACGTACGTGCTCGAACGAAAGCAGTTCGGCCGCC
CGCTGGCGGCGGCGCAACTGGTGCAGAAGAAGCTCGCGGACATGCAGACCGATATCGCGCTTGGGCTTCAAGCTACCTTG
CGCATCGGACGGTTGATGGACGAGGGCAGGATGACGCCGGAAATGATCTCCATCATCAAGCGCAACAATTGCGGCAAGGC
GCTCGATATCGCGCGGGCCGCGCGCGATATGCACGGCGGCAACGGGATTCAGATCGAATATCATGTGATGCGCCACGCCG
CGAACCTTGAGGCCGTCAATACGTATGAAGGCACCCACGACGTCCATGCGCTGGTGCTAGGCCGCGCCATCACCGGCATC
CCGGCGTTTTCCTAA

Upstream 100 bases:

>100_bases
CTTGAAACCTGACGGTGGCTGCAGCGTTGGATTACGGATATACTTTCATCGATCGTGACCTTGCCGACATCGGTATCCGG
AACGGCGTGAAGGGATTGTC

Downstream 100 bases:

>100_bases
AGTCGTATCCCGGTTCTCCGATCCGTCACGCACGGGCCTGGACGCCGCCCGCCATTTTTTTGCCATAGCTGTGATCGGGG
GGTGGCAGGGGAACATTCAT

Product: acyl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSVRPQSKDKPAPVSFQWDDPFRLDDQLTEDERMIRDTARAYAQDKLLPRIVKAYQDEKTDREIFNEMGELGLNGITLPQ
EYGCADASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDENQRKKYLPRLATGEWVGCFGLTEPDAGSDPGGM
KSRAEKVSDGYRLTGSKTWISNAPIADLFVVWARSAAHDNQIRGFVLEKGMKGLSAPKIGGKLSLRASVTGEIVMDGVVV
PEENLLPNVSGLKGPFGCLNRARYGISWGVMGAAEDCMHRARTYVLERKQFGRPLAAAQLVQKKLADMQTDIALGLQATL
RIGRLMDEGRMTPEMISIIKRNNCGKALDIARAARDMHGGNGIQIEYHVMRHAANLEAVNTYEGTHDVHALVLGRAITGI
PAFS

Sequences:

>Translated_404_residues
MSVRPQSKDKPAPVSFQWDDPFRLDDQLTEDERMIRDTARAYAQDKLLPRIVKAYQDEKTDREIFNEMGELGLNGITLPQ
EYGCADASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDENQRKKYLPRLATGEWVGCFGLTEPDAGSDPGGM
KSRAEKVSDGYRLTGSKTWISNAPIADLFVVWARSAAHDNQIRGFVLEKGMKGLSAPKIGGKLSLRASVTGEIVMDGVVV
PEENLLPNVSGLKGPFGCLNRARYGISWGVMGAAEDCMHRARTYVLERKQFGRPLAAAQLVQKKLADMQTDIALGLQATL
RIGRLMDEGRMTPEMISIIKRNNCGKALDIARAARDMHGGNGIQIEYHVMRHAANLEAVNTYEGTHDVHALVLGRAITGI
PAFS
>Mature_403_residues
SVRPQSKDKPAPVSFQWDDPFRLDDQLTEDERMIRDTARAYAQDKLLPRIVKAYQDEKTDREIFNEMGELGLNGITLPQE
YGCADASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDENQRKKYLPRLATGEWVGCFGLTEPDAGSDPGGMK
SRAEKVSDGYRLTGSKTWISNAPIADLFVVWARSAAHDNQIRGFVLEKGMKGLSAPKIGGKLSLRASVTGEIVMDGVVVP
EENLLPNVSGLKGPFGCLNRARYGISWGVMGAAEDCMHRARTYVLERKQFGRPLAAAQLVQKKLADMQTDIALGLQATLR
IGRLMDEGRMTPEMISIIKRNNCGKALDIARAARDMHGGNGIQIEYHVMRHAANLEAVNTYEGTHDVHALVLGRAITGIP
AFS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=404, Percent_Identity=66.3366336633663, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI7669494, Length=383, Percent_Identity=65.5352480417755, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=30.952380952381, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=31.6353887399464, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI226958414, Length=347, Percent_Identity=31.1239193083574, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=29.9191374663073, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.3333333333333, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.3333333333333, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=30.5475504322767, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=30.5475504322767, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI21361497, Length=359, Percent_Identity=29.2479108635098, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=26.7015706806283, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI7656849, Length=382, Percent_Identity=28.0104712041885, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=22.6912928759894, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081958, Length=389, Percent_Identity=23.9074550128535, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=64.4329896907217, Blast_Score=534, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=31.8652849740933, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=30.6068601583113, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=401, Percent_Identity=28.6783042394015, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=29.4270833333333, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=27.8820375335121, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71985184, Length=360, Percent_Identity=30, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=28.8713910761155, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=252, Percent_Identity=34.9206349206349, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=30.6338028169014, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=29.6703296703297, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=32.1739130434783, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17533517, Length=385, Percent_Identity=25.1948051948052, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17551932, Length=273, Percent_Identity=25.2747252747253, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17505929, Length=270, Percent_Identity=22.5925925925926, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920834, Length=402, Percent_Identity=59.7014925373134, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24666513, Length=390, Percent_Identity=30.5128205128205, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=30.4812834224599, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=32.4538258575198, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=29.3650793650794, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=29.6791443850267, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281363737, Length=355, Percent_Identity=29.5774647887324, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 44577; Mature: 44445

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRPQSKDKPAPVSFQWDDPFRLDDQLTEDERMIRDTARAYAQDKLLPRIVKAYQDEKT
CCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DREIFNEMGELGLNGITLPQEYGCADASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYP
HHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYAYGDENQRKKYLPRLATGEWVGCFGLTEPDAGSDPGGMKSRAEKVSDGYRLTGSKTWI
EEEECCCCHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCC
SNAPIADLFVVWARSAAHDNQIRGFVLEKGMKGLSAPKIGGKLSLRASVTGEIVMDGVVV
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCEEC
PEENLLPNVSGLKGPFGCLNRARYGISWGVMGAAEDCMHRARTYVLERKQFGRPLAAAQL
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VQKKLADMQTDIALGLQATLRIGRLMDEGRMTPEMISIIKRNNCGKALDIARAARDMHGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NGIQIEYHVMRHAANLEAVNTYEGTHDVHALVLGRAITGIPAFS
CCEEEEEHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVRPQSKDKPAPVSFQWDDPFRLDDQLTEDERMIRDTARAYAQDKLLPRIVKAYQDEKT
CCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DREIFNEMGELGLNGITLPQEYGCADASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYP
HHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYAYGDENQRKKYLPRLATGEWVGCFGLTEPDAGSDPGGMKSRAEKVSDGYRLTGSKTWI
EEEECCCCHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCC
SNAPIADLFVVWARSAAHDNQIRGFVLEKGMKGLSAPKIGGKLSLRASVTGEIVMDGVVV
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCEEC
PEENLLPNVSGLKGPFGCLNRARYGISWGVMGAAEDCMHRARTYVLERKQFGRPLAAAQL
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VQKKLADMQTDIALGLQATLRIGRLMDEGRMTPEMISIIKRNNCGKALDIARAARDMHGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NGIQIEYHVMRHAANLEAVNTYEGTHDVHALVLGRAITGIPAFS
CCEEEEEHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]