Click here to switch to the map view.

The map label for this gene is yqhH [H]

Identifier: 75674449

GI number: 75674449

Start: 280460

End: 282085

Strand: Direct

Name: yqhH [H]

Synonym: Nwi_0251

Alternate gene names: 75674449

Gene position: 280460-282085 (Clockwise)

Preceding gene: 75674448

Following gene: 75674454

Centisome position: 8.24

GC content: 55.04

Gene sequence:

>1626_bases
TTGCCGGTGACCCTGCTTGCTGACGATGTCGGCCTCGGCAAAACCATTTCTGCAGGACTCGTCGCAAGCGAATTGATTGC
GCGCAATCGCGTTGCCAAGATTCTCATTGTCGCGCCCAAGCTGCTTGGGCCCCAATGGAAGGACGAATTAGAGGCAAAAT
TTGATATTCCGGGCGAGGTCGTCACCGGAAGCAAACTCGCTTCGGCCGAGCCAGACGAGGTCGGCGCCGTAATTACGACC
TATCATTCGGCCCGCGCTCATCTCGACAAGATACCCGATGATCGCTTCGATATGTTAGTTCTAGATGAAGCGCATAAGCT
CCGTAATCTCTACGGTGTTGATCCCACCCCGCAGGTCGCCAAGGTTTTCCATCGCACTTTGCAACAGCGCCGCTTTCGCT
ACGTGCTGATGCTGACGGCAACACCTATTCAGAACCGGCTGTGGGACCTCTATTCCCTAGTTGATCTGCTCACCGTCGCT
CGAGGCCACGAAAATCCCTTCGGAAGCGAAGGCATGTTCGCACGCCGCTTTATCGCAGATAAGCGCGAGACCGCACGCAT
CCTAAAACCCGACGCACGAGAGGATTTTCGCAAGATTGTCTATGGTTACATGTCACGCGTCCGGCGCGGCGATGCCAACC
TAGATTTTCCCGAACGCAAGATCCAACTGCATAAAGTGGCACCCTCATCGGAGGAGCTCGCCCTTATCAAGGCTATTGCC
AAACCGATTCAGAAACTGAACCGCCTTGCGCAGATAAGCATCCTGCAGGCGTTGACCAGCAGCCCGCACGCTCTCATGGT
GCAATTGCAAACCATGGCGCGGAACGGGACGGTGCCGATGGAGTTGGCCGCAACTGTGCAAGCCATCGTCACGCCCATGC
GAACAAGCGCGAAGCTGGAAGGCCTCCGACAACTCGTCTCCATGCTGCAGCAGCAAAATCCCACCAGCTGGCGTATGGTG
GTGTTTACAGGACGACGCGAGACTCAGACCACTATCCAGGCTTTCCTTGAAGAGCTTGGCTTGAAAGTTGGCATCATTAA
CGGCTCGTCCGGGCAGCGTAACCAAGATACGATCGCGCGCTTTCGCGGTAACCCTCCAGAGATAAGGGCTATTGTATCAA
CCGAAGCCGGATCGGAGGGCGTCAATCTCCAGATTGCCAACGTCCTTATCAATTTTGACTTACCGTGGAATCCAATGATT
GTCGAACAACGTATTGGCCGTGTTCAGCGCCTGGGTTCCCAGCACAAAAACGTCGTCATTTACAATGTCATGCTTGCCGG
CACGTTTGAGGAATACATCGTCGGTCGCCTCATGACCAAACTGCAAATGGCGACCGACGCGATCGGCGATATCGAATCTC
TGCTTGAGGCATCAGGTGTCGGCGATGGCGAGGAAGGCACTGGGTTCGATGAGAAGATCCGTGAACTTGTCGTCGCAGCA
TCGATGCTGCCAAGAAGACCCTTGAAGAAGAAAACGCGAATATCGACACCACCCTTGGAGCTATGGATGGCTACGAATAT
GTCGGCCCACAAACGCCGACGCTCGAAAAGGCCCAACCCTCCCTGGAATTCGAACCATTCGTCCGCGCGGCCTTTGTCAA
CCTTGGCGGCACGATTACAGACGTAG

Upstream 100 bases:

>100_bases
TGATTAAGAGCCGGGATGATTTCAATCCGAATTCCGCTGGAAAGACCGGCTGGAGCCCTTTCACCATCAGGTCCAGAACC
TCATCACCTTCTGCCGCCGT

Downstream 100 bases:

>100_bases
CACCGGAGATCCTCCGTGTCACGATTAGGGGTTCGCCCGAATACGCGCGGTTGAGCGAAGACGTTGCAAACAATTATGCG
AAGGCACCTCTTTATCGCCC

Product: helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MPVTLLADDVGLGKTISAGLVASELIARNRVAKILIVAPKLLGPQWKDELEAKFDIPGEVVTGSKLASAEPDEVGAVITT
YHSARAHLDKIPDDRFDMLVLDEAHKLRNLYGVDPTPQVAKVFHRTLQQRRFRYVLMLTATPIQNRLWDLYSLVDLLTVA
RGHENPFGSEGMFARRFIADKRETARILKPDAREDFRKIVYGYMSRVRRGDANLDFPERKIQLHKVAPSSEELALIKAIA
KPIQKLNRLAQISILQALTSSPHALMVQLQTMARNGTVPMELAATVQAIVTPMRTSAKLEGLRQLVSMLQQQNPTSWRMV
VFTGRRETQTTIQAFLEELGLKVGIINGSSGQRNQDTIARFRGNPPEIRAIVSTEAGSEGVNLQIANVLINFDLPWNPMI
VEQRIGRVQRLGSQHKNVVIYNVMLAGTFEEYIVGRLMTKLQMATDAIGDIESLLEASGVGDGEEGTGFDEKIRELVVAA
SMLPRRPLKKKTRISTPPLELWMATNMSAHKRRRSKRPNPPWNSNHSSARPLSTLAARLQT

Sequences:

>Translated_541_residues
MPVTLLADDVGLGKTISAGLVASELIARNRVAKILIVAPKLLGPQWKDELEAKFDIPGEVVTGSKLASAEPDEVGAVITT
YHSARAHLDKIPDDRFDMLVLDEAHKLRNLYGVDPTPQVAKVFHRTLQQRRFRYVLMLTATPIQNRLWDLYSLVDLLTVA
RGHENPFGSEGMFARRFIADKRETARILKPDAREDFRKIVYGYMSRVRRGDANLDFPERKIQLHKVAPSSEELALIKAIA
KPIQKLNRLAQISILQALTSSPHALMVQLQTMARNGTVPMELAATVQAIVTPMRTSAKLEGLRQLVSMLQQQNPTSWRMV
VFTGRRETQTTIQAFLEELGLKVGIINGSSGQRNQDTIARFRGNPPEIRAIVSTEAGSEGVNLQIANVLINFDLPWNPMI
VEQRIGRVQRLGSQHKNVVIYNVMLAGTFEEYIVGRLMTKLQMATDAIGDIESLLEASGVGDGEEGTGFDEKIRELVVAA
SMLPRRPLKKKTRISTPPLELWMATNMSAHKRRRSKRPNPPWNSNHSSARPLSTLAARLQT
>Mature_540_residues
PVTLLADDVGLGKTISAGLVASELIARNRVAKILIVAPKLLGPQWKDELEAKFDIPGEVVTGSKLASAEPDEVGAVITTY
HSARAHLDKIPDDRFDMLVLDEAHKLRNLYGVDPTPQVAKVFHRTLQQRRFRYVLMLTATPIQNRLWDLYSLVDLLTVAR
GHENPFGSEGMFARRFIADKRETARILKPDAREDFRKIVYGYMSRVRRGDANLDFPERKIQLHKVAPSSEELALIKAIAK
PIQKLNRLAQISILQALTSSPHALMVQLQTMARNGTVPMELAATVQAIVTPMRTSAKLEGLRQLVSMLQQQNPTSWRMVV
FTGRRETQTTIQAFLEELGLKVGIINGSSGQRNQDTIARFRGNPPEIRAIVSTEAGSEGVNLQIANVLINFDLPWNPMIV
EQRIGRVQRLGSQHKNVVIYNVMLAGTFEEYIVGRLMTKLQMATDAIGDIESLLEASGVGDGEEGTGFDEKIRELVVAAS
MLPRRPLKKKTRISTPPLELWMATNMSAHKRRRSKRPNPPWNSNHSSARPLSTLAARLQT

Specific function: Transcription Regulator That Activates Transcription By Stimulating RNA Polymerase (Rnap) Recycling In Case Of Stress Conditions Such As Supercoiled DNA Or High Salt Concentrations. Probably Acts By Releasing The Rnap, When It Is Trapped Or Immobilized On

COG id: COG0553

COG function: function code KL; Superfamily II DNA/RNA helicases, SNF2 family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI52630322, Length=473, Percent_Identity=25.1585623678647, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI52630326, Length=473, Percent_Identity=25.1585623678647, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI158420731, Length=473, Percent_Identity=25.1585623678647, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI24308089, Length=477, Percent_Identity=25.3668763102725, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI164419749, Length=468, Percent_Identity=23.9316239316239, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI51599156, Length=475, Percent_Identity=25.2631578947368, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI21071044, Length=482, Percent_Identity=23.8589211618257, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI21071058, Length=471, Percent_Identity=23.7791932059448, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI118421089, Length=458, Percent_Identity=23.7991266375546, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786245, Length=172, Percent_Identity=29.6511627906977, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71995707, Length=477, Percent_Identity=26.6247379454927, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17569817, Length=479, Percent_Identity=25.0521920668058, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193204424, Length=488, Percent_Identity=24.7950819672131, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562600, Length=479, Percent_Identity=24.8434237995825, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539642, Length=483, Percent_Identity=24.0165631469979, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25144179, Length=475, Percent_Identity=21.8947368421053, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17551114, Length=479, Percent_Identity=24.0083507306889, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534248, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71991518, Length=142, Percent_Identity=31.6901408450704, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325175, Length=522, Percent_Identity=24.1379310344828, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322495, Length=393, Percent_Identity=25.6997455470738, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6321275, Length=522, Percent_Identity=23.7547892720307, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319722, Length=471, Percent_Identity=22.5053078556263, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322065, Length=470, Percent_Identity=22.1276595744681, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323021, Length=241, Percent_Identity=25.7261410788382, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321289, Length=149, Percent_Identity=29.5302013422819, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24666729, Length=466, Percent_Identity=26.6094420600858, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281361889, Length=509, Percent_Identity=25.7367387033399, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62472261, Length=471, Percent_Identity=23.3545647558386, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281366478, Length=471, Percent_Identity=23.3545647558386, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667055, Length=471, Percent_Identity=23.3545647558386, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR000330 [H]

Pfam domain/function: PF00271 Helicase_C; PF00176 SNF2_N [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 60354; Mature: 60223

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTLLADDVGLGKTISAGLVASELIARNRVAKILIVAPKLLGPQWKDELEAKFDIPGEV
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCHHCCCCCHHHCCCCCCCCCCE
VTGSKLASAEPDEVGAVITTYHSARAHLDKIPDDRFDMLVLDEAHKLRNLYGVDPTPQVA
ECCCCCCCCCCHHHCHHHEEHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHH
KVFHRTLQQRRFRYVLMLTATPIQNRLWDLYSLVDLLTVARGHENPFGSEGMFARRFIAD
HHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
KRETARILKPDAREDFRKIVYGYMSRVRRGDANLDFPERKIQLHKVAPSSEELALIKAIA
CHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCHHHHHHHHHH
KPIQKLNRLAQISILQALTSSPHALMVQLQTMARNGTVPMELAATVQAIVTPMRTSAKLE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GLRQLVSMLQQQNPTSWRMVVFTGRRETQTTIQAFLEELGLKVGIINGSSGQRNQDTIAR
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
FRGNPPEIRAIVSTEAGSEGVNLQIANVLINFDLPWNPMIVEQRIGRVQRLGSQHKNVVI
HCCCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEE
YNVMLAGTFEEYIVGRLMTKLQMATDAIGDIESLLEASGVGDGEEGTGFDEKIRELVVAA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SMLPRRPLKKKTRISTPPLELWMATNMSAHKRRRSKRPNPPWNSNHSSARPLSTLAARLQ
HHCCCCCCCHHHCCCCCCHHHEEECCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHC
T
C
>Mature Secondary Structure 
PVTLLADDVGLGKTISAGLVASELIARNRVAKILIVAPKLLGPQWKDELEAKFDIPGEV
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCHHCCCCCHHHCCCCCCCCCCE
VTGSKLASAEPDEVGAVITTYHSARAHLDKIPDDRFDMLVLDEAHKLRNLYGVDPTPQVA
ECCCCCCCCCCHHHCHHHEEHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHH
KVFHRTLQQRRFRYVLMLTATPIQNRLWDLYSLVDLLTVARGHENPFGSEGMFARRFIAD
HHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
KRETARILKPDAREDFRKIVYGYMSRVRRGDANLDFPERKIQLHKVAPSSEELALIKAIA
CHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCHHHHHHHHHH
KPIQKLNRLAQISILQALTSSPHALMVQLQTMARNGTVPMELAATVQAIVTPMRTSAKLE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GLRQLVSMLQQQNPTSWRMVVFTGRRETQTTIQAFLEELGLKVGIINGSSGQRNQDTIAR
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
FRGNPPEIRAIVSTEAGSEGVNLQIANVLINFDLPWNPMIVEQRIGRVQRLGSQHKNVVI
HCCCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEE
YNVMLAGTFEEYIVGRLMTKLQMATDAIGDIESLLEASGVGDGEEGTGFDEKIRELVVAA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SMLPRRPLKKKTRISTPPLELWMATNMSAHKRRRSKRPNPPWNSNHSSARPLSTLAARLQ
HHCCCCCCCHHHCCCCCCHHHEEECCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]