Click here to switch to the map view.

The map label for this gene is hemF [H]

Identifier: 74318479

GI number: 74318479

Start: 2531953

End: 2532864

Strand: Direct

Name: hemF [H]

Synonym: Tbd_2461

Alternate gene names: 74318479

Gene position: 2531953-2532864 (Clockwise)

Preceding gene: 74318478

Following gene: 74318480

Centisome position: 87.01

GC content: 67.76

Gene sequence:

>912_bases
ATGTCTGTCACCGCCTGCGATCCCTCCGCCGTCAAAACCTGGCTGCTCGACCTGCAGTCGCGCATCGTCGCCGCGCTCGA
AGCCGCCGACGGCCTGCCCTTCCGTACCGATTCCTGGGATCGCCCGGAGGGCGGCGGCGGGATTTCGCGGCTGATCGAGG
AAGGCAACGTGCTCGAGCGCGGCGGCGTCAATTTCTCGCACGTCACCGGCGTCCAGCTGCCGCCTTCGGCCAGCGCGCAC
CGCCCCGAACTCGCCGGGCGCCGCTGGGAGGCAATGGGCGTCTCGCTGGTCTTGCACCCGCGCAACCCCTACGTGCCGAC
GGTCCACATGAACGTGCGCTGCTTCTCCGCGCTCAAGGACGGTGAAGCACCGGTATGGTGGTTCGGCGGCGGCATGGACC
TGACCCCGTATTACGGCTTCGAACAGGATGCCCGCCACTTCCACCTCGCCTGCAAGAGCGCGCTCGATCCGTTCGGGCCC
GGGCTGCATGCGCGCTTCAAGGACTGGTGCGACCGTTACTTCTTCCTCAAACATCGCAACGAGGCGCGCGGGGTGGGCGG
CATCTTCTTCGACGACTTTTCCGAAGGCGGTTTCGATCACGCCTTCGCGATGACGCGGAGCGTCGGCGACGCCTTCATCG
ACGCCTACCTGCCGATCCTGGAACGCCGCAAGGACATCGCCTACGGCGAGCGCGAACGCGATTTCCAGGCCTACCGCCGC
GGCCGCTACGTCGAATTCAATCTCGTGCTCGACCGCGGCACCCTGTTCGGCCTGCAGTCGGGCGGGCGCACCGAGTCGAT
CCTGATGTCGCTGCCGCCGCTCGTGAAGTGGCGCTACGACTGGCAGCCCGCGCCCGGCACGCCCGAGGCCGAGCTTTACA
CCGCGTTCCTGCCGGCGTGCGACTGGGTCTGA

Upstream 100 bases:

>100_bases
TGTTCGGCGCGCGCGTGCGCGTCGTCGACGGACGCATCGGCACACGCCGCCGCCCGTCGACGCTCATCGACCTTGCCACC
GGAAAAATCCTTCGAGCCTG

Downstream 100 bases:

>100_bases
CGATGCGCAAGATCCCGCGCCGCATTCTCGCCGCGCTCGGCATACTGCTCCTGCTGCTGCTCGTCGCCGCGCTCGTCGCC
TACGAACTCGTGTCGTCGGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSVTACDPSAVKTWLLDLQSRIVAALEAADGLPFRTDSWDRPEGGGGISRLIEEGNVLERGGVNFSHVTGVQLPPSASAH
RPELAGRRWEAMGVSLVLHPRNPYVPTVHMNVRCFSALKDGEAPVWWFGGGMDLTPYYGFEQDARHFHLACKSALDPFGP
GLHARFKDWCDRYFFLKHRNEARGVGGIFFDDFSEGGFDHAFAMTRSVGDAFIDAYLPILERRKDIAYGERERDFQAYRR
GRYVEFNLVLDRGTLFGLQSGGRTESILMSLPPLVKWRYDWQPAPGTPEAELYTAFLPACDWV

Sequences:

>Translated_303_residues
MSVTACDPSAVKTWLLDLQSRIVAALEAADGLPFRTDSWDRPEGGGGISRLIEEGNVLERGGVNFSHVTGVQLPPSASAH
RPELAGRRWEAMGVSLVLHPRNPYVPTVHMNVRCFSALKDGEAPVWWFGGGMDLTPYYGFEQDARHFHLACKSALDPFGP
GLHARFKDWCDRYFFLKHRNEARGVGGIFFDDFSEGGFDHAFAMTRSVGDAFIDAYLPILERRKDIAYGERERDFQAYRR
GRYVEFNLVLDRGTLFGLQSGGRTESILMSLPPLVKWRYDWQPAPGTPEAELYTAFLPACDWV
>Mature_302_residues
SVTACDPSAVKTWLLDLQSRIVAALEAADGLPFRTDSWDRPEGGGGISRLIEEGNVLERGGVNFSHVTGVQLPPSASAHR
PELAGRRWEAMGVSLVLHPRNPYVPTVHMNVRCFSALKDGEAPVWWFGGGMDLTPYYGFEQDARHFHLACKSALDPFGPG
LHARFKDWCDRYFFLKHRNEARGVGGIFFDDFSEGGFDHAFAMTRSVGDAFIDAYLPILERRKDIAYGERERDFQAYRRG
RYVEFNLVLDRGTLFGLQSGGRTESILMSLPPLVKWRYDWQPAPGTPEAELYTAFLPACDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=304, Percent_Identity=42.4342105263158, Blast_Score=246, Evalue=1e-65,
Organism=Escherichia coli, GI1788777, Length=297, Percent_Identity=63.2996632996633, Blast_Score=388, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320249, Length=304, Percent_Identity=45.7236842105263, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI17864388, Length=303, Percent_Identity=47.1947194719472, Blast_Score=275, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34052; Mature: 33921

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTACDPSAVKTWLLDLQSRIVAALEAADGLPFRTDSWDRPEGGGGISRLIEEGNVLER
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEC
GGVNFSHVTGVQLPPSASAHRPELAGRRWEAMGVSLVLHPRNPYVPTVHMNVRCFSALKD
CCCCCCEEECCCCCCCCCCCCCHHCCCEEEECCEEEEEECCCCCCCEEEECCEEEEHHCC
GEAPVWWFGGGMDLTPYYGFEQDARHFHLACKSALDPFGPGLHARFKDWCDRYFFLKHRN
CCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEECC
EARGVGGIFFDDFSEGGFDHAFAMTRSVGDAFIDAYLPILERRKDIAYGERERDFQAYRR
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHC
GRYVEFNLVLDRGTLFGLQSGGRTESILMSLPPLVKWRYDWQPAPGTPEAELYTAFLPAC
CCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHEECCCC
DWV
CCC
>Mature Secondary Structure 
SVTACDPSAVKTWLLDLQSRIVAALEAADGLPFRTDSWDRPEGGGGISRLIEEGNVLER
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEC
GGVNFSHVTGVQLPPSASAHRPELAGRRWEAMGVSLVLHPRNPYVPTVHMNVRCFSALKD
CCCCCCEEECCCCCCCCCCCCCHHCCCEEEECCEEEEEECCCCCCCEEEECCEEEEHHCC
GEAPVWWFGGGMDLTPYYGFEQDARHFHLACKSALDPFGPGLHARFKDWCDRYFFLKHRN
CCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEECC
EARGVGGIFFDDFSEGGFDHAFAMTRSVGDAFIDAYLPILERRKDIAYGERERDFQAYRR
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHC
GRYVEFNLVLDRGTLFGLQSGGRTESILMSLPPLVKWRYDWQPAPGTPEAELYTAFLPAC
CCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHEECCCC
DWV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA