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The map label for this gene is hdfR [H]

Identifier: 74318346

GI number: 74318346

Start: 2401857

End: 2402708

Strand: Direct

Name: hdfR [H]

Synonym: Tbd_2328

Alternate gene names: 74318346

Gene position: 2401857-2402708 (Clockwise)

Preceding gene: 74318342

Following gene: 74318347

Centisome position: 82.54

GC content: 67.25

Gene sequence:

>852_bases
ATGGATACCGAACTCGCCCGGACATTTCTGACCGTCGCGGCAACCGGCAATTTCGTCGCCGCGGCGAGCCGCCTCCACGT
CACGCAATCGACCGTCAGCGCGCGCATTCAGACGCTCGAGACGACGCTCGGCGCGCGCCTTTTCCAGCGCGGGCGGAACG
GCGCGGAATTGACGGCGTCGGGCAAGCGCTTTCTGCGTCACGCGAAGCACCTCGTGCGCACGGTCGAACAGGCCTTGCAC
GACGTCGGCCTCCCGCAGGGCTTCCACGACGTGCTGACGCTGTCAGGGCGGATCGCGTTATGGGAAGGTTTCCTGCCGCA
CTGGGTCGCGTGGATGCGCGAAGCCGCACCCGACGTGTCGCTGCGGCTGGAGATCGGCTTCGAGGCCGATATCATGCAAG
GCCTCATCGAAGGCACGACCGATATCGGCGTCATGTACACGCCGACCTCGCGCCCCGGACTCGTCGTCGAGCCGCTGTTC
GACGAGAACCTCATGCTCGTCACGAGCGATCTCGCGCGCGGCTGGCCCGAGGAGGGCTATATCCACATCGACTGGGGCCC
CGAATTCCACGCCCAGTTCAGCGACCACTTCCCCGACGCGCCGCCGCCGACCGTCGTTGCCAACATCGGCTGGCTCGGCG
TGCAGCAATTGCTGACCTACGGCGGCAGCGGCTATTTCCCGCAGCGGCTGGTGCGCCAGCTCATCGAGGACGGTCGGCTA
TGGCGCGTGCCCGACAGTCCGCAGTTCAAGCTGACCGCGTGGATGGTATTCCCGCGTGAGGGCAGCGCCACGCTGAAGAG
CGCGCTCGACGGGCTGCGCACGCTCGCACGCGACGAGCAGGCGCGCCTCTAA

Upstream 100 bases:

>100_bases
CTTCGTCCTCGTTGCTGTTGCCTACAGCTTAAGGATCGGGCACCCATCTATCCAGCGATTATTTTTGGTTTTTGATATCG
AAAAAAGCGATAATCCACCG

Downstream 100 bases:

>100_bases
GTCCTCCCCCCGTTTCCCCCGCCGCGCGCGAACGACCGGCCGGCGCCACGCCACGCGGCGCCCGGGGGCGCGCTTTGCGC
CGTAAACCCGCGTCACCGCC

Product: transcriptional regulator

Products: NA

Alternate protein names: H-NS-dependent flhDC regulator [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MDTELARTFLTVAATGNFVAAASRLHVTQSTVSARIQTLETTLGARLFQRGRNGAELTASGKRFLRHAKHLVRTVEQALH
DVGLPQGFHDVLTLSGRIALWEGFLPHWVAWMREAAPDVSLRLEIGFEADIMQGLIEGTTDIGVMYTPTSRPGLVVEPLF
DENLMLVTSDLARGWPEEGYIHIDWGPEFHAQFSDHFPDAPPPTVVANIGWLGVQQLLTYGGSGYFPQRLVRQLIEDGRL
WRVPDSPQFKLTAWMVFPREGSATLKSALDGLRTLARDEQARL

Sequences:

>Translated_283_residues
MDTELARTFLTVAATGNFVAAASRLHVTQSTVSARIQTLETTLGARLFQRGRNGAELTASGKRFLRHAKHLVRTVEQALH
DVGLPQGFHDVLTLSGRIALWEGFLPHWVAWMREAAPDVSLRLEIGFEADIMQGLIEGTTDIGVMYTPTSRPGLVVEPLF
DENLMLVTSDLARGWPEEGYIHIDWGPEFHAQFSDHFPDAPPPTVVANIGWLGVQQLLTYGGSGYFPQRLVRQLIEDGRL
WRVPDSPQFKLTAWMVFPREGSATLKSALDGLRTLARDEQARL
>Mature_283_residues
MDTELARTFLTVAATGNFVAAASRLHVTQSTVSARIQTLETTLGARLFQRGRNGAELTASGKRFLRHAKHLVRTVEQALH
DVGLPQGFHDVLTLSGRIALWEGFLPHWVAWMREAAPDVSLRLEIGFEADIMQGLIEGTTDIGVMYTPTSRPGLVVEPLF
DENLMLVTSDLARGWPEEGYIHIDWGPEFHAQFSDHFPDAPPPTVVANIGWLGVQQLLTYGGSGYFPQRLVRQLIEDGRL
WRVPDSPQFKLTAWMVFPREGSATLKSALDGLRTLARDEQARL

Specific function: Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994962, Length=249, Percent_Identity=29.3172690763052, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081904, Length=163, Percent_Identity=33.7423312883436, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI157672245, Length=168, Percent_Identity=31.547619047619, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787806, Length=170, Percent_Identity=27.6470588235294, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693105, Length=171, Percent_Identity=25.1461988304094, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082132, Length=172, Percent_Identity=31.3953488372093, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788887, Length=168, Percent_Identity=29.7619047619048, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790208, Length=195, Percent_Identity=29.2307692307692, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788297, Length=173, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020890
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31494; Mature: 31494

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTELARTFLTVAATGNFVAAASRLHVTQSTVSARIQTLETTLGARLFQRGRNGAELTAS
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHH
GKRFLRHAKHLVRTVEQALHDVGLPQGFHDVLTLSGRIALWEGFLPHWVAWMREAAPDVS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEHHCCHHHHHHHHHHCCCCCE
LRLEIGFEADIMQGLIEGTTDIGVMYTPTSRPGLVVEPLFDENLMLVTSDLARGWPEEGY
EEEEECCCHHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCEEEEECHHHCCCCCCCE
IHIDWGPEFHAQFSDHFPDAPPPTVVANIGWLGVQQLLTYGGSGYFPQRLVRQLIEDGRL
EEEECCCCHHCCHHHCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCE
WRVPDSPQFKLTAWMVFPREGSATLKSALDGLRTLARDEQARL
EECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDTELARTFLTVAATGNFVAAASRLHVTQSTVSARIQTLETTLGARLFQRGRNGAELTAS
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHH
GKRFLRHAKHLVRTVEQALHDVGLPQGFHDVLTLSGRIALWEGFLPHWVAWMREAAPDVS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEHHCCHHHHHHHHHHCCCCCE
LRLEIGFEADIMQGLIEGTTDIGVMYTPTSRPGLVVEPLFDENLMLVTSDLARGWPEEGY
EEEEECCCHHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCEEEEECHHHCCCCCCCE
IHIDWGPEFHAQFSDHFPDAPPPTVVANIGWLGVQQLLTYGGSGYFPQRLVRQLIEDGRL
EEEECCCCHHCCHHHCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCE
WRVPDSPQFKLTAWMVFPREGSATLKSALDGLRTLARDEQARL
EECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA