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The map label for this gene is uvrY [H]

Identifier: 74318255

GI number: 74318255

Start: 2315267

End: 2315902

Strand: Reverse

Name: uvrY [H]

Synonym: Tbd_2237

Alternate gene names: 74318255

Gene position: 2315902-2315267 (Counterclockwise)

Preceding gene: 74318256

Following gene: 74318254

Centisome position: 79.59

GC content: 60.53

Gene sequence:

>636_bases
ATGATTCAGGTTGCCATCGTCGATGACCATCAAATCGTCCGGACCGGCTTTCGCGAGCTTCTCGGCGACGATTCCGCGAT
TCGCATCAGTTTCGAGGCCGCGGATGGCGACGAGGCGCTTGCGCAGTTGCGGACCGCGCCCTGCGACGTGCTGCTGCTCG
ACATTTCCCTCCCCGGGAAAAGTGGGGTCGACGTGCTGAGAACGATCAGGCAGCGTCATCCTGACGTCAAGGTACTGATC
CTGAGCGGCTTTCCCGAGGAAAGCTATGCGCTCGCAATGATCAAGAACGGCGCCAACGGCTACCTGTGCAAGGACTGCGA
ACAGGAAGACCTGCTGCGGGCGATCCACACCGTTTCCAATGGGCGGCGCTACGTTTCCGCGCGCACAGCCGAGTTGCTCG
CCGAAGAAATGAGCGGCGAGCGGCGCGGGGTGCTGCACGAAGCCTTGTCGGACCGCGAGCTTCAGGTGTTTCTCAGGCTC
GCGCGCGGCGAGTCGGTGTCCGACATTGCCTCGCAACTCCACCTCAGCGTCAAAACCATCAGTACCTATCGCTCGCGCGT
GACCGAAAAGCTCAACGTCGCGAGCAATGCGGAACTTGCGACCTATGCATTACGACACGGACTCATTGCAGAATAA

Upstream 100 bases:

>100_bases
AATAATGGCAATCGCGACGTTCGTGGTGAACCTGCTGCGTGGGCGCTAGCAGGCGCGAAAATACCGGATCGATCGTAGCG
GCATTGCCACGGAGCGCTAC

Downstream 100 bases:

>100_bases
GCCGGCTCACAATGAGTTCTCGGCTCGGCTCTCGCCCTCGCATCCCGACATGCTGAAGATCTTCCTGATCGAGGATTCGC
TGCTGCTCCAGGAATTGCTC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MIQVAIVDDHQIVRTGFRELLGDDSAIRISFEAADGDEALAQLRTAPCDVLLLDISLPGKSGVDVLRTIRQRHPDVKVLI
LSGFPEESYALAMIKNGANGYLCKDCEQEDLLRAIHTVSNGRRYVSARTAELLAEEMSGERRGVLHEALSDRELQVFLRL
ARGESVSDIASQLHLSVKTISTYRSRVTEKLNVASNAELATYALRHGLIAE

Sequences:

>Translated_211_residues
MIQVAIVDDHQIVRTGFRELLGDDSAIRISFEAADGDEALAQLRTAPCDVLLLDISLPGKSGVDVLRTIRQRHPDVKVLI
LSGFPEESYALAMIKNGANGYLCKDCEQEDLLRAIHTVSNGRRYVSARTAELLAEEMSGERRGVLHEALSDRELQVFLRL
ARGESVSDIASQLHLSVKTISTYRSRVTEKLNVASNAELATYALRHGLIAE
>Mature_211_residues
MIQVAIVDDHQIVRTGFRELLGDDSAIRISFEAADGDEALAQLRTAPCDVLLLDISLPGKSGVDVLRTIRQRHPDVKVLI
LSGFPEESYALAMIKNGANGYLCKDCEQEDLLRAIHTVSNGRRYVSARTAELLAEEMSGERRGVLHEALSDRELQVFLRL
ARGESVSDIASQLHLSVKTISTYRSRVTEKLNVASNAELATYALRHGLIAE

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=37.799043062201, Blast_Score=156, Evalue=8e-40,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=37, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786747, Length=206, Percent_Identity=33.9805825242718, Blast_Score=113, Evalue=7e-27,
Organism=Escherichia coli, GI1788521, Length=195, Percent_Identity=37.9487179487179, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=30.0492610837438, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1787473, Length=201, Percent_Identity=27.363184079602, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23269; Mature: 23269

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVAIVDDHQIVRTGFRELLGDDSAIRISFEAADGDEALAQLRTAPCDVLLLDISLPGK
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCC
SGVDVLRTIRQRHPDVKVLILSGFPEESYALAMIKNGANGYLCKDCEQEDLLRAIHTVSN
CCHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCCEECCCCHHHHHHHHHHHHC
GRRYVSARTAELLAEEMSGERRGVLHEALSDRELQVFLRLARGESVSDIASQLHLSVKTI
CCEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRSRVTEKLNVASNAELATYALRHGLIAE
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MIQVAIVDDHQIVRTGFRELLGDDSAIRISFEAADGDEALAQLRTAPCDVLLLDISLPGK
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCC
SGVDVLRTIRQRHPDVKVLILSGFPEESYALAMIKNGANGYLCKDCEQEDLLRAIHTVSN
CCHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCCEECCCCHHHHHHHHHHHHC
GRRYVSARTAELLAEEMSGERRGVLHEALSDRELQVFLRLARGESVSDIASQLHLSVKTI
CCEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRSRVTEKLNVASNAELATYALRHGLIAE
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]