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The map label for this gene is nadB1 [H]

Identifier: 74318114

GI number: 74318114

Start: 2186900

End: 2188525

Strand: Direct

Name: nadB1 [H]

Synonym: Tbd_2096

Alternate gene names: 74318114

Gene position: 2186900-2188525 (Clockwise)

Preceding gene: 74318100

Following gene: 74318116

Centisome position: 75.16

GC content: 67.22

Gene sequence:

>1626_bases
ATGCACAGACACGACGTCCTCATCCTCGGGAGCGGCCTTGCCGCACTGACGACCGCACTCAAGCTCGCCGACCAGCGTCG
GGTCGCGATCGTGACCAAACGGCGGATGACCGACGGCGCGAGCGATTGGGCGCAAGGCGGGATCGCGGCTGCCCTCGCCA
GCGGCGACTCGATCGAAGCCCACGTGCACGACACGCTCGTCGCGGGTGCCGGGCTCTGCGACGAGGCGGTCACCCGGCTC
GTCGCGAGCCAGGCGCGCGAGATGATCGACTGGCTCACCCGCAACGGCGTCGCCTTCACGCCGGACCCCGAGAGCCCCGG
TGCGCTCCATCTGGCGCGCGAGGGCGGCCATTCGAAACGCCGCGTCGTCCACGCCGCGGATGCGACGGGCCACGCCGTGC
AGACCACGCTACTCGACCGGGTGCGCGCGCATCCGAACATCGAGACCTTCGAGGATCACGTCGCGATCGACCTCATTTCC
GGCAAGCGCGCCGGCGGCGAGGAGCGCCAGATCCATGGTGCCTATGCGCTGAACAAGGGCAGCGGCGAGGTCGAGACCTT
TGCGGCGGGGCACACCGTGCTGGCCACCGGCGGCGCCGGCAAGGTCTATTTGTATACGACCAACCCCGATACCGCGACCG
GCGACGGCATCGCCATGGCCTGGCGCGCCGGCTGCCGCGTCGCCAATCTCGAGTTCGTGCAGTTCCACCCGACCTGCCTC
TACCATCCGCACGCCAAGTCCTTCCTCATTAGCGAGGCCGTACGCGGCGAGGGCGGACATCTGCTGCTGCCCGACGGCAG
CCGCTTCATGCAGTTCCATGACACGCGCGCAGAACTCGCGCCGCGCGATGTCGTGGCGCGCGCAATCGACTTCGAAATGA
AGAAGCGCGGGATCGACTGCGTCTATCTCGATATCAGCCACAAGCCAGCCGACTTCGTGCGCGCGCATTTCCCGACCATC
TACCAGCGCTGCCTCGAACTCGGCATCGACATCACGCGGGAGCCGATTCCGGTCGTTCCCGCCGCCCACTACACCTGCGG
CGGCGTGGTGACCGATACCGAGGCGCGCACCGATCTTTGCAACCTCCATGCCGTCGGCGAAGTCACCTTCACGGGCCTGC
ACGGGGCGAACCGCCTGGCGTCGAACTCGCTGCTCGAGTGTCTGGTCTTCGGCCACGCGGCGGCGCGCGACATCCTCTCG
ACGCCGCCGGCGCCGACGCTAGAACTGCCGCCCTGGGACGCCTCGCGCGTGACCGACGCCGACGAGGAAGTGGTGATCTC
GCACAACTGGGACGAGCTTCGGCGTTTCATGTGGGACTACGTCGGCATCGTGCGCACGAACAAGCGGCTGGCCCGCGCAT
CGCATCGCATCCGTCTGCTGCGCGGGGAAATCGACGAGTTCTATCGCAATTTCCGCGTCAGCAACGACCTGATCGAACTA
CGCAATCTCGTGCAAAGCGCCGATCTGATCGTGCGCTGCGCCCAACTGCGGCAGGAAAGCCGCGGCCTGCATTACAGCCG
CGACTATCCCGAGATCCTGCCAGTCGCCGGCAACACCGTGCTCAACCCGCGTCCGGGTACGCTGTGTCCGAGCGTTTGTG
GCGTGACCAGCGAAGCGACACTCTGA

Upstream 100 bases:

>100_bases
CCGCAGCTTCCGAACGTGTGAGGGAAAACCGGGCAAAAAGTTCACCCGAAACAAGGTTTTTCGGAGCGCGGCCAAGCCTG
CTATCATCGCCCGACCCACC

Downstream 100 bases:

>100_bases
GCTGGCGCAGGCTGTCGGCGTCGCCGCTGTCGGACAATAGCGTGAGCGTCTGCGGACGGCCGTCCGCGAGGCGATAACGC
AACACGATCAGACGGGTCGA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MHRHDVLILGSGLAALTTALKLADQRRVAIVTKRRMTDGASDWAQGGIAAALASGDSIEAHVHDTLVAGAGLCDEAVTRL
VASQAREMIDWLTRNGVAFTPDPESPGALHLAREGGHSKRRVVHAADATGHAVQTTLLDRVRAHPNIETFEDHVAIDLIS
GKRAGGEERQIHGAYALNKGSGEVETFAAGHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANLEFVQFHPTCL
YHPHAKSFLISEAVRGEGGHLLLPDGSRFMQFHDTRAELAPRDVVARAIDFEMKKRGIDCVYLDISHKPADFVRAHFPTI
YQRCLELGIDITREPIPVVPAAHYTCGGVVTDTEARTDLCNLHAVGEVTFTGLHGANRLASNSLLECLVFGHAAARDILS
TPPAPTLELPPWDASRVTDADEEVVISHNWDELRRFMWDYVGIVRTNKRLARASHRIRLLRGEIDEFYRNFRVSNDLIEL
RNLVQSADLIVRCAQLRQESRGLHYSRDYPEILPVAGNTVLNPRPGTLCPSVCGVTSEATL

Sequences:

>Translated_541_residues
MHRHDVLILGSGLAALTTALKLADQRRVAIVTKRRMTDGASDWAQGGIAAALASGDSIEAHVHDTLVAGAGLCDEAVTRL
VASQAREMIDWLTRNGVAFTPDPESPGALHLAREGGHSKRRVVHAADATGHAVQTTLLDRVRAHPNIETFEDHVAIDLIS
GKRAGGEERQIHGAYALNKGSGEVETFAAGHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANLEFVQFHPTCL
YHPHAKSFLISEAVRGEGGHLLLPDGSRFMQFHDTRAELAPRDVVARAIDFEMKKRGIDCVYLDISHKPADFVRAHFPTI
YQRCLELGIDITREPIPVVPAAHYTCGGVVTDTEARTDLCNLHAVGEVTFTGLHGANRLASNSLLECLVFGHAAARDILS
TPPAPTLELPPWDASRVTDADEEVVISHNWDELRRFMWDYVGIVRTNKRLARASHRIRLLRGEIDEFYRNFRVSNDLIEL
RNLVQSADLIVRCAQLRQESRGLHYSRDYPEILPVAGNTVLNPRPGTLCPSVCGVTSEATL
>Mature_541_residues
MHRHDVLILGSGLAALTTALKLADQRRVAIVTKRRMTDGASDWAQGGIAAALASGDSIEAHVHDTLVAGAGLCDEAVTRL
VASQAREMIDWLTRNGVAFTPDPESPGALHLAREGGHSKRRVVHAADATGHAVQTTLLDRVRAHPNIETFEDHVAIDLIS
GKRAGGEERQIHGAYALNKGSGEVETFAAGHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANLEFVQFHPTCL
YHPHAKSFLISEAVRGEGGHLLLPDGSRFMQFHDTRAELAPRDVVARAIDFEMKKRGIDCVYLDISHKPADFVRAHFPTI
YQRCLELGIDITREPIPVVPAAHYTCGGVVTDTEARTDLCNLHAVGEVTFTGLHGANRLASNSLLECLVFGHAAARDILS
TPPAPTLELPPWDASRVTDADEEVVISHNWDELRRFMWDYVGIVRTNKRLARASHRIRLLRGEIDEFYRNFRVSNDLIEL
RNLVQSADLIVRCAQLRQESRGLHYSRDYPEILPVAGNTVLNPRPGTLCPSVCGVTSEATL

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=530, Percent_Identity=33.2075471698113, Blast_Score=218, Evalue=8e-57,
Organism=Escherichia coli, GI1788928, Length=527, Percent_Identity=60.3415559772296, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=522, Percent_Identity=32.5670498084291, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1786942, Length=528, Percent_Identity=31.4393939393939, Blast_Score=194, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17505833, Length=534, Percent_Identity=31.8352059925094, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=538, Percent_Identity=33.271375464684, Blast_Score=218, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI71986328, Length=464, Percent_Identity=27.801724137931, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322701, Length=554, Percent_Identity=33.3935018050542, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322416, Length=557, Percent_Identity=33.3931777378815, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6320788, Length=487, Percent_Identity=28.1314168377823, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322511, Length=478, Percent_Identity=27.1966527196653, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137288, Length=555, Percent_Identity=32.972972972973, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655642, Length=555, Percent_Identity=32.972972972973, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655647, Length=555, Percent_Identity=32.972972972973, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24663005, Length=554, Percent_Identity=31.0469314079422, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 59062; Mature: 59062

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRHDVLILGSGLAALTTALKLADQRRVAIVTKRRMTDGASDWAQGGIAAALASGDSIEA
CCCCCEEEEECCHHHHHHHHHHHCCCEEEEEEHHHCCCCCCHHHCCCEEEEECCCCCEEE
HVHDTLVAGAGLCDEAVTRLVASQAREMIDWLTRNGVAFTPDPESPGALHLAREGGHSKR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCCCC
RVVHAADATGHAVQTTLLDRVRAHPNIETFEDHVAIDLISGKRAGGEERQIHGAYALNKG
EEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECC
SGEVETFAAGHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANLEFVQFHPTCL
CCCEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEEEEEECCEEE
YHPHAKSFLISEAVRGEGGHLLLPDGSRFMQFHDTRAELAPRDVVARAIDFEMKKRGIDC
ECCCHHHHHHHHHHCCCCCEEECCCCHHHHEEECCHHHCCHHHHHHHHHHHHHHHCCCCE
VYLDISHKPADFVRAHFPTIYQRCLELGIDITREPIPVVPAAHYTCGGVVTDTEARTDLC
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHH
NLHAVGEVTFTGLHGANRLASNSLLECLVFGHAAARDILSTPPAPTLELPPWDASRVTDA
CEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCC
DEEVVISHNWDELRRFMWDYVGIVRTNKRLARASHRIRLLRGEIDEFYRNFRVSNDLIEL
CCCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RNLVQSADLIVRCAQLRQESRGLHYSRDYPEILPVAGNTVLNPRPGTLCPSVCGVTSEAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEECCCCCCCCHHHHCCCCCCC
L
C
>Mature Secondary Structure
MHRHDVLILGSGLAALTTALKLADQRRVAIVTKRRMTDGASDWAQGGIAAALASGDSIEA
CCCCCEEEEECCHHHHHHHHHHHCCCEEEEEEHHHCCCCCCHHHCCCEEEEECCCCCEEE
HVHDTLVAGAGLCDEAVTRLVASQAREMIDWLTRNGVAFTPDPESPGALHLAREGGHSKR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCCCC
RVVHAADATGHAVQTTLLDRVRAHPNIETFEDHVAIDLISGKRAGGEERQIHGAYALNKG
EEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECC
SGEVETFAAGHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANLEFVQFHPTCL
CCCEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEEEEEECCEEE
YHPHAKSFLISEAVRGEGGHLLLPDGSRFMQFHDTRAELAPRDVVARAIDFEMKKRGIDC
ECCCHHHHHHHHHHCCCCCEEECCCCHHHHEEECCHHHCCHHHHHHHHHHHHHHHCCCCE
VYLDISHKPADFVRAHFPTIYQRCLELGIDITREPIPVVPAAHYTCGGVVTDTEARTDLC
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHH
NLHAVGEVTFTGLHGANRLASNSLLECLVFGHAAARDILSTPPAPTLELPPWDASRVTDA
CEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCC
DEEVVISHNWDELRRFMWDYVGIVRTNKRLARASHRIRLLRGEIDEFYRNFRVSNDLIEL
CCCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RNLVQSADLIVRCAQLRQESRGLHYSRDYPEILPVAGNTVLNPRPGTLCPSVCGVTSEAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEECCCCCCCCHHHHCCCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]