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The map label for this gene is degP [H]

Identifier: 74318109

GI number: 74318109

Start: 2182805

End: 2184199

Strand: Reverse

Name: degP [H]

Synonym: Tbd_2091

Alternate gene names: 74318109

Gene position: 2184199-2182805 (Counterclockwise)

Preceding gene: 74318110

Following gene: 74318108

Centisome position: 75.06

GC content: 67.17

Gene sequence:

>1395_bases
ATGTTGAGAGCGGCTCTGGCCATGACGAGCTTCGTGTTTGTGCTGGCGGCGCCGGTCGCGGAAGCGGTCGACGTCGCCGA
TCTGGTCGAAAAGCAGGGTCCGGCGGTGGTCAACATCAGCACCACCAAGCTGGTCAAGCGCGGCGCCGAGGGCTTTCCGT
TCGCGGTCCCGGAAGACCCCGAGATGCAGGAATTCTTTCGCCGCTTCTTTCCGGGCGTGCCGGGTCGGGCGCCCGGGGCA
CCGGCGCAGGAGTTTCCGGCGCATGGCGCCGGCTCCGGCTTCATCGTTAGTAGCGACGGCTACATCCTGACCAACGCCCA
CGTCGTGAAAGGTGCGGACGAAGTCGTCGTCAAGCTGACCGACAAACGCAAGTTCATCGCCAAGGTCGTGGGTTCGGACC
CGCGCACCGACGTGGCCGTGATCCGCATCACGGCGCGCAACCTGCCGGCGGTGCGCCTCGGCGACCCGGAAAAACTTCGC
GTCGGTGAGGCAGTGGCTGCGATCGGCTCGCCTTTCGGCTTCGAGAACTCGGTCACCGCGGGCATCGTGTCGGCCAAGGG
CCGCTCGCTGCCGTCCGAAAGCTACGTGCCCTTCATCCAGACCGACGTCGCGGTTAACCCGGGTAATTCGGGGGGGCCGC
TGTTCAACATGCGCGGCGAAGTCGTCGGCATCAACTCGCAGATCTACAGCCAGAGCGGCGGCTACCAGGGGGTGGCGTTC
GCGATCCCGATCGACATCGCGATGGAGGTCGTCGACCAGTTGAAGGCTGGCGGCAAGGTCTCGCGCGGCTGGCTTGGCGT
CATGATCCAGGAGGTCAGCGCGGACCTCGCCGAATCCTTCGGCCTCGACCGGCCGCGCGGCGCGCTCGTGTCGCAGGTAC
AGGATGGAAGCCCCGCGGCCCGTGCGGGCGTCCAGACCGCCGACGTGATCCTCAGCTTCAACGGCAAGCCGGTCGAGAAT
TCTGGCGACCTGCCGCGCATCGTCGGCAGCACCAAGCCCGGGTCGAAGATCCCGATGCAGGTCTGGCGGCGCGGCAAAAT
GCAGACCCTGCAGGTCGTCCTGGCCGAGCTGCCGAGCGAAGAGCAGGTCGCCGGCGCGGGCAAGAGCGGCAAGAGCTACT
CGCGCGGCGGCCTCGCGCTGTCCGAACTCAACCCCGAACAGCGGCGCGAGCTCAAGATCGACCACGGCCTGCTCGTCGAG
GAAGTCACCGGCGACGCCGCTCGGGCCGGCATCCGGGTGGGGGACATCGTCCTCGCCGTCAACAATGCAAGGATCGCGAC
CGTCGACGCGTTCCGCCAGGCGATCGCGGCGATCCCGAAAGGCAAGAGCGCTGCGCTCCTGGTGCGGCGCGGCGAAGGAT
CGCTGTACATCCCGCTGAAGATTTCGGGTGAGTAA

Upstream 100 bases:

>100_bases
CAGCCCTTGGCGGGCTCTTCGTCCGCAATGCGCGCGCGCCGCGTCCGGCGGTGCTGAGGCGCGAACCATCCCCCTTGTTA
CACATGAAGAAAGGATAGCC

Downstream 100 bases:

>100_bases
GACGCTCACCCTCTACACCCGCGCCGGCTGCCCGCTGTGCGAGGAGATGGCGGGGGCGGCCGCTGCCGCGTTGAGCGGAA
CCGGCCACCGCATCGCGCCG

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MLRAALAMTSFVFVLAAPVAEAVDVADLVEKQGPAVVNISTTKLVKRGAEGFPFAVPEDPEMQEFFRRFFPGVPGRAPGA
PAQEFPAHGAGSGFIVSSDGYILTNAHVVKGADEVVVKLTDKRKFIAKVVGSDPRTDVAVIRITARNLPAVRLGDPEKLR
VGEAVAAIGSPFGFENSVTAGIVSAKGRSLPSESYVPFIQTDVAVNPGNSGGPLFNMRGEVVGINSQIYSQSGGYQGVAF
AIPIDIAMEVVDQLKAGGKVSRGWLGVMIQEVSADLAESFGLDRPRGALVSQVQDGSPAARAGVQTADVILSFNGKPVEN
SGDLPRIVGSTKPGSKIPMQVWRRGKMQTLQVVLAELPSEEQVAGAGKSGKSYSRGGLALSELNPEQRRELKIDHGLLVE
EVTGDAARAGIRVGDIVLAVNNARIATVDAFRQAIAAIPKGKSAALLVRRGEGSLYIPLKISGE

Sequences:

>Translated_464_residues
MLRAALAMTSFVFVLAAPVAEAVDVADLVEKQGPAVVNISTTKLVKRGAEGFPFAVPEDPEMQEFFRRFFPGVPGRAPGA
PAQEFPAHGAGSGFIVSSDGYILTNAHVVKGADEVVVKLTDKRKFIAKVVGSDPRTDVAVIRITARNLPAVRLGDPEKLR
VGEAVAAIGSPFGFENSVTAGIVSAKGRSLPSESYVPFIQTDVAVNPGNSGGPLFNMRGEVVGINSQIYSQSGGYQGVAF
AIPIDIAMEVVDQLKAGGKVSRGWLGVMIQEVSADLAESFGLDRPRGALVSQVQDGSPAARAGVQTADVILSFNGKPVEN
SGDLPRIVGSTKPGSKIPMQVWRRGKMQTLQVVLAELPSEEQVAGAGKSGKSYSRGGLALSELNPEQRRELKIDHGLLVE
EVTGDAARAGIRVGDIVLAVNNARIATVDAFRQAIAAIPKGKSAALLVRRGEGSLYIPLKISGE
>Mature_464_residues
MLRAALAMTSFVFVLAAPVAEAVDVADLVEKQGPAVVNISTTKLVKRGAEGFPFAVPEDPEMQEFFRRFFPGVPGRAPGA
PAQEFPAHGAGSGFIVSSDGYILTNAHVVKGADEVVVKLTDKRKFIAKVVGSDPRTDVAVIRITARNLPAVRLGDPEKLR
VGEAVAAIGSPFGFENSVTAGIVSAKGRSLPSESYVPFIQTDVAVNPGNSGGPLFNMRGEVVGINSQIYSQSGGYQGVAF
AIPIDIAMEVVDQLKAGGKVSRGWLGVMIQEVSADLAESFGLDRPRGALVSQVQDGSPAARAGVQTADVILSFNGKPVEN
SGDLPRIVGSTKPGSKIPMQVWRRGKMQTLQVVLAELPSEEQVAGAGKSGKSYSRGGLALSELNPEQRRELKIDHGLLVE
EVTGDAARAGIRVGDIVLAVNNARIATVDAFRQAIAAIPKGKSAALLVRRGEGSLYIPLKISGE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=283, Percent_Identity=36.3957597173145, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4506141, Length=349, Percent_Identity=35.243553008596, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI22129776, Length=340, Percent_Identity=33.2352941176471, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI7019477, Length=347, Percent_Identity=34.5821325648415, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1786356, Length=458, Percent_Identity=37.117903930131, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789629, Length=443, Percent_Identity=37.4717832957111, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=39.4927536231884, Blast_Score=192, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24646839, Length=257, Percent_Identity=36.5758754863813, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 48680; Mature: 48680

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRAALAMTSFVFVLAAPVAEAVDVADLVEKQGPAVVNISTTKLVKRGAEGFPFAVPEDP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCCCCCCCC
EMQEFFRRFFPGVPGRAPGAPAQEFPAHGAGSGFIVSSDGYILTNAHVVKGADEVVVKLT
CHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCEEEEECCCEEEECCEEECCCCEEEEEEC
DKRKFIAKVVGSDPRTDVAVIRITARNLPAVRLGDPEKLRVGEAVAAIGSPFGFENSVTA
CHHHHHHHHHCCCCCCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCE
GIVSAKGRSLPSESYVPFIQTDVAVNPGNSGGPLFNMRGEVVGINSQIYSQSGGYQGVAF
EEEECCCCCCCCCCCCCEEEECEEECCCCCCCCEEECCCCEEEECHHHHCCCCCCCCEEE
AIPIDIAMEVVDQLKAGGKVSRGWLGVMIQEVSADLAESFGLDRPRGALVSQVQDGSPAA
EEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHH
RAGVQTADVILSFNGKPVENSGDLPRIVGSTKPGSKIPMQVWRRGKMQTLQVVLAELPSE
HCCCCEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCH
EQVAGAGKSGKSYSRGGLALSELNPEQRRELKIDHGLLVEEVTGDAARAGIRVGDIVLAV
HHHCCCCCCCCCCCCCCEEHHHCCHHHHHHEECCCCEEEEHHCCHHHHCCCEEEEEEEEE
NNARIATVDAFRQAIAAIPKGKSAALLVRRGEGSLYIPLKISGE
CCCEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCC
>Mature Secondary Structure
MLRAALAMTSFVFVLAAPVAEAVDVADLVEKQGPAVVNISTTKLVKRGAEGFPFAVPEDP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCCCCCCCC
EMQEFFRRFFPGVPGRAPGAPAQEFPAHGAGSGFIVSSDGYILTNAHVVKGADEVVVKLT
CHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCEEEEECCCEEEECCEEECCCCEEEEEEC
DKRKFIAKVVGSDPRTDVAVIRITARNLPAVRLGDPEKLRVGEAVAAIGSPFGFENSVTA
CHHHHHHHHHCCCCCCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCE
GIVSAKGRSLPSESYVPFIQTDVAVNPGNSGGPLFNMRGEVVGINSQIYSQSGGYQGVAF
EEEECCCCCCCCCCCCCEEEECEEECCCCCCCCEEECCCCEEEECHHHHCCCCCCCCEEE
AIPIDIAMEVVDQLKAGGKVSRGWLGVMIQEVSADLAESFGLDRPRGALVSQVQDGSPAA
EEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHH
RAGVQTADVILSFNGKPVENSGDLPRIVGSTKPGSKIPMQVWRRGKMQTLQVVLAELPSE
HCCCCEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCH
EQVAGAGKSGKSYSRGGLALSELNPEQRRELKIDHGLLVEEVTGDAARAGIRVGDIVLAV
HHHCCCCCCCCCCCCCCEEHHHCCHHHHHHEECCCCEEEEHHCCHHHHCCCEEEEEEEEE
NNARIATVDAFRQAIAAIPKGKSAALLVRRGEGSLYIPLKISGE
CCCEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]