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The map label for this gene is 74318043

Identifier: 74318043

GI number: 74318043

Start: 2116263

End: 2117186

Strand: Direct

Name: 74318043

Synonym: Tbd_2025

Alternate gene names: NA

Gene position: 2116263-2117186 (Clockwise)

Preceding gene: 74318041

Following gene: 74318046

Centisome position: 72.73

GC content: 69.37

Gene sequence:

>924_bases
ATGCACACCGCCTACCTCACCCACGCCGATTGCCTGATGCACGACATGGGCAGCTGGCATCCCGAAAGCCCGGCCCGCCT
GCGCGCGATCGACGATCGCCTGCACGCCGCGCACCTGTTCGATCATCTCGCGCATCACGAGGCACCGCGCGTGCAACGCG
CGCAGTTGCTGCGCGTGCACGACGCGGCTTACGTCGACTTCATTGAGGCGAGCTCGCCTGAACACGGCGTGCGCGCGCTC
GACGCCGACACCAGCATGAATCCGCACACGCTCTCCGCCGCGCTGCGGGCAGCCGGCGGCGCCGCGATGGCGGTCGATCT
CGTGATGGGAGACGACACCGCGAACGCCTTCGTCGCCTGCCGCCCGCCCGGCCATCACGCGACGCGGAGGCGGGCGATGG
GCTTCTGCATCTTCAACAACGTCGCGGTCGCGGCGGCCCAGGCGCTCGACGTCCACGGACTCGAGCGTGTCGCGATCGTC
GACTTCGACGTCCATCACGGCAACGGGACGGAGGACATTTTTCGCGACGACCCGCGCGTGATGCTGTGCTCGACCTTCCA
GCATCCCTTCTATCCGTTCGCCGGCGCCGACACGGCCAGCGCGCACATCGTCAATGTGCCGCTGCCGGCCGGCACCGACG
GCGCACGCTACCGCGATGCCTTCCGCGCGCAGATCGTGCCGCGCCTCGACGCCTTCGCACCGCAGATGCTGTTCTGCTCG
GCCGGCTTCGACGGCCACCGCGAGGACGACATGGCCCAGTTCGGCCTGCTCGAAGCCGATTACGTCTGGATCACCGAACA
GGTCATGGCCGTCGCGGCGCGCCACGCGTGCGGGCGCATCGTCTCGGTGCTGGAGGGGGGCTACGACCTGAGTTCGCTCG
GCCGCAGCGCCGCGGCGCACATCAAGACGCTCGCAGCGCTCTGA

Upstream 100 bases:

>100_bases
GGCGGTCCGAAGAGGCGTGGCGGCGCTTGGCGCGGTGAGCTCATCCTAGGCCACCGCCTGTGCCCGCGCCACCTGTCGTA
TAGTGGAGAAGAACGCCGCC

Downstream 100 bases:

>100_bases
GCGCGGGCCTGCACAACCGGCGCGTCGCGTGCAACCCGCAAAAAAAAAGCGGGCGCCCGCTGGCGCCCGCTTGCCTTCCG
CGAGAGGGCTCGGCTCAGTA

Product: histone deacetylase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MHTAYLTHADCLMHDMGSWHPESPARLRAIDDRLHAAHLFDHLAHHEAPRVQRAQLLRVHDAAYVDFIEASSPEHGVRAL
DADTSMNPHTLSAALRAAGGAAMAVDLVMGDDTANAFVACRPPGHHATRRRAMGFCIFNNVAVAAAQALDVHGLERVAIV
DFDVHHGNGTEDIFRDDPRVMLCSTFQHPFYPFAGADTASAHIVNVPLPAGTDGARYRDAFRAQIVPRLDAFAPQMLFCS
AGFDGHREDDMAQFGLLEADYVWITEQVMAVAARHACGRIVSVLEGGYDLSSLGRSAAAHIKTLAAL

Sequences:

>Translated_307_residues
MHTAYLTHADCLMHDMGSWHPESPARLRAIDDRLHAAHLFDHLAHHEAPRVQRAQLLRVHDAAYVDFIEASSPEHGVRAL
DADTSMNPHTLSAALRAAGGAAMAVDLVMGDDTANAFVACRPPGHHATRRRAMGFCIFNNVAVAAAQALDVHGLERVAIV
DFDVHHGNGTEDIFRDDPRVMLCSTFQHPFYPFAGADTASAHIVNVPLPAGTDGARYRDAFRAQIVPRLDAFAPQMLFCS
AGFDGHREDDMAQFGLLEADYVWITEQVMAVAARHACGRIVSVLEGGYDLSSLGRSAAAHIKTLAAL
>Mature_307_residues
MHTAYLTHADCLMHDMGSWHPESPARLRAIDDRLHAAHLFDHLAHHEAPRVQRAQLLRVHDAAYVDFIEASSPEHGVRAL
DADTSMNPHTLSAALRAAGGAAMAVDLVMGDDTANAFVACRPPGHHATRRRAMGFCIFNNVAVAAAQALDVHGLERVAIV
DFDVHHGNGTEDIFRDDPRVMLCSTFQHPFYPFAGADTASAHIVNVPLPAGTDGARYRDAFRAQIVPRLDAFAPQMLFCS
AGFDGHREDDMAQFGLLEADYVWITEQVMAVAARHACGRIVSVLEGGYDLSSLGRSAAAHIKTLAAL

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=312, Percent_Identity=34.2948717948718, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI20070354, Length=325, Percent_Identity=33.8461538461538, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI226529806, Length=325, Percent_Identity=32.6153846153846, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI17158039, Length=325, Percent_Identity=28.9230769230769, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI62750347, Length=328, Percent_Identity=29.5731707317073, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI30795204, Length=325, Percent_Identity=28.9230769230769, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI30795202, Length=325, Percent_Identity=28.9230769230769, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI62750349, Length=328, Percent_Identity=29.5731707317073, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI153085395, Length=326, Percent_Identity=31.2883435582822, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI148539870, Length=246, Percent_Identity=34.9593495934959, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI169234807, Length=246, Percent_Identity=34.9593495934959, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI13128862, Length=270, Percent_Identity=24.8148148148148, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI13128860, Length=268, Percent_Identity=23.134328358209, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI293336691, Length=269, Percent_Identity=23.4200743494424, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI209862883, Length=170, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI217272877, Length=169, Percent_Identity=31.3609467455621, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=306, Percent_Identity=33.9869281045752, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17540332, Length=306, Percent_Identity=33.9869281045752, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI193206283, Length=306, Percent_Identity=33.9869281045752, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25154020, Length=297, Percent_Identity=31.986531986532, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25154022, Length=298, Percent_Identity=31.8791946308725, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI193209491, Length=320, Percent_Identity=31.5625, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17537347, Length=296, Percent_Identity=31.4189189189189, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17534739, Length=324, Percent_Identity=25.6172839506173, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508561, Length=264, Percent_Identity=25.3787878787879, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561978, Length=274, Percent_Identity=23.7226277372263, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=269, Percent_Identity=31.9702602230483, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323999, Length=268, Percent_Identity=26.4925373134328, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321244, Length=257, Percent_Identity=25.2918287937743, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6325141, Length=285, Percent_Identity=23.859649122807, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325325, Length=138, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24642146, Length=312, Percent_Identity=33.6538461538462, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24642144, Length=312, Percent_Identity=33.6538461538462, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24642142, Length=312, Percent_Identity=33.6538461538462, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI281360899, Length=312, Percent_Identity=33.6538461538462, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24641720, Length=335, Percent_Identity=29.8507462686567, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360801, Length=339, Percent_Identity=30.0884955752212, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281360799, Length=339, Percent_Identity=30.0884955752212, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24657891, Length=274, Percent_Identity=25.5474452554745, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644244, Length=273, Percent_Identity=24.1758241758242, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33311; Mature: 33311

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTAYLTHADCLMHDMGSWHPESPARLRAIDDRLHAAHLFDHLAHHEAPRVQRAQLLRVH
CCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DAAYVDFIEASSPEHGVRALDADTSMNPHTLSAALRAAGGAAMAVDLVMGDDTANAFVAC
HHHHHEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEE
RPPGHHATRRRAMGFCIFNNVAVAAAQALDVHGLERVAIVDFDVHHGNGTEDIFRDDPRV
CCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHCCCCCE
MLCSTFQHPFYPFAGADTASAHIVNVPLPAGTDGARYRDAFRAQIVPRLDAFAPQMLFCS
EEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AGFDGHREDDMAQFGLLEADYVWITEQVMAVAARHACGRIVSVLEGGYDLSSLGRSAAAH
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IKTLAAL
HHHHHCC
>Mature Secondary Structure
MHTAYLTHADCLMHDMGSWHPESPARLRAIDDRLHAAHLFDHLAHHEAPRVQRAQLLRVH
CCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DAAYVDFIEASSPEHGVRALDADTSMNPHTLSAALRAAGGAAMAVDLVMGDDTANAFVAC
HHHHHEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEE
RPPGHHATRRRAMGFCIFNNVAVAAAQALDVHGLERVAIVDFDVHHGNGTEDIFRDDPRV
CCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHCCCCCE
MLCSTFQHPFYPFAGADTASAHIVNVPLPAGTDGARYRDAFRAQIVPRLDAFAPQMLFCS
EEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AGFDGHREDDMAQFGLLEADYVWITEQVMAVAARHACGRIVSVLEGGYDLSSLGRSAAAH
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IKTLAAL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]