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The map label for this gene is pgsA1 [H]

Identifier: 74318025

GI number: 74318025

Start: 2094362

End: 2094955

Strand: Reverse

Name: pgsA1 [H]

Synonym: Tbd_2007

Alternate gene names: 74318025

Gene position: 2094955-2094362 (Counterclockwise)

Preceding gene: 74318026

Following gene: 74318023

Centisome position: 72.0

GC content: 69.19

Gene sequence:

>594_bases
GTGGAGACGCGCGTTTTGAATCTGCCGAACAGCATCAGCCTGCTGCGCCTGGCGGCCGTGCCGCTCGTCGCCTGGCTGAT
TCTGCAACAGCACTGGTTCGCAGCCTGCCTGCTGTTTCTCGCGGCGGCTGTCTCCGACGCGATCGACGGCCTGCTCGCAC
GCTGGCTCGAGCAGACGACGCCGCTCGGCGCGGCGCTCGATAGTGTCGCCGACAAGGCGCTGGGCCTGGTGACGCTCGTG
CTGCTGACGCAGGCCGGCGCGATCCCCGTCTGGGTGGCCGTCGCGATCCTGCTGCGCGACAGCGTGATCGTCCTCGGCGC
GCTGTGCTATCGCGGCCTCGCGGGTCACCTCGACATCCATCCGACCTGGCTCGGCAAGGCGCACATGTTCGTCGCGTTCG
CGATGCTTGCGCTCGTGCTGGGCACGCGTGCCGACCTGCTCGCGCTCGGCGCCTGGCAAACGCCGCTATTCGCGGCCGTA
TTCGGAATCGCCGTCGCCTCGGGCGTGCAATACGTCTGGATATGGGGCGGCCGGGCGAGGCGCGAGCGGCAGGATGCCGT
CTTCAAGGCCGGCAGCGAGGGCCTGGAACCGTAA

Upstream 100 bases:

>100_bases
CGCGCAGGAGCTGAAGACGCCGTACCCGGTCTCGGTCAAGCGGCTCGACAAGGTCTGGGACACGCTTGCCAGGCAGCCGC
TCGATCAGTAGGGTAGGCGC

Downstream 100 bases:

>100_bases
CCCACTCAAGGCTGCCCGCCTTGGTTGATTCAACGCGCTGGTGGTGCCGTGGGGTACGACCAGGCGCGCCGCAGCGCGTC
GAGGGTCCGCGTCACCTCGT

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
METRVLNLPNSISLLRLAAVPLVAWLILQQHWFAACLLFLAAAVSDAIDGLLARWLEQTTPLGAALDSVADKALGLVTLV
LLTQAGAIPVWVAVAILLRDSVIVLGALCYRGLAGHLDIHPTWLGKAHMFVAFAMLALVLGTRADLLALGAWQTPLFAAV
FGIAVASGVQYVWIWGGRARRERQDAVFKAGSEGLEP

Sequences:

>Translated_197_residues
METRVLNLPNSISLLRLAAVPLVAWLILQQHWFAACLLFLAAAVSDAIDGLLARWLEQTTPLGAALDSVADKALGLVTLV
LLTQAGAIPVWVAVAILLRDSVIVLGALCYRGLAGHLDIHPTWLGKAHMFVAFAMLALVLGTRADLLALGAWQTPLFAAV
FGIAVASGVQYVWIWGGRARRERQDAVFKAGSEGLEP
>Mature_197_residues
METRVLNLPNSISLLRLAAVPLVAWLILQQHWFAACLLFLAAAVSDAIDGLLARWLEQTTPLGAALDSVADKALGLVTLV
LLTQAGAIPVWVAVAILLRDSVIVLGALCYRGLAGHLDIHPTWLGKAHMFVAFAMLALVLGTRADLLALGAWQTPLFAAV
FGIAVASGVQYVWIWGGRARRERQDAVFKAGSEGLEP

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=148, Percent_Identity=31.7567567567568, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI10092647, Length=148, Percent_Identity=31.7567567567568, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984834, Length=186, Percent_Identity=28.494623655914, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71984838, Length=164, Percent_Identity=29.2682926829268, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320059, Length=114, Percent_Identity=32.4561403508772, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21054; Mature: 21054

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRVLNLPNSISLLRLAAVPLVAWLILQQHWFAACLLFLAAAVSDAIDGLLARWLEQTT
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLGAALDSVADKALGLVTLVLLTQAGAIPVWVAVAILLRDSVIVLGALCYRGLAGHLDIH
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTWLGKAHMFVAFAMLALVLGTRADLLALGAWQTPLFAAVFGIAVASGVQYVWIWGGRAR
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCHHH
RERQDAVFKAGSEGLEP
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure
METRVLNLPNSISLLRLAAVPLVAWLILQQHWFAACLLFLAAAVSDAIDGLLARWLEQTT
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLGAALDSVADKALGLVTLVLLTQAGAIPVWVAVAILLRDSVIVLGALCYRGLAGHLDIH
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTWLGKAHMFVAFAMLALVLGTRADLLALGAWQTPLFAAVFGIAVASGVQYVWIWGGRAR
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCHHH
RERQDAVFKAGSEGLEP
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]