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The map label for this gene is lspA [H]

Identifier: 74317876

GI number: 74317876

Start: 1953426

End: 1953899

Strand: Direct

Name: lspA [H]

Synonym: Tbd_1858

Alternate gene names: 74317876

Gene position: 1953426-1953899 (Clockwise)

Preceding gene: 74317875

Following gene: 74317877

Centisome position: 67.13

GC content: 64.98

Gene sequence:

>474_bases
ATGCGCAAGTGGCTGGGCCTCGCCTTCGCCATCATCGTCGCGGACCACCTGACCAAGTTCTGGGTCTCGTCGACTCTCGA
ATACCAGGAAGCGATTCCGGTCCTGCCGTTCTTTTCGCTCGTGCTCGTGCACAACACCGGCGCCGCATTCAGCTTTCTCG
CGAACGCGGGCGGCTGGCAGCGCTGGTTCTTCATCGCGGTCGGCATCGTCGCCACCGTGATCATCGTGCGACTGCTCGGG
CGCCACGGCGACGAGCCCCGGCTGGCGCTTCCGCTCGCACTTGTCCTCGGCGGCGCGCTCGGCAACGTGATCGACCGCGT
CGTGCTGGGGCACGTCGTCGATTTCCTGTATTTCCACTATCGAAGCTTCGCCTGGCCTGCATTCAACGTTGCCGATTCGG
CGATCACCGTCGGCGCGGCCCTGCTGATCTGGGACAGCCTGCGCGGCAAGCCGAGCCCGGCCAAGGAATCATGA

Upstream 100 bases:

>100_bases
GACGCGCACCCCGAGCACCCGGGCTTGTGCGGCCGCTGCGTCAGCAATCTCTTCGGAGACGGCGAGGCGCGCCGCCATGC
GTAAACCCGCGACGCCTGCG

Downstream 100 bases:

>100_bases
GCTCGCGCGCCGTCGCCGCCGGCGACACGCTCGAACTTCGCTACGCGCTGCGTCCGCGCGGAGGCGACGATCTCGTCTCG
AACTTCGACGACCCTGAAGC

Product: signal peptidase II

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MRKWLGLAFAIIVADHLTKFWVSSTLEYQEAIPVLPFFSLVLVHNTGAAFSFLANAGGWQRWFFIAVGIVATVIIVRLLG
RHGDEPRLALPLALVLGGALGNVIDRVVLGHVVDFLYFHYRSFAWPAFNVADSAITVGAALLIWDSLRGKPSPAKES

Sequences:

>Translated_157_residues
MRKWLGLAFAIIVADHLTKFWVSSTLEYQEAIPVLPFFSLVLVHNTGAAFSFLANAGGWQRWFFIAVGIVATVIIVRLLG
RHGDEPRLALPLALVLGGALGNVIDRVVLGHVVDFLYFHYRSFAWPAFNVADSAITVGAALLIWDSLRGKPSPAKES
>Mature_157_residues
MRKWLGLAFAIIVADHLTKFWVSSTLEYQEAIPVLPFFSLVLVHNTGAAFSFLANAGGWQRWFFIAVGIVATVIIVRLLG
RHGDEPRLALPLALVLGGALGNVIDRVVLGHVVDFLYFHYRSFAWPAFNVADSAITVGAALLIWDSLRGKPSPAKES

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=156, Percent_Identity=38.4615384615385, Blast_Score=109, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 17215; Mature: 17215

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKWLGLAFAIIVADHLTKFWVSSTLEYQEAIPVLPFFSLVLVHNTGAAFSFLANAGGWQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCCCCHH
RWFFIAVGIVATVIIVRLLGRHGDEPRLALPLALVLGGALGNVIDRVVLGHVVDFLYFHY
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSFAWPAFNVADSAITVGAALLIWDSLRGKPSPAKES
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRKWLGLAFAIIVADHLTKFWVSSTLEYQEAIPVLPFFSLVLVHNTGAAFSFLANAGGWQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCCCCHH
RWFFIAVGIVATVIIVRLLGRHGDEPRLALPLALVLGGALGNVIDRVVLGHVVDFLYFHY
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSFAWPAFNVADSAITVGAALLIWDSLRGKPSPAKES
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA