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The map label for this gene is rmlA1 [H]

Identifier: 74317797

GI number: 74317797

Start: 1878398

End: 1879279

Strand: Reverse

Name: rmlA1 [H]

Synonym: Tbd_1779

Alternate gene names: 74317797

Gene position: 1879279-1878398 (Counterclockwise)

Preceding gene: 74317798

Following gene: 74317796

Centisome position: 64.58

GC content: 62.47

Gene sequence:

>882_bases
ATGAAGCGCAAGGGCATCATCCTCGCCGGCGGTTCCGGTACCCGCCTCTATCCGGCGACCCTGGCAGTCTCGAAGCAGCT
GCTGCCGATTTACGACAAGCCGATGATCTATTACCCGCTCACGACGCTGATGCTGGCGGGGATTCAGGACATTCTCGTCA
TCTCGACCCCGCAGGACACGCCACGCTTCGAGCAGTTGCTCGGCGACGGCAGTCAGTGGGGCATCAATCTGCAGTATGCG
GTCCAGGCCAAGCCCGAGGGGCTCGCGCAGGCCTTCGTGATCGGCGCGGACTTCGTCGGCAACGGGCCGAGTGCCCTCGT
GCTCGGCGACAATATCTTCTACGGCCACGAGATGACCGACGATCTCGGGTCGGCCAGCGTCAGGGACACCGGCGCAACGG
TCTTCGCGTATCGCGTGCACGATCCGGAACGTTACGGCGTGGTTGAATTCGACGACGCAGGAAACGCGATCAGCCTGGAA
GAAAAGCCCGCGCAGCCGAAGTCGCATTACGCCGTCACCGGCCTCTATTTCTACGACAGCCAGGTCGTCGACATCGCGCG
CAATCTCAAGCCCTCGGCGCGCGGCGAACTGGAAATCACTGACGTCAACCGCCACTACCTCGAAGCGGGCGAGCTCAAGG
TCTCGATCATGGGCCGCGGCCACGCCTGGCTCGACACGGGCACCCACGAATCGATGCTCGAGGCCTCGCTCTTCATCGAG
ACGATCGAGAAGCGCCAGGGGCTCAAGATCGCCTGCCCGGAAGAGATTGCGTACCGCAAGCGCTACATCGACGCCGAACA
ACTCGCGAAGCTGGCCGCGCCGATGAAGAAGAACGGCTACGGAAGGTACCTGCTGGAAATTCTGGACGAGCATGTCTTCT
AG

Upstream 100 bases:

>100_bases
CGGTGCGCTGGTACCTCGACAACATGGCCTGGGTCGAACACGTCGCGAGCGGCGCGTATCGCAATTGGGTCGAAACGAAT
TATTCAGAAAGAGTTCAGGC

Downstream 100 bases:

>100_bases
CGTGTGCCCCCACTCCGTTTCATCCGTCCTCGGGAGAGCGGCATGAACGTCGTCAAGACCTCGCTTCCGGAAGTCCTCTT
GCTCGAGCCCAAGGTCTTCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKRKGIILAGGSGTRLYPATLAVSKQLLPIYDKPMIYYPLTTLMLAGIQDILVISTPQDTPRFEQLLGDGSQWGINLQYA
VQAKPEGLAQAFVIGADFVGNGPSALVLGDNIFYGHEMTDDLGSASVRDTGATVFAYRVHDPERYGVVEFDDAGNAISLE
EKPAQPKSHYAVTGLYFYDSQVVDIARNLKPSARGELEITDVNRHYLEAGELKVSIMGRGHAWLDTGTHESMLEASLFIE
TIEKRQGLKIACPEEIAYRKRYIDAEQLAKLAAPMKKNGYGRYLLEILDEHVF

Sequences:

>Translated_293_residues
MKRKGIILAGGSGTRLYPATLAVSKQLLPIYDKPMIYYPLTTLMLAGIQDILVISTPQDTPRFEQLLGDGSQWGINLQYA
VQAKPEGLAQAFVIGADFVGNGPSALVLGDNIFYGHEMTDDLGSASVRDTGATVFAYRVHDPERYGVVEFDDAGNAISLE
EKPAQPKSHYAVTGLYFYDSQVVDIARNLKPSARGELEITDVNRHYLEAGELKVSIMGRGHAWLDTGTHESMLEASLFIE
TIEKRQGLKIACPEEIAYRKRYIDAEQLAKLAAPMKKNGYGRYLLEILDEHVF
>Mature_293_residues
MKRKGIILAGGSGTRLYPATLAVSKQLLPIYDKPMIYYPLTTLMLAGIQDILVISTPQDTPRFEQLLGDGSQWGINLQYA
VQAKPEGLAQAFVIGADFVGNGPSALVLGDNIFYGHEMTDDLGSASVRDTGATVFAYRVHDPERYGVVEFDDAGNAISLE
EKPAQPKSHYAVTGLYFYDSQVVDIARNLKPSARGELEITDVNRHYLEAGELKVSIMGRGHAWLDTGTHESMLEASLFIE
TIEKRQGLKIACPEEIAYRKRYIDAEQLAKLAAPMKKNGYGRYLLEILDEHVF

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=73.6842105263158, Blast_Score=450, Evalue=1e-128,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=64.9122807017544, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1787488, Length=279, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=27.0833333333333, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=252, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=21.9123505976096, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=21.9123505976096, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32388; Mature: 32388

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKGIILAGGSGTRLYPATLAVSKQLLPIYDKPMIYYPLTTLMLAGIQDILVISTPQDT
CCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFEQLLGDGSQWGINLQYAVQAKPEGLAQAFVIGADFVGNGPSALVLGDNIFYGHEMTD
HHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCCC
DLGSASVRDTGATVFAYRVHDPERYGVVEFDDAGNAISLEEKPAQPKSHYAVTGLYFYDS
CCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECC
QVVDIARNLKPSARGELEITDVNRHYLEAGELKVSIMGRGHAWLDTGTHESMLEASLFIE
HHHHHHHCCCCCCCCCEEEEECCHHEEECCCEEEEEEECCCEEEECCCHHHHHHHHHHHH
TIEKRQGLKIACPEEIAYRKRYIDAEQLAKLAAPMKKNGYGRYLLEILDEHVF
HHHHHCCCEEECCHHHHHHHHCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKRKGIILAGGSGTRLYPATLAVSKQLLPIYDKPMIYYPLTTLMLAGIQDILVISTPQDT
CCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFEQLLGDGSQWGINLQYAVQAKPEGLAQAFVIGADFVGNGPSALVLGDNIFYGHEMTD
HHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCCC
DLGSASVRDTGATVFAYRVHDPERYGVVEFDDAGNAISLEEKPAQPKSHYAVTGLYFYDS
CCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECC
QVVDIARNLKPSARGELEITDVNRHYLEAGELKVSIMGRGHAWLDTGTHESMLEASLFIE
HHHHHHHCCCCCCCCCEEEEECCHHEEECCCEEEEEEECCCEEEECCCHHHHHHHHHHHH
TIEKRQGLKIACPEEIAYRKRYIDAEQLAKLAAPMKKNGYGRYLLEILDEHVF
HHHHHCCCEEECCHHHHHHHHCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]