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The map label for this gene is lolC [H]

Identifier: 74317779

GI number: 74317779

Start: 1854174

End: 1855418

Strand: Reverse

Name: lolC [H]

Synonym: Tbd_1761

Alternate gene names: 74317779

Gene position: 1855418-1854174 (Counterclockwise)

Preceding gene: 74317780

Following gene: 74317778

Centisome position: 63.76

GC content: 63.86

Gene sequence:

>1245_bases
TTGCTTCCTCTTGAGCTACTGGTCGGTCTGCGCTACACCCACGCGAAGCGCCGTAACCATTTCATCTCCTTCATTTCCGT
CGTCTCGATGGGCGGCATCGCACTCGGCGTGATGGCGCTGATCGTCGTGCTGTCGGTCATGAACGGCTTCCAGGAGGAAC
TGCGTGCGCGCATCCTCGGCGTCGCGGCGCATCTCGAGATCAGCGGTCCGGGGGACCGTCTCGCCGACTGGCGTTCCGTG
CTGGCGCAGGCGCAGCGCAACAAGGATGTCGTCTCCGGCGCGCCCTACGTCAATGCGCAGGGCATGCTCGCCAACGGCGA
CATGGTCCGCGGGGCGATCATTCGCGGCATCGTCCCCGGGATGGAAAACGCGGTGGCCGATTTTTCGCGGCACATGAAAG
CCGGGCGCCTGACCGACCTCAAGCCCGGCGAATTTGGCATCATCCTTGGGGGAGAACTGGCACGCGCGCTGAACGTCTTT
CCGGGTGACAAGCTCGTACTGCTCACGCCGCAGGGCAACATCACGCCGGCCGGGGTCATGCCGCGCGTCAAGCAGTTCAC
GGTTACCGGCATCTTCGAGGCCGGCATGTTCGAATACGACTCGGGCCTCGCCCTGATCCATCTGCAGGACGCGCAGAAGC
TGCTGCGACTCGGGCAGGACGTGTCGGGCGTGCGCCTCAAGCTCGATGAACTTTTCCGTGCGCCGTTCGTGACGCGCGAA
CTCGCGCAAACGCTGACGGGCGATTACTACCTCACCGACTGGACCCAGAGCCACGCCAATTTCTTTCGCGCCGTTGCGAT
CGAGAAGCGCATGATGTTCCTGATCCTGCTGTTGATCGTCGCGGTTGCCGCGTTCAACATCGTCTCCACGCTCGTGATGG
CGGTCACCGACAAACAGTCGGATATCGCGATCCTGCGCACCCTCGGCGCCCGACCGGGGTCGGTCATGGCGATCTTCATC
GTGCAGGGCGCCTTCATCGGCGTGCTCGGCGCCGCGATCGGGGTGACGGGCGGTGTATTCCTCGCGCTCAATCTCGAGAC
CGTCGTGCCAATCATCGAGCGCATGGCAGGCATGGATCTCTTCCCGGCCGACGTCTACTACATCAACGAGCTGCCCTCAA
AGCTCGACTGGAGCGAGGTCACGCTGATCGGCGGCGTGTCCTTGCTGATCAGCCTGCTCGCGACGCTCTATCCGAGCTGG
CGCGCGTCCCGCATCAACCCCGCCGAGGCGCTGCGCTATGAATGA

Upstream 100 bases:

>100_bases
TCGAACACCGGCGCGCGCCGCAGACGCGCAGCGTGGTCTTGCACCTGCTCGGCGAGTAGAGCTATGGCATACTCGACCGA
TTCATCCAGCGGGTCCCGTT

Downstream 100 bases:

>100_bases
AACCGTGCTGCGCTGCAGCGGGCTCGGCAAGACATTCCGCCAGGGCAAGGTCGACGTGCCGGTGCTGCGTTCGGTCGACC
TTGCGGTCGGCACCGCGGAG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLPLELLVGLRYTHAKRRNHFISFISVVSMGGIALGVMALIVVLSVMNGFQEELRARILGVAAHLEISGPGDRLADWRSV
LAQAQRNKDVVSGAPYVNAQGMLANGDMVRGAIIRGIVPGMENAVADFSRHMKAGRLTDLKPGEFGIILGGELARALNVF
PGDKLVLLTPQGNITPAGVMPRVKQFTVTGIFEAGMFEYDSGLALIHLQDAQKLLRLGQDVSGVRLKLDELFRAPFVTRE
LAQTLTGDYYLTDWTQSHANFFRAVAIEKRMMFLILLLIVAVAAFNIVSTLVMAVTDKQSDIAILRTLGARPGSVMAIFI
VQGAFIGVLGAAIGVTGGVFLALNLETVVPIIERMAGMDLFPADVYYINELPSKLDWSEVTLIGGVSLLISLLATLYPSW
RASRINPAEALRYE

Sequences:

>Translated_414_residues
MLPLELLVGLRYTHAKRRNHFISFISVVSMGGIALGVMALIVVLSVMNGFQEELRARILGVAAHLEISGPGDRLADWRSV
LAQAQRNKDVVSGAPYVNAQGMLANGDMVRGAIIRGIVPGMENAVADFSRHMKAGRLTDLKPGEFGIILGGELARALNVF
PGDKLVLLTPQGNITPAGVMPRVKQFTVTGIFEAGMFEYDSGLALIHLQDAQKLLRLGQDVSGVRLKLDELFRAPFVTRE
LAQTLTGDYYLTDWTQSHANFFRAVAIEKRMMFLILLLIVAVAAFNIVSTLVMAVTDKQSDIAILRTLGARPGSVMAIFI
VQGAFIGVLGAAIGVTGGVFLALNLETVVPIIERMAGMDLFPADVYYINELPSKLDWSEVTLIGGVSLLISLLATLYPSW
RASRINPAEALRYE
>Mature_414_residues
MLPLELLVGLRYTHAKRRNHFISFISVVSMGGIALGVMALIVVLSVMNGFQEELRARILGVAAHLEISGPGDRLADWRSV
LAQAQRNKDVVSGAPYVNAQGMLANGDMVRGAIIRGIVPGMENAVADFSRHMKAGRLTDLKPGEFGIILGGELARALNVF
PGDKLVLLTPQGNITPAGVMPRVKQFTVTGIFEAGMFEYDSGLALIHLQDAQKLLRLGQDVSGVRLKLDELFRAPFVTRE
LAQTLTGDYYLTDWTQSHANFFRAVAIEKRMMFLILLLIVAVAAFNIVSTLVMAVTDKQSDIAILRTLGARPGSVMAIFI
VQGAFIGVLGAAIGVTGGVFLALNLETVVPIIERMAGMDLFPADVYYINELPSKLDWSEVTLIGGVSLLISLLATLYPSW
RASRINPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=410, Percent_Identity=38.0487804878049, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1787360, Length=414, Percent_Identity=37.9227053140097, Blast_Score=218, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44919; Mature: 44919

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLELLVGLRYTHAKRRNHFISFISVVSMGGIALGVMALIVVLSVMNGFQEELRARILG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAHLEISGPGDRLADWRSVLAQAQRNKDVVSGAPYVNAQGMLANGDMVRGAIIRGIVPG
HHEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCC
MENAVADFSRHMKAGRLTDLKPGEFGIILGGELARALNVFPGDKLVLLTPQGNITPAGVM
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
PRVKQFTVTGIFEAGMFEYDSGLALIHLQDAQKLLRLGQDVSGVRLKLDELFRAPFVTRE
CHHHHEEEHHHHHCCCEEECCCEEEEEEHHHHHHHHCCCCCCHHEEEHHHHHCCCHHHHH
LAQTLTGDYYLTDWTQSHANFFRAVAIEKRMMFLILLLIVAVAAFNIVSTLVMAVTDKQS
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAILRTLGARPGSVMAIFIVQGAFIGVLGAAIGVTGGVFLALNLETVVPIIERMAGMDL
CHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCC
FPADVYYINELPSKLDWSEVTLIGGVSLLISLLATLYPSWRASRINPAEALRYE
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MLPLELLVGLRYTHAKRRNHFISFISVVSMGGIALGVMALIVVLSVMNGFQEELRARILG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAHLEISGPGDRLADWRSVLAQAQRNKDVVSGAPYVNAQGMLANGDMVRGAIIRGIVPG
HHEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCC
MENAVADFSRHMKAGRLTDLKPGEFGIILGGELARALNVFPGDKLVLLTPQGNITPAGVM
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
PRVKQFTVTGIFEAGMFEYDSGLALIHLQDAQKLLRLGQDVSGVRLKLDELFRAPFVTRE
CHHHHEEEHHHHHCCCEEECCCEEEEEEHHHHHHHHCCCCCCHHEEEHHHHHCCCHHHHH
LAQTLTGDYYLTDWTQSHANFFRAVAIEKRMMFLILLLIVAVAAFNIVSTLVMAVTDKQS
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAILRTLGARPGSVMAIFIVQGAFIGVLGAAIGVTGGVFLALNLETVVPIIERMAGMDL
CHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCC
FPADVYYINELPSKLDWSEVTLIGGVSLLISLLATLYPSWRASRINPAEALRYE
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]