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The map label for this gene is comA [H]

Identifier: 74317777

GI number: 74317777

Start: 1851154

End: 1853490

Strand: Reverse

Name: comA [H]

Synonym: Tbd_1759

Alternate gene names: 74317777

Gene position: 1853490-1851154 (Counterclockwise)

Preceding gene: 74317778

Following gene: 74317776

Centisome position: 63.7

GC content: 70.13

Gene sequence:

>2337_bases
ATGCGGGCCTATCTCCTCGCGTTTTGCCTCGGGATAGGCTGGTTGCAGCAGCAGGCCGAGCTGCCGCCGACCTCATGGCT
CTGGCTGTTGCCGCTGCTGTCGACCGTGCTTCTGCTGCCGCGTTTTTCCGCAGGGCCGGCCGCGCTCCTTCGCCGCGCCG
CCATCACGCTGTTGTGCGCGGCCCTGGGCGTCGCCTGGGCGACATGGCGCGCCGAACTGCGTCTTGCCGAACGGCTACCC
GACCACTGGCAGGGCGTCGACATCGAGCTCGTCGGCGTCATTGCCGCGCTGCCGCATGCCGACGCCCGCGGCGAACGCTT
CGTCCTCGATGTCGAAAAGGTTCTTACGCCGGGCGTGCCGACCATGCCGCGCGTGCAGCTCGCGCGTTACTGGCCGCGCG
ACGGCGTGCGCGAGGTCCGCATGCGGGCGGGCGAGCGTTGGCATCTGACGGTGCGCCTCAAAATCCCGCACGGCACGCAC
AATCTGCACGGCTTCGACCTCGAGGCGTGGATGCTCGAGCAGGGGATCGCCGCGTCGGGCTACGTGCGCGAGAAGCCCGT
GCCGCGACGCCTCGCAGCACAAGCGGCGACCGCCCGAGGCCGGATCGCGGCGGCGCGCGCCGACATCCGCAGCCGGATTT
TCACCCGGCTCGAGGATGGTCCCTACGCCGGCGTCATCGCCGCGCTTGTCGTCGGCGACCAGCGCAGCATTCCGCACGCG
CAATGGCGCGCGTTCACCCGCACGGGGGTCAACCATCTGCTGTCGATTTCGGGACTGCACGTCACGATGATCGCCGCGCT
GGCCGGCTGGTTCGTCGCGACGGCGTGGCGTCGCCTGCCGCGCGCCGCAGAACGCATCGCGGCCCGGCAGGCGGGCTTGA
TCGCCGCGGTCCTGGCGGCCTTCGGATATTCGCTGCTCGCCGGGTTTCAGGTGCCGGCGCAGCGCACGCTTTTCACCTTG
GCCGTGCTCGCGCTGGCCTTCTGGGGCCGGCGCGAGCCCCGGCCGTTTTCTGCGTTGCTCTGGGCCTTGCTCATCGTCCT
GCTGATCGATCCCTGGGCCGTCGTGTCCGCGGGATTCTGGCTGTCCTTCGGCGCGATGGCGGCGATCCTGTGGGTGAGCT
TCGGGCGAGTCGCCCGGCCCGCCAAGCTGCGCGGCTGGATCAGCGTTCAGGCGGCCGTGACGCTCGCGCTTGCGCCGGCG
CTGCTCCTGCTATTTCAGCAGGTGTCGCTCGTCTCGCCGTTCGCGAACGCGGTCGCGATCCCTGTCGTCAGTTGGCTCGT
CACGCCGCTCGCGCTGCTCGGCGTCATCGTGCCGCCGCTGTGGGATGCGGCGGCAGCGGTCATGGAATGGCTGGGCAGCG
GTCTGGCGTGGGCGTCGAACCTGTCCTGGGCAGTCATGGTACGGCCCGCCCCGCAGCCATGGACGGCGGCGCTTGCGCTC
GCCGGCACGTTCTGGCTGCTGTTGCCGCGAGGCTTCCCGGCGCGCGCGCTTGGCGGACTGTTTTTTCTGCCGCTCGCATT
TTCCCCGGTAGAGACGCTTGCGCCCGGAGGATTTCGCGCCGACGTGATCGACGTCGGACAGGGGACGGCGATCCTGATCC
GTACCGCTCGCCATGCGTTGCTGTACGACACGGGTGCGGCATTTGCCGACAGCGACGCCGGCGAGCGCATCGTCGTTCCG
TATCTGCGGGCGATCGGCGTCGGGGAGCTATCGGGTCTGATCGTCTCGCACGACGACAACGACCACAGCGGGGGGCTGCG
CTCGGTGCTGCGCGACCTCCGTACGGGCTGGCTCCTGCACGGGCTGCCGGCCGACAGCCCGCTCTTACGCGGCGCGCCCG
AGCCGCGGCGCTGCGCTCGCGGCCAGCGCTGGAGCTGGGACGGCGTTCGTTTCGCCATCCTCAATCCGTCGCGGGCCGCC
TACGAAGGGGGCAAGCGCAGCGACAACGATTTCAGTTGCGTGCTCAGGGTCAGCGCCGGCACGCAGAGCCTGTTGATTAC
CGGCGACGCCGAGCGGCGCGGCGAACTCGAGCTCCTCGAGTCAGGCCAGGATATCGGCGCGACGGTGCTCGTGGCCGGGC
ACCACGGCAGCCGCACCTCGTCGATCGCGGAATTCGTCGACCGCGTCCACCCCGAGCATGTGGTGTTCACCGTCGGCCAC
CGCAATCGCTTCGGCCACCCGCATCCCGAGGTGGTCGGCCGTTTCCGCGAGGCCGGCTCGCAGGTGCTGCGAAGCGATCG
GGCGGGGCTCGTGCGCCTGACGTTTGGACAAGCCGGAGTGACGGCCTCAGAATATCGACCCGCCCACCGCCGTTACTGGC
ACGCCCCCCCGTCATGA

Upstream 100 bases:

>100_bases
AGCCTCGTCGTCGTCACCCACGACGTCGAGCTCGCCGCGCGCATGGATCGACAGTTGCGCCTCGTCGACGGGACATTGCA
GGCGGCGTAACCGCGGCGCG

Downstream 100 bases:

>100_bases
ACGAAATTGTCCGCCCGCGCTGCTACGAAGCGACCGACCGCGAGTCGGCGCGGCAAGCCCTCGCACGCGTGCTGCCCGTT
GCCGAAAACGATCTGCCCTG

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MRAYLLAFCLGIGWLQQQAELPPTSWLWLLPLLSTVLLLPRFSAGPAALLRRAAITLLCAALGVAWATWRAELRLAERLP
DHWQGVDIELVGVIAALPHADARGERFVLDVEKVLTPGVPTMPRVQLARYWPRDGVREVRMRAGERWHLTVRLKIPHGTH
NLHGFDLEAWMLEQGIAASGYVREKPVPRRLAAQAATARGRIAAARADIRSRIFTRLEDGPYAGVIAALVVGDQRSIPHA
QWRAFTRTGVNHLLSISGLHVTMIAALAGWFVATAWRRLPRAAERIAARQAGLIAAVLAAFGYSLLAGFQVPAQRTLFTL
AVLALAFWGRREPRPFSALLWALLIVLLIDPWAVVSAGFWLSFGAMAAILWVSFGRVARPAKLRGWISVQAAVTLALAPA
LLLLFQQVSLVSPFANAVAIPVVSWLVTPLALLGVIVPPLWDAAAAVMEWLGSGLAWASNLSWAVMVRPAPQPWTAALAL
AGTFWLLLPRGFPARALGGLFFLPLAFSPVETLAPGGFRADVIDVGQGTAILIRTARHALLYDTGAAFADSDAGERIVVP
YLRAIGVGELSGLIVSHDDNDHSGGLRSVLRDLRTGWLLHGLPADSPLLRGAPEPRRCARGQRWSWDGVRFAILNPSRAA
YEGGKRSDNDFSCVLRVSAGTQSLLITGDAERRGELELLESGQDIGATVLVAGHHGSRTSSIAEFVDRVHPEHVVFTVGH
RNRFGHPHPEVVGRFREAGSQVLRSDRAGLVRLTFGQAGVTASEYRPAHRRYWHAPPS

Sequences:

>Translated_778_residues
MRAYLLAFCLGIGWLQQQAELPPTSWLWLLPLLSTVLLLPRFSAGPAALLRRAAITLLCAALGVAWATWRAELRLAERLP
DHWQGVDIELVGVIAALPHADARGERFVLDVEKVLTPGVPTMPRVQLARYWPRDGVREVRMRAGERWHLTVRLKIPHGTH
NLHGFDLEAWMLEQGIAASGYVREKPVPRRLAAQAATARGRIAAARADIRSRIFTRLEDGPYAGVIAALVVGDQRSIPHA
QWRAFTRTGVNHLLSISGLHVTMIAALAGWFVATAWRRLPRAAERIAARQAGLIAAVLAAFGYSLLAGFQVPAQRTLFTL
AVLALAFWGRREPRPFSALLWALLIVLLIDPWAVVSAGFWLSFGAMAAILWVSFGRVARPAKLRGWISVQAAVTLALAPA
LLLLFQQVSLVSPFANAVAIPVVSWLVTPLALLGVIVPPLWDAAAAVMEWLGSGLAWASNLSWAVMVRPAPQPWTAALAL
AGTFWLLLPRGFPARALGGLFFLPLAFSPVETLAPGGFRADVIDVGQGTAILIRTARHALLYDTGAAFADSDAGERIVVP
YLRAIGVGELSGLIVSHDDNDHSGGLRSVLRDLRTGWLLHGLPADSPLLRGAPEPRRCARGQRWSWDGVRFAILNPSRAA
YEGGKRSDNDFSCVLRVSAGTQSLLITGDAERRGELELLESGQDIGATVLVAGHHGSRTSSIAEFVDRVHPEHVVFTVGH
RNRFGHPHPEVVGRFREAGSQVLRSDRAGLVRLTFGQAGVTASEYRPAHRRYWHAPPS
>Mature_778_residues
MRAYLLAFCLGIGWLQQQAELPPTSWLWLLPLLSTVLLLPRFSAGPAALLRRAAITLLCAALGVAWATWRAELRLAERLP
DHWQGVDIELVGVIAALPHADARGERFVLDVEKVLTPGVPTMPRVQLARYWPRDGVREVRMRAGERWHLTVRLKIPHGTH
NLHGFDLEAWMLEQGIAASGYVREKPVPRRLAAQAATARGRIAAARADIRSRIFTRLEDGPYAGVIAALVVGDQRSIPHA
QWRAFTRTGVNHLLSISGLHVTMIAALAGWFVATAWRRLPRAAERIAARQAGLIAAVLAAFGYSLLAGFQVPAQRTLFTL
AVLALAFWGRREPRPFSALLWALLIVLLIDPWAVVSAGFWLSFGAMAAILWVSFGRVARPAKLRGWISVQAAVTLALAPA
LLLLFQQVSLVSPFANAVAIPVVSWLVTPLALLGVIVPPLWDAAAAVMEWLGSGLAWASNLSWAVMVRPAPQPWTAALAL
AGTFWLLLPRGFPARALGGLFFLPLAFSPVETLAPGGFRADVIDVGQGTAILIRTARHALLYDTGAAFADSDAGERIVVP
YLRAIGVGELSGLIVSHDDNDHSGGLRSVLRDLRTGWLLHGLPADSPLLRGAPEPRRCARGQRWSWDGVRFAILNPSRAA
YEGGKRSDNDFSCVLRVSAGTQSLLITGDAERRGELELLESGQDIGATVLVAGHHGSRTSSIAEFVDRVHPEHVVFTVGH
RNRFGHPHPEVVGRFREAGSQVLRSDRAGLVRLTFGQAGVTASEYRPAHRRYWHAPPS

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=648, Percent_Identity=30.2469135802469, Blast_Score=233, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 84684; Mature: 84684

Theoretical pI: Translated: 11.33; Mature: 11.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYLLAFCLGIGWLQQQAELPPTSWLWLLPLLSTVLLLPRFSAGPAALLRRAAITLLCA
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALGVAWATWRAELRLAERLPDHWQGVDIELVGVIAALPHADARGERFVLDVEKVLTPGVP
HHHHHHHHHHHHHHHHHHCCHHHCCCCEEHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCC
TMPRVQLARYWPRDGVREVRMRAGERWHLTVRLKIPHGTHNLHGFDLEAWMLEQGIAASG
CCCHHHHHHHCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCC
YVREKPVPRRLAAQAATARGRIAAARADIRSRIFTRLEDGPYAGVIAALVVGDQRSIPHA
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHH
QWRAFTRTGVNHLLSISGLHVTMIAALAGWFVATAWRRLPRAAERIAARQAGLIAAVLAA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGYSLLAGFQVPAQRTLFTLAVLALAFWGRREPRPFSALLWALLIVLLIDPWAVVSAGFW
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
LSFGAMAAILWVSFGRVARPAKLRGWISVQAAVTLALAPALLLLFQQVSLVSPFANAVAI
HHHHHHHHHHHHHHHHCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVSWLVTPLALLGVIVPPLWDAAAAVMEWLGSGLAWASNLSWAVMVRPAPQPWTAALAL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCCHHHHHHH
AGTFWLLLPRGFPARALGGLFFLPLAFSPVETLAPGGFRADVIDVGQGTAILIRTARHAL
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCEECEEECCCCCEEEEEHHHHHE
LYDTGAAFADSDAGERIVVPYLRAIGVGELSGLIVSHDDNDHSGGLRSVLRDLRTGWLLH
EEECCCCCCCCCCCCEEEHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCEEE
GLPADSPLLRGAPEPRRCARGQRWSWDGVRFAILNPSRAAYEGGKRSDNDFSCVLRVSAG
CCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCEEEEEEEECC
TQSLLITGDAERRGELELLESGQDIGATVLVAGHHGSRTSSIAEFVDRVHPEHVVFTVGH
CCEEEEECCCCCCCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECC
RNRFGHPHPEVVGRFREAGSQVLRSDRAGLVRLTFGQAGVTASEYRPAHRRYWHAPPS
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCHHHCCCCCCCC
>Mature Secondary Structure
MRAYLLAFCLGIGWLQQQAELPPTSWLWLLPLLSTVLLLPRFSAGPAALLRRAAITLLCA
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALGVAWATWRAELRLAERLPDHWQGVDIELVGVIAALPHADARGERFVLDVEKVLTPGVP
HHHHHHHHHHHHHHHHHHCCHHHCCCCEEHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCC
TMPRVQLARYWPRDGVREVRMRAGERWHLTVRLKIPHGTHNLHGFDLEAWMLEQGIAASG
CCCHHHHHHHCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCC
YVREKPVPRRLAAQAATARGRIAAARADIRSRIFTRLEDGPYAGVIAALVVGDQRSIPHA
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHH
QWRAFTRTGVNHLLSISGLHVTMIAALAGWFVATAWRRLPRAAERIAARQAGLIAAVLAA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGYSLLAGFQVPAQRTLFTLAVLALAFWGRREPRPFSALLWALLIVLLIDPWAVVSAGFW
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
LSFGAMAAILWVSFGRVARPAKLRGWISVQAAVTLALAPALLLLFQQVSLVSPFANAVAI
HHHHHHHHHHHHHHHHCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVSWLVTPLALLGVIVPPLWDAAAAVMEWLGSGLAWASNLSWAVMVRPAPQPWTAALAL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCCHHHHHHH
AGTFWLLLPRGFPARALGGLFFLPLAFSPVETLAPGGFRADVIDVGQGTAILIRTARHAL
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCEECEEECCCCCEEEEEHHHHHE
LYDTGAAFADSDAGERIVVPYLRAIGVGELSGLIVSHDDNDHSGGLRSVLRDLRTGWLLH
EEECCCCCCCCCCCCEEEHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCEEE
GLPADSPLLRGAPEPRRCARGQRWSWDGVRFAILNPSRAAYEGGKRSDNDFSCVLRVSAG
CCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCEEEEEEEECC
TQSLLITGDAERRGELELLESGQDIGATVLVAGHHGSRTSSIAEFVDRVHPEHVVFTVGH
CCEEEEECCCCCCCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECC
RNRFGHPHPEVVGRFREAGSQVLRSDRAGLVRLTFGQAGVTASEYRPAHRRYWHAPPS
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]