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The map label for this gene is uvrB

Identifier: 74317586

GI number: 74317586

Start: 1650662

End: 1652689

Strand: Reverse

Name: uvrB

Synonym: Tbd_1568

Alternate gene names: 74317586

Gene position: 1652689-1650662 (Counterclockwise)

Preceding gene: 74317591

Following gene: 74317584

Centisome position: 56.8

GC content: 64.35

Gene sequence:

>2028_bases
ATGTTCGTCACCTTTCCCGATAGCCCGTTCCGTCTTTTTCAGCCCTTTCCCCCGGCCGGCGACCAGCCGACGGCGATCGC
CCGGTTGATCGAGGGGATCGACGACGGCCTGTCGTACCAGACCCTGCTCGGGGTGACCGGTTCCGGCAAGACCTACACCA
TGGCGAACGTGATCGCGCGCGCGGGGCGGCCGGCCCTGATCATGGCGCCCAACAAGACGCTCGCCGCGCAGCTTTACGCC
GAGATGCGCGAGTTCTTTCCGGAGAACGCGGTCGAGTACTTCGTCTCCTACTACGACTACTACCAGCCCGAGGCCTACGT
CCCGGCGCGCGATCTCTTCATCGAAAAGGACTCGAGCATCAACGAGCACATCGAGCAGATGCGGCTCTCGGCGACCAAAT
CGCTGCTCGAGCGGCGCGACACGGTCATCGTCTGCACCGTGTCGGCGATCTACGGTATCGGCGACCCGTCCGACTACCAC
AGCATGATCCTGCTCCTGCGGCAGAACGACAAAATGACGCAGCGCGAGGTCATCGCGCGCCTGACGCAGATGCAGTACGA
CCGCAACGACGTCGACTTCAAGCGCGGCGTCTTTCGCGTGCGCGGCGACGTGATCGACATCTTCCCGGCCGAACACGCCG
AGACCGCGATCCGCGTCGAGCTCTTCGACGACGTGGTCGAGACGCTGCATCTCTTCGATCCACTGACCGGCCAGATCCTG
CAGAAGGTCTCGCGCTTCACGGTCTTCCCGTCGAGCCACTACGTCACGCCGCGTGAGACGACGCTGCGCGCGATCGAGGC
GATCAAGGTCGAGCTGCGCGAGCGCCTTGACTGGTATTACGCCAACAACAAGCTCGTCGAGGCGCAAAGGCTCGAGCAGC
GCACGCGTTTCGACCTCGAGATGATGGTCGAACTCGGCTTCTGCAAGGGCATCGAGAACTACTCGCGGCATCTGTCGGGC
CGCAAGGCCGGCGAGCCGCCGCCGACCCTGATCGACTATCTGGCGAAGGACGCGCTGATGTTCATCGACGAGTCGCACGT
CACCGTGACCCAGGTCGGCGGCATGTACAAAGGCGACCGCTCGCGCAAGGAAAACCTCGTCGACTACGGTTTCCGGTTGC
CCTCAGCGCTCGACAACCGGCCGCTGAAATTCGAGGAATTCGAGGCGCTGATGCCGCAGACCGTGTTCGTCTCGGCGACG
CCGGCGAAGTACGAAGCCGAACACGCGGGGCAGGTCGTCGAACAGCTCGTGCGCCCGACCGGGTTGATCGACCCCATCGT
CGAGGTGCGGCCGGTCACGACCCAGGTCGACGACCTCATGAGCGAGGTCAAGAAACGCGTGGCCGTGGGCGAGCGCGTCC
TCGTCACGACGCTGACCAAGCGCATGGCCGAGGACCTGACCGACTACCTCGCCGAGCACGGCGTCAAGGTGCGCTACCTG
CACTCCGACATCGACACGGTTGAGCGCGTCGAGATCATCCGCGACCTGCGGCTCGGCGAGTTCGACGTGCTGGTCGGCAT
CAACCTGCTGCGCGAGGGCCTCGACATCCCCGAGGTGTCGCTGGTCGCGATTCTGGATGCCGACAAGGAGGGCTTCCTGC
GCTCCGAGCGCTCGCTGATCCAGACCATCGGCCGCGCCGCGCGCCATCTGAACGGCACGGCGATCCTCTACGCCGACCGG
ATCACCGATTCGATGCAGCGCGCGATCGGCGAGACCGAGCGCCGGCGCGCCAAGCAGATCGCGTTCAATACCGAACACGG
CATCACCCCGCGCGGCGTCGTCAAGCGCATCAAGGACATCATCGACGGCGTCTACGATGCCGACGCCAGCCGCCAGGAAC
TCAAGGCCGCGCAGACCGCCGCGGAATACAAGGTCATGGACGAGAAATCCCTGACCAAGCGAGTCAAGAAGATAGAGAAG
GAAATGCAGGACGCGGCGAAGAACCTCGAGTTCGAAAAGGCCGCGGTGCTGCGGGATCAGTTGAAGGAGCTGAAGGCGTT
GCTGTTCGGGGTGGAGGAGCGGGAGTAG

Upstream 100 bases:

>100_bases
AACGAAAAGCGCCGTCCGGCGCGCTCGCCGGATTCGCAAGCGCCCGGGCGCAGCGCGCCTGCCATCCTGAGGCACGCCAA
CTCATGAAATATTCGTCCTG

Downstream 100 bases:

>100_bases
CGGCGGAGTTTATCCCGAGCTGGAGCGCGGATCTATTTCGCTACCATCGCCTTGTTATGACCCTTCTGCGAATTACGGGT
ACCGGGAACAAGCCGAACAG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MFVTFPDSPFRLFQPFPPAGDQPTAIARLIEGIDDGLSYQTLLGVTGSGKTYTMANVIARAGRPALIMAPNKTLAAQLYA
EMREFFPENAVEYFVSYYDYYQPEAYVPARDLFIEKDSSINEHIEQMRLSATKSLLERRDTVIVCTVSAIYGIGDPSDYH
SMILLLRQNDKMTQREVIARLTQMQYDRNDVDFKRGVFRVRGDVIDIFPAEHAETAIRVELFDDVVETLHLFDPLTGQIL
QKVSRFTVFPSSHYVTPRETTLRAIEAIKVELRERLDWYYANNKLVEAQRLEQRTRFDLEMMVELGFCKGIENYSRHLSG
RKAGEPPPTLIDYLAKDALMFIDESHVTVTQVGGMYKGDRSRKENLVDYGFRLPSALDNRPLKFEEFEALMPQTVFVSAT
PAKYEAEHAGQVVEQLVRPTGLIDPIVEVRPVTTQVDDLMSEVKKRVAVGERVLVTTLTKRMAEDLTDYLAEHGVKVRYL
HSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARHLNGTAILYADR
ITDSMQRAIGETERRRAKQIAFNTEHGITPRGVVKRIKDIIDGVYDADASRQELKAAQTAAEYKVMDEKSLTKRVKKIEK
EMQDAAKNLEFEKAAVLRDQLKELKALLFGVEERE

Sequences:

>Translated_675_residues
MFVTFPDSPFRLFQPFPPAGDQPTAIARLIEGIDDGLSYQTLLGVTGSGKTYTMANVIARAGRPALIMAPNKTLAAQLYA
EMREFFPENAVEYFVSYYDYYQPEAYVPARDLFIEKDSSINEHIEQMRLSATKSLLERRDTVIVCTVSAIYGIGDPSDYH
SMILLLRQNDKMTQREVIARLTQMQYDRNDVDFKRGVFRVRGDVIDIFPAEHAETAIRVELFDDVVETLHLFDPLTGQIL
QKVSRFTVFPSSHYVTPRETTLRAIEAIKVELRERLDWYYANNKLVEAQRLEQRTRFDLEMMVELGFCKGIENYSRHLSG
RKAGEPPPTLIDYLAKDALMFIDESHVTVTQVGGMYKGDRSRKENLVDYGFRLPSALDNRPLKFEEFEALMPQTVFVSAT
PAKYEAEHAGQVVEQLVRPTGLIDPIVEVRPVTTQVDDLMSEVKKRVAVGERVLVTTLTKRMAEDLTDYLAEHGVKVRYL
HSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARHLNGTAILYADR
ITDSMQRAIGETERRRAKQIAFNTEHGITPRGVVKRIKDIIDGVYDADASRQELKAAQTAAEYKVMDEKSLTKRVKKIEK
EMQDAAKNLEFEKAAVLRDQLKELKALLFGVEERE
>Mature_675_residues
MFVTFPDSPFRLFQPFPPAGDQPTAIARLIEGIDDGLSYQTLLGVTGSGKTYTMANVIARAGRPALIMAPNKTLAAQLYA
EMREFFPENAVEYFVSYYDYYQPEAYVPARDLFIEKDSSINEHIEQMRLSATKSLLERRDTVIVCTVSAIYGIGDPSDYH
SMILLLRQNDKMTQREVIARLTQMQYDRNDVDFKRGVFRVRGDVIDIFPAEHAETAIRVELFDDVVETLHLFDPLTGQIL
QKVSRFTVFPSSHYVTPRETTLRAIEAIKVELRERLDWYYANNKLVEAQRLEQRTRFDLEMMVELGFCKGIENYSRHLSG
RKAGEPPPTLIDYLAKDALMFIDESHVTVTQVGGMYKGDRSRKENLVDYGFRLPSALDNRPLKFEEFEALMPQTVFVSAT
PAKYEAEHAGQVVEQLVRPTGLIDPIVEVRPVTTQVDDLMSEVKKRVAVGERVLVTTLTKRMAEDLTDYLAEHGVKVRYL
HSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARHLNGTAILYADR
ITDSMQRAIGETERRRAKQIAFNTEHGITPRGVVKRIKDIIDGVYDADASRQELKAAQTAAEYKVMDEKSLTKRVKKIEK
EMQDAAKNLEFEKAAVLRDQLKELKALLFGVEERE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=675, Percent_Identity=66.5185185185185, Blast_Score=902, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=240, Percent_Identity=22.5, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_THIDA (Q3SIK7)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315326.1
- ProteinModelPortal:   Q3SIK7
- STRING:   Q3SIK7
- GeneID:   3672048
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1568
- NMPDR:   fig|292415.3.peg.1568
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   Q3SIK7
- ProtClustDB:   PRK05298
- BioCyc:   TDEN292415:TBD_1568-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76863; Mature: 76863

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVTFPDSPFRLFQPFPPAGDQPTAIARLIEGIDDGLSYQTLLGVTGSGKTYTMANVIAR
CEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEECCCCCCHHHHHHHHH
AGRPALIMAPNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPARDLFIEKDSSI
CCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHEEECCCCH
NEHIEQMRLSATKSLLERRDTVIVCTVSAIYGIGDPSDYHSMILLLRQNDKMTQREVIAR
HHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHEEEEEECCCCHHHHHHHHH
LTQMQYDRNDVDFKRGVFRVRGDVIDIFPAEHAETAIRVELFDDVVETLHLFDPLTGQIL
HHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCHHHHHH
QKVSRFTVFPSSHYVTPRETTLRAIEAIKVELRERLDWYYANNKLVEAQRLEQRTRFDLE
HHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
MMVELGFCKGIENYSRHLSGRKAGEPPPTLIDYLAKDALMFIDESHVTVTQVGGMYKGDR
HHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEHHCCCCCCCC
SRKENLVDYGFRLPSALDNRPLKFEEFEALMPQTVFVSATPAKYEAEHAGQVVEQLVRPT
HHHHHHHHHCCCCCHHHCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
GLIDPIVEVRPVTTQVDDLMSEVKKRVAVGERVLVTTLTKRMAEDLTDYLAEHGVKVRYL
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
HSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLI
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QTIGRAARHLNGTAILYADRITDSMQRAIGETERRRAKQIAFNTEHGITPRGVVKRIKDI
HHHHHHHHHCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHEECCCCCCCHHHHHHHHHHH
IDGVYDADASRQELKAAQTAAEYKVMDEKSLTKRVKKIEKEMQDAAKNLEFEKAAVLRDQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LKELKALLFGVEERE
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MFVTFPDSPFRLFQPFPPAGDQPTAIARLIEGIDDGLSYQTLLGVTGSGKTYTMANVIAR
CEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEECCCCCCHHHHHHHHH
AGRPALIMAPNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPARDLFIEKDSSI
CCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHEEECCCCH
NEHIEQMRLSATKSLLERRDTVIVCTVSAIYGIGDPSDYHSMILLLRQNDKMTQREVIAR
HHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHEEEEEECCCCHHHHHHHHH
LTQMQYDRNDVDFKRGVFRVRGDVIDIFPAEHAETAIRVELFDDVVETLHLFDPLTGQIL
HHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCHHHHHH
QKVSRFTVFPSSHYVTPRETTLRAIEAIKVELRERLDWYYANNKLVEAQRLEQRTRFDLE
HHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
MMVELGFCKGIENYSRHLSGRKAGEPPPTLIDYLAKDALMFIDESHVTVTQVGGMYKGDR
HHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEHHCCCCCCCC
SRKENLVDYGFRLPSALDNRPLKFEEFEALMPQTVFVSATPAKYEAEHAGQVVEQLVRPT
HHHHHHHHHCCCCCHHHCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
GLIDPIVEVRPVTTQVDDLMSEVKKRVAVGERVLVTTLTKRMAEDLTDYLAEHGVKVRYL
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
HSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLI
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QTIGRAARHLNGTAILYADRITDSMQRAIGETERRRAKQIAFNTEHGITPRGVVKRIKDI
HHHHHHHHHCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHEECCCCCCCHHHHHHHHHHH
IDGVYDADASRQELKAAQTAAEYKVMDEKSLTKRVKKIEKEMQDAAKNLEFEKAAVLRDQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LKELKALLFGVEERE
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA