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The map label for this gene is fabF [H]

Identifier: 74317565

GI number: 74317565

Start: 1631554

End: 1632786

Strand: Reverse

Name: fabF [H]

Synonym: Tbd_1547

Alternate gene names: 74317565

Gene position: 1632786-1631554 (Counterclockwise)

Preceding gene: 74317566

Following gene: 74317564

Centisome position: 56.11

GC content: 64.15

Gene sequence:

>1233_bases
TTGTCCAAACGTCGTGTCGTCGTCACCGGGCTGGGGATCGTTTCTCCAGTCGGAAACACCATCCCGGAAGCCTGGGACAA
CCTTGTCGCGGGGCGCCCGGGCATCTCCCGGATCACCCGTTTCGATCCCACGCCCTTCGCTTCGCAGATGGCGGGTGAGG
TACGGAATTTTGATGTCGCACAATACCTCAATCCGAAGGATGCGCGCCGTATGGATGTCTTCATCCAGTTCGGCATGGCG
GCCGGGATCCAGGCGATTCGTGATTCGGGCATCGAAGTCACCGAAGCCAATTCCGATCGTATCGGTATCAACATCGGCTC
CGGAATCGGCGGCTTGCCGCTGATCGAGGAGACGCACGGTCTCCTGATGGAATCGGGTCCGCGGAAGATTTCGCCCTTTT
TTATCCCCGGTTCCATCATCAACATGATTTCGGGCAACCTGTCGATCCTATACGGCATCAACGGCCCCAACCTCGCGGTC
GTGACGGCGTGCACGACGGGCTTGCACGCCGTCGGCCTGTCGGCCCGCATGATCCAGGCCGGCGACACCGACGTGATGAT
CGCGGGCGGTGCGGAATGTGCGACGTCGCCGCTCGGCGTCGGCGGTTTCGCGGCGGCGCGCGCGCTGTCGACGCGCAACG
ACGATCCCGCGACGGCGAGTCGGCCGTGGGACAAGGATCGCGACGGCTTCGTGCTCGGCGAGGGTGCGGGCGTACTCGTG
CTCGAGGAATACGAACACGCCAAGGCGCGCGGGGCAAAAATCTACTCCGAAGTCGCCGGCTTCGGCATGAGCGGCGACGC
CTACCACATGACCGCACCGAGCACGGACGGCCCGCGGCGCTCGATGGTGAACGCGATGCGCGACGCCGGGCTCAACCCCG
ATCAGATCCAGTACATCAACGCGCACGGCACCTCGACGCCGCTCGGCGACAAGAACGAAACCGAGGCGATCAAACTCGCG
CTGGGCGACGCCGCGTACAAGGCCGTGGTCAACTCGACCAAGTCGATGACCGGCCATCTGCTCGGCGGCGCCGGCGGGGT
CGAGTCGGTATTCAGCGTGCTCGCGGTGCATCACCAGGTCTCGCCGCCGACGATCAACATTTTCTCGCAGGACCCCGAGT
GCGATCTCGACTACTGCGCGAACACGGCCCGCGACATGAAGATCGACGCGGCGCTCAAGAACAACTTCGGGTTCGGCGGC
ACCAACGGCTCGCTGGTCTTCAAGCGCGTTTGA

Upstream 100 bases:

>100_bases
CATTGATCCGGCACATGCAGTGCTCGTGTCGGAACGGGAGACTGCGCCAGAGTCCGCGTCCCCATTCCGGCGTGCCGAAT
CGGTAAAGAAGGACTGACTT

Downstream 100 bases:

>100_bases
GCCTGCCTCCCGGCGACGCGAAAACGTGACAGCAGATCGGGGCAGCCAGGCGCGGGCGCCACGTCGGCGCCCCGCCTGAC
CCGGAAACCGAATGTCCCCC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSKRRVVVTGLGIVSPVGNTIPEAWDNLVAGRPGISRITRFDPTPFASQMAGEVRNFDVAQYLNPKDARRMDVFIQFGMA
AGIQAIRDSGIEVTEANSDRIGINIGSGIGGLPLIEETHGLLMESGPRKISPFFIPGSIINMISGNLSILYGINGPNLAV
VTACTTGLHAVGLSARMIQAGDTDVMIAGGAECATSPLGVGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVLV
LEEYEHAKARGAKIYSEVAGFGMSGDAYHMTAPSTDGPRRSMVNAMRDAGLNPDQIQYINAHGTSTPLGDKNETEAIKLA
LGDAAYKAVVNSTKSMTGHLLGGAGGVESVFSVLAVHHQVSPPTINIFSQDPECDLDYCANTARDMKIDAALKNNFGFGG
TNGSLVFKRV

Sequences:

>Translated_410_residues
MSKRRVVVTGLGIVSPVGNTIPEAWDNLVAGRPGISRITRFDPTPFASQMAGEVRNFDVAQYLNPKDARRMDVFIQFGMA
AGIQAIRDSGIEVTEANSDRIGINIGSGIGGLPLIEETHGLLMESGPRKISPFFIPGSIINMISGNLSILYGINGPNLAV
VTACTTGLHAVGLSARMIQAGDTDVMIAGGAECATSPLGVGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVLV
LEEYEHAKARGAKIYSEVAGFGMSGDAYHMTAPSTDGPRRSMVNAMRDAGLNPDQIQYINAHGTSTPLGDKNETEAIKLA
LGDAAYKAVVNSTKSMTGHLLGGAGGVESVFSVLAVHHQVSPPTINIFSQDPECDLDYCANTARDMKIDAALKNNFGFGG
TNGSLVFKRV
>Mature_409_residues
SKRRVVVTGLGIVSPVGNTIPEAWDNLVAGRPGISRITRFDPTPFASQMAGEVRNFDVAQYLNPKDARRMDVFIQFGMAA
GIQAIRDSGIEVTEANSDRIGINIGSGIGGLPLIEETHGLLMESGPRKISPFFIPGSIINMISGNLSILYGINGPNLAVV
TACTTGLHAVGLSARMIQAGDTDVMIAGGAECATSPLGVGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVLVL
EEYEHAKARGAKIYSEVAGFGMSGDAYHMTAPSTDGPRRSMVNAMRDAGLNPDQIQYINAHGTSTPLGDKNETEAIKLAL
GDAAYKAVVNSTKSMTGHLLGGAGGVESVFSVLAVHHQVSPPTINIFSQDPECDLDYCANTARDMKIDAALKNNFGFGGT
NGSLVFKRV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=46.5060240963855, Blast_Score=354, Evalue=8e-98,
Organism=Homo sapiens, GI223972627, Length=151, Percent_Identity=49.6688741721854, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=25.531914893617, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=60.5326876513317, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=37.1359223300971, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=36.7149758454106, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=41.5686274509804, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=428, Percent_Identity=24.0654205607477, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=414, Percent_Identity=23.4299516908213, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=35.9550561797753, Blast_Score=259, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=43.6450839328537, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI19920632, Length=429, Percent_Identity=24.9417249417249, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221330659, Length=429, Percent_Identity=24.9417249417249, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24581345, Length=429, Percent_Identity=23.3100233100233, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43040; Mature: 42909

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVVTGLGIVSPVGNTIPEAWDNLVAGRPGISRITRFDPTPFASQMAGEVRNFDVA
CCCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCCCHH
QYLNPKDARRMDVFIQFGMAAGIQAIRDSGIEVTEANSDRIGINIGSGIGGLPLIEETHG
HHCCCCCCHHEEEEEEHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCHHHHCC
LLMESGPRKISPFFIPGSIINMISGNLSILYGINGPNLAVVTACTTGLHAVGLSARMIQA
HHCCCCCCCCCCEEECHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHCCCEEEEEC
GDTDVMIAGGAECATSPLGVGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVLV
CCCEEEEECCCHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYSEVAGFGMSGDAYHMTAPSTDGPRRSMVNAMRDAGLNPDQIQYIN
EECCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEE
AHGTSTPLGDKNETEAIKLALGDAAYKAVVNSTKSMTGHLLGGAGGVESVFSVLAVHHQV
CCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCC
SPPTINIFSQDPECDLDYCANTARDMKIDAALKNNFGFGGTNGSLVFKRV
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SKRRVVVTGLGIVSPVGNTIPEAWDNLVAGRPGISRITRFDPTPFASQMAGEVRNFDVA
CCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCCCHH
QYLNPKDARRMDVFIQFGMAAGIQAIRDSGIEVTEANSDRIGINIGSGIGGLPLIEETHG
HHCCCCCCHHEEEEEEHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCHHHHCC
LLMESGPRKISPFFIPGSIINMISGNLSILYGINGPNLAVVTACTTGLHAVGLSARMIQA
HHCCCCCCCCCCEEECHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHCCCEEEEEC
GDTDVMIAGGAECATSPLGVGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVLV
CCCEEEEECCCHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYSEVAGFGMSGDAYHMTAPSTDGPRRSMVNAMRDAGLNPDQIQYIN
EECCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEE
AHGTSTPLGDKNETEAIKLALGDAAYKAVVNSTKSMTGHLLGGAGGVESVFSVLAVHHQV
CCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCC
SPPTINIFSQDPECDLDYCANTARDMKIDAALKNNFGFGGTNGSLVFKRV
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]