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The map label for this gene is pcoA [H]

Identifier: 74317342

GI number: 74317342

Start: 1403210

End: 1404895

Strand: Direct

Name: pcoA [H]

Synonym: Tbd_1324

Alternate gene names: 74317342

Gene position: 1403210-1404895 (Clockwise)

Preceding gene: 74317341

Following gene: 74317343

Centisome position: 48.22

GC content: 64.47

Gene sequence:

>1686_bases
ATGAACCCTCATTCTCGATTCTTGCCTGCAACGCCGAATCTCCCGCGCCGGCGGTTTCTCCAGGGACTGGCGGCCGGCGG
CATCTTGCTCGGTGCGCCCTCCTTGATACTGCCGGCCTCGGCACGGGAAGCCGGCACGGCCGCAGGCAGTGCGCCGGTAC
TCAGCGGCACCGAATTTGATCTCACGATCGCGGAGACGGCGGTGAACTTCACCGGTAAACCGCGTATGGCGACGACGATC
AACGGCTCGATTCCCGGGCCTACGCTGCGCCTGCGCGAGGGCGACACCGTGACCATCCGCGTACACAACCGGCTGACCGA
GGACACGTCGATCCACTGGCACGGCATCCTGCTGCCCTTCGAGATGGACGGCGTGCCGGGCATCAGCTTCAAAGGAATTC
CGCCCGGCCAGACCTTTACCTACCGCTTCAAGGTGAAGCAAACCGGCACCTATTGGTACCACTCGCACTCCGGCATGCAG
GAGCAGACCGGGATGTACGGCACGATCATCATCGACCCCGCGCGTGGTAACTCCGTCGGCGCCGATCGCGATTACGTCGT
GCAATTGTCGGACTGGACCGACGAGCATCCGATGCGGGTGCTCCACAAGCTCAAGGTGCAGGGCGACTACTTCAACTTCA
ATCAGCCGACCGCCGGGGACTTCTTCCGCGACGTGTCGAAGGAAGGGCTCAAGGCCGCGATCGACAAGCGCCGGATGTGG
AACGAGATGCGCATGAGCCCGACCGATCTGGCCGACGTCTCCGCTCACACCTATACCTATCTGATGAACGGCGCGGCGCC
GGCCGGCAACTGGACCGGGCTGTTCCGCCCCGGCGGGAAGGTGCGATTGCGCTTCGTCAACAGTGCAGCGATGACCTTCT
TCGACGTGCGCATTCCGGGACTCAAGATGACCGTCGTGCAGACCGACGGGCAGGATGTCGAACCGGTCACGGTCGACGAA
ATCCGCATCGGCGTCGCAGAGACCTACGACGTGATCGTGAGCCCCAAGGACGAGGCGTATACGATCTTCGCGCAGTCGAT
GGATCGGACCGGCTTCGCGCGCGGCACGCTCGCGACCCGTGCGGGACTTGTCGCGGCGGTTCCGTCACCGGACAAGCCCG
TGGCGCTCGAAATGCAGGACATGATGGGCGACATGACCGGCCTCGCGCGGGCCCACCATGCCCGGACCGAGTATGGCCCC
AGTGTCGACATGCGCGTCGACACCCCGCGCACCGACCTGGACGACCCCGGCGTCGGCTTGCGCGACAACGGCCGGCGCGT
GCTGACCTATGACCATCTCCACAGCGTCGGCGGGCCGCTGGACGCGCGGGGCCCCGGACGCGAGATCGAGCTCCATCTCA
CCGGCAATATGGAGCGCTACGCCTGGTCCATTGACGGCGTTGAGTTCGAGAAGTCCACGCCGGTGCATTTCCGTCACAAC
GAGCGGCTTCGCGTGGTCTTCGTCAACGATACGATGATGACGCACCCGATGCACTTGCACGGGATGTGGAGCGAACTCGA
AAGTCCGGAAGGGAAGTTCCAGGTGCGCAAGCACACGATCGCAGTACAGCCCGCGCAGCGCGTGAGCTTTCTGGTCACCG
CCGATGCCCTAGGGCGTTGGGCATGGCACTGCCATTTGGGGCTGCACATGGACATGGGCATGTTCCGCGAAGTCGTCGTG
GCCTGA

Upstream 100 bases:

>100_bases
AGAGCATGACGCGATTGTAATGGCGCGGTCATGTCGGGGTTGGGGCGCCGATGGCTAAATATCGCGTGTCTTCCAATCCA
GGTGACCCCGGGACCGTTAC

Downstream 100 bases:

>100_bases
GTTGCGCAACCGAGGAGAAATCACGATGAATGAGTTTCGAGTGCGCGCGATCGCTGTCGTCATGACACTCGCGGCGTCCA
CCGCCGCGGCCCAGGATCAC

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MNPHSRFLPATPNLPRRRFLQGLAAGGILLGAPSLILPASAREAGTAAGSAPVLSGTEFDLTIAETAVNFTGKPRMATTI
NGSIPGPTLRLREGDTVTIRVHNRLTEDTSIHWHGILLPFEMDGVPGISFKGIPPGQTFTYRFKVKQTGTYWYHSHSGMQ
EQTGMYGTIIIDPARGNSVGADRDYVVQLSDWTDEHPMRVLHKLKVQGDYFNFNQPTAGDFFRDVSKEGLKAAIDKRRMW
NEMRMSPTDLADVSAHTYTYLMNGAAPAGNWTGLFRPGGKVRLRFVNSAAMTFFDVRIPGLKMTVVQTDGQDVEPVTVDE
IRIGVAETYDVIVSPKDEAYTIFAQSMDRTGFARGTLATRAGLVAAVPSPDKPVALEMQDMMGDMTGLARAHHARTEYGP
SVDMRVDTPRTDLDDPGVGLRDNGRRVLTYDHLHSVGGPLDARGPGREIELHLTGNMERYAWSIDGVEFEKSTPVHFRHN
ERLRVVFVNDTMMTHPMHLHGMWSELESPEGKFQVRKHTIAVQPAQRVSFLVTADALGRWAWHCHLGLHMDMGMFREVVV
A

Sequences:

>Translated_561_residues
MNPHSRFLPATPNLPRRRFLQGLAAGGILLGAPSLILPASAREAGTAAGSAPVLSGTEFDLTIAETAVNFTGKPRMATTI
NGSIPGPTLRLREGDTVTIRVHNRLTEDTSIHWHGILLPFEMDGVPGISFKGIPPGQTFTYRFKVKQTGTYWYHSHSGMQ
EQTGMYGTIIIDPARGNSVGADRDYVVQLSDWTDEHPMRVLHKLKVQGDYFNFNQPTAGDFFRDVSKEGLKAAIDKRRMW
NEMRMSPTDLADVSAHTYTYLMNGAAPAGNWTGLFRPGGKVRLRFVNSAAMTFFDVRIPGLKMTVVQTDGQDVEPVTVDE
IRIGVAETYDVIVSPKDEAYTIFAQSMDRTGFARGTLATRAGLVAAVPSPDKPVALEMQDMMGDMTGLARAHHARTEYGP
SVDMRVDTPRTDLDDPGVGLRDNGRRVLTYDHLHSVGGPLDARGPGREIELHLTGNMERYAWSIDGVEFEKSTPVHFRHN
ERLRVVFVNDTMMTHPMHLHGMWSELESPEGKFQVRKHTIAVQPAQRVSFLVTADALGRWAWHCHLGLHMDMGMFREVVV
A
>Mature_561_residues
MNPHSRFLPATPNLPRRRFLQGLAAGGILLGAPSLILPASAREAGTAAGSAPVLSGTEFDLTIAETAVNFTGKPRMATTI
NGSIPGPTLRLREGDTVTIRVHNRLTEDTSIHWHGILLPFEMDGVPGISFKGIPPGQTFTYRFKVKQTGTYWYHSHSGMQ
EQTGMYGTIIIDPARGNSVGADRDYVVQLSDWTDEHPMRVLHKLKVQGDYFNFNQPTAGDFFRDVSKEGLKAAIDKRRMW
NEMRMSPTDLADVSAHTYTYLMNGAAPAGNWTGLFRPGGKVRLRFVNSAAMTFFDVRIPGLKMTVVQTDGQDVEPVTVDE
IRIGVAETYDVIVSPKDEAYTIFAQSMDRTGFARGTLATRAGLVAAVPSPDKPVALEMQDMMGDMTGLARAHHARTEYGP
SVDMRVDTPRTDLDDPGVGLRDNGRRVLTYDHLHSVGGPLDARGPGREIELHLTGNMERYAWSIDGVEFEKSTPVHFRHN
ERLRVVFVNDTMMTHPMHLHGMWSELESPEGKFQVRKHTIAVQPAQRVSFLVTADALGRWAWHCHLGLHMDMGMFREVVV
A

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=576, Percent_Identity=25.3472222222222, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1789394, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323703, Length=516, Percent_Identity=24.8062015503876, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320714, Length=551, Percent_Identity=22.1415607985481, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321067, Length=284, Percent_Identity=27.8169014084507, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650186, Length=588, Percent_Identity=21.7687074829932, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI18859919, Length=295, Percent_Identity=27.7966101694915, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574104, Length=312, Percent_Identity=27.5641025641026, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221329998, Length=564, Percent_Identity=24.468085106383, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221330000, Length=566, Percent_Identity=24.0282685512367, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360167, Length=301, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24585842, Length=301, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 62186; Mature: 62186

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPHSRFLPATPNLPRRRFLQGLAAGGILLGAPSLILPASAREAGTAAGSAPVLSGTEFD
CCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCEECCCEEE
LTIAETAVNFTGKPRMATTINGSIPGPTLRLREGDTVTIRVHNRLTEDTSIHWHGILLPF
EEEEEEEECCCCCCCEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEEEEE
EMDGVPGISFKGIPPGQTFTYRFKVKQTGTYWYHSHSGMQEQTGMYGTIIIDPARGNSVG
ECCCCCCCEECCCCCCCEEEEEEEEEECCEEEEECCCCCHHHCCCEEEEEEECCCCCCCC
ADRDYVVQLSDWTDEHPMRVLHKLKVQGDYFNFNQPTAGDFFRDVSKEGLKAAIDKRRMW
CCCEEEEEECCCCCCCHHHHHHHHEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NEMRMSPTDLADVSAHTYTYLMNGAAPAGNWTGLFRPGGKVRLRFVNSAAMTFFDVRIPG
HHHCCCCCCHHHCCCEEEEEEEECCCCCCCCCEEECCCCEEEEEEECCCEEEEEEEECCC
LKMTVVQTDGQDVEPVTVDEIRIGVAETYDVIVSPKDEAYTIFAQSMDRTGFARGTLATR
EEEEEEECCCCCCCCEEHHHEEEEEEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHH
AGLVAAVPSPDKPVALEMQDMMGDMTGLARAHHARTEYGPSVDMRVDTPRTDLDDPGVGL
CCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCC
RDNGRRVLTYDHLHSVGGPLDARGPGREIELHLTGNMERYAWSIDGVEFEKSTPVHFRHN
CCCCCEEEEEHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEECCCCCEEEECC
ERLRVVFVNDTMMTHPMHLHGMWSELESPEGKFQVRKHTIAVQPAQRVSFLVTADALGRW
CEEEEEEECCCEEECCEEEEECHHHHCCCCCCEEEEEEEEEECCHHHEEEEEEECHHCCE
AWHCHLGLHMDMGMFREVVVA
EEEEEEEEECCHHHHHHHHCC
>Mature Secondary Structure
MNPHSRFLPATPNLPRRRFLQGLAAGGILLGAPSLILPASAREAGTAAGSAPVLSGTEFD
CCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCEECCCEEE
LTIAETAVNFTGKPRMATTINGSIPGPTLRLREGDTVTIRVHNRLTEDTSIHWHGILLPF
EEEEEEEECCCCCCCEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEEEEE
EMDGVPGISFKGIPPGQTFTYRFKVKQTGTYWYHSHSGMQEQTGMYGTIIIDPARGNSVG
ECCCCCCCEECCCCCCCEEEEEEEEEECCEEEEECCCCCHHHCCCEEEEEEECCCCCCCC
ADRDYVVQLSDWTDEHPMRVLHKLKVQGDYFNFNQPTAGDFFRDVSKEGLKAAIDKRRMW
CCCEEEEEECCCCCCCHHHHHHHHEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NEMRMSPTDLADVSAHTYTYLMNGAAPAGNWTGLFRPGGKVRLRFVNSAAMTFFDVRIPG
HHHCCCCCCHHHCCCEEEEEEEECCCCCCCCCEEECCCCEEEEEEECCCEEEEEEEECCC
LKMTVVQTDGQDVEPVTVDEIRIGVAETYDVIVSPKDEAYTIFAQSMDRTGFARGTLATR
EEEEEEECCCCCCCCEEHHHEEEEEEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHH
AGLVAAVPSPDKPVALEMQDMMGDMTGLARAHHARTEYGPSVDMRVDTPRTDLDDPGVGL
CCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCC
RDNGRRVLTYDHLHSVGGPLDARGPGREIELHLTGNMERYAWSIDGVEFEKSTPVHFRHN
CCCCCEEEEEHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEECCCCCEEEECC
ERLRVVFVNDTMMTHPMHLHGMWSELESPEGKFQVRKHTIAVQPAQRVSFLVTADALGRW
CEEEEEEECCCEEECCEEEEECHHHHCCCCCCEEEEEEEEEECCHHHEEEEEEECHHCCE
AWHCHLGLHMDMGMFREVVVA
EEEEEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]