Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 74317064

GI number: 74317064

Start: 1110966

End: 1112441

Strand: Direct

Name: ppx [H]

Synonym: Tbd_1046

Alternate gene names: 74317064

Gene position: 1110966-1112441 (Clockwise)

Preceding gene: 74317063

Following gene: 74317065

Centisome position: 38.18

GC content: 70.73

Gene sequence:

>1476_bases
ATGAAAAGCTACGACACGCTCGCCGCCGTCGACCTCGGTTCCAACTCCTTCCGCCTCGAAGTGGCGCGCGTCGCAGGCGA
CCAGCTGTACCCCCTCGATTCGCTCAAGGAAACGGTGCGGCTCGCGGCCGGCCTGCAGGACGACAAGATTCTCGACGGTG
CGGCGCGGGAACGCGCGCTGGCCTGCCTGAGGCGCTTCGGCGAGCGCCTGCGCGGCCTGCCCGCGGAAGCCGTACGCTGC
GTCGGCACCTCGACGCTGCGCGTCGCGCGCAACGCCGATGCCTTCCTCGCCGAGGCCGAGGCGGCGCTCGGGCACCCGAT
CGAGATCGTCGCCGGCCGCGAGGAGGCGCGCCTGATCTACCTCGGGGTCGCGCATTCGCTGCCGGCCTCTCCCGACCGCC
GGCTCGTCGTCGACATCGGCGGCGGCTCGACCGAATTCATCGTCGGCCACGGCCTGAAGCCGCACGAGCGCGAAAGCCTG
CACCTCGGCTGCGTGCATTTCTCGCGGCGCTTTTTCGAGCAGGGGGCGGTCAGCCGCGCCGCGCTCAAGGCCGCCGAACT
GAGCGCGCGTGCGGAGGTCGAGCGCATCGCTCATGCCTTCGGACGCGGCAACTGGCAGCAGGCGGTCGGCTCGAGCGGCA
CCGCGCGTGCGCTGCGCGACATCCTCGAGCAAAGCGGCTGGTCGGCAGGCGGCATCACCCGCGACGGCCTCGACCGCCTG
CGCGATGCGCTGCTCGCGGCGGGCGACGTCGAGCGTCTCGAATTGCCCGGTCTTTCGCGGGATCGCCGGCCGGTTATAGC
CGGCGGCTTCGCGATCATGGCGGGACTGTTCGCCGAGCTCGGAATCGAGCAGATGGACGTCGCCGAGACCGCCATGCGCG
AGGGCATCCTCTACGATCTGCTCGGCCGCTTTCACGCCGACGACATGCGCGAGGCGACGGTCGCCGAATTCGCCCGTCGC
TATCACGTCGACGCGGGCCAGGCCGAGCGCGTCGGACGCACCGTGCTGAGGCTGTTCGCGGCGACCGGGCGTGAAGACGA
CAATGACGCCCGGGTTCTCGGCTGGGCCGCGCGCCTGCACGAGATCGGTCTGTCGGTCTCGCACAGCGGCTACCACCGCC
ACTCGGCCTACATCCTCGAAAACGCCGACATGCCGGGGTTTTCACGCACCGAACAGGCGCGGCTCGCGCTCCTAGCGCGG
GCGCAACGGGGCGCGCTGACCAAGGTGGCGGCCGTTGCAGCGGGCGCCGTCGACGAGCGCGACCGCCGCGCGATCTGGCT
GCTGCGCCAGGCAGTGATTCTCTGCCGCAGCCGTGCCGATCCTCGCCTCGCCGAGGTCAGCGCCGAATCGACGTCGAAGC
GCTTCTGTCTGACGCTGCCTCCGGGCTGGCTCGAGCAGCGGCCGCTCACGCAACGTGCGCTCGACGACGAGATCCAGCAC
TGGCAGGCGCTGGGGCTCAAGTACGTGCTCGGTTAA

Upstream 100 bases:

>100_bases
TCCGCCGTGTGCGCCATGCCGTCGCCTGCGGGCTGATCGCGGATGCCGCGGGGATCGTCGCGGCGATCGGCATGGCCTAT
CTCTTTTTCGGAGCCGTTGC

Downstream 100 bases:

>100_bases
CCGGCGTCCTCCTTGTCGCTAACGATCGGTTATATCGATAGATAAGTCATAAAAATATCGTTGGTTAAATAGATAGAAAT
ATCTATCTTTTCCCCTGCAA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKSYDTLAAVDLGSNSFRLEVARVAGDQLYPLDSLKETVRLAAGLQDDKILDGAARERALACLRRFGERLRGLPAEAVRC
VGTSTLRVARNADAFLAEAEAALGHPIEIVAGREEARLIYLGVAHSLPASPDRRLVVDIGGGSTEFIVGHGLKPHERESL
HLGCVHFSRRFFEQGAVSRAALKAAELSARAEVERIAHAFGRGNWQQAVGSSGTARALRDILEQSGWSAGGITRDGLDRL
RDALLAAGDVERLELPGLSRDRRPVIAGGFAIMAGLFAELGIEQMDVAETAMREGILYDLLGRFHADDMREATVAEFARR
YHVDAGQAERVGRTVLRLFAATGREDDNDARVLGWAARLHEIGLSVSHSGYHRHSAYILENADMPGFSRTEQARLALLAR
AQRGALTKVAAVAAGAVDERDRRAIWLLRQAVILCRSRADPRLAEVSAESTSKRFCLTLPPGWLEQRPLTQRALDDEIQH
WQALGLKYVLG

Sequences:

>Translated_491_residues
MKSYDTLAAVDLGSNSFRLEVARVAGDQLYPLDSLKETVRLAAGLQDDKILDGAARERALACLRRFGERLRGLPAEAVRC
VGTSTLRVARNADAFLAEAEAALGHPIEIVAGREEARLIYLGVAHSLPASPDRRLVVDIGGGSTEFIVGHGLKPHERESL
HLGCVHFSRRFFEQGAVSRAALKAAELSARAEVERIAHAFGRGNWQQAVGSSGTARALRDILEQSGWSAGGITRDGLDRL
RDALLAAGDVERLELPGLSRDRRPVIAGGFAIMAGLFAELGIEQMDVAETAMREGILYDLLGRFHADDMREATVAEFARR
YHVDAGQAERVGRTVLRLFAATGREDDNDARVLGWAARLHEIGLSVSHSGYHRHSAYILENADMPGFSRTEQARLALLAR
AQRGALTKVAAVAAGAVDERDRRAIWLLRQAVILCRSRADPRLAEVSAESTSKRFCLTLPPGWLEQRPLTQRALDDEIQH
WQALGLKYVLG
>Mature_491_residues
MKSYDTLAAVDLGSNSFRLEVARVAGDQLYPLDSLKETVRLAAGLQDDKILDGAARERALACLRRFGERLRGLPAEAVRC
VGTSTLRVARNADAFLAEAEAALGHPIEIVAGREEARLIYLGVAHSLPASPDRRLVVDIGGGSTEFIVGHGLKPHERESL
HLGCVHFSRRFFEQGAVSRAALKAAELSARAEVERIAHAFGRGNWQQAVGSSGTARALRDILEQSGWSAGGITRDGLDRL
RDALLAAGDVERLELPGLSRDRRPVIAGGFAIMAGLFAELGIEQMDVAETAMREGILYDLLGRFHADDMREATVAEFARR
YHVDAGQAERVGRTVLRLFAATGREDDNDARVLGWAARLHEIGLSVSHSGYHRHSAYILENADMPGFSRTEQARLALLAR
AQRGALTKVAAVAAGAVDERDRRAIWLLRQAVILCRSRADPRLAEVSAESTSKRFCLTLPPGWLEQRPLTQRALDDEIQH
WQALGLKYVLG

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=486, Percent_Identity=38.2716049382716, Blast_Score=332, Evalue=5e-92,
Organism=Escherichia coli, GI48994966, Length=488, Percent_Identity=38.1147540983607, Blast_Score=303, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 53605; Mature: 53605

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYDTLAAVDLGSNSFRLEVARVAGDQLYPLDSLKETVRLAAGLQDDKILDGAARERAL
CCCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHCHHHHHHHH
ACLRRFGERLRGLPAEAVRCVGTSTLRVARNADAFLAEAEAALGHPIEIVAGREEARLIY
HHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCEEEE
LGVAHSLPASPDRRLVVDIGGGSTEFIVGHGLKPHERESLHLGCVHFSRRFFEQGAVSRA
EEECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCCHHHH
ALKAAELSARAEVERIAHAFGRGNWQQAVGSSGTARALRDILEQSGWSAGGITRDGLDRL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
RDALLAAGDVERLELPGLSRDRRPVIAGGFAIMAGLFAELGIEQMDVAETAMREGILYDL
HHHHHHCCCCHHEECCCCCCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
LGRFHADDMREATVAEFARRYHVDAGQAERVGRTVLRLFAATGREDDNDARVLGWAARLH
HHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EIGLSVSHSGYHRHSAYILENADMPGFSRTEQARLALLARAQRGALTKVAAVAAGAVDER
HHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
DRRAIWLLRQAVILCRSRADPRLAEVSAESTSKRFCLTLPPGWLEQRPLTQRALDDEIQH
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
WQALGLKYVLG
HHHHCCHHHCC
>Mature Secondary Structure
MKSYDTLAAVDLGSNSFRLEVARVAGDQLYPLDSLKETVRLAAGLQDDKILDGAARERAL
CCCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHCHHHHHHHH
ACLRRFGERLRGLPAEAVRCVGTSTLRVARNADAFLAEAEAALGHPIEIVAGREEARLIY
HHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCEEEE
LGVAHSLPASPDRRLVVDIGGGSTEFIVGHGLKPHERESLHLGCVHFSRRFFEQGAVSRA
EEECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCCHHHH
ALKAAELSARAEVERIAHAFGRGNWQQAVGSSGTARALRDILEQSGWSAGGITRDGLDRL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
RDALLAAGDVERLELPGLSRDRRPVIAGGFAIMAGLFAELGIEQMDVAETAMREGILYDL
HHHHHHCCCCHHEECCCCCCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
LGRFHADDMREATVAEFARRYHVDAGQAERVGRTVLRLFAATGREDDNDARVLGWAARLH
HHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EIGLSVSHSGYHRHSAYILENADMPGFSRTEQARLALLARAQRGALTKVAAVAAGAVDER
HHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
DRRAIWLLRQAVILCRSRADPRLAEVSAESTSKRFCLTLPPGWLEQRPLTQRALDDEIQH
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
WQALGLKYVLG
HHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]