Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 74317043

GI number: 74317043

Start: 1092753

End: 1093946

Strand: Direct

Name: moeA [H]

Synonym: Tbd_1025

Alternate gene names: 74317043

Gene position: 1092753-1093946 (Clockwise)

Preceding gene: 74317042

Following gene: 74317044

Centisome position: 37.55

GC content: 70.69

Gene sequence:

>1194_bases
ATGCTCTCAGCCGACCAACTGCTTGATGCCTTGCTCGAACGCGCGCGCCCGCTCGCGGCGACCGCCGTGGTACCCGTCGC
CAACGCACTCGGGCGCGTCCTCGCCGCGCCCTTGACCTCCGCGATCACCGTGCCGCCCGCGGACAACAGCGCCATGGACG
GCTACGCGGTTCGCACCGCGGATGTCGCGGCGCCCGGCGCGACCCTGCCGGTGACGCAGCGCATCCTCGCCGGCGCGGTC
GGCGAGGCGCTGCGCCCCGGGACCGCCGCCCGCATCTTCACCGGCGCACCGGTTCCCGCGGGTGCCGACGCCGTGCTGAT
GCAGGAAGACTGCAACGTTGCCGGGGACGAGGTCGTCGTCAACGCGATGCCGCGGCAGGGCGAGAACATCCGCCGCGCCG
GCGAGGACATCGTGGCGGGGGCCGAGGTGCTTGCCGCCGGAACGCGCATCGGCGCGGCCGAAATGGGTCTGGCGGCGTCG
GTCGGCGCCGCGGAGCTGGCCGTGTTTCGCCGGCTCAAGGTCGCGTGCTTCTTCACCGGCGACGAACTCGTCACGCCGGG
CACGCCGCTGCGGCCGGGGCAGATCTACAACTCGAACCGCTATACGCTGACCGGGCTCGTGCAGGGGCTCGGCTGCGAAC
TCATCGACCTCGGCATCGTGCCTGATACCCTGGAAGCGACCGAGGCCGCGCTCGAAGGCGCGGCGAGCGTCGCCGACGTC
GTCATCACGAGCGGCGGGGTGTCGGTCGGCGAGGCCGACTACGTCAAGGCGGCCGTCGACAGGCTCGGCCGCGTGGAAAT
GTGGAAAGTCGCGATGAAACCCGGCAAGCCGCTCGTCTACGGACGCGTGAACGATACCGATTTCATCGGCCTCCCCGGCA
ATCCCGTCTCGGCCTTCGTGACCTTCTGTCTCTTCGTGCGTCCCTTCCTGCTCAAGCGCATGGGCGCCGGCGACGTGCTC
TACCGCGCTTTCAGCGTGCCCGCCGGGTTCACCTGGGCCAAGCCCGGCACGCGGCGTGAATTCCTGCGCGCGCAGCTGCA
GCACGACGGGCGGCTCGCGCTCTTCGCGAACCAGAGTTCGGGCGTCCTCACGTCCTGTGCGTGGGCCCACGGTCTCGTCG
ATGTGGCGATCGGGCAGACCGTGGCGCCGGGCGATCTCGTGCGTTTCATCCCGTTCTCGGAGCTCCTCGCATGA

Upstream 100 bases:

>100_bases
GCGAATATTCTCGCAGTCGCGTCCGACGTCGACCCGCCGCGCGCTTTTCCCCGCATCGACATCGATTCGATTTCCCAACT
CACCGACTTCATCCTGAACC

Downstream 100 bases:

>100_bases
TCGTCCGCCTGCTGTATTTCGCGCGCCTGCGCGAGCGCTTCGGCCTGGCCGAAGAAACGCTTGATGTCGCCGGGGGCAGC
GTGGCCGATCTGATCGCGCA

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLSADQLLDALLERARPLAATAVVPVANALGRVLAAPLTSAITVPPADNSAMDGYAVRTADVAAPGATLPVTQRILAGAV
GEALRPGTAARIFTGAPVPAGADAVLMQEDCNVAGDEVVVNAMPRQGENIRRAGEDIVAGAEVLAAGTRIGAAEMGLAAS
VGAAELAVFRRLKVACFFTGDELVTPGTPLRPGQIYNSNRYTLTGLVQGLGCELIDLGIVPDTLEATEAALEGAASVADV
VITSGGVSVGEADYVKAAVDRLGRVEMWKVAMKPGKPLVYGRVNDTDFIGLPGNPVSAFVTFCLFVRPFLLKRMGAGDVL
YRAFSVPAGFTWAKPGTRREFLRAQLQHDGRLALFANQSSGVLTSCAWAHGLVDVAIGQTVAPGDLVRFIPFSELLA

Sequences:

>Translated_397_residues
MLSADQLLDALLERARPLAATAVVPVANALGRVLAAPLTSAITVPPADNSAMDGYAVRTADVAAPGATLPVTQRILAGAV
GEALRPGTAARIFTGAPVPAGADAVLMQEDCNVAGDEVVVNAMPRQGENIRRAGEDIVAGAEVLAAGTRIGAAEMGLAAS
VGAAELAVFRRLKVACFFTGDELVTPGTPLRPGQIYNSNRYTLTGLVQGLGCELIDLGIVPDTLEATEAALEGAASVADV
VITSGGVSVGEADYVKAAVDRLGRVEMWKVAMKPGKPLVYGRVNDTDFIGLPGNPVSAFVTFCLFVRPFLLKRMGAGDVL
YRAFSVPAGFTWAKPGTRREFLRAQLQHDGRLALFANQSSGVLTSCAWAHGLVDVAIGQTVAPGDLVRFIPFSELLA
>Mature_397_residues
MLSADQLLDALLERARPLAATAVVPVANALGRVLAAPLTSAITVPPADNSAMDGYAVRTADVAAPGATLPVTQRILAGAV
GEALRPGTAARIFTGAPVPAGADAVLMQEDCNVAGDEVVVNAMPRQGENIRRAGEDIVAGAEVLAAGTRIGAAEMGLAAS
VGAAELAVFRRLKVACFFTGDELVTPGTPLRPGQIYNSNRYTLTGLVQGLGCELIDLGIVPDTLEATEAALEGAASVADV
VITSGGVSVGEADYVKAAVDRLGRVEMWKVAMKPGKPLVYGRVNDTDFIGLPGNPVSAFVTFCLFVRPFLLKRMGAGDVL
YRAFSVPAGFTWAKPGTRREFLRAQLQHDGRLALFANQSSGVLTSCAWAHGLVDVAIGQTVAPGDLVRFIPFSELLA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=394, Percent_Identity=37.5634517766497, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI10880983, Length=394, Percent_Identity=37.5634517766497, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1787049, Length=380, Percent_Identity=46.0526315789474, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI25147659, Length=339, Percent_Identity=34.2182890855457, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=329, Percent_Identity=25.8358662613982, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136978, Length=370, Percent_Identity=32.4324324324324, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24638841, Length=370, Percent_Identity=32.4324324324324, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41145; Mature: 41145

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSADQLLDALLERARPLAATAVVPVANALGRVLAAPLTSAITVPPADNSAMDGYAVRTA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEE
DVAAPGATLPVTQRILAGAVGEALRPGTAARIFTGAPVPAGADAVLMQEDCNVAGDEVVV
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEE
NAMPRQGENIRRAGEDIVAGAEVLAAGTRIGAAEMGLAASVGAAELAVFRRLKVACFFTG
ECCCCCCCHHHHHCHHHHHHHHHHHHCCCCCHHHHCHHHHCCHHHHHHHHHEEEEEEEEC
DELVTPGTPLRPGQIYNSNRYTLTGLVQGLGCELIDLGIVPDTLEATEAALEGAASVADV
CCEECCCCCCCCCEEECCCCEEEEEHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHE
VITSGGVSVGEADYVKAAVDRLGRVEMWKVAMKPGKPLVYGRVNDTDFIGLPGNPVSAFV
EEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCCEEEECCCCHHHHHH
TFCLFVRPFLLKRMGAGDVLYRAFSVPAGFTWAKPGTRREFLRAQLQHDGRLALFANQSS
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCC
GVLTSCAWAHGLVDVAIGQTVAPGDLVRFIPFSELLA
CCHHHHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHC
>Mature Secondary Structure
MLSADQLLDALLERARPLAATAVVPVANALGRVLAAPLTSAITVPPADNSAMDGYAVRTA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEE
DVAAPGATLPVTQRILAGAVGEALRPGTAARIFTGAPVPAGADAVLMQEDCNVAGDEVVV
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEE
NAMPRQGENIRRAGEDIVAGAEVLAAGTRIGAAEMGLAASVGAAELAVFRRLKVACFFTG
ECCCCCCCHHHHHCHHHHHHHHHHHHCCCCCHHHHCHHHHCCHHHHHHHHHEEEEEEEEC
DELVTPGTPLRPGQIYNSNRYTLTGLVQGLGCELIDLGIVPDTLEATEAALEGAASVADV
CCEECCCCCCCCCEEECCCCEEEEEHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHE
VITSGGVSVGEADYVKAAVDRLGRVEMWKVAMKPGKPLVYGRVNDTDFIGLPGNPVSAFV
EEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCCEEEECCCCHHHHHH
TFCLFVRPFLLKRMGAGDVLYRAFSVPAGFTWAKPGTRREFLRAQLQHDGRLALFANQSS
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCC
GVLTSCAWAHGLVDVAIGQTVAPGDLVRFIPFSELLA
CCHHHHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]