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The map label for this gene is pip [H]

Identifier: 74316905

GI number: 74316905

Start: 935930

End: 936892

Strand: Reverse

Name: pip [H]

Synonym: Tbd_0887

Alternate gene names: 74316905

Gene position: 936892-935930 (Counterclockwise)

Preceding gene: 74316909

Following gene: 74316904

Centisome position: 32.2

GC content: 69.16

Gene sequence:

>963_bases
ATGTCAGGCCCCGCGTCGCTCTATCCGCCGATCACCCCCTACGCCAGCGGCCTGCTCGAGACCGACGGCGTCCACCGCAT
CTACTGGGAAACCTCGGGCAACCCCGCAGGCATCCCCGTGCTCTTCGTCCACGGTGGCCCGGGGGCCGGCACGTCGGCCA
ACCAGAGACGCTTCTTCGATCCCGCGCGCTACCGCATCGTGCTGTTCGATCAGCGCGGCTGCGGCCGCTCGACGCCGCAC
GGCGAACTCGCCGACAATACGACGCCGCACCTCATCGCCGACATGGAAGCGCTGCGCGACGAACTCGACGTCGCCTCATG
GCTCGTGTTCGGCGGCTCCTGGGGATCGACGCTCGCGCTGGCCTATGCCCAGGCTCATCCCGAGCGCTGCCGCGGCCTCG
TGCTGCGTGGCATCTTCCTCTGCCGCCCGCAGGAGATCGACTGGTTTCTCTACGGGATCCGCAGCTTTTTCCCCGAAGCG
CAGCGCCAGCTCGCGGAATTCATCCCCGAAGACGAGCGTGACGATCTGCTCGTCGCCTACCATCGCCGCCTGGTCGATCC
CGATCCGGCCGTGCATCGCCCGGCCGCTTGGCAGTGGGCGACCTTCGAGGCCTCGTGCTCGACGCTGCTGCCGAGTGCCG
AACTCGTCGCCGCGTTCGGCAGCGAACGGACCGCGCTCTCGTTGTCGCGCATCGAGGCGCACTACTTCGTCAATGGCATC
TTCCTTCCCGACGACAGCCTGCTCGCCAACGTCGCGCGCATCCGCCACATCCCCGCGCTGATCGTGCAGGGTCGCTACGA
CGCCGTCTGCCCGATCACCTCGGCCGACGACCTCGCGCGGGCCTGGCCCGAAGCGCACTACCAGGTCGTGCCGGACGCGG
GCCACTCGGCGTTCGAGCCCGGCATCGCCCGTGCACTGGTCGCCGCCTGCGACCGCTTCGCTGCCACCGGAGCCCTGATC
TGA

Upstream 100 bases:

>100_bases
ACGTACCCGCCCGGCGCCTGTCGATACGGGCGCGGCCGGCGACCCTTCTGCCAGGGCGGCGAGACGCTATCATGCGAGTT
CTCCGTCGTAACCCAAGCTC

Downstream 100 bases:

>100_bases
TGACGCTCTCGCCCCACGTCTTCGACGCCACCGCCGACAATTTCAATCGCCTGGTTCTGGAGAATTCGCACAAGGGACCC
GTGCTGGTCCACTTCTGGAC

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSGPASLYPPITPYASGLLETDGVHRIYWETSGNPAGIPVLFVHGGPGAGTSANQRRFFDPARYRIVLFDQRGCGRSTPH
GELADNTTPHLIADMEALRDELDVASWLVFGGSWGSTLALAYAQAHPERCRGLVLRGIFLCRPQEIDWFLYGIRSFFPEA
QRQLAEFIPEDERDDLLVAYHRRLVDPDPAVHRPAAWQWATFEASCSTLLPSAELVAAFGSERTALSLSRIEAHYFVNGI
FLPDDSLLANVARIRHIPALIVQGRYDAVCPITSADDLARAWPEAHYQVVPDAGHSAFEPGIARALVAACDRFAATGALI

Sequences:

>Translated_320_residues
MSGPASLYPPITPYASGLLETDGVHRIYWETSGNPAGIPVLFVHGGPGAGTSANQRRFFDPARYRIVLFDQRGCGRSTPH
GELADNTTPHLIADMEALRDELDVASWLVFGGSWGSTLALAYAQAHPERCRGLVLRGIFLCRPQEIDWFLYGIRSFFPEA
QRQLAEFIPEDERDDLLVAYHRRLVDPDPAVHRPAAWQWATFEASCSTLLPSAELVAAFGSERTALSLSRIEAHYFVNGI
FLPDDSLLANVARIRHIPALIVQGRYDAVCPITSADDLARAWPEAHYQVVPDAGHSAFEPGIARALVAACDRFAATGALI
>Mature_319_residues
SGPASLYPPITPYASGLLETDGVHRIYWETSGNPAGIPVLFVHGGPGAGTSANQRRFFDPARYRIVLFDQRGCGRSTPHG
ELADNTTPHLIADMEALRDELDVASWLVFGGSWGSTLALAYAQAHPERCRGLVLRGIFLCRPQEIDWFLYGIRSFFPEAQ
RQLAEFIPEDERDDLLVAYHRRLVDPDPAVHRPAAWQWATFEASCSTLLPSAELVAAFGSERTALSLSRIEAHYFVNGIF
LPDDSLLANVARIRHIPALIVQGRYDAVCPITSADDLARAWPEAHYQVVPDAGHSAFEPGIARALVAACDRFAATGALI

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 35105; Mature: 34974

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPASLYPPITPYASGLLETDGVHRIYWETSGNPAGIPVLFVHGGPGAGTSANQRRFFD
CCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCC
PARYRIVLFDQRGCGRSTPHGELADNTTPHLIADMEALRDELDVASWLVFGGSWGSTLAL
CCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHH
AYAQAHPERCRGLVLRGIFLCRPQEIDWFLYGIRSFFPEAQRQLAEFIPEDERDDLLVAY
HHHHCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHH
HRRLVDPDPAVHRPAAWQWATFEASCSTLLPSAELVAAFGSERTALSLSRIEAHYFVNGI
HHHHCCCCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHCCCCCEEHHHHHEEEEEEEEE
FLPDDSLLANVARIRHIPALIVQGRYDAVCPITSADDLARAWPEAHYQVVPDAGHSAFEP
ECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCH
GIARALVAACDRFAATGALI
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SGPASLYPPITPYASGLLETDGVHRIYWETSGNPAGIPVLFVHGGPGAGTSANQRRFFD
CCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCC
PARYRIVLFDQRGCGRSTPHGELADNTTPHLIADMEALRDELDVASWLVFGGSWGSTLAL
CCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHH
AYAQAHPERCRGLVLRGIFLCRPQEIDWFLYGIRSFFPEAQRQLAEFIPEDERDDLLVAY
HHHHCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHH
HRRLVDPDPAVHRPAAWQWATFEASCSTLLPSAELVAAFGSERTALSLSRIEAHYFVNGI
HHHHCCCCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHCCCCCEEHHHHHEEEEEEEEE
FLPDDSLLANVARIRHIPALIVQGRYDAVCPITSADDLARAWPEAHYQVVPDAGHSAFEP
ECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCH
GIARALVAACDRFAATGALI
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]