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The map label for this gene is lpxD

Identifier: 74316813

GI number: 74316813

Start: 838568

End: 839599

Strand: Direct

Name: lpxD

Synonym: Tbd_0795

Alternate gene names: 74316813

Gene position: 838568-839599 (Clockwise)

Preceding gene: 74316812

Following gene: 74316814

Centisome position: 28.82

GC content: 67.83

Gene sequence:

>1032_bases
ATGGCGGTCACGCTTGCAGCGCTGGTCGAGCGCTTTGGCGGCGAGCTGGTCGGCGACAGCGCGCGTTCGGTGCGCCAGGT
CGCGCCGCTCGACCGCGCCTGCGCCGATGACATCGGTTTCGTCTCGCAGAGCAAATATCTCGCCGAGCTCGCAACGACCG
GCGCGGGTGCGGTCATCCTGCCGCCGGACGCGCGCGATGCGACCGACCTGCCGCGCATTCTGACGCCGAATCCCTATCTC
TATTTCGCGCGCGTCTCGGCGCTGCTGAATCCACCGCCGCGTCCGGCAGCGGGTGTGCATCCCGCTGCGACCGTGGCCGC
CGACGCCGAAGTCGCAGCCGACGCGAGCATCGCCGCGGGCGCGGTGATCGGCAGCGGCGCGCGGATCGGTGCGCGCAGCG
TCATCGGTGCGAACAGCGTCGTCGGCGACGGCGCGCGGGTGGGGGAAGACTGCCTGCTGCACGCCAACGTGAGCCTCTAT
CACGGCTGCCAGGTCGGCGACCGCGTCATCCTGCACGCCGGCTGCGTCATCGGCGCCGACGGCTTCGGCTTCGCGCCGAA
CGAAGGCCGCTGGGAAAAGATCCCGCAGATCGGCCGCGTGCTGATCGGCGACGACGTCGAAGTCGGCGCCTGCACGACGA
TCGATCGCGGGGCGCTCGAGGACACCGTGATCGAGGAGGGCGTCAAGCTCGACAATCTGATCCAGGTCGCGCACAACGTC
GTGATCGGCGCGCACTCGGCCATCGCCGCCTGCACCGGAATCGCGGGCAGCGCGAAGATCGGCCGCCACTGCACGATCGG
CGGGGCGGCGATGATATTCGGCCATATCGAGATTGCCGACGGCACGCGCATATCGACCAACACGCTGATCACCAAGTCGC
TGCCGAAGCGCGGCACCTACACATCGGCGCTGCCCTTCTCGGAGCACGAGGTCTGGCAGAAGAACGCAGTCCACATGCGT
AACCTCGACAAGCTCGTCACCCGCGTCAAGCAGCTCGAGAAAAGGCTCAACGAACTGGAAAACAAGACATGA

Upstream 100 bases:

>100_bases
GAAATACGACCTCATCGTCGAGCAGGCCGTCTACGTCGATGCCAAGAGCGACATCACCGACCGGGTGATGAAGGCGCTGG
GCGGGAAATAATCGGCGGCG

Downstream 100 bases:

>100_bases
TCATGGACATCGAGCAGGTGATGCAGTACCTGCCGCATCGTTACCCCTTCCTGCTGGTCGACAAGGTCACCGAGCTCGAA
CTCGGCAAGCGCATCACCGC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MAVTLAALVERFGGELVGDSARSVRQVAPLDRACADDIGFVSQSKYLAELATTGAGAVILPPDARDATDLPRILTPNPYL
YFARVSALLNPPPRPAAGVHPAATVAADAEVAADASIAAGAVIGSGARIGARSVIGANSVVGDGARVGEDCLLHANVSLY
HGCQVGDRVILHAGCVIGADGFGFAPNEGRWEKIPQIGRVLIGDDVEVGACTTIDRGALEDTVIEEGVKLDNLIQVAHNV
VIGAHSAIAACTGIAGSAKIGRHCTIGGAAMIFGHIEIADGTRISTNTLITKSLPKRGTYTSALPFSEHEVWQKNAVHMR
NLDKLVTRVKQLEKRLNELENKT

Sequences:

>Translated_343_residues
MAVTLAALVERFGGELVGDSARSVRQVAPLDRACADDIGFVSQSKYLAELATTGAGAVILPPDARDATDLPRILTPNPYL
YFARVSALLNPPPRPAAGVHPAATVAADAEVAADASIAAGAVIGSGARIGARSVIGANSVVGDGARVGEDCLLHANVSLY
HGCQVGDRVILHAGCVIGADGFGFAPNEGRWEKIPQIGRVLIGDDVEVGACTTIDRGALEDTVIEEGVKLDNLIQVAHNV
VIGAHSAIAACTGIAGSAKIGRHCTIGGAAMIFGHIEIADGTRISTNTLITKSLPKRGTYTSALPFSEHEVWQKNAVHMR
NLDKLVTRVKQLEKRLNELENKT
>Mature_342_residues
AVTLAALVERFGGELVGDSARSVRQVAPLDRACADDIGFVSQSKYLAELATTGAGAVILPPDARDATDLPRILTPNPYLY
FARVSALLNPPPRPAAGVHPAATVAADAEVAADASIAAGAVIGSGARIGARSVIGANSVVGDGARVGEDCLLHANVSLYH
GCQVGDRVILHAGCVIGADGFGFAPNEGRWEKIPQIGRVLIGDDVEVGACTTIDRGALEDTVIEEGVKLDNLIQVAHNVV
IGAHSAIAACTGIAGSAKIGRHCTIGGAAMIFGHIEIADGTRISTNTLITKSLPKRGTYTSALPFSEHEVWQKNAVHMRN
LDKLVTRVKQLEKRLNELENKT

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=339, Percent_Identity=41.5929203539823, Blast_Score=284, Evalue=5e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_THIDA (Q3SKN1)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314553.1
- ProteinModelPortal:   Q3SKN1
- STRING:   Q3SKN1
- GeneID:   3673492
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0795
- NMPDR:   fig|292415.3.peg.102
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- PhylomeDB:   Q3SKN1
- BioCyc:   TDEN292415:TBD_0795-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.- [C]

Molecular weight: Translated: 35725; Mature: 35594

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTLAALVERFGGELVGDSARSVRQVAPLDRACADDIGFVSQSKYLAELATTGAGAVIL
CEEEHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEE
PPDARDATDLPRILTPNPYLYFARVSALLNPPPRPAAGVHPAATVAADAEVAADASIAAG
CCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHCCCHHHHH
AVIGSGARIGARSVIGANSVVGDGARVGEDCLLHANVSLYHGCQVGDRVILHAGCVIGAD
HEECCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCEEEEEECEEEECC
GFGFAPNEGRWEKIPQIGRVLIGDDVEVGACTTIDRGALEDTVIEEGVKLDNLIQVAHNV
CCCCCCCCCCHHHHHHHCCEEECCCCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VIGAHSAIAACTGIAGSAKIGRHCTIGGAAMIFGHIEIADGTRISTNTLITKSLPKRGTY
HHCCHHHHHHHHCCCCCCCCCCEEECCCEEEEEEEEEECCCCEEECCEEEECCCCCCCCC
TSALPFSEHEVWQKNAVHMRNLDKLVTRVKQLEKRLNELENKT
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVTLAALVERFGGELVGDSARSVRQVAPLDRACADDIGFVSQSKYLAELATTGAGAVIL
EEEHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEE
PPDARDATDLPRILTPNPYLYFARVSALLNPPPRPAAGVHPAATVAADAEVAADASIAAG
CCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHCCCHHHHH
AVIGSGARIGARSVIGANSVVGDGARVGEDCLLHANVSLYHGCQVGDRVILHAGCVIGAD
HEECCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCEEEEEECEEEECC
GFGFAPNEGRWEKIPQIGRVLIGDDVEVGACTTIDRGALEDTVIEEGVKLDNLIQVAHNV
CCCCCCCCCCHHHHHHHCCEEECCCCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VIGAHSAIAACTGIAGSAKIGRHCTIGGAAMIFGHIEIADGTRISTNTLITKSLPKRGTY
HHCCHHHHHHHHCCCCCCCCCCEEECCCEEEEEEEEEECCCCEEECCEEEECCCCCCCCC
TSALPFSEHEVWQKNAVHMRNLDKLVTRVKQLEKRLNELENKT
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA