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The map label for this gene is yciR [C]

Identifier: 74316634

GI number: 74316634

Start: 645161

End: 647185

Strand: Reverse

Name: yciR [C]

Synonym: Tbd_0616

Alternate gene names: 74316634

Gene position: 647185-645161 (Counterclockwise)

Preceding gene: 74316635

Following gene: 74316632

Centisome position: 22.24

GC content: 65.38

Gene sequence:

>2025_bases
ATGCCTGAGTGTACCGAGCCCATCTCGTCGCCGTGCGGGGGACGCTTCAAGCGCGCCGAAATCTGGAAGCTCGCGCTGCT
CGCGGGCTTCGTCATCCAGTTGTTCCTGATCCTGTTCGTCACGGCGATCGGGCTGCAGCAACTGCGTATGACCACCGAAA
ACCTGAAGACCGTGGTCGACGTCCACATGCGCAAGCAAAACCTCACCAAGACCATGGTTCTCACGGCGCGCGAGCGCACG
CTGATCATGTTCATGCTGACCAAGATCGACGACCCGTTCGAGCGCGACCAGCTGCTGCTGCGCTTCCGCGAGAAGGGGTC
GGAGTTCGTCGCCGCGCGCTTGCAACTGCTCGAACTGCCGCTGAGCGCCCGCGAACGGCACCTGATCGACCTCCATAAGG
AACGCATCGCTTTCGCCCAGCCGATCCAGGAGGAAGTCATCGAGCTGATCAGCGCGGATTTCACCCAGGACGGCGTCGAC
CTCGCGCTCAGGCAGGCCATCCCGGCGCAGAACAGCGTCATGGTGCTTCTCTCGCGTCTCGACGAAGAAGTGCATCGGGT
CGCGATCGCGGCGAGCGAAAGGGCCTACGAAGCGCATCGCGTGGCGCGCTTCTGGATGTACTTCCTCTCCGGCATCGCGC
TGCTCGTGGGCCTCGTCGTCGCCGCCGCGGTGCTGTTCTATTCCGCGCGCTTCAGCCGCGAGCGCGAACGTCTGGTGACC
AAGGACACGCTCACCGGCCTGCCCAACCGCATGCTGCTGCGCGACCGCCTCGAGCAGGCACTCGCACGCGCCCGTCGGCG
CGGCACGCTCGTCGGCGTGATGTTCATCGACCTCGACCGCTTCAAGCGCGTCAACGACACCCTCGGCCACGCCAGCGGCG
ACGAACTCATCTGCGAAGTCGGCCAGCGCCTGCGCGCGATCGCGCGCGACGAGGACACGGTGGCGAGGCTCGGCGGCGAC
GAGTTCGTCGTCGTCGCCAACGATGCGCGCGGCGTCGGCCAGATCCTCCATATCGTCGAAAAGGTCCGCGCGGCACTCGC
CGCCCCGTATCGGGTCGGCGAACGCGAACTCTTCTGCTGCAGCAGCATCGGCATCAGCGTGTTTCCGAACGACGGCGCCG
ACTGCAGCAGTCTGCTGAAGAACGCCGACACCGCGATGTACCACGCCAAGGGCAGCGGACGGGACCGTTTCCAGCTTTAC
GACGCGGGCATGAACGCGATGGCCGAGGAGCGGCTGCAACTCGAAACCGACCTGCACTACGCGCTCGAACGCGGCGAGTT
CGTGCTGCACTACCAGCCGCAGATCGATCTCACGAGCGGCCGCGTCTGTGCGGTCGAGGCCCTGGTCCGCTGGAACCATC
CGCAGAAAGGCGTTCTGGCGCCCGCGTCGTTCCTCGAAATGCTCGAAGAGACCGGCCAGATACTCGACGTCGGCCGTGCG
CTTCTGCTCGCCGCGTGCCAACAGACCGCACAGTGGCACGCCGCCGGCTTCAAGGATCTCGACGTCGCCGTCAACCTCTC
GGGCAAGGAATTCTGGCACGGTTCGCTGATCAGCTCGATCAGCGAGGCACTGAAGCTGTCGGGCCTGCCCGCGCAATTCC
TGCAGATCGAACTGACCGAAAGCATTTTCATGAAGGACATCGACAATGCCGTCGCGCGGATTCAGGCGCTCAAGGCGCTC
GGCGTCGCGGTCGCGGTCGACGACTTCGGCACCGGCTATTCGTCGCTCGCCCACCTCAAGCGCTTTCCGGTCAACGTCCT
CAAGATCGACCGCTATTTCATCAACGAACTGCCTACCGCCTCGGTCAACGAAGCGCTCGTCGCATCGATCCTGGCGCTCA
GCGACGGGCTGCATCTCGACGCCGTCGCCGAGGGCGTGGAAAACATCGAACAGCTCGCGCGGCTGCGGCAGCTCGGCTGC
CGCATCGTCCAGGGTTATCTCGTCAGCAAGCCGGTCGCGGCCGAGCAGTTGACCGCGCTGCTGCGCCGCGACTGGCACGA
AGTGCTCGGCGGCGCCGTGGCCTAG

Upstream 100 bases:

>100_bases
GGGGTCACGCTCGGTCATGCGGCGCGTGCGGGCGCCTGCCTGCCCATTGCCCGGCTCGTCCCCACCCCGCCGGGCCGTTC
CCCCACTCCCCGGGATACCC

Downstream 100 bases:

>100_bases
CGGCGAACGCCGCGCTGCCGCAGCGCCTCGAACACCGCGACGGCGAGCGCGGCCGAGGCATTGAGCGATTCGACCCGCCC
CGGCATCGGGATGCGTGCGC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MPECTEPISSPCGGRFKRAEIWKLALLAGFVIQLFLILFVTAIGLQQLRMTTENLKTVVDVHMRKQNLTKTMVLTARERT
LIMFMLTKIDDPFERDQLLLRFREKGSEFVAARLQLLELPLSARERHLIDLHKERIAFAQPIQEEVIELISADFTQDGVD
LALRQAIPAQNSVMVLLSRLDEEVHRVAIAASERAYEAHRVARFWMYFLSGIALLVGLVVAAAVLFYSARFSRERERLVT
KDTLTGLPNRMLLRDRLEQALARARRRGTLVGVMFIDLDRFKRVNDTLGHASGDELICEVGQRLRAIARDEDTVARLGGD
EFVVVANDARGVGQILHIVEKVRAALAAPYRVGERELFCCSSIGISVFPNDGADCSSLLKNADTAMYHAKGSGRDRFQLY
DAGMNAMAEERLQLETDLHYALERGEFVLHYQPQIDLTSGRVCAVEALVRWNHPQKGVLAPASFLEMLEETGQILDVGRA
LLLAACQQTAQWHAAGFKDLDVAVNLSGKEFWHGSLISSISEALKLSGLPAQFLQIELTESIFMKDIDNAVARIQALKAL
GVAVAVDDFGTGYSSLAHLKRFPVNVLKIDRYFINELPTASVNEALVASILALSDGLHLDAVAEGVENIEQLARLRQLGC
RIVQGYLVSKPVAAEQLTALLRRDWHEVLGGAVA

Sequences:

>Translated_674_residues
MPECTEPISSPCGGRFKRAEIWKLALLAGFVIQLFLILFVTAIGLQQLRMTTENLKTVVDVHMRKQNLTKTMVLTARERT
LIMFMLTKIDDPFERDQLLLRFREKGSEFVAARLQLLELPLSARERHLIDLHKERIAFAQPIQEEVIELISADFTQDGVD
LALRQAIPAQNSVMVLLSRLDEEVHRVAIAASERAYEAHRVARFWMYFLSGIALLVGLVVAAAVLFYSARFSRERERLVT
KDTLTGLPNRMLLRDRLEQALARARRRGTLVGVMFIDLDRFKRVNDTLGHASGDELICEVGQRLRAIARDEDTVARLGGD
EFVVVANDARGVGQILHIVEKVRAALAAPYRVGERELFCCSSIGISVFPNDGADCSSLLKNADTAMYHAKGSGRDRFQLY
DAGMNAMAEERLQLETDLHYALERGEFVLHYQPQIDLTSGRVCAVEALVRWNHPQKGVLAPASFLEMLEETGQILDVGRA
LLLAACQQTAQWHAAGFKDLDVAVNLSGKEFWHGSLISSISEALKLSGLPAQFLQIELTESIFMKDIDNAVARIQALKAL
GVAVAVDDFGTGYSSLAHLKRFPVNVLKIDRYFINELPTASVNEALVASILALSDGLHLDAVAEGVENIEQLARLRQLGC
RIVQGYLVSKPVAAEQLTALLRRDWHEVLGGAVA
>Mature_673_residues
PECTEPISSPCGGRFKRAEIWKLALLAGFVIQLFLILFVTAIGLQQLRMTTENLKTVVDVHMRKQNLTKTMVLTARERTL
IMFMLTKIDDPFERDQLLLRFREKGSEFVAARLQLLELPLSARERHLIDLHKERIAFAQPIQEEVIELISADFTQDGVDL
ALRQAIPAQNSVMVLLSRLDEEVHRVAIAASERAYEAHRVARFWMYFLSGIALLVGLVVAAAVLFYSARFSRERERLVTK
DTLTGLPNRMLLRDRLEQALARARRRGTLVGVMFIDLDRFKRVNDTLGHASGDELICEVGQRLRAIARDEDTVARLGGDE
FVVVANDARGVGQILHIVEKVRAALAAPYRVGERELFCCSSIGISVFPNDGADCSSLLKNADTAMYHAKGSGRDRFQLYD
AGMNAMAEERLQLETDLHYALERGEFVLHYQPQIDLTSGRVCAVEALVRWNHPQKGVLAPASFLEMLEETGQILDVGRAL
LLAACQQTAQWHAAGFKDLDVAVNLSGKEFWHGSLISSISEALKLSGLPAQFLQIELTESIFMKDIDNAVARIQALKALG
VAVAVDDFGTGYSSLAHLKRFPVNVLKIDRYFINELPTASVNEALVASILALSDGLHLDAVAEGVENIEQLARLRQLGCR
IVQGYLVSKPVAAEQLTALLRRDWHEVLGGAVA

Specific function: Unknown

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MHYT domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=426, Percent_Identity=37.0892018779343, Blast_Score=296, Evalue=4e-81,
Organism=Escherichia coli, GI87081921, Length=442, Percent_Identity=33.9366515837104, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI226510982, Length=429, Percent_Identity=29.6037296037296, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1790496, Length=247, Percent_Identity=32.7935222672065, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788502, Length=257, Percent_Identity=31.1284046692607, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081980, Length=268, Percent_Identity=32.4626865671642, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787055, Length=256, Percent_Identity=30.078125, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1786507, Length=290, Percent_Identity=28.6206896551724, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87081845, Length=250, Percent_Identity=28.8, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI87081743, Length=235, Percent_Identity=28.936170212766, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI145693134, Length=168, Percent_Identity=37.5, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI87081977, Length=150, Percent_Identity=36.6666666666667, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788849, Length=246, Percent_Identity=32.520325203252, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788381, Length=442, Percent_Identity=23.7556561085973, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI87082096, Length=234, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786584, Length=171, Percent_Identity=29.8245614035088, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI87081881, Length=168, Percent_Identity=30.952380952381, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787816, Length=164, Percent_Identity=33.5365853658537, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787802, Length=149, Percent_Identity=31.5436241610738, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788956, Length=155, Percent_Identity=31.6129032258064, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1787262, Length=184, Percent_Identity=32.0652173913043, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081974, Length=100, Percent_Identity=39, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1787410, Length=223, Percent_Identity=26.457399103139, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082007, Length=164, Percent_Identity=29.2682926829268, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 74969; Mature: 74838

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPECTEPISSPCGGRFKRAEIWKLALLAGFVIQLFLILFVTAIGLQQLRMTTENLKTVVD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHMRKQNLTKTMVLTARERTLIMFMLTKIDDPFERDQLLLRFREKGSEFVAARLQLLELP
HHHHHHCCHHHHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCC
LSARERHLIDLHKERIAFAQPIQEEVIELISADFTQDGVDLALRQAIPAQNSVMVLLSRL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
DEEVHRVAIAASERAYEAHRVARFWMYFLSGIALLVGLVVAAAVLFYSARFSRERERLVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDTLTGLPNRMLLRDRLEQALARARRRGTLVGVMFIDLDRFKRVNDTLGHASGDELICEV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHHHHH
GQRLRAIARDEDTVARLGGDEFVVVANDARGVGQILHIVEKVRAALAAPYRVGERELFCC
HHHHHHHHCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
SSIGISVFPNDGADCSSLLKNADTAMYHAKGSGRDRFQLYDAGMNAMAEERLQLETDLHY
ECCCCEECCCCCCCHHHHHHCCCHHEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
ALERGEFVLHYQPQIDLTSGRVCAVEALVRWNHPQKGVLAPASFLEMLEETGQILDVGRA
HHHCCCEEEEECCCEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLLAACQQTAQWHAAGFKDLDVAVNLSGKEFWHGSLISSISEALKLSGLPAQFLQIELTE
HHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SIFMKDIDNAVARIQALKALGVAVAVDDFGTGYSSLAHLKRFPVNVLKIDRYFINELPTA
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCC
SVNEALVASILALSDGLHLDAVAEGVENIEQLARLRQLGCRIVQGYLVSKPVAAEQLTAL
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LRRDWHEVLGGAVA
HHHHHHHHCCCCCC
>Mature Secondary Structure 
PECTEPISSPCGGRFKRAEIWKLALLAGFVIQLFLILFVTAIGLQQLRMTTENLKTVVD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHMRKQNLTKTMVLTARERTLIMFMLTKIDDPFERDQLLLRFREKGSEFVAARLQLLELP
HHHHHHCCHHHHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCC
LSARERHLIDLHKERIAFAQPIQEEVIELISADFTQDGVDLALRQAIPAQNSVMVLLSRL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
DEEVHRVAIAASERAYEAHRVARFWMYFLSGIALLVGLVVAAAVLFYSARFSRERERLVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDTLTGLPNRMLLRDRLEQALARARRRGTLVGVMFIDLDRFKRVNDTLGHASGDELICEV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHHHHH
GQRLRAIARDEDTVARLGGDEFVVVANDARGVGQILHIVEKVRAALAAPYRVGERELFCC
HHHHHHHHCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
SSIGISVFPNDGADCSSLLKNADTAMYHAKGSGRDRFQLYDAGMNAMAEERLQLETDLHY
ECCCCEECCCCCCCHHHHHHCCCHHEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
ALERGEFVLHYQPQIDLTSGRVCAVEALVRWNHPQKGVLAPASFLEMLEETGQILDVGRA
HHHCCCEEEEECCCEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLLAACQQTAQWHAAGFKDLDVAVNLSGKEFWHGSLISSISEALKLSGLPAQFLQIELTE
HHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SIFMKDIDNAVARIQALKALGVAVAVDDFGTGYSSLAHLKRFPVNVLKIDRYFINELPTA
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCC
SVNEALVASILALSDGLHLDAVAEGVENIEQLARLRQLGCRIVQGYLVSKPVAAEQLTAL
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LRRDWHEVLGGAVA
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]