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The map label for this gene is 74316525

Identifier: 74316525

GI number: 74316525

Start: 533043

End: 534863

Strand: Direct

Name: 74316525

Synonym: Tbd_0507

Alternate gene names: NA

Gene position: 533043-534863 (Clockwise)

Preceding gene: 74316524

Following gene: 74316527

Centisome position: 18.32

GC content: 67.66

Gene sequence:

>1821_bases
ATGTCACGTCACAGCCCATTCCCTGTCCACCTTTCCGCCACGCACCGCGCCGAGCGCGACGGCTCCGCCCGCCTCGGCCT
AAGCCTGCTGGCGGCCGCCATGCTCGCGAGCTACGCCGGTCTCGGCGAAGCCGCGCCGCAGGCCACGCCGCCGGCTACGG
TCGCGAAAGCGCAACCCTATCTCGGCTGGGCCAAGGGCCGGCTGCTCGTCGCGCCGCGAGCGGGCTTGCCCCCCGGCCAG
CTCGACAAGGCACTCAGAAAGGTAAACGGGCGCTCGGCGACCCACATCAAGCCCTTGAACGTGCACGTCGTCGAGTTGCC
GGTGGGTGCCGACGAGGTGAGCGCGGCGCGCGAGTTGCGCAAGAACCGCAGCTTCAAATACGTCGAACTCGACATGGCGG
TTGCGGCGGCGGCTACGGTGACCGATCCCGCCTACGGCAACAGCTGGGCGTTGCCGAAAATCCAGGCACCGACCGCGTGG
GACAGCAGCAACGGCAGCGGTGTGACCGTCGCCATCCTCGATACCGGCCTCGACGCCGTCCACCCCGATCTCGTCGCCAA
CGTCGTACCGGGCTGGAACGTCTACGACAACAACTCCAATACCGCCGACGTCAACGGTCACGGCACCTGGGTCGCCGGCG
TCGCGGCGATGGCGGCGAACAACGCCAAGGGCAGCGCGGGCGTGGCGTGGGGCGCGAAGATCATGCCGATACGCATCGCC
GATGCCAATGCCTACGCCTACTGGAGCACGGTCGCGCAGGGCATTTACTGGGCGGCGGACAACGGCGCCAAGGTGGTCAA
CATCAGCTACAACGGCGTGTCGGGAAGCTCGACCGTGCAGTCCGCGGCGCAGTATCTGCGCGGGAAGGGCGGCGTCGTGA
TCGTGGCGGCCGGCAATAGCGGCGGCCTGGAGAGCATCGCCGCCAACGACTCGCTGCTCACGGTCGCGGCGACCGATCAG
AACGACGTACGTGCGAGCTTCTCCAGCTACGGCGCCTATGTTGACCTGTCCGCGCCGGGGGTGAATCTCTATACGACGAC
GGTCGGCGGCGGCTTCGCCAACGCGTCGGGCACCTCGTTTTCCAGTCCGGTCGTCGCCGCGACGGCCGCGCTGATGCTGT
CGGCCAACGCCAAGCTTGCGCCTGCCGACGTGGACCGCATTCTCAAGGCGACCGCTCGCGATCTCGGTACGGCGGGCTAT
GACCAGTACCACGGCACGGGCCGCGTCAATGCCGCGTCGGCCGTGCAGAGCGCCAAGCAGACGATCGCGGCGGACACCCA
AGCGCCAACGGTCAGCATCGCGTCGCCGACTGGTGGCCAGGTTTCCGGCGTGGTCCCGGTCGACGTCCTGGCGTCGGACA
ACGTCGGTGTGACGCGCGCCGACTTCTACGTCAACGGCCAGCTCGTCGCGACCGATGCGCTGGCGCCGTTCGCCTTCGCC
TGGGACACGACGACCAAAGCGGACGGCAGCTACACCCTGAGCGTGCAGGCCTACGACGCCGCCGGCAACCGCGGGACGTC
GCCTTCGGTCACCGTCACCAGCGGCAACGACAGCGCCGCCCCGACGATCGCCAGCTTCAGCCTGACCGACGGCATGAAGC
TCTCGGGCAAGCAGATGGTCAAGGTCAGCGCGAGCGACAACCAGAAGGTCGCAAAGATTTCCTTGGTGATCGACGGCAAG
GAAGTCGCCACCGCGTTCGGCGGTTCGCTCAGCTACAACTGGAATACCAACAAGCTGGCGCGGGGTGCGCACACCGTGAC
CGTGCGCGTGACCGACAACTCGGGCAACGTCACGACGAAGACCGTGACGGTCTACAAGTGA

Upstream 100 bases:

>100_bases
ACCGGTCTCGAAAGAGATAGCGGCGCTGCCGTGGATGACCCGTGCTGGGTCCCCAGCGTGTGCATGCCTGTCGGGAGTTC
TTCGAACGCCAGGAGCCCCC

Downstream 100 bases:

>100_bases
GCTGCCACACATGGCCGAATAGGGGAGCGCCCTTCGGGGCGCTTTTTTTCGCCTTATTGAACCGGCGGCCGGGCGAGTGC
GGCCGCGACGCTGACCAGTT

Product: serine protease

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MSRHSPFPVHLSATHRAERDGSARLGLSLLAAAMLASYAGLGEAAPQATPPATVAKAQPYLGWAKGRLLVAPRAGLPPGQ
LDKALRKVNGRSATHIKPLNVHVVELPVGADEVSAARELRKNRSFKYVELDMAVAAAATVTDPAYGNSWALPKIQAPTAW
DSSNGSGVTVAILDTGLDAVHPDLVANVVPGWNVYDNNSNTADVNGHGTWVAGVAAMAANNAKGSAGVAWGAKIMPIRIA
DANAYAYWSTVAQGIYWAADNGAKVVNISYNGVSGSSTVQSAAQYLRGKGGVVIVAAGNSGGLESIAANDSLLTVAATDQ
NDVRASFSSYGAYVDLSAPGVNLYTTTVGGGFANASGTSFSSPVVAATAALMLSANAKLAPADVDRILKATARDLGTAGY
DQYHGTGRVNAASAVQSAKQTIAADTQAPTVSIASPTGGQVSGVVPVDVLASDNVGVTRADFYVNGQLVATDALAPFAFA
WDTTTKADGSYTLSVQAYDAAGNRGTSPSVTVTSGNDSAAPTIASFSLTDGMKLSGKQMVKVSASDNQKVAKISLVIDGK
EVATAFGGSLSYNWNTNKLARGAHTVTVRVTDNSGNVTTKTVTVYK

Sequences:

>Translated_606_residues
MSRHSPFPVHLSATHRAERDGSARLGLSLLAAAMLASYAGLGEAAPQATPPATVAKAQPYLGWAKGRLLVAPRAGLPPGQ
LDKALRKVNGRSATHIKPLNVHVVELPVGADEVSAARELRKNRSFKYVELDMAVAAAATVTDPAYGNSWALPKIQAPTAW
DSSNGSGVTVAILDTGLDAVHPDLVANVVPGWNVYDNNSNTADVNGHGTWVAGVAAMAANNAKGSAGVAWGAKIMPIRIA
DANAYAYWSTVAQGIYWAADNGAKVVNISYNGVSGSSTVQSAAQYLRGKGGVVIVAAGNSGGLESIAANDSLLTVAATDQ
NDVRASFSSYGAYVDLSAPGVNLYTTTVGGGFANASGTSFSSPVVAATAALMLSANAKLAPADVDRILKATARDLGTAGY
DQYHGTGRVNAASAVQSAKQTIAADTQAPTVSIASPTGGQVSGVVPVDVLASDNVGVTRADFYVNGQLVATDALAPFAFA
WDTTTKADGSYTLSVQAYDAAGNRGTSPSVTVTSGNDSAAPTIASFSLTDGMKLSGKQMVKVSASDNQKVAKISLVIDGK
EVATAFGGSLSYNWNTNKLARGAHTVTVRVTDNSGNVTTKTVTVYK
>Mature_605_residues
SRHSPFPVHLSATHRAERDGSARLGLSLLAAAMLASYAGLGEAAPQATPPATVAKAQPYLGWAKGRLLVAPRAGLPPGQL
DKALRKVNGRSATHIKPLNVHVVELPVGADEVSAARELRKNRSFKYVELDMAVAAAATVTDPAYGNSWALPKIQAPTAWD
SSNGSGVTVAILDTGLDAVHPDLVANVVPGWNVYDNNSNTADVNGHGTWVAGVAAMAANNAKGSAGVAWGAKIMPIRIAD
ANAYAYWSTVAQGIYWAADNGAKVVNISYNGVSGSSTVQSAAQYLRGKGGVVIVAAGNSGGLESIAANDSLLTVAATDQN
DVRASFSSYGAYVDLSAPGVNLYTTTVGGGFANASGTSFSSPVVAATAALMLSANAKLAPADVDRILKATARDLGTAGYD
QYHGTGRVNAASAVQSAKQTIAADTQAPTVSIASPTGGQVSGVVPVDVLASDNVGVTRADFYVNGQLVATDALAPFAFAW
DTTTKADGSYTLSVQAYDAAGNRGTSPSVTVTSGNDSAAPTIASFSLTDGMKLSGKQMVKVSASDNQKVAKISLVIDGKE
VATAFGGSLSYNWNTNKLARGAHTVTVRVTDNSGNVTTKTVTVYK

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI20336180, Length=358, Percent_Identity=26.8156424581006, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI20336184, Length=359, Percent_Identity=26.7409470752089, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI4505577, Length=358, Percent_Identity=26.8156424581006, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI20336182, Length=359, Percent_Identity=26.7409470752089, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI20336188, Length=359, Percent_Identity=26.7409470752089, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI20336190, Length=359, Percent_Identity=26.7409470752089, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI27894285, Length=359, Percent_Identity=26.7409470752089, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI295424143, Length=334, Percent_Identity=26.9461077844311, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI20336242, Length=334, Percent_Identity=26.9461077844311, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI20336186, Length=309, Percent_Identity=27.1844660194175, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI76443679, Length=363, Percent_Identity=26.4462809917355, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4506775, Length=274, Percent_Identity=29.9270072992701, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI4505579, Length=329, Percent_Identity=26.1398176291793, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI31317307, Length=298, Percent_Identity=28.5234899328859, Blast_Score=67, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71988308, Length=298, Percent_Identity=29.8657718120805, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988312, Length=298, Percent_Identity=29.8657718120805, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988315, Length=298, Percent_Identity=29.8657718120805, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=298, Percent_Identity=29.8657718120805, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=298, Percent_Identity=29.8657718120805, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=298, Percent_Identity=29.8657718120805, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=297, Percent_Identity=27.6094276094276, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25141268, Length=297, Percent_Identity=27.6094276094276, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=282, Percent_Identity=31.2056737588652, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324576, Length=244, Percent_Identity=31.9672131147541, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319893, Length=230, Percent_Identity=29.1304347826087, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45550681, Length=275, Percent_Identity=29.0909090909091, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17864552, Length=363, Percent_Identity=27.8236914600551, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650058, Length=363, Percent_Identity=27.8236914600551, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45553515, Length=363, Percent_Identity=27.5482093663912, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650060, Length=363, Percent_Identity=27.8236914600551, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45553513, Length=363, Percent_Identity=27.8236914600551, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650056, Length=363, Percent_Identity=27.8236914600551, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 61904; Mature: 61773

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRHSPFPVHLSATHRAERDGSARLGLSLLAAAMLASYAGLGEAAPQATPPATVAKAQPY
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCC
LGWAKGRLLVAPRAGLPPGQLDKALRKVNGRSATHIKPLNVHVVELPVGADEVSAARELR
CEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECEEEEEEECCCCHHHHHHHHHH
KNRSFKYVELDMAVAAAATVTDPAYGNSWALPKIQAPTAWDSSNGSGVTVAILDTGLDAV
HCCCEEEEEEEEEEEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCEEEEEEEECCCCCC
HPDLVANVVPGWNVYDNNSNTADVNGHGTWVAGVAAMAANNAKGSAGVAWGAKIMPIRIA
CCHHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEEEE
DANAYAYWSTVAQGIYWAADNGAKVVNISYNGVSGSSTVQSAAQYLRGKGGVVIVAAGNS
CCCCEEHHHHHHCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCC
GGLESIAANDSLLTVAATDQNDVRASFSSYGAYVDLSAPGVNLYTTTVGGGFANASGTSF
CCCCEEECCCCEEEEEECCCCHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCCCCCC
SSPVVAATAALMLSANAKLAPADVDRILKATARDLGTAGYDQYHGTGRVNAASAVQSAKQ
CCCHHHHHEEHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
TIAADTQAPTVSIASPTGGQVSGVVPVDVLASDNVGVTRADFYVNGQLVATDALAPFAFA
HHHCCCCCCEEEEECCCCCCEECEEEEEEEECCCCCEEEEEEEECCEEEEECCCCCEEEE
WDTTTKADGSYTLSVQAYDAAGNRGTSPSVTVTSGNDSAAPTIASFSLTDGMKLSGKQMV
ECCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCEECCCEEE
KVSASDNQKVAKISLVIDGKEVATAFGGSLSYNWNTNKLARGAHTVTVRVTDNSGNVTTK
EEECCCCCEEEEEEEEECCHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCCEEEE
TVTVYK
EEEEEC
>Mature Secondary Structure 
SRHSPFPVHLSATHRAERDGSARLGLSLLAAAMLASYAGLGEAAPQATPPATVAKAQPY
CCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCC
LGWAKGRLLVAPRAGLPPGQLDKALRKVNGRSATHIKPLNVHVVELPVGADEVSAARELR
CEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECEEEEEEECCCCHHHHHHHHHH
KNRSFKYVELDMAVAAAATVTDPAYGNSWALPKIQAPTAWDSSNGSGVTVAILDTGLDAV
HCCCEEEEEEEEEEEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCEEEEEEEECCCCCC
HPDLVANVVPGWNVYDNNSNTADVNGHGTWVAGVAAMAANNAKGSAGVAWGAKIMPIRIA
CCHHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEEEE
DANAYAYWSTVAQGIYWAADNGAKVVNISYNGVSGSSTVQSAAQYLRGKGGVVIVAAGNS
CCCCEEHHHHHHCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCC
GGLESIAANDSLLTVAATDQNDVRASFSSYGAYVDLSAPGVNLYTTTVGGGFANASGTSF
CCCCEEECCCCEEEEEECCCCHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCCCCCC
SSPVVAATAALMLSANAKLAPADVDRILKATARDLGTAGYDQYHGTGRVNAASAVQSAKQ
CCCHHHHHEEHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
TIAADTQAPTVSIASPTGGQVSGVVPVDVLASDNVGVTRADFYVNGQLVATDALAPFAFA
HHHCCCCCCEEEEECCCCCCEECEEEEEEEECCCCCEEEEEEEECCEEEEECCCCCEEEE
WDTTTKADGSYTLSVQAYDAAGNRGTSPSVTVTSGNDSAAPTIASFSLTDGMKLSGKQMV
ECCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCEECCCEEE
KVSASDNQKVAKISLVIDGKEVATAFGGSLSYNWNTNKLARGAHTVTVRVTDNSGNVTTK
EEECCCCCEEEEEEEEECCHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCCEEEE
TVTVYK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]