Click here to switch to the map view.

The map label for this gene is aroB

Identifier: 74316333

GI number: 74316333

Start: 339421

End: 340500

Strand: Direct

Name: aroB

Synonym: Tbd_0315

Alternate gene names: 74316333

Gene position: 339421-340500 (Clockwise)

Preceding gene: 74316325

Following gene: 74316334

Centisome position: 11.66

GC content: 67.59

Gene sequence:

>1080_bases
ATGCAAACCCTTACCGTCGATCTCGGCGACCGTTCCTATCCGATCCACATCGGCGCCGCCCTCTTGACCCGCGCCGACCT
GGTCCTGCCGCACCTCGCGCAGAAACGCGTGATGGTCGTGACCAACACGACCGTCGGCCCCTTGTACCTCGCGCAGTTGA
AGGCCGCGCTCGAGGCGGCGGGCGTGCGCGTGGCCGAGGTCGTCCTTCCTGACGGCGAGGCCTATAAGAACTGGGAAACG
CTGAACCTGGTGTTCGACGCGCTGCTGCGTGAGCGTGCCGAGCGCAAGACGACGCTGATCGCGCTCGGCGGCGGCGTGAT
CGGCGACATGACCGGGTTCGCCGCGGCGTGCTACCAGCGCGGCGTGCCTTTCATCCAGATTCCGACGACGCTGCTGTCAC
AGGTCGATTCCTCGGTCGGCGGCAAGACCGGGATCAACCATCCGCTCGGCAAGAACATGATCGGCGCCTTCTACCAGCCC
AAACTCGTGCTCGCCGATGCCGCCACCCTGGGCACGCTGCCCGCGCGCGAACTCTCGGCCGGCCTGGCCGAAGTGATCAA
GTACGGGCTGATCTGGGACGTCGAATTCCTCGCCTGGCTCGAGGCCAACATGGACCGGCTGCGTGCGCTCGACGCCGAGG
CGATTTCGCATGCGATCTACCGCTCCTGCGAGATCAAGGCCCAGGTCGTCGCCGAGGACGAGCGCGAAGGCGGCCTGCGC
GCGATCCTCAACCTCGGCCACACCTTCGGTCACGCGATCGAGACCGGCATGGGCTACGGCGCCTGGCTGCACGGTGAAGC
GGTGGCCGCCGGCATGGTGCTCGCCGCCGAAACCTCGCAACGTCTGGGCTGGCTCGGCGAAGCCGACGTCGCGCGGACCC
GCGCGCTGATCCGCGCCGCGGGGCTGCCGGACGTCGCGCCCAATCTCGGTGTCGACGCCTATCTCGAGTACATGGGCCAC
GACAAGAAAGTCGAGGGCGGAAAAATGCGCTTCGTGCTGCTGAAAAAACTCGGCGAGGCCGTGATCACCGACGCCGTCCC
CGCCGACGTGCTCACCGCCGTGCTGACCCCGCCGCACTGA

Upstream 100 bases:

>100_bases
ACCGCAGCGGACTTCGGCGCGCGACGGCCGCCGCCGTCCGTGCGGGGGCAAGGCGCGGTGCCATTGGTTACAATCGCGCA
ACCCCTATCGATTCACCACC

Downstream 100 bases:

>100_bases
GGAGAACCCAATGGAGCCGTCCTTCGCCCCCTATGCCGCGCATTCCAGCCAGACCCGGGGACGCGTGCACCGCGAGGCAC
CGGCGGCCCCGCGCTCGGAG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MQTLTVDLGDRSYPIHIGAALLTRADLVLPHLAQKRVMVVTNTTVGPLYLAQLKAALEAAGVRVAEVVLPDGEAYKNWET
LNLVFDALLRERAERKTTLIALGGGVIGDMTGFAAACYQRGVPFIQIPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQP
KLVLADAATLGTLPARELSAGLAEVIKYGLIWDVEFLAWLEANMDRLRALDAEAISHAIYRSCEIKAQVVAEDEREGGLR
AILNLGHTFGHAIETGMGYGAWLHGEAVAAGMVLAAETSQRLGWLGEADVARTRALIRAAGLPDVAPNLGVDAYLEYMGH
DKKVEGGKMRFVLLKKLGEAVITDAVPADVLTAVLTPPH

Sequences:

>Translated_359_residues
MQTLTVDLGDRSYPIHIGAALLTRADLVLPHLAQKRVMVVTNTTVGPLYLAQLKAALEAAGVRVAEVVLPDGEAYKNWET
LNLVFDALLRERAERKTTLIALGGGVIGDMTGFAAACYQRGVPFIQIPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQP
KLVLADAATLGTLPARELSAGLAEVIKYGLIWDVEFLAWLEANMDRLRALDAEAISHAIYRSCEIKAQVVAEDEREGGLR
AILNLGHTFGHAIETGMGYGAWLHGEAVAAGMVLAAETSQRLGWLGEADVARTRALIRAAGLPDVAPNLGVDAYLEYMGH
DKKVEGGKMRFVLLKKLGEAVITDAVPADVLTAVLTPPH
>Mature_359_residues
MQTLTVDLGDRSYPIHIGAALLTRADLVLPHLAQKRVMVVTNTTVGPLYLAQLKAALEAAGVRVAEVVLPDGEAYKNWET
LNLVFDALLRERAERKTTLIALGGGVIGDMTGFAAACYQRGVPFIQIPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQP
KLVLADAATLGTLPARELSAGLAEVIKYGLIWDVEFLAWLEANMDRLRALDAEAISHAIYRSCEIKAQVVAEDEREGGLR
AILNLGHTFGHAIETGMGYGAWLHGEAVAAGMVLAAETSQRLGWLGEADVARTRALIRAAGLPDVAPNLGVDAYLEYMGH
DKKVEGGKMRFVLLKKLGEAVITDAVPADVLTAVLTPPH

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=356, Percent_Identity=58.1460674157303, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6320332, Length=369, Percent_Identity=38.4823848238482, Blast_Score=222, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_THIDA (Q3SLY4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314073.1
- ProteinModelPortal:   Q3SLY4
- SMR:   Q3SLY4
- STRING:   Q3SLY4
- GeneID:   3672101
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0315
- NMPDR:   fig|292415.3.peg.547
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- PhylomeDB:   Q3SLY4
- ProtClustDB:   PRK00002
- BioCyc:   TDEN292415:TBD_0315-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38361; Mature: 38361

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLTVDLGDRSYPIHIGAALLTRADLVLPHLAQKRVMVVTNTTVGPLYLAQLKAALEAA
CCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
GVRVAEVVLPDGEAYKNWETLNLVFDALLRERAERKTTLIALGGGVIGDMTGFAAACYQR
CCEEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHC
GVPFIQIPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQPKLVLADAATLGTLPARELSA
CCCEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEECCHHHCCCCHHHHHH
GLAEVIKYGLIWDVEFLAWLEANMDRLRALDAEAISHAIYRSCEIKAQVVAEDEREGGLR
HHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHH
AILNLGHTFGHAIETGMGYGAWLHGEAVAAGMVLAAETSQRLGWLGEADVARTRALIRAA
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHEEEEECCHHHHCCCCCHHHHHHHHHHHHC
GLPDVAPNLGVDAYLEYMGHDKKVEGGKMRFVLLKKLGEAVITDAVPADVLTAVLTPPH
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MQTLTVDLGDRSYPIHIGAALLTRADLVLPHLAQKRVMVVTNTTVGPLYLAQLKAALEAA
CCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
GVRVAEVVLPDGEAYKNWETLNLVFDALLRERAERKTTLIALGGGVIGDMTGFAAACYQR
CCEEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHC
GVPFIQIPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQPKLVLADAATLGTLPARELSA
CCCEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEECCHHHCCCCHHHHHH
GLAEVIKYGLIWDVEFLAWLEANMDRLRALDAEAISHAIYRSCEIKAQVVAEDEREGGLR
HHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHH
AILNLGHTFGHAIETGMGYGAWLHGEAVAAGMVLAAETSQRLGWLGEADVARTRALIRAA
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHEEEEECCHHHHCCCCCHHHHHHHHHHHHC
GLPDVAPNLGVDAYLEYMGHDKKVEGGKMRFVLLKKLGEAVITDAVPADVLTAVLTPPH
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA