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The map label for this gene is ubiB [H]

Identifier: 74316231

GI number: 74316231

Start: 233773

End: 235341

Strand: Reverse

Name: ubiB [H]

Synonym: Tbd_0213

Alternate gene names: 74316231

Gene position: 235341-233773 (Counterclockwise)

Preceding gene: 74316233

Following gene: 74316230

Centisome position: 8.09

GC content: 67.24

Gene sequence:

>1569_bases
ATGAAACTCCTGCGTCTCGCGCGCATCATCCGCACCGGCCTGCGCTTCGGTCTCGAAGAGTTCTTCCTCGGACACGAGCG
CGTACGCCCCTTGCGCTGGCTCGTGCGCATCACGCTGTTCTGGCGACCGCTGCGCGAGCCGCGCGCCGTGCGCCTGCGCC
GCGCGCTCGAGTCGCTCGGACCGATATTCGTCAAGTTCGGGCAACTCCTGTCGACCCGCCCCGACCTCGTGCCTGCGGAC
ATCGTCGAAGAGCTGTCGCGCCTGCAGGACCGCGTCCCGCCCTTTCCCTCGGTGCAGGCGATCGCGACGATCGAGGCCGC
CTACCGCACGCCGCTGTCTTCGGCTTTCGCCGAGTTCGACGCCACCCCGGTCGCCTCGGCTTCGGTCGCCCAGGTGCATT
TCGCGCGGCTGCACGACGGTACCGAGGTGGCGGTCAAGGTCCTGCGCCCCGGCATCGCGCCGGTCATCGCGCACGACGTC
TCGCTCATGTACCTCGCGGCGGCGCTCGTCGAGAAGCTGTTCGCCGACGGCAAGCGGCTGCGTCCGCGCGAGGTCGTCTC
CGAGTTCGAAAAACATCTGGCCGACGAGCTCGACCTCATGCGCGAGGCGTCCAACTGCTCGCAGCTGCGGCGCAACTTCC
GCGACTCGCCGCTGCTCGCGGTGCCCGAGGTGTACTGGGACTACTGCAGTGCGGACGTCATGGTGATGGACCGCATGGAC
GGCATTCCGGTCAGTCAGATCGAGCGCCTGCGCGAAGCCGGCGTCGACTTCGGGCGACTGGCCGCGACCGGTGTCGAAAT
TTTCTTCACCCAGGTGTTCCGCGACGGCTTTTTCCACGCCGACATGCATCCGGGCAACATCCTCGTACGGCCGGCTCGCG
ACCTCGCCGGCAGCCCGGCGGCCGGCGAGGTCGCGCGCGTCGACCAGTATGTCGCGCTCGATTTCGGCATCATGGGAACG
CTCACCGAGATCGACAAGCAGTACCTCGCGCGCAATTTCCTCGCCTTCTTCCGCAGGGATTACCGCGGCGTCGCGCTCGC
GCATCTCGAATCGGGATGGGTTCCGCCCGACACGCGCGTCGACGAACTCGAAGCGGCCGTGCGCGCCGTGTGCGAACCGG
TATTCGATCGGCCGCTCAAGGACATCTCGTTCGGCCGCGTGCTGCTGCAGCTCTTTCAGGCCTCGCGCCGCTTCAACGTG
GAAATCCAGCCGCAGCTCGCGCTGCTGCAGAAGACGCTGCTCAACATCGAAGGACTGGGGCGTCAGCTCGACCCGGATCT
CGATCTGTGGAAGACCGCAAAGCCATTCCTCGAGCGCTGGATGAACGAGCAGATCGGCTGGCGGGCGCTGCTCAAGAGCC
TCGAAGCCGAGGCGCCGAAATGGGCGACCCTGCTGCCGCAGCTGCCGCGGCTGGCTCACGCCGCGCTCGCCGACAACCGT
CTCGCGCTGGTGGAAGCGGATCTCGTGCTGATGCTGCGCCAGCAGCAGACGCGCAACACATGGCTCGGGGCGATCGCCGT
GCTGCTCACCGTGCTGTCGGGGCTCGTGCTCTATTCCATCCTGCAGTAG

Upstream 100 bases:

>100_bases
GGGGCGTCGACGTCGCACGCTTCAATCGGCAGGTGGACGCCCTCGCCGACGACAGCGAGCGCCTCGCCGCGCGCCTGCGT
CGCCTGGAAGCCGAGGCCCG

Downstream 100 bases:

>100_bases
GGGCAAGGCGTGCTGATCGGTTTTGTCGCTCTCTACCTCGTCGTGTCGATCGGTATCGGACTGTACGGCGCGACCAAGGT
CCATGGCGCCGGCGATTACA

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MKLLRLARIIRTGLRFGLEEFFLGHERVRPLRWLVRITLFWRPLREPRAVRLRRALESLGPIFVKFGQLLSTRPDLVPAD
IVEELSRLQDRVPPFPSVQAIATIEAAYRTPLSSAFAEFDATPVASASVAQVHFARLHDGTEVAVKVLRPGIAPVIAHDV
SLMYLAAALVEKLFADGKRLRPREVVSEFEKHLADELDLMREASNCSQLRRNFRDSPLLAVPEVYWDYCSADVMVMDRMD
GIPVSQIERLREAGVDFGRLAATGVEIFFTQVFRDGFFHADMHPGNILVRPARDLAGSPAAGEVARVDQYVALDFGIMGT
LTEIDKQYLARNFLAFFRRDYRGVALAHLESGWVPPDTRVDELEAAVRAVCEPVFDRPLKDISFGRVLLQLFQASRRFNV
EIQPQLALLQKTLLNIEGLGRQLDPDLDLWKTAKPFLERWMNEQIGWRALLKSLEAEAPKWATLLPQLPRLAHAALADNR
LALVEADLVLMLRQQQTRNTWLGAIAVLLTVLSGLVLYSILQ

Sequences:

>Translated_522_residues
MKLLRLARIIRTGLRFGLEEFFLGHERVRPLRWLVRITLFWRPLREPRAVRLRRALESLGPIFVKFGQLLSTRPDLVPAD
IVEELSRLQDRVPPFPSVQAIATIEAAYRTPLSSAFAEFDATPVASASVAQVHFARLHDGTEVAVKVLRPGIAPVIAHDV
SLMYLAAALVEKLFADGKRLRPREVVSEFEKHLADELDLMREASNCSQLRRNFRDSPLLAVPEVYWDYCSADVMVMDRMD
GIPVSQIERLREAGVDFGRLAATGVEIFFTQVFRDGFFHADMHPGNILVRPARDLAGSPAAGEVARVDQYVALDFGIMGT
LTEIDKQYLARNFLAFFRRDYRGVALAHLESGWVPPDTRVDELEAAVRAVCEPVFDRPLKDISFGRVLLQLFQASRRFNV
EIQPQLALLQKTLLNIEGLGRQLDPDLDLWKTAKPFLERWMNEQIGWRALLKSLEAEAPKWATLLPQLPRLAHAALADNR
LALVEADLVLMLRQQQTRNTWLGAIAVLLTVLSGLVLYSILQ
>Mature_522_residues
MKLLRLARIIRTGLRFGLEEFFLGHERVRPLRWLVRITLFWRPLREPRAVRLRRALESLGPIFVKFGQLLSTRPDLVPAD
IVEELSRLQDRVPPFPSVQAIATIEAAYRTPLSSAFAEFDATPVASASVAQVHFARLHDGTEVAVKVLRPGIAPVIAHDV
SLMYLAAALVEKLFADGKRLRPREVVSEFEKHLADELDLMREASNCSQLRRNFRDSPLLAVPEVYWDYCSADVMVMDRMD
GIPVSQIERLREAGVDFGRLAATGVEIFFTQVFRDGFFHADMHPGNILVRPARDLAGSPAAGEVARVDQYVALDFGIMGT
LTEIDKQYLARNFLAFFRRDYRGVALAHLESGWVPPDTRVDELEAAVRAVCEPVFDRPLKDISFGRVLLQLFQASRRFNV
EIQPQLALLQKTLLNIEGLGRQLDPDLDLWKTAKPFLERWMNEQIGWRALLKSLEAEAPKWATLLPQLPRLAHAALADNR
LALVEADLVLMLRQQQTRNTWLGAIAVLLTVLSGLVLYSILQ

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=261, Percent_Identity=31.0344827586207, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI41393593, Length=283, Percent_Identity=32.5088339222615, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI217035081, Length=215, Percent_Identity=33.0232558139535, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI32261307, Length=336, Percent_Identity=29.1666666666667, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI27363457, Length=214, Percent_Identity=29.4392523364486, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI34147522, Length=210, Percent_Identity=29.0476190476191, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217416386, Length=190, Percent_Identity=28.9473684210526, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI2367309, Length=524, Percent_Identity=51.9083969465649, Blast_Score=503, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17559152, Length=232, Percent_Identity=29.3103448275862, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565180, Length=278, Percent_Identity=28.4172661870504, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325148, Length=438, Percent_Identity=25.3424657534247, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323282, Length=253, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=212, Percent_Identity=28.7735849056604, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI22024280, Length=291, Percent_Identity=30.9278350515464, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24662575, Length=254, Percent_Identity=30.7086614173228, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 59017; Mature: 59017

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLRLARIIRTGLRFGLEEFFLGHERVRPLRWLVRITLFWRPLREPRAVRLRRALESLG
CHHHHHHHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
PIFVKFGQLLSTRPDLVPADIVEELSRLQDRVPPFPSVQAIATIEAAYRTPLSSAFAEFD
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCC
ATPVASASVAQVHFARLHDGTEVAVKVLRPGIAPVIAHDVSLMYLAAALVEKLFADGKRL
CCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPREVVSEFEKHLADELDLMREASNCSQLRRNFRDSPLLAVPEVYWDYCSADVMVMDRMD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHCCCCEEECCCC
GIPVSQIERLREAGVDFGRLAATGVEIFFTQVFRDGFFHADMHPGNILVRPARDLAGSPA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHCCCCC
AGEVARVDQYVALDFGIMGTLTEIDKQYLARNFLAFFRRDYRGVALAHLESGWVPPDTRV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCH
DELEAAVRAVCEPVFDRPLKDISFGRVLLQLFQASRRFNVEIQPQLALLQKTLLNIEGLG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHCC
RQLDPDLDLWKTAKPFLERWMNEQIGWRALLKSLEAEAPKWATLLPQLPRLAHAALADNR
CCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LALVEADLVLMLRQQQTRNTWLGAIAVLLTVLSGLVLYSILQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKLLRLARIIRTGLRFGLEEFFLGHERVRPLRWLVRITLFWRPLREPRAVRLRRALESLG
CHHHHHHHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
PIFVKFGQLLSTRPDLVPADIVEELSRLQDRVPPFPSVQAIATIEAAYRTPLSSAFAEFD
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCC
ATPVASASVAQVHFARLHDGTEVAVKVLRPGIAPVIAHDVSLMYLAAALVEKLFADGKRL
CCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPREVVSEFEKHLADELDLMREASNCSQLRRNFRDSPLLAVPEVYWDYCSADVMVMDRMD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHCCCCEEECCCC
GIPVSQIERLREAGVDFGRLAATGVEIFFTQVFRDGFFHADMHPGNILVRPARDLAGSPA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHCCCCC
AGEVARVDQYVALDFGIMGTLTEIDKQYLARNFLAFFRRDYRGVALAHLESGWVPPDTRV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCH
DELEAAVRAVCEPVFDRPLKDISFGRVLLQLFQASRRFNVEIQPQLALLQKTLLNIEGLG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHCC
RQLDPDLDLWKTAKPFLERWMNEQIGWRALLKSLEAEAPKWATLLPQLPRLAHAALADNR
CCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LALVEADLVLMLRQQQTRNTWLGAIAVLLTVLSGLVLYSILQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA