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The map label for this gene is gcvPA

Identifier: 74316194

GI number: 74316194

Start: 188261

End: 189655

Strand: Reverse

Name: gcvPA

Synonym: Tbd_0176

Alternate gene names: 74316194

Gene position: 189655-188261 (Counterclockwise)

Preceding gene: 74316195

Following gene: 74316193

Centisome position: 6.52

GC content: 67.81

Gene sequence:

>1395_bases
ATGCCCTTCATCCCCCACACTGAAGAAGACGTCTCCGCCATGCTCGGCGCCATCGGCGCGGCGAGCATCGAGGACTTGTT
CGACGAAATCCCGCCCGCGCTAAAGACCGGCAAGCTCAAGGACGTCCCCGACGGCCTGCCCGAGATGGCGGTCGCGCGGC
TGATGCAGGAACGCGCGTCGCAGGACGGCTTCTGGTCGAACTTCATCGGCGCCGGCGTCTACGAACACCACATCCCGGCG
GCGATCTGGCAGATCACCACGCGCGGCGAGTTCTACTCGGCGTATACGCCCTATCAGGCCGAAGCGAGCCAGGGCACGCT
GCAGCTGATCTACGAATACCAGACGATGATGACGCGGCTGACCGGGCTCGACGTCTCGAACGCCTCGCTTTACGACGGCG
CGTCGGCGCTCGCCGAAGCGGTGCTGATGGCGGTCCGCTCGCACAAGAGTTCGCGCCGCGTGCTCGTGCCGAAGACGGTG
CATCCGGTCTACCGCAGCGTCGTCGTCACGACCGTCAGGAACCAGGGCATCGATCTCGTCGAGCTCGAGTACGACCCGGC
GACGGGCAAGACCGTGCTGCCCTCGGAGCCGGGCGCATTCGCCGGGCTGGTGATTCCGCAACCCAACTTCTTCGGCGTGC
TCGAAGACGTGCACACGATGACCGACTGGACGCACGCCAACGGCGGACTCGCGATCGCGCTCGTCAACCCGACGACGCTC
GCGGTGCTCGAAGCGCCCGGCAAGTGGGGGACGAAAGGTGCCGACATCGCGGTCGGCGAAGGCCAGCCGCTCGGCGCGCC
GATGGCCTCGGGCGGCCCCTACTTCGGCTTCATGTGCTGCCGCCAGGACTTCGTGCGGCAGATGCCGGGCCGCATCGTCG
GCCGCACGGTCGACCTCGACGGCAAGCCCGGCTTCGCGCTCACGCTACAGGCGCGCGAGCAGCACATCCGCCGCTCCAAG
GCCACGTCCAACATCTGCACCAACCAGGGCCTCGTCGTTACCGCCGCCACGCAATACATGGCGCTGCTCGGTCCACAGGG
GCTGGCCAAGGTCGCGGCGGCGAGCCACGCCAACACCGTCGCGCTCGCCGAGAAGCTCGGCGCGATTCCCGGCGTGGCGC
GCGCCTTCGCGAGTCCGTGCTTCCACGAGGTCGTGCTCAAGCTCGACGACGGCACCCTGAAAGGCACCAGCGCGAAGGAC
GTGCTGCGCGCACTGCGCGCGCAGGGCATCCTCGGCGGTCTCGACATATCGGGCTGGTATCCCGAACTCGGCCAGGCGAT
CCTGGTCTGCGTCACCGAGACCAAGACCGGCGCCGACCTCGACCACTACGCCCAGCATCTGGAACGCATCCTGTCGAAGC
GGCGCGAAGCGCCGCCCTGTGCATACAAGAACTGA

Upstream 100 bases:

>100_bases
AGGGGTCAGGATTCAGGGAATGTGCGGCTCCGCCGCGCCCTGGTTCTGATTCCGAATCCGCGCCCTGACCCCTGAATCCT
GAACCCTGCCCCCTAGAATC

Downstream 100 bases:

>100_bases
GAGACCCCCATGAGCGACGTGACGCGCGACAAGCAGTTCTACGACCTGGCCGATGCCTACATCGCGGTAGCCAACACCCA
ATTGAGCGAGACCAAGCCGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MPFIPHTEEDVSAMLGAIGAASIEDLFDEIPPALKTGKLKDVPDGLPEMAVARLMQERASQDGFWSNFIGAGVYEHHIPA
AIWQITTRGEFYSAYTPYQAEASQGTLQLIYEYQTMMTRLTGLDVSNASLYDGASALAEAVLMAVRSHKSSRRVLVPKTV
HPVYRSVVVTTVRNQGIDLVELEYDPATGKTVLPSEPGAFAGLVIPQPNFFGVLEDVHTMTDWTHANGGLAIALVNPTTL
AVLEAPGKWGTKGADIAVGEGQPLGAPMASGGPYFGFMCCRQDFVRQMPGRIVGRTVDLDGKPGFALTLQAREQHIRRSK
ATSNICTNQGLVVTAATQYMALLGPQGLAKVAAASHANTVALAEKLGAIPGVARAFASPCFHEVVLKLDDGTLKGTSAKD
VLRALRAQGILGGLDISGWYPELGQAILVCVTETKTGADLDHYAQHLERILSKRREAPPCAYKN

Sequences:

>Translated_464_residues
MPFIPHTEEDVSAMLGAIGAASIEDLFDEIPPALKTGKLKDVPDGLPEMAVARLMQERASQDGFWSNFIGAGVYEHHIPA
AIWQITTRGEFYSAYTPYQAEASQGTLQLIYEYQTMMTRLTGLDVSNASLYDGASALAEAVLMAVRSHKSSRRVLVPKTV
HPVYRSVVVTTVRNQGIDLVELEYDPATGKTVLPSEPGAFAGLVIPQPNFFGVLEDVHTMTDWTHANGGLAIALVNPTTL
AVLEAPGKWGTKGADIAVGEGQPLGAPMASGGPYFGFMCCRQDFVRQMPGRIVGRTVDLDGKPGFALTLQAREQHIRRSK
ATSNICTNQGLVVTAATQYMALLGPQGLAKVAAASHANTVALAEKLGAIPGVARAFASPCFHEVVLKLDDGTLKGTSAKD
VLRALRAQGILGGLDISGWYPELGQAILVCVTETKTGADLDHYAQHLERILSKRREAPPCAYKN
>Mature_463_residues
PFIPHTEEDVSAMLGAIGAASIEDLFDEIPPALKTGKLKDVPDGLPEMAVARLMQERASQDGFWSNFIGAGVYEHHIPAA
IWQITTRGEFYSAYTPYQAEASQGTLQLIYEYQTMMTRLTGLDVSNASLYDGASALAEAVLMAVRSHKSSRRVLVPKTVH
PVYRSVVVTTVRNQGIDLVELEYDPATGKTVLPSEPGAFAGLVIPQPNFFGVLEDVHTMTDWTHANGGLAIALVNPTTLA
VLEAPGKWGTKGADIAVGEGQPLGAPMASGGPYFGFMCCRQDFVRQMPGRIVGRTVDLDGKPGFALTLQAREQHIRRSKA
TSNICTNQGLVVTAATQYMALLGPQGLAKVAAASHANTVALAEKLGAIPGVARAFASPCFHEVVLKLDDGTLKGTSAKDV
LRALRAQGILGGLDISGWYPELGQAILVCVTETKTGADLDHYAQHLERILSKRREAPPCAYKN

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=411, Percent_Identity=36.2530413625304, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1789269, Length=359, Percent_Identity=35.6545961002786, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535605, Length=360, Percent_Identity=37.2222222222222, Blast_Score=199, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6323843, Length=450, Percent_Identity=31.1111111111111, Blast_Score=193, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24645648, Length=355, Percent_Identity=37.7464788732394, Blast_Score=232, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_THIDA (Q3SMB8)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_313934.1
- STRING:   Q3SMB8
- GeneID:   3673622
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0176
- NMPDR:   fig|292415.3.peg.125
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   TDEN292415:TBD_0176-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49680; Mature: 49549

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFIPHTEEDVSAMLGAIGAASIEDLFDEIPPALKTGKLKDVPDGLPEMAVARLMQERAS
CCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCC
QDGFWSNFIGAGVYEHHIPAAIWQITTRGEFYSAYTPYQAEASQGTLQLIYEYQTMMTRL
CCCCHHHHHHCCHHHHCCCHHHEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
TGLDVSNASLYDGASALAEAVLMAVRSHKSSRRVLVPKTVHPVYRSVVVTTVRNQGIDLV
HCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCEE
ELEYDPATGKTVLPSEPGAFAGLVIPQPNFFGVLEDVHTMTDWTHANGGLAIALVNPTTL
EEEECCCCCCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEECCCCEEEEEECCCEE
AVLEAPGKWGTKGADIAVGEGQPLGAPMASGGPYFGFMCCRQDFVRQMPGRIVGRTVDLD
EEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCEEEECC
GKPGFALTLQAREQHIRRSKATSNICTNQGLVVTAATQYMALLGPQGLAKVAAASHANTV
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHHHHCCCHHH
ALAEKLGAIPGVARAFASPCFHEVVLKLDDGTLKGTSAKDVLRALRAQGILGGLDISGWY
HHHHHHCCCHHHHHHHHCHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
PELGQAILVCVTETKTGADLDHYAQHLERILSKRREAPPCAYKN
HHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PFIPHTEEDVSAMLGAIGAASIEDLFDEIPPALKTGKLKDVPDGLPEMAVARLMQERAS
CCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCC
QDGFWSNFIGAGVYEHHIPAAIWQITTRGEFYSAYTPYQAEASQGTLQLIYEYQTMMTRL
CCCCHHHHHHCCHHHHCCCHHHEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
TGLDVSNASLYDGASALAEAVLMAVRSHKSSRRVLVPKTVHPVYRSVVVTTVRNQGIDLV
HCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCEE
ELEYDPATGKTVLPSEPGAFAGLVIPQPNFFGVLEDVHTMTDWTHANGGLAIALVNPTTL
EEEECCCCCCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEECCCCEEEEEECCCEE
AVLEAPGKWGTKGADIAVGEGQPLGAPMASGGPYFGFMCCRQDFVRQMPGRIVGRTVDLD
EEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCEEEECC
GKPGFALTLQAREQHIRRSKATSNICTNQGLVVTAATQYMALLGPQGLAKVAAASHANTV
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHHHHCCCHHH
ALAEKLGAIPGVARAFASPCFHEVVLKLDDGTLKGTSAKDVLRALRAQGILGGLDISGWY
HHHHHHCCCHHHHHHHHCHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
PELGQAILVCVTETKTGADLDHYAQHLERILSKRREAPPCAYKN
HHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA