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The map label for this gene is cbbA [H]

Identifier: 74316181

GI number: 74316181

Start: 176404

End: 177471

Strand: Direct

Name: cbbA [H]

Synonym: Tbd_0163

Alternate gene names: 74316181

Gene position: 176404-177471 (Clockwise)

Preceding gene: 74316180

Following gene: 74316182

Centisome position: 6.06

GC content: 63.86

Gene sequence:

>1068_bases
ATGGCCCTGATTTCCCTTCGTCAACTGCTCGACCATGCCGCCGAAAACGGCTACGGTCTGCCCGCGTTCAACGTCAACAA
CATGGAGCAGGTCAAGGCCATCATGGAAGCGGCGGCCGCGGTCGACTCGCCCGTGATCCTGCAGGGTTCGGCCGGTGCGC
GTTCCTACGCCGGCGAGCCCTTCCTGCGCCACCTGATCCTTGCCGCGATCGAGATGTACCCACAGATCCCGATCTGCATG
CACCAGGACCATGGCGCCTCGCCGAGCATCTGCTTCCGCTCGATCCAGTCGGGATTCTCCTCGGTCATGATGGACGGCTC
GCTGAAGGAAGACGGCAAGACCCCCGCCAGCTACGAATACAACGTCGAGACCACCCGCAAGGTCTCGGAACTTGCCCACG
CCTGCGGCGTCTCGGTCGAAGGTGAACTCGGCTGCCTGGGCTCGCTCGAGACCGGCAAGGCCGGCGAGGAAGACGGCCAC
GGCGCCGAAGGCACGCTCGACCACTCGATGCTCCTGACCGACCCCGACGAGGCCGCCGACTTCGTCTCCAAGACCAGGGT
CGACGCGCTCGCGATCGCCATCGGCACCTCGCACGGCGCCTACAAGTTCACGCAGAAGCCCACCGGCAAGGTGCTGCGCA
TCGACCGCGTGAAGGAAATCCACGCCCGCATCCCTAACGTGCACCTCGTCATGCACGGCTCGTCGTCGGTGCCCGAAGAC
TGGCTCGCGATCATCAACAGCTACGGTGGCGACATGGGCCAGACCTACGGCGTGCCGGTCGAAGAGATCGTCGAAGGCAT
CAAGAACGGCGTGCGCAAGGTCAACATCGACACCGACCTGCGCATGGCGTCGACCGGCGCGATCCGCAAGCACCTGGCCG
AGAACAAGTCCAACTTCGACCCGCGCAAATTCCTCAAGGAAGCGACCAAGGGCATGAGCGACATCTGCAAGGCCCGCTAC
GAAGCCTTCGGCGCCGCCGGCCAGGCCAGCAAGATCAAGAAGGTGTTCAACCTCGAAGAAATGCAGAAGCGCTACGACAA
GGGCGAGCTCGACCCCAAGGTCAACTGA

Upstream 100 bases:

>100_bases
ATCGGCCAGTCGGGCGGCACCAATACGATGAAGATCGTCCGTGTGGGCGCTTCGAAGAAACCCTGAATCTGAAGCACGTT
TTTTACCTAGGAGAGTGTAA

Downstream 100 bases:

>100_bases
TCGCCGGCTAGCCGGAATCAGATGCTGGATTGAAATGGGACGCTGCGGCGTCCCATTTTTATGTTCGGCGATTCTGCGAT
GTTGAGCGGATCGATTCCGG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MALISLRQLLDHAAENGYGLPAFNVNNMEQVKAIMEAAAAVDSPVILQGSAGARSYAGEPFLRHLILAAIEMYPQIPICM
HQDHGASPSICFRSIQSGFSSVMMDGSLKEDGKTPASYEYNVETTRKVSELAHACGVSVEGELGCLGSLETGKAGEEDGH
GAEGTLDHSMLLTDPDEAADFVSKTRVDALAIAIGTSHGAYKFTQKPTGKVLRIDRVKEIHARIPNVHLVMHGSSSVPED
WLAIINSYGGDMGQTYGVPVEEIVEGIKNGVRKVNIDTDLRMASTGAIRKHLAENKSNFDPRKFLKEATKGMSDICKARY
EAFGAAGQASKIKKVFNLEEMQKRYDKGELDPKVN

Sequences:

>Translated_355_residues
MALISLRQLLDHAAENGYGLPAFNVNNMEQVKAIMEAAAAVDSPVILQGSAGARSYAGEPFLRHLILAAIEMYPQIPICM
HQDHGASPSICFRSIQSGFSSVMMDGSLKEDGKTPASYEYNVETTRKVSELAHACGVSVEGELGCLGSLETGKAGEEDGH
GAEGTLDHSMLLTDPDEAADFVSKTRVDALAIAIGTSHGAYKFTQKPTGKVLRIDRVKEIHARIPNVHLVMHGSSSVPED
WLAIINSYGGDMGQTYGVPVEEIVEGIKNGVRKVNIDTDLRMASTGAIRKHLAENKSNFDPRKFLKEATKGMSDICKARY
EAFGAAGQASKIKKVFNLEEMQKRYDKGELDPKVN
>Mature_354_residues
ALISLRQLLDHAAENGYGLPAFNVNNMEQVKAIMEAAAAVDSPVILQGSAGARSYAGEPFLRHLILAAIEMYPQIPICMH
QDHGASPSICFRSIQSGFSSVMMDGSLKEDGKTPASYEYNVETTRKVSELAHACGVSVEGELGCLGSLETGKAGEEDGHG
AEGTLDHSMLLTDPDEAADFVSKTRVDALAIAIGTSHGAYKFTQKPTGKVLRIDRVKEIHARIPNVHLVMHGSSSVPEDW
LAIINSYGGDMGQTYGVPVEEIVEGIKNGVRKVNIDTDLRMASTGAIRKHLAENKSNFDPRKFLKEATKGMSDICKARYE
AFGAAGQASKIKKVFNLEEMQKRYDKGELDPKVN

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=330, Percent_Identity=33.6363636363636, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=31.0030395136778, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1788072, Length=333, Percent_Identity=27.6276276276276, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789293, Length=358, Percent_Identity=28.2122905027933, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322790, Length=372, Percent_Identity=26.0752688172043, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38410; Mature: 38279

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISLRQLLDHAAENGYGLPAFNVNNMEQVKAIMEAAAAVDSPVILQGSAGARSYAGEP
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCH
FLRHLILAAIEMYPQIPICMHQDHGASPSICFRSIQSGFSSVMMDGSLKEDGKTPASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
NVETTRKVSELAHACGVSVEGELGCLGSLETGKAGEEDGHGAEGTLDHSMLLTDPDEAAD
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHH
FVSKTRVDALAIAIGTSHGAYKFTQKPTGKVLRIDRVKEIHARIPNVHLVMHGSSSVPED
HHHHHHHHHEEEEEECCCCCEEECCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCHH
WLAIINSYGGDMGQTYGVPVEEIVEGIKNGVRKVNIDTDLRMASTGAIRKHLAENKSNFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCCCC
PRKFLKEATKGMSDICKARYEAFGAAGQASKIKKVFNLEEMQKRYDKGELDPKVN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ALISLRQLLDHAAENGYGLPAFNVNNMEQVKAIMEAAAAVDSPVILQGSAGARSYAGEP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCH
FLRHLILAAIEMYPQIPICMHQDHGASPSICFRSIQSGFSSVMMDGSLKEDGKTPASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
NVETTRKVSELAHACGVSVEGELGCLGSLETGKAGEEDGHGAEGTLDHSMLLTDPDEAAD
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHH
FVSKTRVDALAIAIGTSHGAYKFTQKPTGKVLRIDRVKEIHARIPNVHLVMHGSSSVPED
HHHHHHHHHEEEEEECCCCCEEECCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCHH
WLAIINSYGGDMGQTYGVPVEEIVEGIKNGVRKVNIDTDLRMASTGAIRKHLAENKSNFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCCCC
PRKFLKEATKGMSDICKARYEAFGAAGQASKIKKVFNLEEMQKRYDKGELDPKVN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]