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The map label for this gene is gor [H]

Identifier: 73543117

GI number: 73543117

Start: 3774369

End: 3775760

Strand: Direct

Name: gor [H]

Synonym: Reut_A3435

Alternate gene names: 73543117

Gene position: 3774369-3775760 (Clockwise)

Preceding gene: 73543116

Following gene: 73543120

Centisome position: 99.16

GC content: 66.59

Gene sequence:

>1392_bases
ATGGAGCGCGTGCCGCGCTCACGCGGCAAGGGTGGCAAGCCGATGCGTACGCGCAAGGCGGATTTCGTCGTGATCGGCGG
CGGCTCGGCCGGCGTCGCCTGCGCGCGGCGCGCTGCGTCGCATGGTGCCAGCGTCGTGCTGATCGAACGCGATGAAATCG
GCGGCACCTGCGTCAACCGCGGCTGCGTGCCGAAGAAGATGCTGTCGTATGGCGCCACGTGGGCTGCCATCCTGTCCGGC
TGCCTGTCGCACACCGGCGGGCATGAGGACTGGCGCGACGCGATCGTGCGCGTCAATGCGGAAGTGGCGCGACTGAACGT
GGTCTACGCACAGCGCCTGCTGGAGGCCGGCGTTGACATCCTGCGCGGCGACGCGGTTGTGACGGCGCCCGATGAAGTGC
GCGTGGGCGACGAAGTCATCCGCGCCAAGCGCATCCTGATCGCTACCGGCGCGCGACCGAAGACGCTCGATATTCCCGGC
GGCGAACTCGCGAGCAATTCCGACGATGTGTTCACGTGGCAGACCGTTCCGGGATCGATCGCGGTCATCGGCGGCGGCTA
TATCGGCGTGGAGCAGGCATCGATCCTGTCGCGCTACGGGGTCAAGGTCGACCTGCTGGTCGCCGGTGACAGGCTCCTGC
CGCATTTCGATGCGGAAATCGCAGAAGCCCTCGCGGGCGCGTTGGAAACCAAGGGCGTGCGGCTGCACCTCAATGCCAGC
GTCAACCTGATCAGCCAAGCCAATGGCGCGCTCGAGGTCTGCTATCGCCCCGGCAACAAGCCCGGGCAGACGGAGTCGAT
ACGCGCGCAAGCGGCACTGGTCGCGGTCGGGCGCGTGTCCAACGTGGACGGGCTTGGCCTCGATGCAATTGGCGTCAAGC
TCGGCGACAAGGGCGGCATCAAAGTGGATCGCCAATTCCGCAGTTCGGTGCGTTCGATCCATGCGATCGGTGATGCGATC
GAGGGCCTGCACCTGACGCCGGTTGCCACCTCACAGGGCCGCTGGCTGGCAGACCGGCTGTTCGGCCGGCGCGGCGAACG
CGCGGACTTCGATTTCGTGCCGACCGCGGTGTTCTGCGAACCGGCGATCGGCGCCGTGGGGCTCACGGAAGCGCAGGCCA
TCGAAGAGGCCGGCAAGCCCGAGCGCATCCGCACCGTGGTCAAGCGCTTTGTCTCGCTGGAAAACCGCTTTGGTGGCAAT
GGCATGCAATCGGTGTTCAAGCTCGTGCTCAATGCGCGTACCGGGCGCGTGCTCGGCGTGCATCTGATGGATAACGCGGC
GCCAGAGATCGTGCAGGCCATGGCCGTTGCGCTGCGGCTCGGCGTGAGGGAATCCCATCTGGAGACGACGCTGCAACTGC
ATCCGACGGTGGCGGAAGAGCTGTTCGGTTGA

Upstream 100 bases:

>100_bases
CGTGCCGCGACAGGAGGCATGGATGAGCAAGCGCCAGACAACAACCGCCACGTCCGACAACGGACCAAGGCGGGCCCGTC
AAGTCAGTGCCGAGCCGGCG

Downstream 100 bases:

>100_bases
GAGGAAGGTGAAATCAAGGGGCCGTGACGTCCGCGCGCGTCACAGGTCCTGTTCGCTGACCGGCAGTTGCAGCAACGCCC
TGACGCCCCGCCCCTGCGAT

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase:pyridine nucleotide-disulphide oxidoreductase dimerisation region:FAD dependent oxidoreductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MERVPRSRGKGGKPMRTRKADFVVIGGGSAGVACARRAASHGASVVLIERDEIGGTCVNRGCVPKKMLSYGATWAAILSG
CLSHTGGHEDWRDAIVRVNAEVARLNVVYAQRLLEAGVDILRGDAVVTAPDEVRVGDEVIRAKRILIATGARPKTLDIPG
GELASNSDDVFTWQTVPGSIAVIGGGYIGVEQASILSRYGVKVDLLVAGDRLLPHFDAEIAEALAGALETKGVRLHLNAS
VNLISQANGALEVCYRPGNKPGQTESIRAQAALVAVGRVSNVDGLGLDAIGVKLGDKGGIKVDRQFRSSVRSIHAIGDAI
EGLHLTPVATSQGRWLADRLFGRRGERADFDFVPTAVFCEPAIGAVGLTEAQAIEEAGKPERIRTVVKRFVSLENRFGGN
GMQSVFKLVLNARTGRVLGVHLMDNAAPEIVQAMAVALRLGVRESHLETTLQLHPTVAEELFG

Sequences:

>Translated_463_residues
MERVPRSRGKGGKPMRTRKADFVVIGGGSAGVACARRAASHGASVVLIERDEIGGTCVNRGCVPKKMLSYGATWAAILSG
CLSHTGGHEDWRDAIVRVNAEVARLNVVYAQRLLEAGVDILRGDAVVTAPDEVRVGDEVIRAKRILIATGARPKTLDIPG
GELASNSDDVFTWQTVPGSIAVIGGGYIGVEQASILSRYGVKVDLLVAGDRLLPHFDAEIAEALAGALETKGVRLHLNAS
VNLISQANGALEVCYRPGNKPGQTESIRAQAALVAVGRVSNVDGLGLDAIGVKLGDKGGIKVDRQFRSSVRSIHAIGDAI
EGLHLTPVATSQGRWLADRLFGRRGERADFDFVPTAVFCEPAIGAVGLTEAQAIEEAGKPERIRTVVKRFVSLENRFGGN
GMQSVFKLVLNARTGRVLGVHLMDNAAPEIVQAMAVALRLGVRESHLETTLQLHPTVAEELFG
>Mature_463_residues
MERVPRSRGKGGKPMRTRKADFVVIGGGSAGVACARRAASHGASVVLIERDEIGGTCVNRGCVPKKMLSYGATWAAILSG
CLSHTGGHEDWRDAIVRVNAEVARLNVVYAQRLLEAGVDILRGDAVVTAPDEVRVGDEVIRAKRILIATGARPKTLDIPG
GELASNSDDVFTWQTVPGSIAVIGGGYIGVEQASILSRYGVKVDLLVAGDRLLPHFDAEIAEALAGALETKGVRLHLNAS
VNLISQANGALEVCYRPGNKPGQTESIRAQAALVAVGRVSNVDGLGLDAIGVKLGDKGGIKVDRQFRSSVRSIHAIGDAI
EGLHLTPVATSQGRWLADRLFGRRGERADFDFVPTAVFCEPAIGAVGLTEAQAIEEAGKPERIRTVVKRFVSLENRFGGN
GMQSVFKLVLNARTGRVLGVHLMDNAAPEIVQAMAVALRLGVRESHLETTLQLHPTVAEELFG

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=454, Percent_Identity=36.1233480176211, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI148277071, Length=452, Percent_Identity=31.1946902654867, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI148277065, Length=452, Percent_Identity=31.1946902654867, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI33519430, Length=452, Percent_Identity=31.1946902654867, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI33519428, Length=452, Percent_Identity=31.1946902654867, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI33519426, Length=452, Percent_Identity=31.1946902654867, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=31.2227074235808, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI22035672, Length=461, Percent_Identity=30.3687635574837, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI91199540, Length=478, Percent_Identity=28.8702928870293, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI291045268, Length=458, Percent_Identity=27.9475982532751, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1789915, Length=452, Percent_Identity=35.1769911504425, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=30.3296703296703, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786307, Length=460, Percent_Identity=26.0869565217391, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=27.0562770562771, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=32.7800829875519, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71983419, Length=452, Percent_Identity=34.7345132743363, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71983429, Length=452, Percent_Identity=34.7345132743363, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71982272, Length=489, Percent_Identity=29.4478527607362, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32565766, Length=473, Percent_Identity=29.1754756871036, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=32.409381663113, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6321091, Length=478, Percent_Identity=26.5690376569038, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=25.2136752136752, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=32.6226012793177, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=32.6226012793177, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=32.6226012793177, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17737741, Length=468, Percent_Identity=32.6923076923077, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21358499, Length=469, Percent_Identity=29.4243070362473, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49081; Mature: 49081

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERVPRSRGKGGKPMRTRKADFVVIGGGSAGVACARRAASHGASVVLIERDEIGGTCVNR
CCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
GCVPKKMLSYGATWAAILSGCLSHTGGHEDWRDAIVRVNAEVARLNVVYAQRLLEAGVDI
CCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHEEECCHHHHHHHHHHHHHHHHCHHE
LRGDAVVTAPDEVRVGDEVIRAKRILIATGARPKTLDIPGGELASNSDDVFTWQTVPGSI
ECCCEEEECCCCCCCCHHHHHHCEEEEEECCCCCEEECCCCCCCCCCCCEEEEEECCCEE
AVIGGGYIGVEQASILSRYGVKVDLLVAGDRLLPHFDAEIAEALAGALETKGVRLHLNAS
EEEECCEECHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCC
VNLISQANGALEVCYRPGNKPGQTESIRAQAALVAVGRVSNVDGLGLDAIGVKLGDKGGI
EEEEECCCCCEEEEECCCCCCCCCHHHHHHHHEEEECCCCCCCCCCCEEEEEEECCCCCC
KVDRQFRSSVRSIHAIGDAIEGLHLTPVATSQGRWLADRLFGRRGERADFDFVPTAVFCE
EECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCHHEEEC
PAIGAVGLTEAQAIEEAGKPERIRTVVKRFVSLENRFGGNGMQSVFKLVLNARTGRVLGV
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEE
HLMDNAAPEIVQAMAVALRLGVRESHLETTLQLHPTVAEELFG
EECCCCHHHHHHHHHHHHHHCCCHHHHHHEEEECCHHHHHHCC
>Mature Secondary Structure
MERVPRSRGKGGKPMRTRKADFVVIGGGSAGVACARRAASHGASVVLIERDEIGGTCVNR
CCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
GCVPKKMLSYGATWAAILSGCLSHTGGHEDWRDAIVRVNAEVARLNVVYAQRLLEAGVDI
CCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHEEECCHHHHHHHHHHHHHHHHCHHE
LRGDAVVTAPDEVRVGDEVIRAKRILIATGARPKTLDIPGGELASNSDDVFTWQTVPGSI
ECCCEEEECCCCCCCCHHHHHHCEEEEEECCCCCEEECCCCCCCCCCCCEEEEEECCCEE
AVIGGGYIGVEQASILSRYGVKVDLLVAGDRLLPHFDAEIAEALAGALETKGVRLHLNAS
EEEECCEECHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCC
VNLISQANGALEVCYRPGNKPGQTESIRAQAALVAVGRVSNVDGLGLDAIGVKLGDKGGI
EEEEECCCCCEEEEECCCCCCCCCHHHHHHHHEEEECCCCCCCCCCCEEEEEEECCCCCC
KVDRQFRSSVRSIHAIGDAIEGLHLTPVATSQGRWLADRLFGRRGERADFDFVPTAVFCE
EECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCHHEEEC
PAIGAVGLTEAQAIEEAGKPERIRTVVKRFVSLENRFGGNGMQSVFKLVLNARTGRVLGV
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEE
HLMDNAAPEIVQAMAVALRLGVRESHLETTLQLHPTVAEELFG
EECCCCHHHHHHHHHHHHHHCCCHHHHHHEEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]