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The map label for this gene is serA [H]

Identifier: 73543103

GI number: 73543103

Start: 3755244

End: 3756269

Strand: Direct

Name: serA [H]

Synonym: Reut_A3421

Alternate gene names: 73543103

Gene position: 3755244-3756269 (Clockwise)

Preceding gene: 73543101

Following gene: 73543104

Centisome position: 98.65

GC content: 65.89

Gene sequence:

>1026_bases
ATGAAGATTGCTGTACTCGACGATTACCAGGACGCCGTGCGCAAGCTGCCCTGCTTCAGCCTGCTGGAAGGGCACGACGT
CAAGGTGTTCAACAACACCGTCAAGGGCGTGGGCCAGCTGGCCGCGCGCCTCTCCGATGTGGAAGCGGTCGTGCTGATCC
GCGAACGCACCCGCATTACGCGCCAACTGCTCGAAAAGCTGCCCAAGCTGAAGATCATCAGCCAGACCGGTCGCGTCGGC
ACCGCGCCGAACACGCATATCGATGTCGAAGCGTGCACGGACCGCGGCGTGGCGGTGCTTGAGGGCGTAGGCTCGCCGGT
GGCGCCGGCCGAGCTGACGTGGGCGCTGATCATGGCGGCCCAGCGCCGCATTCCGCAATACGTGGCGAGCCTGAAGCACG
GCGCCTGGCAGCAGTCGGGCCTGAAGTCGACCACCATGCCGCCGAACTTCGGCCTAGGCCAGGTATTGCGCGGCCAGACG
CTCGGTATCTGGGGCTACGGCAAGATCGGCCGGCTGCTGGCCGGATATGGCCGTGCCTTCGGGATGAACGTGCTGGTGTG
GGGGCGAGAGGCATCGCAGGAAGCCGCACGCGCCGACGGCCTGGCAGTGGCCGAGTCCAAGGACCAGTTCTTTGCCGATT
GCGATGTGCTGTCGCTGCACCTGCGCCTGAACGACGACACGCGCGGCATCGTCAAGCTGACCGACCTGACCCGCATGAAG
CCAACCGCGCTGTTCGTCAACACCAGCCGCGCCGAGTTGCTGGAAGAGAACGCGCTGGTCGCCGCCCTGAACCGCGGCCG
TCCGGGCATGGCTGCCGTGGATGTGTTCGAGTCCGAGCCGATCCTGCAGGGCCACGCACTGCTGCGCATGGAAAACTGCA
TCTGCACGCCGCACCTCGGCTACGTCGAGCGCGACAGCTACGAGCTGTACTTCCGCACGGCGTTCCAGAACATTCTCGAC
GTACTGGCCGGCCAGCACGACAGCATCGTCAACCCGAAGGCCCTGACGCCGGCGCTGTCGCGCTAA

Upstream 100 bases:

>100_bases
CCGGCACGCGATGCCCGACAATAGCGCCTGGCGCTCGCGGTTTCCGTTGCCGTGCGCACCATTCCCGATCCCCAGGCCAG
CCGACAATAAAGAGTTACTG

Downstream 100 bases:

>100_bases
GTCTTTGTGTACCCGCCCTCTCCCGTCTGTCTTTGGGAGAGGGATGTCTCTTGCGGGGCGGCACGGCCACCCGCTGCCGC
CATGTTTGTCCCCGCGGACG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKIAVLDDYQDAVRKLPCFSLLEGHDVKVFNNTVKGVGQLAARLSDVEAVVLIRERTRITRQLLEKLPKLKIISQTGRVG
TAPNTHIDVEACTDRGVAVLEGVGSPVAPAELTWALIMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPNFGLGQVLRGQT
LGIWGYGKIGRLLAGYGRAFGMNVLVWGREASQEAARADGLAVAESKDQFFADCDVLSLHLRLNDDTRGIVKLTDLTRMK
PTALFVNTSRAELLEENALVAALNRGRPGMAAVDVFESEPILQGHALLRMENCICTPHLGYVERDSYELYFRTAFQNILD
VLAGQHDSIVNPKALTPALSR

Sequences:

>Translated_341_residues
MKIAVLDDYQDAVRKLPCFSLLEGHDVKVFNNTVKGVGQLAARLSDVEAVVLIRERTRITRQLLEKLPKLKIISQTGRVG
TAPNTHIDVEACTDRGVAVLEGVGSPVAPAELTWALIMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPNFGLGQVLRGQT
LGIWGYGKIGRLLAGYGRAFGMNVLVWGREASQEAARADGLAVAESKDQFFADCDVLSLHLRLNDDTRGIVKLTDLTRMK
PTALFVNTSRAELLEENALVAALNRGRPGMAAVDVFESEPILQGHALLRMENCICTPHLGYVERDSYELYFRTAFQNILD
VLAGQHDSIVNPKALTPALSR
>Mature_341_residues
MKIAVLDDYQDAVRKLPCFSLLEGHDVKVFNNTVKGVGQLAARLSDVEAVVLIRERTRITRQLLEKLPKLKIISQTGRVG
TAPNTHIDVEACTDRGVAVLEGVGSPVAPAELTWALIMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPNFGLGQVLRGQT
LGIWGYGKIGRLLAGYGRAFGMNVLVWGREASQEAARADGLAVAESKDQFFADCDVLSLHLRLNDDTRGIVKLTDLTRMK
PTALFVNTSRAELLEENALVAALNRGRPGMAAVDVFESEPILQGHALLRMENCICTPHLGYVERDSYELYFRTAFQNILD
VLAGQHDSIVNPKALTPALSR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=325, Percent_Identity=30.4615384615385, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI61743967, Length=309, Percent_Identity=31.3915857605178, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4557497, Length=309, Percent_Identity=31.3915857605178, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI145580578, Length=309, Percent_Identity=28.4789644012945, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557499, Length=309, Percent_Identity=28.4789644012945, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI6912396, Length=261, Percent_Identity=30.2681992337165, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI145580575, Length=309, Percent_Identity=28.8025889967638, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI87082289, Length=311, Percent_Identity=30.2250803858521, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789279, Length=279, Percent_Identity=27.9569892473118, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787645, Length=284, Percent_Identity=26.4084507042254, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=314, Percent_Identity=30.5732484076433, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=326, Percent_Identity=28.8343558282209, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=291, Percent_Identity=25.7731958762887, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=291, Percent_Identity=25.085910652921, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=219, Percent_Identity=28.310502283105, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646446, Length=301, Percent_Identity=30.2325581395349, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646448, Length=301, Percent_Identity=30.2325581395349, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646452, Length=301, Percent_Identity=30.2325581395349, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646450, Length=301, Percent_Identity=30.2325581395349, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI62472511, Length=301, Percent_Identity=30.2325581395349, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19921140, Length=294, Percent_Identity=29.2517006802721, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574286, Length=266, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585514, Length=219, Percent_Identity=28.7671232876712, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574282, Length=219, Percent_Identity=28.7671232876712, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45551003, Length=219, Percent_Identity=28.7671232876712, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45552429, Length=219, Percent_Identity=28.7671232876712, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574284, Length=219, Percent_Identity=28.7671232876712, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI28571528, Length=266, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24585516, Length=242, Percent_Identity=25.2066115702479, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37339; Mature: 37339

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVLDDYQDAVRKLPCFSLLEGHDVKVFNNTVKGVGQLAARLSDVEAVVLIRERTRIT
CEEEEECCHHHHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
RQLLEKLPKLKIISQTGRVGTAPNTHIDVEACTDRGVAVLEGVGSPVAPAELTWALIMAA
HHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHH
QRRIPQYVASLKHGAWQQSGLKSTTMPPNFGLGQVLRGQTLGIWGYGKIGRLLAGYGRAF
HHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHH
GMNVLVWGREASQEAARADGLAVAESKDQFFADCDVLSLHLRLNDDTRGIVKLTDLTRMK
CCEEEEECCCHHHHHHHHCCEEEECCCCCCEECCEEEEEEEEECCCCCCEEEEECCCCCC
PTALFVNTSRAELLEENALVAALNRGRPGMAAVDVFESEPILQGHALLRMENCICTPHLG
CEEEEEECHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHEECCCCCCCCCC
YVERDSYELYFRTAFQNILDVLAGQHDSIVNPKALTPALSR
CEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKIAVLDDYQDAVRKLPCFSLLEGHDVKVFNNTVKGVGQLAARLSDVEAVVLIRERTRIT
CEEEEECCHHHHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
RQLLEKLPKLKIISQTGRVGTAPNTHIDVEACTDRGVAVLEGVGSPVAPAELTWALIMAA
HHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHH
QRRIPQYVASLKHGAWQQSGLKSTTMPPNFGLGQVLRGQTLGIWGYGKIGRLLAGYGRAF
HHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHH
GMNVLVWGREASQEAARADGLAVAESKDQFFADCDVLSLHLRLNDDTRGIVKLTDLTRMK
CCEEEEECCCHHHHHHHHCCEEEECCCCCCEECCEEEEEEEEECCCCCCEEEEECCCCCC
PTALFVNTSRAELLEENALVAALNRGRPGMAAVDVFESEPILQGHALLRMENCICTPHLG
CEEEEEECHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHEECCCCCCCCCC
YVERDSYELYFRTAFQNILDVLAGQHDSIVNPKALTPALSR
CEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]