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The map label for this gene is degS [H]

Identifier: 73543100

GI number: 73543100

Start: 3750701

End: 3752146

Strand: Direct

Name: degS [H]

Synonym: Reut_A3418

Alternate gene names: 73543100

Gene position: 3750701-3752146 (Clockwise)

Preceding gene: 73543096

Following gene: 73543101

Centisome position: 98.53

GC content: 68.33

Gene sequence:

>1446_bases
ATGCCGCCTGCGCGGCATCGGTGTTTACCCCCGGCCAAGATGAAACTCCGCCAGAAGATCCTGTTGCTCGCCGTCGCGCC
GCTCGCGGTGGCCATGCTCGGCATCGCGCTTGCCGTGCGTTTCCAGGCGACGCAACTGGCCCGGCACGAGCGCGCGCTGG
TCGAGGCCGCCTATATCCAGAGCAAGGAAACCGAGCTGCGCCACTACGTAGAACTCGCGCAGAGCGCCATCGCGCCGATG
GTGCGTTCGGGCCACACGGATGCCGCCACGCGCCAGGCTGCCATGGAAGCCCTGGCCCGGCTCGACTACGGGCCGGACGG
CTATTTCTTCCTGTACGACATGCAGGGCCGCAACCTCATGCACCCGCGCCAGCCCGAACTGGTCGGGCAGGACCTGTGGA
CGCTGCGCGACCCGCAGGGCGCGCTCACCATCCAGAAGCTGATTGCGGCGGCCAAGGCGGGCGGCGGCTCGGTACGCTAC
CTGTGGAAAAAACCGTCTTCGCAGCAGCTCGCGCCCAAGCTCGGCTACGTGGTGGCCGTACCCGAATGGGGCTGGATGCT
CGGCACTGGCATCTATCTGGATGATGTGGAAAACACGCTGCGCCAGCTCGATGCGCGCGCAGAGACGGATATCCGCGAAA
CCATGGCCTGGATTGGCGTGATTGCGGCCGTCAGCATCCTGCTGGTGGCGGCGAGCGGCCTGGCGCTCAATATCAGCGAA
CACCGCGAGGCCGATGCCAAGCTGCGCCAGCTCGCGCAGCGCGTGGTGCAGTCGCAAGAAGAAGAGCGCGCGCGGCTGTC
GCGCGAGCTCCATGACGGCATCAGCCAGTTGCTGGTGTCGGTCAAGCTCGTACTGGAAGCAGCCGCCAACCGGCTGCGCC
TGGCCCCGGCCGAAGGCGCGGCCGTGGCGCCGGTGCTTGGCATGGCGCTGAACCGGCTCGATACGGTGTTCAACGAGGTG
CGGCGCGTGGCCCGCAACCTGCGCCCGGCGTTGCTCGATGACCTTGGCATCTTTGCGGCCTTGCAGCATCTCGCTCGCGA
GATGCAGGGCGGCAGCCAGCTCGAGATCACCGTGGCCCAGCGCGGCGCGCCGCGCGAACTGCCCGACGAACAGGCCACCG
CGTTGTACCGGATCGCGCAGGAAGCGCTGACCAATGTCGAGCGCCATGCCGGCGCGCGGCAAGTGACCGTCGCGCTGGTG
TTCGATCCGGATGCCACCAGCCTGACCGTGCGCGACGATGGCCGCGGGTTTGACGTGGCCCGCATGCAGCTCGATCCCCA
GCGCGGCATCGGCCTGCGCAACCTGCGCGAGCGCATCGCGGCGCTGGGCGGGCAGTTCGGCATTGTTTCCGGCATCGGCG
GCACCGAGCTGGTGGCCACGCTGCCGGTCGTGAAGGCGGCCGCCCGACCCACCACTCCCCTTCCCGCAGAATCTTCGCAG
TCATGA

Upstream 100 bases:

>100_bases
GCTGCATGCATCCGGCGTGTAGTATTGACACCCGCCATACCCCGCACAAGCGCGAAACTACGCAGCACTTCTGCGTAGTA
CTACGCAAATCGACGGTGAC

Downstream 100 bases:

>100_bases
CCCAGATATCGGACCCCGACGAACCGGAAGGCCATTCCATCGATGCGCCCGCGCGCGTGCTGCTGATCGACGACCATGCG
CTCGTGCGTGACGGCATGCG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MPPARHRCLPPAKMKLRQKILLLAVAPLAVAMLGIALAVRFQATQLARHERALVEAAYIQSKETELRHYVELAQSAIAPM
VRSGHTDAATRQAAMEALARLDYGPDGYFFLYDMQGRNLMHPRQPELVGQDLWTLRDPQGALTIQKLIAAAKAGGGSVRY
LWKKPSSQQLAPKLGYVVAVPEWGWMLGTGIYLDDVENTLRQLDARAETDIRETMAWIGVIAAVSILLVAASGLALNISE
HREADAKLRQLAQRVVQSQEEERARLSRELHDGISQLLVSVKLVLEAAANRLRLAPAEGAAVAPVLGMALNRLDTVFNEV
RRVARNLRPALLDDLGIFAALQHLAREMQGGSQLEITVAQRGAPRELPDEQATALYRIAQEALTNVERHAGARQVTVALV
FDPDATSLTVRDDGRGFDVARMQLDPQRGIGLRNLRERIAALGGQFGIVSGIGGTELVATLPVVKAAARPTTPLPAESSQ
S

Sequences:

>Translated_481_residues
MPPARHRCLPPAKMKLRQKILLLAVAPLAVAMLGIALAVRFQATQLARHERALVEAAYIQSKETELRHYVELAQSAIAPM
VRSGHTDAATRQAAMEALARLDYGPDGYFFLYDMQGRNLMHPRQPELVGQDLWTLRDPQGALTIQKLIAAAKAGGGSVRY
LWKKPSSQQLAPKLGYVVAVPEWGWMLGTGIYLDDVENTLRQLDARAETDIRETMAWIGVIAAVSILLVAASGLALNISE
HREADAKLRQLAQRVVQSQEEERARLSRELHDGISQLLVSVKLVLEAAANRLRLAPAEGAAVAPVLGMALNRLDTVFNEV
RRVARNLRPALLDDLGIFAALQHLAREMQGGSQLEITVAQRGAPRELPDEQATALYRIAQEALTNVERHAGARQVTVALV
FDPDATSLTVRDDGRGFDVARMQLDPQRGIGLRNLRERIAALGGQFGIVSGIGGTELVATLPVVKAAARPTTPLPAESSQ
S
>Mature_480_residues
PPARHRCLPPAKMKLRQKILLLAVAPLAVAMLGIALAVRFQATQLARHERALVEAAYIQSKETELRHYVELAQSAIAPMV
RSGHTDAATRQAAMEALARLDYGPDGYFFLYDMQGRNLMHPRQPELVGQDLWTLRDPQGALTIQKLIAAAKAGGGSVRYL
WKKPSSQQLAPKLGYVVAVPEWGWMLGTGIYLDDVENTLRQLDARAETDIRETMAWIGVIAAVSILLVAASGLALNISEH
READAKLRQLAQRVVQSQEEERARLSRELHDGISQLLVSVKLVLEAAANRLRLAPAEGAAVAPVLGMALNRLDTVFNEVR
RVARNLRPALLDDLGIFAALQHLAREMQGGSQLEITVAQRGAPRELPDEQATALYRIAQEALTNVERHAGARQVTVALVF
DPDATSLTVRDDGRGFDVARMQLDPQRGIGLRNLRERIAALGGQFGIVSGIGGTELVATLPVVKAAARPTTPLPAESSQS

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=229, Percent_Identity=34.4978165938865, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788812, Length=200, Percent_Identity=27, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787474, Length=207, Percent_Identity=28.5024154589372, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52376; Mature: 52245

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPARHRCLPPAKMKLRQKILLLAVAPLAVAMLGIALAVRFQATQLARHERALVEAAYIQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKETELRHYVELAQSAIAPMVRSGHTDAATRQAAMEALARLDYGPDGYFFLYDMQGRNLM
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
HPRQPELVGQDLWTLRDPQGALTIQKLIAAAKAGGGSVRYLWKKPSSQQLAPKLGYVVAV
CCCCCHHHCCCHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEC
PEWGWMLGTGIYLDDVENTLRQLDARAETDIRETMAWIGVIAAVSILLVAASGLALNISE
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHH
HREADAKLRQLAQRVVQSQEEERARLSRELHDGISQLLVSVKLVLEAAANRLRLAPAEGA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
AVAPVLGMALNRLDTVFNEVRRVARNLRPALLDDLGIFAALQHLAREMQGGSQLEITVAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
RGAPRELPDEQATALYRIAQEALTNVERHAGARQVTVALVFDPDATSLTVRDDGRGFDVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCEEE
RMQLDPQRGIGLRNLRERIAALGGQFGIVSGIGGTELVATLPVVKAAARPTTPLPAESSQ
EEEECHHHCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
S
C
>Mature Secondary Structure 
PPARHRCLPPAKMKLRQKILLLAVAPLAVAMLGIALAVRFQATQLARHERALVEAAYIQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKETELRHYVELAQSAIAPMVRSGHTDAATRQAAMEALARLDYGPDGYFFLYDMQGRNLM
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
HPRQPELVGQDLWTLRDPQGALTIQKLIAAAKAGGGSVRYLWKKPSSQQLAPKLGYVVAV
CCCCCHHHCCCHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEC
PEWGWMLGTGIYLDDVENTLRQLDARAETDIRETMAWIGVIAAVSILLVAASGLALNISE
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHH
HREADAKLRQLAQRVVQSQEEERARLSRELHDGISQLLVSVKLVLEAAANRLRLAPAEGA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
AVAPVLGMALNRLDTVFNEVRRVARNLRPALLDDLGIFAALQHLAREMQGGSQLEITVAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
RGAPRELPDEQATALYRIAQEALTNVERHAGARQVTVALVFDPDATSLTVRDDGRGFDVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCEEE
RMQLDPQRGIGLRNLRERIAALGGQFGIVSGIGGTELVATLPVVKAAARPTTPLPAESSQ
EEEECHHHCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]