| Definition | Ralstonia eutropha JMP134 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_007347 |
| Length | 3,806,533 |
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The map label for this gene is topB [H]
Identifier: 73543094
GI number: 73543094
Start: 3743021
End: 3745711
Strand: Direct
Name: topB [H]
Synonym: Reut_A3412
Alternate gene names: 73543094
Gene position: 3743021-3745711 (Clockwise)
Preceding gene: 73543093
Following gene: 73543096
Centisome position: 98.33
GC content: 64.25
Gene sequence:
>2691_bases ATGTCAAAAGCCCTCATCATCGCGGAAAAGCCATCGGTCGCGGCCGATATCGCCCGTGCCCTCGGGGGCTTTACCAAGCA CGACGAGTACTTTGAAAGTGACGACTACGTGCTGTCGTCCGCCGTGGGCCACCTGGTGGAGATCGCCGCGCCCGACGAAT ACGAGGTCAAGCGCGGCAAATGGAGCTTCGCCAACCTGCCGGTGATCCCGCCGCATTTCGACCTGCGGCCGATCGCCAAG ACCGAGTCGCGGCTCAAGGTGCTCAACAAGCTCATCAAGCGCAAGGACGTGACCGGCCTGATCAACGCGTGTGACGCGGG GCGCGAAGGGGAACTGATCTTCCGCCTGATCGCGCAGCAGGCCAAGGCGAAGCAGCCGGTGCGCCGGCTGTGGCTGCAGT CGATGACGCCGCAGGCGATTCGCGACGGCTTTGCGAGCCTGCGTGCCGACGAAGACATGCTGCCGCTTGCCGATGCCGCG CGGTGCCGCTCCGAAGCCGACTGGCTGGTGGGTATCAACGGCACGCGCGCCATGACCGCCTTCAACAGCAAGGGCGGTGG CTTCTTCCTGACCACCGTGGGCCGCGTGCAGACGCCGACGCTGTCGATCGTGGTCGAGCGCGAAGAGAAGATCAAGCACT TCGTGCCGCGCGATTACTGGGAGGTGCACGCCGAGTTCATCGCCGCCGCCGGCCTGTACGAAGGCCGCTGGTTCGACCCG AAGTTCAAGAAGAGCGAGTTCGATCCCGAGGCCCGCGAATCGCGCCTGTGGAGCGAGGCCGAGGCCAAGAGCATCGTGGC CGCATGCCGCGACAAGACCGGCACCGTCACCGAGGAATCGAAGCCGTCGACGCAGCAGTCGCCGGCGCTGTTCGACCTGA CCACGCTGCAGCGCGAAGCCAACTCGCGCTTCGGCTTCTCGGCCAAGAACACGCTCGGCCTGGCGCAGGCGCTGTATGAA AAGCACAAGGTCCTGACCTACCCGCGTACCGACGCGCGCGCGCTGCCCGAGGACTACATGGAAACGGTCAAGCAGACCAT GACCATGCTGGCCGACAGCTCGCCCAATTACCTGCCGCACGCGAAGAAAATCCTGTCGCAGGGCTGGGTCAAGCCGAACA AGAAGATTTTCGACAACAGCAAGATCAGCGATCACTTCGCTATCATCCCGACGCTGCAGGCGCCCAAGAACCTGTCGGAG CCGGAACAGAAGCTGTATGACCTGGTTGTGCGCCGCTTCCTGGCGGTGTTTTTCCCGGCAGCCGAATTCCAGGTCACGAC CCGCATCACGGAGGTTGCTGGCCACCACTTCAAGACCGAAGGCAAGGTGCTGGTCAACCCGGGCTGGCTCGTGATCTACG GCCGCGAGGCGCAGGGCGACAAGGACGCCGCCAATCTGGTGCCGGTGGCCAAGGACGAGAAGGTCAAGACCGACAAAGTC GAAAGCGTGGGCCTGACGACCAAGCCGCCCGCGCGTTACAACGAAGCGACGCTGCTGTCAGCGATGGAAGGCGCGGGCAA GCTGGTGGATGACGACGCGCTGCGCGAAGCCATGGCCGGCAAGGGCCTTGGTACGCCGGCGACGCGCGCGGCCATCATCG AAGGCCTGCTGACGGAAAAATACCTCGTGCGCGAAGGCCGCGAACTGATTCCGACCGCCAAGGCGTTCCAGTTGATGACG CTGCTGCGCGGCCTCGGCGTGCAGGAACTGACCCAGGCCGAGCTGACCGGCGAGTGGGAGCACAAGCTGTCGCAGATCGA ACGCGGGCGCCTGAAGCGCGACGAGTTCATGCTCGAAATCGCGCAGATGACGCAGCAGATCGTCAAGCGCGCCAAGGAAT ACGACAGCGATACGATCCCGGGTGACTACGCCACGCTGGATACGCCGTGCCCGCAGTGCGGCGGCCAGGTGAAGGAAAAC TATCGCCGCTTTGCCTGCATGGCATGCGAGTTCTCGATCAGCAAGATCCCTGGCGGCCGCCAGTTCGAGATCGAAGAGGT CGAGGAACTGCTCCTGAAGCGCGAAATCGGCCCGCTGCAGGGCTTCCGCAGCAAGATGGGCCGGCCGTTTGCCGCCATCC TCAAGATCGCCAAGGACGACGAAGGCCATTTCAAGATGGAATTCGACTTCGGCCAGAACGATGACGAAGGCGACGGCGAG CCGGTCGACTTCAGCGGCCAGGAGCCGGTTGGCACCTGCCCGAAATGCGGCGGCGCGGTGTTCGAGCACGGCATGAAGTA CGTGTGCGAAAACAGTGTGGCCAGCCCGAAGAGCTGCGACTTCACGACCGGCAAGATCATCCTGCAGCAGGAAATCAGCC GCGAGCAGGTCGGCAAGTTGCTGAACGATGGCCGTACGGATCTGCTGACTGGCTTCAAGTCGTCGCGTACGGGCCGCAAT TTCAAGGCTTTCCTGGTCAGACAGGCGGACGGCAAGATCGGCTTCGAATTCGAGGCCCGCGAGCCGAAGGCCGGTGCCAA GGCCTCAGGCAAGACCGCATCGCGCGCGGCTGCCGAAACCGGGGAAGCCGAAGCGGCGGCGGCAAAGGCGCCGGCCAAGA AGGCTGCGGCAACGAAGACCGCCACCAAGACCACGGCGACCAAGACCGCCGCGAAGAAGGCGCCCGCCAAGACGGTAGCG GCCAAGAAGACCCGCGCCGCGGGCAAGGCGACGGTCGAAGCCGAGGAATAA
Upstream 100 bases:
>100_bases GCGCTTATGATTGGCGCCTCAAAGCCCCCGGGGGCGTTTGTCTACTAAGTTTGTTGTGCAATTCGCGTGTTGCCGGAAGC AGCCCGCAAGGACCCGTTCA
Downstream 100 bases:
>100_bases GCGGCGAGGCGGTGCGGGCGCGGCGGCGTTTCAGCTGCGGCTACCCGCCCGCTCAGGAAAACTGCTCGTCCCGGCCTCTG ACCTGGCCTTCTTCCAGCAG
Product: DNA topoisomerase III
Products: NA
Alternate protein names: DNA topoisomerase III [H]
Number of amino acids: Translated: 896; Mature: 895
Protein sequence:
>896_residues MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAK TESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFASLRADEDMLPLADAA RCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVHAEFIAAAGLYEGRWFDP KFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYE KHKVLTYPRTDARALPEDYMETVKQTMTMLADSSPNYLPHAKKILSQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSE PEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKV ESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMT LLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMLEIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKEN YRRFACMACEFSISKIPGGRQFEIEEVEELLLKREIGPLQGFRSKMGRPFAAILKIAKDDEGHFKMEFDFGQNDDEGDGE PVDFSGQEPVGTCPKCGGAVFEHGMKYVCENSVASPKSCDFTTGKIILQQEISREQVGKLLNDGRTDLLTGFKSSRTGRN FKAFLVRQADGKIGFEFEAREPKAGAKASGKTASRAAAETGEAEAAAAKAPAKKAAATKTATKTTATKTAAKKAPAKTVA AKKTRAAGKATVEAEE
Sequences:
>Translated_896_residues MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAK TESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFASLRADEDMLPLADAA RCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVHAEFIAAAGLYEGRWFDP KFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYE KHKVLTYPRTDARALPEDYMETVKQTMTMLADSSPNYLPHAKKILSQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSE PEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKV ESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMT LLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMLEIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKEN YRRFACMACEFSISKIPGGRQFEIEEVEELLLKREIGPLQGFRSKMGRPFAAILKIAKDDEGHFKMEFDFGQNDDEGDGE PVDFSGQEPVGTCPKCGGAVFEHGMKYVCENSVASPKSCDFTTGKIILQQEISREQVGKLLNDGRTDLLTGFKSSRTGRN FKAFLVRQADGKIGFEFEAREPKAGAKASGKTASRAAAETGEAEAAAAKAPAKKAAATKTATKTTATKTAAKKAPAKTVA AKKTRAAGKATVEAEE >Mature_895_residues SKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKT ESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFASLRADEDMLPLADAAR CRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVHAEFIAAAGLYEGRWFDPK FKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEK HKVLTYPRTDARALPEDYMETVKQTMTMLADSSPNYLPHAKKILSQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSEP EQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVE SVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTL LRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMLEIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENY RRFACMACEFSISKIPGGRQFEIEEVEELLLKREIGPLQGFRSKMGRPFAAILKIAKDDEGHFKMEFDFGQNDDEGDGEP VDFSGQEPVGTCPKCGGAVFEHGMKYVCENSVASPKSCDFTTGKIILQQEISREQVGKLLNDGRTDLLTGFKSSRTGRNF KAFLVRQADGKIGFEFEAREPKAGAKASGKTASRAAAETGEAEAAAAKAPAKKAAATKTATKTTATKTAAKKAPAKTVAA KKTRAAGKATVEAEE
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. TOP3 is a potent decatenase [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=641, Percent_Identity=26.3650546021841, Blast_Score=149, Evalue=1e-35, Organism=Homo sapiens, GI4507635, Length=662, Percent_Identity=23.2628398791541, Blast_Score=107, Evalue=4e-23, Organism=Escherichia coli, GI1788061, Length=620, Percent_Identity=33.7096774193548, Blast_Score=333, Evalue=4e-92, Organism=Escherichia coli, GI1787529, Length=673, Percent_Identity=26.8945022288262, Blast_Score=161, Evalue=2e-40, Organism=Caenorhabditis elegans, GI32563869, Length=627, Percent_Identity=24.5614035087719, Blast_Score=124, Evalue=3e-28, Organism=Caenorhabditis elegans, GI17555378, Length=636, Percent_Identity=24.8427672955975, Blast_Score=113, Evalue=4e-25, Organism=Saccharomyces cerevisiae, GI6323263, Length=670, Percent_Identity=24.1791044776119, Blast_Score=95, Evalue=4e-20, Organism=Drosophila melanogaster, GI24585251, Length=653, Percent_Identity=26.1868300153139, Blast_Score=110, Evalue=3e-24,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR005738 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 98721; Mature: 98589
Theoretical pI: Translated: 8.65; Mature: 8.65
Prosite motif: PS00154 ATPASE_E1_E2 ; PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGK CCCEEEEECCCCHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHEEECCCCCCHHCCCC WSFANLPVIPPHFDLRPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQQ CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH AKAKQPVRRLWLQSMTPQAIRDGFASLRADEDMLPLADAARCRSEADWLVGINGTRAMTA HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCEEEEE FNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVHAEFIAAAGLYEGRWFDP ECCCCCCEEEEECCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC KFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREA CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHH NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMETVKQTMTMLADSSPNYLPH CCCCCCCCHHHHHHHHHHHHHHCEEECCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCHH AKKILSQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPA HHHHHHHCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC AEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKV CCEEHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCH ESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEK HHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH YLVREGRELIPTAKAFQLMTLLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMLEI HHHHCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHH AQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACMACEFSISKIPGGR HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCHHHCCCCC QFEIEEVEELLLKREIGPLQGFRSKMGRPFAAILKIAKDDEGHFKMEFDFGQNDDEGDGE EECHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC PVDFSGQEPVGTCPKCGGAVFEHGMKYVCENSVASPKSCDFTTGKIILQQEISREQVGKL CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHH LNDGRTDLLTGFKSSRTGRNFKAFLVRQADGKIGFEFEAREPKAGAKASGKTASRAAAET HHCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHC GEAEAAAAKAPAKKAAATKTATKTTATKTAAKKAPAKTVAAKKTRAAGKATVEAEE CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCC >Mature Secondary Structure SKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGK CCEEEEECCCCHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHEEECCCCCCHHCCCC WSFANLPVIPPHFDLRPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQQ CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH AKAKQPVRRLWLQSMTPQAIRDGFASLRADEDMLPLADAARCRSEADWLVGINGTRAMTA HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCEEEEE FNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVHAEFIAAAGLYEGRWFDP ECCCCCCEEEEECCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC KFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREA CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHH NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMETVKQTMTMLADSSPNYLPH CCCCCCCCHHHHHHHHHHHHHHCEEECCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCHH AKKILSQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPA HHHHHHHCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC AEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKV CCEEHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCH ESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEK HHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH YLVREGRELIPTAKAFQLMTLLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMLEI HHHHCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHH AQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACMACEFSISKIPGGR HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCHHHCCCCC QFEIEEVEELLLKREIGPLQGFRSKMGRPFAAILKIAKDDEGHFKMEFDFGQNDDEGDGE EECHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC PVDFSGQEPVGTCPKCGGAVFEHGMKYVCENSVASPKSCDFTTGKIILQQEISREQVGKL CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHH LNDGRTDLLTGFKSSRTGRNFKAFLVRQADGKIGFEFEAREPKAGAKASGKTASRAAAET HHCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHC GEAEAAAAKAPAKKAAATKTATKTTATKTAAKKAPAKTVAAKKTRAAGKATVEAEE CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA