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The map label for this gene is phhA [H]

Identifier: 73543069

GI number: 73543069

Start: 3714366

End: 3715316

Strand: Direct

Name: phhA [H]

Synonym: Reut_A3387

Alternate gene names: 73543069

Gene position: 3714366-3715316 (Clockwise)

Preceding gene: 73543062

Following gene: 73543070

Centisome position: 97.58

GC content: 65.83

Gene sequence:

>951_bases
ATGTCCGCTACCGCCAGCGCCCTCGCCCACGAGGCTTCCGGCCAGTTCGACGGTGCCTTTCAGGGCACCATGACCGACAA
GCTCAGGGAACAGTTCGACGCCGGCCTGCTGTCCGGTCAGGAACTGCGCCCGGACTTCACCATCGCGCAACCGGTCCACC
GCTACACCAGCACCGACCACGCCATCTGGCGCAAGCTCTACGAGCGCCAGGCTTCGATGCTGCGCGGGCGCGTCAGCAAT
GAATTCCTGCAAGGCCTCGCCACACTCGGCATGGAGAAGGACCACGTGCCGGAGTTCGACCAGCTCAACGAAACGCTGAT
GCGCGCCACCGGCTGGCAGGTCGTGGCCGTGCCGGGCCTGGTGCCGGACGAAGTGTTCTTCGACCATCTGGCCAACCGCC
GCTTCCCGGCGAGCTGGTGGATGCGCAAACCCGAGCAGCTCGACTACCTGCAGGAACCGGACTGCTTCCACGATGTGTTC
GGCCATGTGCCCCTGCTGATCAACCCGGTCTTCGCCGACTACATGGAGGCGTACGGCAAGGGCGGGCTCAAGGCCCATGG
CCTGGGCGCGCTCGACATGCTCTCGCGCCTGTACTGGTACACGGTGGAATTCGGCCTGATCCGCACGCCCGAAGGCCTGC
GCATCTACGGCGCCGGCATCCTGTCCAGCCAGGGTGAGTCGGTCTACAGCCTCGATTCGGCCAGCCCGAACCGCATCGGC
TTCGACGTGCGCCGCATCATGCGCACGCGCTACCGCATCGACACGTTCCAGAAGAGCTACTTCGTGATCGACAGCTTCGA
GCAGCTCTTCGACGCGACCCGCCCGGACTTCGAGCCGCTGTACCAGGAACTGCGTGACCAGCCGACGCTGGGCGCCGGCG
ACGTGATCGACGGCGACCTCGTGCTCAACGTTGGCACCCGCGAAGGCTGGGGCGACAGCGACGATATCTGA

Upstream 100 bases:

>100_bases
AGCAGCCCATTTTGCGGCCGAATTGCAGCACCACACGCCTAAACTACGCAGATAAACCGCATATCACGGCGCATAACGCC
AAACCCAGGAGACAAAGCTG

Downstream 100 bases:

>100_bases
GCGGGCGGCCGGTTTGTGGTCCATCGGCGGCCACTACGCGGCATCCCGCTTTATGAAACAATGCCGGCATGCCCGCCAGG
GCGGGCCGGTTTTTTCTTTT

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSATASALAHEASGQFDGAFQGTMTDKLREQFDAGLLSGQELRPDFTIAQPVHRYTSTDHAIWRKLYERQASMLRGRVSN
EFLQGLATLGMEKDHVPEFDQLNETLMRATGWQVVAVPGLVPDEVFFDHLANRRFPASWWMRKPEQLDYLQEPDCFHDVF
GHVPLLINPVFADYMEAYGKGGLKAHGLGALDMLSRLYWYTVEFGLIRTPEGLRIYGAGILSSQGESVYSLDSASPNRIG
FDVRRIMRTRYRIDTFQKSYFVIDSFEQLFDATRPDFEPLYQELRDQPTLGAGDVIDGDLVLNVGTREGWGDSDDI

Sequences:

>Translated_316_residues
MSATASALAHEASGQFDGAFQGTMTDKLREQFDAGLLSGQELRPDFTIAQPVHRYTSTDHAIWRKLYERQASMLRGRVSN
EFLQGLATLGMEKDHVPEFDQLNETLMRATGWQVVAVPGLVPDEVFFDHLANRRFPASWWMRKPEQLDYLQEPDCFHDVF
GHVPLLINPVFADYMEAYGKGGLKAHGLGALDMLSRLYWYTVEFGLIRTPEGLRIYGAGILSSQGESVYSLDSASPNRIG
FDVRRIMRTRYRIDTFQKSYFVIDSFEQLFDATRPDFEPLYQELRDQPTLGAGDVIDGDLVLNVGTREGWGDSDDI
>Mature_315_residues
SATASALAHEASGQFDGAFQGTMTDKLREQFDAGLLSGQELRPDFTIAQPVHRYTSTDHAIWRKLYERQASMLRGRVSNE
FLQGLATLGMEKDHVPEFDQLNETLMRATGWQVVAVPGLVPDEVFFDHLANRRFPASWWMRKPEQLDYLQEPDCFHDVFG
HVPLLINPVFADYMEAYGKGGLKAHGLGALDMLSRLYWYTVEFGLIRTPEGLRIYGAGILSSQGESVYSLDSASPNRIGF
DVRRIMRTRYRIDTFQKSYFVIDSFEQLFDATRPDFEPLYQELRDQPTLGAGDVIDGDLVLNVGTREGWGDSDDI

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=228, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI88900505, Length=228, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI88900501, Length=228, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI31795563, Length=235, Percent_Identity=31.063829787234, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4557819, Length=231, Percent_Identity=29.4372294372294, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4759248, Length=228, Percent_Identity=31.140350877193, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531391, Length=220, Percent_Identity=32.7272727272727, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71980736, Length=216, Percent_Identity=31.4814814814815, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115532103, Length=247, Percent_Identity=28.7449392712551, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115533973, Length=247, Percent_Identity=28.7449392712551, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=149, Percent_Identity=28.8590604026846, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI62472054, Length=223, Percent_Identity=31.8385650224215, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24660393, Length=223, Percent_Identity=31.8385650224215, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24654994, Length=263, Percent_Identity=29.6577946768061, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136776, Length=228, Percent_Identity=28.5087719298246, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17136774, Length=228, Percent_Identity=28.5087719298246, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 35807; Mature: 35675

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATASALAHEASGQFDGAFQGTMTDKLREQFDAGLLSGQELRPDFTIAQPVHRYTSTDH
CCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHH
AIWRKLYERQASMLRGRVSNEFLQGLATLGMEKDHVPEFDQLNETLMRATGWQVVAVPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
VPDEVFFDHLANRRFPASWWMRKPEQLDYLQEPDCFHDVFGHVPLLINPVFADYMEAYGK
CCHHHHHHHHHCCCCCHHHHHCCCHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
GGLKAHGLGALDMLSRLYWYTVEFGLIRTPEGLRIYGAGILSSQGESVYSLDSASPNRIG
CCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEEECCCCCCCCCCEEEECCCCCCHHH
FDVRRIMRTRYRIDTFQKSYFVIDSFEQLFDATRPDFEPLYQELRDQPTLGAGDVIDGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEECCCE
VLNVGTREGWGDSDDI
EEEECCCCCCCCCCCC
>Mature Secondary Structure 
SATASALAHEASGQFDGAFQGTMTDKLREQFDAGLLSGQELRPDFTIAQPVHRYTSTDH
CCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHH
AIWRKLYERQASMLRGRVSNEFLQGLATLGMEKDHVPEFDQLNETLMRATGWQVVAVPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
VPDEVFFDHLANRRFPASWWMRKPEQLDYLQEPDCFHDVFGHVPLLINPVFADYMEAYGK
CCHHHHHHHHHCCCCCHHHHHCCCHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
GGLKAHGLGALDMLSRLYWYTVEFGLIRTPEGLRIYGAGILSSQGESVYSLDSASPNRIG
CCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEEECCCCCCCCCCEEEECCCCCCHHH
FDVRRIMRTRYRIDTFQKSYFVIDSFEQLFDATRPDFEPLYQELRDQPTLGAGDVIDGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEECCCE
VLNVGTREGWGDSDDI
EEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]