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The map label for this gene is trpC [H]

Identifier: 73542710

GI number: 73542710

Start: 3328388

End: 3329191

Strand: Direct

Name: trpC [H]

Synonym: Reut_A3026

Alternate gene names: 73542710

Gene position: 3328388-3329191 (Clockwise)

Preceding gene: 73542709

Following gene: 73542711

Centisome position: 87.44

GC content: 67.41

Gene sequence:

>804_bases
ATGTCCGACATCCTCGACAAGATCCTGGCCGTCAAGGCCGACGAAGTCTCCGCCGCGCGCAAGAAGCGCGACCTGCCGAG
CCTGCGCGCCGAGGCCGAGAGCCTGCGCAATGAAGCGGGCTTCGCACCGCGCGGCTTCGAACGTTCGCTGCGCGACAAGA
TTGCCGCCGGCCACGCCGGCGTGATCGCCGAAGTCAAGAAGGCATCGCCGTCCAAGGGCGTGCTGCGCGAGAACTTCGTG
CCCGAGGCCATCGCCGAAAGCTACGCGAGCCACGGTGCGGCCTGCCTGTCGGTGCTGACCGACGTGAATTTCTTCCAGGG
CCACGCCGACTACCTGAAGCGCGCGCGTGGCGCCTGCCCGCTGCCCGCGCTGCGCAAGGACTTCATGGTCGACCTGTACC
AGGTCTATGAAGCGCGCAGCTGGGGCGCGGACTGCATCCTGCTGATCGTCGCCGCGCTCGACCCTGGCCTGATGGCCGAC
CTGGAAGCGTGCGCGCACGAGCTGGGCATGGACGTGCTCGTGGAAGTCCACGGCGCCGACGAACTCGACAGCGCACTGCG
CTTGAAGACGCCGCTGCTGGGCGTCAACAACCGCAACCTGCGCACGTTCGAAGTCTCGCTCGACAACACGCTGGACCTGC
TGCCGAGCATGCCGGCCGACCGGCTCGTGGTGACGGAATCCGGCATCCTGGGCCCGAACGACGTGAAACGCATGCGCGAT
GCCGATGTGCACGCGTTCCTGGTCGGCGAAGCGTTCATGCGCGCGAAGGACCCCGGCGTGGAACTGGCGCGGTTGTTCGC
GTAA

Upstream 100 bases:

>100_bases
GATGGCATCCGCCGCGCGCGCGAAGCCATCGCGAGCGGCGCCGCACGCGAGAAGCTCGACCACTTCGTGCGCGCCACGCA
GCAATTCAAGTAAGGCAACC

Downstream 100 bases:

>100_bases
GCCGATGGCGCAGGAAATCGAGCTGAAGCTCGCCGTTCCCGACGATGCGCTGGCGCAGCTTGCTGCGTGGCTCGACGCCA
ACGGCGAATCGAAGGGCGAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSDILDKILAVKADEVSAARKKRDLPSLRAEAESLRNEAGFAPRGFERSLRDKIAAGHAGVIAEVKKASPSKGVLRENFV
PEAIAESYASHGAACLSVLTDVNFFQGHADYLKRARGACPLPALRKDFMVDLYQVYEARSWGADCILLIVAALDPGLMAD
LEACAHELGMDVLVEVHGADELDSALRLKTPLLGVNNRNLRTFEVSLDNTLDLLPSMPADRLVVTESGILGPNDVKRMRD
ADVHAFLVGEAFMRAKDPGVELARLFA

Sequences:

>Translated_267_residues
MSDILDKILAVKADEVSAARKKRDLPSLRAEAESLRNEAGFAPRGFERSLRDKIAAGHAGVIAEVKKASPSKGVLRENFV
PEAIAESYASHGAACLSVLTDVNFFQGHADYLKRARGACPLPALRKDFMVDLYQVYEARSWGADCILLIVAALDPGLMAD
LEACAHELGMDVLVEVHGADELDSALRLKTPLLGVNNRNLRTFEVSLDNTLDLLPSMPADRLVVTESGILGPNDVKRMRD
ADVHAFLVGEAFMRAKDPGVELARLFA
>Mature_266_residues
SDILDKILAVKADEVSAARKKRDLPSLRAEAESLRNEAGFAPRGFERSLRDKIAAGHAGVIAEVKKASPSKGVLRENFVP
EAIAESYASHGAACLSVLTDVNFFQGHADYLKRARGACPLPALRKDFMVDLYQVYEARSWGADCILLIVAALDPGLMADL
EACAHELGMDVLVEVHGADELDSALRLKTPLLGVNNRNLRTFEVSLDNTLDLLPSMPADRLVVTESGILGPNDVKRMRDA
DVHAFLVGEAFMRAKDPGVELARLFA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=37.4517374517375, Blast_Score=154, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322638, Length=266, Percent_Identity=36.4661654135338, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28993; Mature: 28861

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDKILAVKADEVSAARKKRDLPSLRAEAESLRNEAGFAPRGFERSLRDKIAAGHAG
CHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
VIAEVKKASPSKGVLRENFVPEAIAESYASHGAACLSVLTDVNFFQGHADYLKRARGACP
HHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
LPALRKDFMVDLYQVYEARSWGADCILLIVAALDPGLMADLEACAHELGMDVLVEVHGAD
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCH
ELDSALRLKTPLLGVNNRNLRTFEVSLDNTLDLLPSMPADRLVVTESGILGPNDVKRMRD
HHHHHHHHHCCEECCCCCCEEEEEEECCCHHHHHCCCCCCCEEEECCCCCCHHHHHHHHH
ADVHAFLVGEAFMRAKDPGVELARLFA
CCHHHHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
SDILDKILAVKADEVSAARKKRDLPSLRAEAESLRNEAGFAPRGFERSLRDKIAAGHAG
HHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
VIAEVKKASPSKGVLRENFVPEAIAESYASHGAACLSVLTDVNFFQGHADYLKRARGACP
HHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
LPALRKDFMVDLYQVYEARSWGADCILLIVAALDPGLMADLEACAHELGMDVLVEVHGAD
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCH
ELDSALRLKTPLLGVNNRNLRTFEVSLDNTLDLLPSMPADRLVVTESGILGPNDVKRMRD
HHHHHHHHHCCEECCCCCCEEEEEEECCCHHHHHCCCCCCCEEEECCCCCCHHHHHHHHH
ADVHAFLVGEAFMRAKDPGVELARLFA
CCHHHHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA