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The map label for this gene is rppH

Identifier: 73542637

GI number: 73542637

Start: 3239097

End: 3239792

Strand: Direct

Name: rppH

Synonym: Reut_A2953

Alternate gene names: 73542637

Gene position: 3239097-3239792 (Clockwise)

Preceding gene: 73542632

Following gene: 73542638

Centisome position: 85.09

GC content: 65.23

Gene sequence:

>696_bases
ATGCTCGATCGTGAAGGCTTTCGCCCGAACGTCGGCATCATCCTCATCAACGCACGAAACGAGGTTTTCTGGGGCAAGCG
AATCGGCGAGCATTCCTGGCAGTTTCCGCAAGGCGGCATCAAGTACGGCGAAACGCCCGAACAGGCCATGTATCGCGAAC
TGCATGAGGAGATCGGCCTGCTACCGGAGCACGTCAGGATCGTCGGTCGCACGCGCGACTGGTTGCGCTATGAGGTGCCG
GACAAGTTCATCCGCCGCGAGATCCGCGGCCATTACAGGGGCCAGAAGCAGATCTGGTTCCTGCTGCGCATGGCAGGCAG
GGACTGTGACGTACACCTGCGCGCCACGGAGCATCCCGAGTTCGATGCCTGGCGGTGGAGCGACTACTGGGTGCCGCTGG
AGGCAGTCATCGAGTTCAAGCGCGACGTGTACCAGCTTGCACTGACAGAGCTGTCGCGCTTCCTGAACCGCAATCCGCGC
GTGCCGCTGAGCCCGTACGGCGTGCATCACGGCCGCCATGGCAGCGGGCAGCGGTATGCGCAGCAGCCCGGCCAGCCGCC
CACGCTGGCGCAGCGCCGGCCGCTGCAGCCCGTCACGCAGGTCGCGCCTGTTGCACCGGCAGCGGAAGCGGTGCAGGCAG
TGGAAAGCGATGCAGTTTTGCCGGCTACGCCGGCCCCCAACCCGACGGAGTCCTGA

Upstream 100 bases:

>100_bases
CTGCCCTTCCCGCTCGGGGAAAACCAGCAGCACCCCGCCTGAGCCGGGCCGCGCGCATCCTTTATAATCGACATAATTCT
AAAGGATTCGAGGTGCAGTC

Downstream 100 bases:

>100_bases
TGAATCGTGTTACCGGCCTGGGCCGCCGCGGCGGCCTGACCGCTGCTGGCCTGTTGCTTGCCGCCGCCTGCCTGGCACTG
GCAGGCTGCAAGACCACCGG

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEIGLLPEHVRIVGRTRDWLRYEVP
DKFIRREIRGHYRGQKQIWFLLRMAGRDCDVHLRATEHPEFDAWRWSDYWVPLEAVIEFKRDVYQLALTELSRFLNRNPR
VPLSPYGVHHGRHGSGQRYAQQPGQPPTLAQRRPLQPVTQVAPVAPAAEAVQAVESDAVLPATPAPNPTES

Sequences:

>Translated_231_residues
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEIGLLPEHVRIVGRTRDWLRYEVP
DKFIRREIRGHYRGQKQIWFLLRMAGRDCDVHLRATEHPEFDAWRWSDYWVPLEAVIEFKRDVYQLALTELSRFLNRNPR
VPLSPYGVHHGRHGSGQRYAQQPGQPPTLAQRRPLQPVTQVAPVAPAAEAVQAVESDAVLPATPAPNPTES
>Mature_231_residues
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEIGLLPEHVRIVGRTRDWLRYEVP
DKFIRREIRGHYRGQKQIWFLLRMAGRDCDVHLRATEHPEFDAWRWSDYWVPLEAVIEFKRDVYQLALTELSRFLNRNPR
VPLSPYGVHHGRHGSGQRYAQQPGQPPTLAQRRPLQPVTQVAPVAPAAEAVQAVESDAVLPATPAPNPTES

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=152, Percent_Identity=50, Blast_Score=179, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_CUPPJ (Q46X20)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_297157.1
- ProteinModelPortal:   Q46X20
- SMR:   Q46X20
- GeneID:   3608974
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2953
- NMPDR:   fig|264198.3.peg.2903
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- BioCyc:   REUT264198:REUT_A2953-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 26723; Mature: 26723

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEIGL
CCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVRIVGRTRDWLRYEVPDKFIRREIRGHYRGQKQIWFLLRMAGRDCDVHLRATEHPE
CHHHHHHHCCCCHHHEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCC
FDAWRWSDYWVPLEAVIEFKRDVYQLALTELSRFLNRNPRVPLSPYGVHHGRHGSGQRYA
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
QQPGQPPTLAQRRPLQPVTQVAPVAPAAEAVQAVESDAVLPATPAPNPTES
HCCCCCCCHHCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEIGL
CCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVRIVGRTRDWLRYEVPDKFIRREIRGHYRGQKQIWFLLRMAGRDCDVHLRATEHPE
CHHHHHHHCCCCHHHEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCC
FDAWRWSDYWVPLEAVIEFKRDVYQLALTELSRFLNRNPRVPLSPYGVHHGRHGSGQRYA
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
QQPGQPPTLAQRRPLQPVTQVAPVAPAAEAVQAVESDAVLPATPAPNPTES
HCCCCCCCHHCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA