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The map label for this gene is pkn1 [H]

Identifier: 73542580

GI number: 73542580

Start: 3174150

End: 3175379

Strand: Reverse

Name: pkn1 [H]

Synonym: Reut_A2895

Alternate gene names: 73542580

Gene position: 3175379-3174150 (Counterclockwise)

Preceding gene: 73542582

Following gene: 73542579

Centisome position: 83.42

GC content: 68.21

Gene sequence:

>1230_bases
ATGGGCAGCAAGAAGCGCCGGAATTCCGCCACAGGCATGGCGCAGGCGGAAGGCGTTGCGGCAACGGTCGCTGATCGGCC
GGGCCGCTGGCGCGGCGCCATCGTCGCCATGCTGGTATGCACCGGTGTGGCGGCGGGCTTCGGTGCGACCTGGTGGTTCC
AGCACGGCAGGCACGGTGAGCAAGGGCAGGGCGTGGTCGTTGGCGATGGCATGCGTGGCCCGGCCGGCATGGTCCATGTG
CCCGGCGGCGAATTCCTCATGGGCAGCGACAGCAAGATGGCGCAGGCCAACGAGAAGCCCGCGCACAAGGTGCGCATCCA
CGGCTTCTGGATGGACCAGCACCATGTCACCAATGCCGAGTTCCGCAAGTTCGTCGAGGCGACCGGCTATGTCACCACGG
CCGAGAAATCGCCTGACTGGGAAACGCTGAAAGTCCAACTGCCGCCCGGTACGCCACGCCCGCCCGCCAGTGCAATGGTC
GCGGGCGCCATGGTGTTCGTGGGCACGTCGCGGCCCGTGCCGCTGCAGGACTATTCGCGCTGGTGGCGCTACGTCCCGGG
TGCGGACTGGCGCCATCCGGGCGGGCCGGGTACGTCGATCGAGGGCAAGGACAATCACCCGGTTGTGCAGGTCTCCTATG
AAGACGCGCAGGCCTATGCCAAGTGGGCAGGCAAGCGTCTGCCGACCGAAGCCGAGTGGGAGTTCGCCGCGCGCGGCGGG
CTGGAGCAGGCCACCTACGCGTGGGGCGAGAAGTTCGCGCCCGATGGCAAACAGATGGCCAATGTCTGGCAGGGCCAGCA
GGGGCAGCCGTTCCCCGTGATCAGCCCGAAGGCTGGCGGCGCGCTCGGCACGAGCCCGGTCGGCACGTTTCCGGCCAACG
GCTACGGCCTCTATGACATGACTGGCAATGCGTGGCAGTGGGTCGCGGACTGGTACCGCGCCGACCAGTTCCGGCGAGAG
GCTGCGCAGGGCAGGCTGGTCGACGATCCTCCTGGCCCGTTGGCGTCATGGGATCCGAGCGAGCCTGGCGTGCCCGTCGG
CGCGCCCAAGCGCGTCACGCGCGGCGGGTCGTTTCTCTGCAATGAGGATTACTGCCTGAGCTACCGGCCCAGCGCGCGGC
GCGGCACCGATCCGTACAACAGCATGTCGCATCTCGGCTTCCGTCTGGTGATGGACGACAGCCGCTGGGCCGAAATGCGA
AAGCAGCAGCCAGTGGCCATGGCGCGATAG

Upstream 100 bases:

>100_bases
TCACCACCCGAGAAAACTCAATTCCGTTTCGCTTTTCCTTCTGTAACGATAGCTTCGGGGTGCGGTCTACGCACCACTTA
TGCATTGCGGAGGAAGAGTC

Downstream 100 bases:

>100_bases
CCGTTGTTCGGCTCGTTCTGCTTGTTCTGCTTTCGAACCGTTTTCCAACAACAGGAGCGCGCGCGATGCACCCCTCCACA
CCCAGGCCGCCGGCCCGCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MGSKKRRNSATGMAQAEGVAATVADRPGRWRGAIVAMLVCTGVAAGFGATWWFQHGRHGEQGQGVVVGDGMRGPAGMVHV
PGGEFLMGSDSKMAQANEKPAHKVRIHGFWMDQHHVTNAEFRKFVEATGYVTTAEKSPDWETLKVQLPPGTPRPPASAMV
AGAMVFVGTSRPVPLQDYSRWWRYVPGADWRHPGGPGTSIEGKDNHPVVQVSYEDAQAYAKWAGKRLPTEAEWEFAARGG
LEQATYAWGEKFAPDGKQMANVWQGQQGQPFPVISPKAGGALGTSPVGTFPANGYGLYDMTGNAWQWVADWYRADQFRRE
AAQGRLVDDPPGPLASWDPSEPGVPVGAPKRVTRGGSFLCNEDYCLSYRPSARRGTDPYNSMSHLGFRLVMDDSRWAEMR
KQQPVAMAR

Sequences:

>Translated_409_residues
MGSKKRRNSATGMAQAEGVAATVADRPGRWRGAIVAMLVCTGVAAGFGATWWFQHGRHGEQGQGVVVGDGMRGPAGMVHV
PGGEFLMGSDSKMAQANEKPAHKVRIHGFWMDQHHVTNAEFRKFVEATGYVTTAEKSPDWETLKVQLPPGTPRPPASAMV
AGAMVFVGTSRPVPLQDYSRWWRYVPGADWRHPGGPGTSIEGKDNHPVVQVSYEDAQAYAKWAGKRLPTEAEWEFAARGG
LEQATYAWGEKFAPDGKQMANVWQGQQGQPFPVISPKAGGALGTSPVGTFPANGYGLYDMTGNAWQWVADWYRADQFRRE
AAQGRLVDDPPGPLASWDPSEPGVPVGAPKRVTRGGSFLCNEDYCLSYRPSARRGTDPYNSMSHLGFRLVMDDSRWAEMR
KQQPVAMAR
>Mature_408_residues
GSKKRRNSATGMAQAEGVAATVADRPGRWRGAIVAMLVCTGVAAGFGATWWFQHGRHGEQGQGVVVGDGMRGPAGMVHVP
GGEFLMGSDSKMAQANEKPAHKVRIHGFWMDQHHVTNAEFRKFVEATGYVTTAEKSPDWETLKVQLPPGTPRPPASAMVA
GAMVFVGTSRPVPLQDYSRWWRYVPGADWRHPGGPGTSIEGKDNHPVVQVSYEDAQAYAKWAGKRLPTEAEWEFAARGGL
EQATYAWGEKFAPDGKQMANVWQGQQGQPFPVISPKAGGALGTSPVGTFPANGYGLYDMTGNAWQWVADWYRADQFRREA
AQGRLVDDPPGPLASWDPSEPGVPVGAPKRVTRGGSFLCNEDYCLSYRPSARRGTDPYNSMSHLGFRLVMDDSRWAEMRK
QQPVAMAR

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=330, Percent_Identity=40.6060606060606, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI257470975, Length=330, Percent_Identity=38.7878787878788, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI257470977, Length=330, Percent_Identity=37.8787878787879, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI194248088, Length=322, Percent_Identity=35.0931677018634, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI194248087, Length=322, Percent_Identity=33.5403726708075, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI194248090, Length=221, Percent_Identity=39.3665158371041, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226437577, Length=218, Percent_Identity=39.4495412844037, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20130397, Length=316, Percent_Identity=36.7088607594937, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 44646; Mature: 44514

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKKRRNSATGMAQAEGVAATVADRPGRWRGAIVAMLVCTGVAAGFGATWWFQHGRHGE
CCCCCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
QGQGVVVGDGMRGPAGMVHVPGGEFLMGSDSKMAQANEKPAHKVRIHGFWMDQHHVTNAE
CCCEEEEECCCCCCCCEEECCCCCEEECCCCHHHHCCCCCCEEEEEEEEEECCCCCCHHH
FRKFVEATGYVTTAEKSPDWETLKVQLPPGTPRPPASAMVAGAMVFVGTSRPVPLQDYSR
HHHHHHHCCCEEECCCCCCCEEEEEECCCCCCCCCHHHHHHEEEEEEECCCCCCHHHHHH
WWRYVPGADWRHPGGPGTSIEGKDNHPVVQVSYEDAQAYAKWAGKRLPTEAEWEFAARGG
HHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHCCC
LEQATYAWGEKFAPDGKQMANVWQGQQGQPFPVISPKAGGALGTSPVGTFPANGYGLYDM
CCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEC
TGNAWQWVADWYRADQFRREAAQGRLVDDPPGPLASWDPSEPGVPVGAPKRVTRGGSFLC
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
NEDYCLSYRPSARRGTDPYNSMSHLGFRLVMDDSRWAEMRKQQPVAMAR
CCCCEEEECCCCCCCCCCCHHHHHCEEEEEECCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GSKKRRNSATGMAQAEGVAATVADRPGRWRGAIVAMLVCTGVAAGFGATWWFQHGRHGE
CCCCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
QGQGVVVGDGMRGPAGMVHVPGGEFLMGSDSKMAQANEKPAHKVRIHGFWMDQHHVTNAE
CCCEEEEECCCCCCCCEEECCCCCEEECCCCHHHHCCCCCCEEEEEEEEEECCCCCCHHH
FRKFVEATGYVTTAEKSPDWETLKVQLPPGTPRPPASAMVAGAMVFVGTSRPVPLQDYSR
HHHHHHHCCCEEECCCCCCCEEEEEECCCCCCCCCHHHHHHEEEEEEECCCCCCHHHHHH
WWRYVPGADWRHPGGPGTSIEGKDNHPVVQVSYEDAQAYAKWAGKRLPTEAEWEFAARGG
HHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHCCC
LEQATYAWGEKFAPDGKQMANVWQGQQGQPFPVISPKAGGALGTSPVGTFPANGYGLYDM
CCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEC
TGNAWQWVADWYRADQFRREAAQGRLVDDPPGPLASWDPSEPGVPVGAPKRVTRGGSFLC
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
NEDYCLSYRPSARRGTDPYNSMSHLGFRLVMDDSRWAEMRKQQPVAMAR
CCCCEEEECCCCCCCCCCCHHHHHCEEEEEECCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]