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The map label for this gene is yeaE [H]

Identifier: 73542566

GI number: 73542566

Start: 3156618

End: 3157451

Strand: Direct

Name: yeaE [H]

Synonym: Reut_A2881

Alternate gene names: 73542566

Gene position: 3156618-3157451 (Clockwise)

Preceding gene: 73542565

Following gene: 73542567

Centisome position: 82.93

GC content: 66.55

Gene sequence:

>834_bases
ATGAAACATGTCACCCTGCCCGATGGCGAGCGCGTACCCGCGCTTGGCATGGGAACGTGGAATATGGGCGAGAACCGCGC
CGCGCGTGTCGAGGAAATCGCCACGCTCCGGCTGGGCCTGGACCTGGGCCTGCGCCTGATCGACACCGCCGAGATGTACG
GCGAAGGCCAGTCCGAGGAGATGATCGGCGAAGCCATTGCCGGGCGCCGCGACAAGGTCTTCCTGGTCAGCAAGGTCTAC
CCGCACAACGCCAGCAAGCGCGGCACCGTGGCTGCGTGCGAGCGCAGCCTGCGGCGGCTTGGCACCGATCGTCTCGATCT
GTACCTGCTGCACTGGCGCGGCGGCATTGCATTCGAGGAAACGGTGGAAGCGCTGCAGAAGCTGCAGCGTGACGGCAAGA
TCCGCCGCTATGGCGTGAGCAACCTGGACCTGTCCGATATGGAGGAACTGTGGGATGTCCCCGGTGGCGACCAGGTGGCG
GTCAACCAGCTGCTCTACAACCTCACGCGGCGCGGCATTGAATGGGATCTGCTGCCGTGGCTGCGCGAGCGCCGCGTGCC
GGTGATGGCCTACTCCCCGATCGAGCAGGCGCGGCTGGTGCGGCATCCGAAGCTCGTGCGCTTCGCGCAAGACAGCGGCA
TGACGCCGGCGCAGGTGGCGCTGGCGTGGCTACTTGCGCACGACGACATCATTGCGATTCCGAAGACCGGCCATCGCGAG
CGCCTGCGCGAAAACCTGGGCGCGCTACAGCATCCGCTCACGCCGGAACAGCTGCAGGAACTCGACCGCCTGTTCCCGCC
GCCGACTGGGCCAGGGGCGCTTGAAATGCTCTAG

Upstream 100 bases:

>100_bases
CGGACATTTCCACGCTTAATCCAGGCCCGGCGTTCTTGTAGATTGGTAGCTTGTTAACTAGTCAGTGCGCGCATGCCAAC
GCGCTACGAGGATAGCCACC

Downstream 100 bases:

>100_bases
CGCCGGCGCGGCTTACTTGTTGTGCGCAACGTAGCGCTCGCGCTCGACATAGCGCGTCAGGTAGCTGCGCGCCTTCTCGC
GGGTATCCGTCGTCACGCGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKHVTLPDGERVPALGMGTWNMGENRAARVEEIATLRLGLDLGLRLIDTAEMYGEGQSEEMIGEAIAGRRDKVFLVSKVY
PHNASKRGTVAACERSLRRLGTDRLDLYLLHWRGGIAFEETVEALQKLQRDGKIRRYGVSNLDLSDMEELWDVPGGDQVA
VNQLLYNLTRRGIEWDLLPWLRERRVPVMAYSPIEQARLVRHPKLVRFAQDSGMTPAQVALAWLLAHDDIIAIPKTGHRE
RLRENLGALQHPLTPEQLQELDRLFPPPTGPGALEML

Sequences:

>Translated_277_residues
MKHVTLPDGERVPALGMGTWNMGENRAARVEEIATLRLGLDLGLRLIDTAEMYGEGQSEEMIGEAIAGRRDKVFLVSKVY
PHNASKRGTVAACERSLRRLGTDRLDLYLLHWRGGIAFEETVEALQKLQRDGKIRRYGVSNLDLSDMEELWDVPGGDQVA
VNQLLYNLTRRGIEWDLLPWLRERRVPVMAYSPIEQARLVRHPKLVRFAQDSGMTPAQVALAWLLAHDDIIAIPKTGHRE
RLRENLGALQHPLTPEQLQELDRLFPPPTGPGALEML
>Mature_277_residues
MKHVTLPDGERVPALGMGTWNMGENRAARVEEIATLRLGLDLGLRLIDTAEMYGEGQSEEMIGEAIAGRRDKVFLVSKVY
PHNASKRGTVAACERSLRRLGTDRLDLYLLHWRGGIAFEETVEALQKLQRDGKIRRYGVSNLDLSDMEELWDVPGGDQVA
VNQLLYNLTRRGIEWDLLPWLRERRVPVMAYSPIEQARLVRHPKLVRFAQDSGMTPAQVALAWLLAHDDIIAIPKTGHRE
RLRENLGALQHPLTPEQLQELDRLFPPPTGPGALEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=284, Percent_Identity=27.4647887323944, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI5453543, Length=304, Percent_Identity=26.6447368421053, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI223468663, Length=295, Percent_Identity=27.7966101694915, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI310109920, Length=304, Percent_Identity=26.6447368421053, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI24497577, Length=309, Percent_Identity=27.1844660194175, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI5174391, Length=309, Percent_Identity=27.1844660194175, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI24497585, Length=308, Percent_Identity=27.5974025974026, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI45446745, Length=304, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4503285, Length=304, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI24497583, Length=304, Percent_Identity=25.9868421052632, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI4502049, Length=296, Percent_Identity=27.027027027027, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI291291012, Length=266, Percent_Identity=26.3157894736842, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI223718702, Length=192, Percent_Identity=31.7708333333333, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI41327764, Length=165, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI41152114, Length=192, Percent_Identity=31.25, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=50.8896797153025, Blast_Score=300, Evalue=5e-83,
Organism=Escherichia coli, GI1786400, Length=270, Percent_Identity=28.5185185185185, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI87081735, Length=306, Percent_Identity=31.6993464052288, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082198, Length=270, Percent_Identity=30.7407407407407, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788070, Length=298, Percent_Identity=27.8523489932886, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789375, Length=314, Percent_Identity=27.3885350318471, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787674, Length=251, Percent_Identity=28.2868525896414, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789199, Length=352, Percent_Identity=26.1363636363636, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI48994888, Length=279, Percent_Identity=28.673835125448, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561298, Length=288, Percent_Identity=29.5138888888889, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71998625, Length=276, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537077, Length=304, Percent_Identity=25.3289473684211, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17564128, Length=311, Percent_Identity=28.2958199356913, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17537075, Length=304, Percent_Identity=25, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=27.4368231046931, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17537079, Length=308, Percent_Identity=24.3506493506494, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17566692, Length=302, Percent_Identity=24.5033112582781, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561300, Length=268, Percent_Identity=25, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17538386, Length=283, Percent_Identity=26.1484098939929, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320576, Length=282, Percent_Identity=28.0141843971631, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324694, Length=283, Percent_Identity=25.7950530035336, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322556, Length=275, Percent_Identity=25.4545454545455, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320079, Length=291, Percent_Identity=24.0549828178694, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45553081, Length=295, Percent_Identity=27.7966101694915, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24663317, Length=299, Percent_Identity=26.4214046822742, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24644950, Length=313, Percent_Identity=28.1150159744409, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281366140, Length=257, Percent_Identity=27.2373540856031, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24662789, Length=280, Percent_Identity=26.0714285714286, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI20129731, Length=301, Percent_Identity=25.2491694352159, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24657054, Length=296, Percent_Identity=25.6756756756757, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662781, Length=294, Percent_Identity=23.469387755102, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24662785, Length=293, Percent_Identity=22.8668941979522, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31290; Mature: 31290

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVTLPDGERVPALGMGTWNMGENRAARVEEIATLRLGLDLGLRLIDTAEMYGEGQSEE
CCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHH
MIGEAIAGRRDKVFLVSKVYPHNASKRGTVAACERSLRRLGTDRLDLYLLHWRGGIAFEE
HHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
TVEALQKLQRDGKIRRYGVSNLDLSDMEELWDVPGGDQVAVNQLLYNLTRRGIEWDLLPW
HHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LRERRVPVMAYSPIEQARLVRHPKLVRFAQDSGMTPAQVALAWLLAHDDIIAIPKTGHRE
HHHCCCCEEEECCHHHHHHHCCCHHHEECCCCCCCHHHHHHHHHHHCCCEEECCCCCHHH
RLRENLGALQHPLTPEQLQELDRLFPPPTGPGALEML
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKHVTLPDGERVPALGMGTWNMGENRAARVEEIATLRLGLDLGLRLIDTAEMYGEGQSEE
CCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHH
MIGEAIAGRRDKVFLVSKVYPHNASKRGTVAACERSLRRLGTDRLDLYLLHWRGGIAFEE
HHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
TVEALQKLQRDGKIRRYGVSNLDLSDMEELWDVPGGDQVAVNQLLYNLTRRGIEWDLLPW
HHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LRERRVPVMAYSPIEQARLVRHPKLVRFAQDSGMTPAQVALAWLLAHDDIIAIPKTGHRE
HHHCCCCEEEECCHHHHHHHCCCHHHEECCCCCCCHHHHHHHHHHHCCCEEECCCCCHHH
RLRENLGALQHPLTPEQLQELDRLFPPPTGPGALEML
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]