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The map label for this gene is clpA [H]

Identifier: 73542437

GI number: 73542437

Start: 3021882

End: 3024179

Strand: Reverse

Name: clpA [H]

Synonym: Reut_A2752

Alternate gene names: 73542437

Gene position: 3024179-3021882 (Counterclockwise)

Preceding gene: 73542438

Following gene: 73542436

Centisome position: 79.45

GC content: 62.92

Gene sequence:

>2298_bases
ATGATTGCGCAAGAATTGGAAGTGAGCCTGCACATGGCGTTCGTTGAGGCCCGGCAGGCACGCCACGAGTTCATTACCGT
GGAGCACCTGCTGCTGGCGTTGCTCGACAATCCCACGGCAGCCGAGGTCTTGCGCGCCTGCGCGGCCAATATCGAGGACT
TGCGCACGAGCCTGAAGAATTTTATTGCTGACAACACGCCGGTGGTTCCGGGGACCGACGAAGTCGATACCCAGCCCACG
CTCGGTTTCCAGCGCGTGATCCAGCGCGCGATCATGCACGTCCAGTCGACTTCCAACGGCAAGAAGGAAGTGACGGGCGC
CAATGTGCTGGTCGCGATCTTCGGCGAGAAGGATTCCCATGCCGTCTACTACCTGCAGCAACAGGGCGTGACGCGCCTGG
ACGTCGTCAATTTCATCAGCCACGGCATCCGCAAGGATCAGTCCGAACCGGCCAAGCACGGTGACGGCACTGGCGAAGGC
GAGGGCGGCGACGGCAAGGAAAGCCCGCTCGAACAGTACACGCAGAACCTGAACGCGCTGGCCAAGGCCGGCAAGATCGA
TCCGCTGATCGGCCGCGAGAGCGAAGTCGAGCGCGTGGTGCAGGTGCTGTGCCGCCGGCGCAAGAACAACCCTCTGCTGG
TCGGCGAGGCTGGCGTCGGCAAGACCGCGATCGCCGAAGGCCTGGCCTGGCGCATCACCAAGAACGAGGTACCCGACATC
CTCGAGAAGGCGACCGTCTACTCACTCGATATGGGCGCGTTGCTGGCCGGCACCAAGTACCGTGGTGACTTCGAGCAGCG
CCTCAAGGGTGTGCTGAAGTCGCTCAAGGACAATCCGAACGCGATCCTGTTCATCGACGAGATCCACACGCTGATCGGCG
CGGGCGCCGCATCGGGCGGCACGCTGGACGCGAGTAACCTGCTCAAGCCGGCGCTGTCGTCGGGCCAGCTCAAGTGCATC
GGTGCAACTACCTTCACCGAGTATCGTGGCATCTTCGAAAAGGACGCAGCGCTGTCGCGGCGTTTCCAGAAGATCGACGT
GGTTGAACCGTCGGTGGACCAGACCGTGCAGATCCTGCGCGGCCTGAAGTCGCGCTTCGAGGAACACCATGGCGTCAAGT
ACGCGTCTTCCGCGCTGACCGCGGCGGCCGAACTGTCGGCGCGCTTCATCACCGACCGTCACCTGCCTGACAAGGCGATC
GACGTGATCGACGAAGCCGGCGCAGCGCAACGCATCCTGCCGAAGTCGAAGCAGAAGAAGACCATCGGCAAGAGCGAGAT
CGAGGACATCGTCTCGCGCATCGCCCGCATCCCGCCGCAGAGCGTGAACCAGGACGACCGCAGCAAGCTGCAGACGCTGG
AACGCGACCTGAAGTCGGTGGTGTTCGGCCAGGATCCGGCCATCGAGGCGCTGGCGTCGGCGATCAAGATGTCGCGCGCG
GGCCTTGGCAAGACCGACAAGCCGATCGGCTCGTTCCTGTTCTCGGGCCCCACCGGCGTGGGCAAGACCGAAGTCGCCAA
GCAGCTCGCGTTCATCATGGGCATCGAACTGCTGCGCTTCGACATGTCAGAGTACATGGAGCGCCATGCGGTGAGCCGCC
TGATCGGTGCGCCGCCGGGATACGTCGGTTTCGACCAGGGCGGCCTGCTGACCGAGGCCGTCACCAAGAAGCCGCACTGC
GTGCTGCTGCTCGATGAAATCGAAAAAGCGCATCCGGATATCTTCAATATCCTGCTGCAGGTGATGGACCATGGATCGCT
GACCGATAACAACGGCCGGCGCGCCGACTTCCGCAATGTGATCATCATCATGACCACGAACGCGGGGGCGGAGACCATGA
ACCGCGCCACCATCGGTTTCACGACGTCGCGCCAGCAGGGCGACGAGATGGCCGACATCAAGCGCATGTTCACGCCGGAG
TTCCGCAACCGGCTGGATGCCACCATCAGCTTCCGTTCGCTGGACGAGGAAATCATCCTGCGCGTGGTCGACAAGTTCCT
GATGCAGCTCGAAGAGCAGCTGCACGAGAAGAAGGTGGAAGCGAGCTTCACCGAAAAGCTGCGCAAGTTCCTGGCACGCA
AGGGCTTCGACCCACTGATGGGCGCACGCCCGATGCAGCGCCTGATTCAGGACATGATCCGCAAGGCTCTGGCCGACGAA
CTGCTGTTCGGCAAGCTGGTGTCCGGTGGCAAGGTCGTGGTGGATCTCGACGAGCAGGACCAGATCAAGCTGGACTTCTC
CGAGGCCGATCCGGAACCGCCGGAAGCACCGGAAAGCGAGCAGCGCGCAGAGGCCTGA

Upstream 100 bases:

>100_bases
GCGGTATCTACACCAGAGATATCGCCGCGACAAAAGTCGAGCTGGTGTCAACGCACGCGCGGCAGGCGGGGCACCCCTTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
GCGGGCGCGCGAGGACATTGTCTGCAATTGCGGCCATCCTCGGGCAAAATACAGGGGCGGCAGAAATGCCGCCCTTTGTT
TTTGTCCAGGCAGCTGCCAG

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQSEPAKHGDGTGEG
EGGDGKESPLEQYTQNLNALAKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKNEVPDI
LEKATVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILRGLKSRFEEHHGVKYASSALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKSEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNVIIIMTTNAGAETMNRATIGFTTSRQQGDEMADIKRMFTPE
FRNRLDATISFRSLDEEIILRVVDKFLMQLEEQLHEKKVEASFTEKLRKFLARKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVSGGKVVVDLDEQDQIKLDFSEADPEPPEAPESEQRAEA

Sequences:

>Translated_765_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQSEPAKHGDGTGEG
EGGDGKESPLEQYTQNLNALAKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKNEVPDI
LEKATVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILRGLKSRFEEHHGVKYASSALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKSEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNVIIIMTTNAGAETMNRATIGFTTSRQQGDEMADIKRMFTPE
FRNRLDATISFRSLDEEIILRVVDKFLMQLEEQLHEKKVEASFTEKLRKFLARKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVSGGKVVVDLDEQDQIKLDFSEADPEPPEAPESEQRAEA
>Mature_765_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQSEPAKHGDGTGEG
EGGDGKESPLEQYTQNLNALAKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKNEVPDI
LEKATVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILRGLKSRFEEHHGVKYASSALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKSEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNVIIIMTTNAGAETMNRATIGFTTSRQQGDEMADIKRMFTPE
FRNRLDATISFRSLDEEIILRVVDKFLMQLEEQLHEKKVEASFTEKLRKFLARKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVSGGKVVVDLDEQDQIKLDFSEADPEPPEAPESEQRAEA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=345, Percent_Identity=30.1449275362319, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1787109, Length=760, Percent_Identity=62.5, Blast_Score=978, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=399, Percent_Identity=45.6140350877193, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=253, Percent_Identity=56.9169960474308, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=259, Percent_Identity=53.2818532818533, Blast_Score=268, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84214; Mature: 84214

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIADNTPVVPGTDEVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIRKDQSEPAKHGDGTGEGEGGDGKESPLEQYTQNLNAL
EEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKNEVPDI
HHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEECHHHHHHH
LEKATVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGG
HHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
TLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILR
CCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSRFEEHHGVKYASSALTAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHHHH
TIGKSEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
HCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNV
CCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
IIIMTTNAGAETMNRATIGFTTSRQQGDEMADIKRMFTPEFRNRLDATISFRSLDEEIIL
EEEEECCCCHHHHCCCEEEEECCHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHH
RVVDKFLMQLEEQLHEKKVEASFTEKLRKFLARKGFDPLMGARPMQRLIQDMIRKALADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHH
LLFGKLVSGGKVVVDLDEQDQIKLDFSEADPEPPEAPESEQRAEA
HHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIADNTPVVPGTDEVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIRKDQSEPAKHGDGTGEGEGGDGKESPLEQYTQNLNAL
EEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKNEVPDI
HHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEECHHHHHHH
LEKATVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGG
HHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
TLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILR
CCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSRFEEHHGVKYASSALTAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHHHH
TIGKSEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
HCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNV
CCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
IIIMTTNAGAETMNRATIGFTTSRQQGDEMADIKRMFTPEFRNRLDATISFRSLDEEIIL
EEEEECCCCHHHHCCCEEEEECCHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHH
RVVDKFLMQLEEQLHEKKVEASFTEKLRKFLARKGFDPLMGARPMQRLIQDMIRKALADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHH
LLFGKLVSGGKVVVDLDEQDQIKLDFSEADPEPPEAPESEQRAEA
HHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]