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The map label for this gene is pcoA [H]

Identifier: 73542174

GI number: 73542174

Start: 2728331

End: 2730127

Strand: Reverse

Name: pcoA [H]

Synonym: Reut_A2489

Alternate gene names: 73542174

Gene position: 2730127-2728331 (Counterclockwise)

Preceding gene: 73542177

Following gene: 73542173

Centisome position: 71.72

GC content: 65.94

Gene sequence:

>1797_bases
ATGCGACGCGATCCCACGACCGGCTTGCTGCTGCCCAACCTGTCCCGGCGCCGCTTCGTGCAAGGGCTGGCGGCCGGTGG
CGTGCTGGCCGGTTTGCCGGTGTGGCAGGGGAGCGCACACGCGCAGCCGGCGGCGACGGCATTCGGCACGGCGCCCGTGC
TGCGTGGCACCGAATTCGACCTTGTGGTCGCCGAATCGATGGTCAACTTCACGGGCAAGCCTGCCCTGGCCACGACCATC
AACGGCATGTTGCCGGGACCGACACTGCGCTGGCGCGAGGGCGATACGGTCACCATCCGCGTGACCAACCGCCTGCGCGA
ACACACGTCGATCCACTGGCACGGCATCATCCTGCCGTACCAGATGGACGGCGTGCCCGGCATCAGCTTTGGCGGCATCG
CGCCCGGCGAGACCTTCACCTACCGCTTCAAGGTCGCGCAAAGCGGCAGCTACTGGTACCACTCGCATTCCGGCTTCCAG
GAGATGATCGGGCTGTACGGCGGCATCATCGTCGACCCCGCCGGGGAAGATCCTGTGCGCGCCGACCGCGACTACACCGT
GTTGTTGTCCGACTGGACCGACGAAGACCCGATGCGCGTGCTGTCGAAGCTGAAGGTCCAGAGCGATTACTACAACTACA
ACCAGCCCACCGCTGTCGATTTCTTCCGCGACGTGTCGAACGACGGCCTGAAGGCCGCGCTCGACAAGCGCCGCATGTGG
AACCAGATGCGCATGAACCCGACCGATCTCGCGGACATGTCGGGTGCAACGCTCACGTACCTGACCAATGGCCTCACACC
GGCGGGCAACTGGACGGGGCTGTTCCGGCCCGGCGAGCGCGTGCGGCTGCGCTTCATCAACGGCGCCGGCAATACCTTCT
TCGACGTGCGCATTCCGGGCCTGAAGCTTCGGGTGGTGCAGGTCGATGGCGTCAACATCGAGCCGGTCACGGTCGATGAA
TTCCGCTTCGGACCCGGCGAAACTTGCGACGTCGTGGTCGAACCGCGCGACGACGCCTACACGATCTTCTCGCAGTCGAT
GGATCGCACCGGCTATGCCAGGGGCACGCTGAGCGTGCGCGACGGCTTGCCGGCACCGGTGCCGGCGCTGGACAAGGCCG
AGTGGCTGACGATGGGCGACATGATGGGTGACATGGCCGGCATGCATGGCGCAGACCATGGCGGCATGGCCATGGATCAC
AGCCAGCACGCGATGGACCACAGCCAGCATGCGACGCACGGCGCGGCAGCAGACAACCCCCTCAAGGTCCCCGGCAAGGC
CGTGCGCCACGCACGCACGGAATACGGCGCCAGTACCGACATGCGCGTGGACACGCCGCGCACGAATCTCGACGACCCCG
GCATCGGCCTGCGCAACAATGGCAGGCGCGTGCTGACGCTGGCGGACATGCACACGCTCGGTGGCCCGCCGGATCCGCGC
GGGCCGGGGCGAGAGATCGAACTGCATCTCACCGGCAATATGGAGCGCTATACGTGGTCGTTCGATGGCGTCGAGTTCGG
CAAGTCGACGCCCGTGCATTTCCGCCATGGCGAGCGGCTGCGCGTCATTCTCCACAACGACACGATGATGACCCACCCGA
TGCACATGCACGGCATGTGGAGCGATCTTGAAGCACCGGACGGTACGTTCCAGGCACGCCGTCACACGATCCCGGTGCAG
CCGGCGCAGCGCATCAGCTTCCTGGTCACGGCGGATGCTCTTGGGCGCTGGGCCTGGCATTGTCACCTGATGCTCCATAT
GGATGCGGGCATGTTCCGCGAAGTGGTGGTGTCGTGA

Upstream 100 bases:

>100_bases
GGATTGTAATTTCGGGGTCATGTGCAAGTTCGCCGGCATTCCGTATGCTTTGCCTGCCGTCGTCATGTGCGGCGATCGAC
TCTTCAAGGACTGACTTTCG

Downstream 100 bases:

>100_bases
TGACAAGAACCGCTGCACGCTTTTCGGCCTCGCATGCGTACGCAAGGAACCTGCTTGCGGCGATCCTCGCTACGGCAGGA
ATCGGATCGGCCTGGGCGCA

Product: twin-arginine translocation pathway signal:copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MRRDPTTGLLLPNLSRRRFVQGLAAGGVLAGLPVWQGSAHAQPAATAFGTAPVLRGTEFDLVVAESMVNFTGKPALATTI
NGMLPGPTLRWREGDTVTIRVTNRLREHTSIHWHGIILPYQMDGVPGISFGGIAPGETFTYRFKVAQSGSYWYHSHSGFQ
EMIGLYGGIIVDPAGEDPVRADRDYTVLLSDWTDEDPMRVLSKLKVQSDYYNYNQPTAVDFFRDVSNDGLKAALDKRRMW
NQMRMNPTDLADMSGATLTYLTNGLTPAGNWTGLFRPGERVRLRFINGAGNTFFDVRIPGLKLRVVQVDGVNIEPVTVDE
FRFGPGETCDVVVEPRDDAYTIFSQSMDRTGYARGTLSVRDGLPAPVPALDKAEWLTMGDMMGDMAGMHGADHGGMAMDH
SQHAMDHSQHATHGAAADNPLKVPGKAVRHARTEYGASTDMRVDTPRTNLDDPGIGLRNNGRRVLTLADMHTLGGPPDPR
GPGREIELHLTGNMERYTWSFDGVEFGKSTPVHFRHGERLRVILHNDTMMTHPMHMHGMWSDLEAPDGTFQARRHTIPVQ
PAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVS

Sequences:

>Translated_598_residues
MRRDPTTGLLLPNLSRRRFVQGLAAGGVLAGLPVWQGSAHAQPAATAFGTAPVLRGTEFDLVVAESMVNFTGKPALATTI
NGMLPGPTLRWREGDTVTIRVTNRLREHTSIHWHGIILPYQMDGVPGISFGGIAPGETFTYRFKVAQSGSYWYHSHSGFQ
EMIGLYGGIIVDPAGEDPVRADRDYTVLLSDWTDEDPMRVLSKLKVQSDYYNYNQPTAVDFFRDVSNDGLKAALDKRRMW
NQMRMNPTDLADMSGATLTYLTNGLTPAGNWTGLFRPGERVRLRFINGAGNTFFDVRIPGLKLRVVQVDGVNIEPVTVDE
FRFGPGETCDVVVEPRDDAYTIFSQSMDRTGYARGTLSVRDGLPAPVPALDKAEWLTMGDMMGDMAGMHGADHGGMAMDH
SQHAMDHSQHATHGAAADNPLKVPGKAVRHARTEYGASTDMRVDTPRTNLDDPGIGLRNNGRRVLTLADMHTLGGPPDPR
GPGREIELHLTGNMERYTWSFDGVEFGKSTPVHFRHGERLRVILHNDTMMTHPMHMHGMWSDLEAPDGTFQARRHTIPVQ
PAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVS
>Mature_598_residues
MRRDPTTGLLLPNLSRRRFVQGLAAGGVLAGLPVWQGSAHAQPAATAFGTAPVLRGTEFDLVVAESMVNFTGKPALATTI
NGMLPGPTLRWREGDTVTIRVTNRLREHTSIHWHGIILPYQMDGVPGISFGGIAPGETFTYRFKVAQSGSYWYHSHSGFQ
EMIGLYGGIIVDPAGEDPVRADRDYTVLLSDWTDEDPMRVLSKLKVQSDYYNYNQPTAVDFFRDVSNDGLKAALDKRRMW
NQMRMNPTDLADMSGATLTYLTNGLTPAGNWTGLFRPGERVRLRFINGAGNTFFDVRIPGLKLRVVQVDGVNIEPVTVDE
FRFGPGETCDVVVEPRDDAYTIFSQSMDRTGYARGTLSVRDGLPAPVPALDKAEWLTMGDMMGDMAGMHGADHGGMAMDH
SQHAMDHSQHATHGAAADNPLKVPGKAVRHARTEYGASTDMRVDTPRTNLDDPGIGLRNNGRRVLTLADMHTLGGPPDPR
GPGREIELHLTGNMERYTWSFDGVEFGKSTPVHFRHGERLRVILHNDTMMTHPMHMHGMWSDLEAPDGTFQARRHTIPVQ
PAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVS

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=466, Percent_Identity=26.1802575107296, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321067, Length=564, Percent_Identity=22.8723404255319, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320714, Length=294, Percent_Identity=25.5102040816327, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=278, Percent_Identity=26.6187050359712, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24650186, Length=339, Percent_Identity=27.7286135693215, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574104, Length=305, Percent_Identity=30.1639344262295, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18859919, Length=272, Percent_Identity=27.2058823529412, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281360167, Length=267, Percent_Identity=28.8389513108614, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330000, Length=267, Percent_Identity=29.2134831460674, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585842, Length=267, Percent_Identity=28.8389513108614, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221329998, Length=267, Percent_Identity=28.8389513108614, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 66187; Mature: 66187

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRDPTTGLLLPNLSRRRFVQGLAAGGVLAGLPVWQGSAHAQPAATAFGTAPVLRGTEFD
CCCCCCCEEECCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHCCCCCCCCCCCEE
LVVAESMVNFTGKPALATTINGMLPGPTLRWREGDTVTIRVTNRLREHTSIHWHGIILPY
EEEEHHHHCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECHHHHCCCEEEEEEEEEE
QMDGVPGISFGGIAPGETFTYRFKVAQSGSYWYHSHSGFQEMIGLYGGIIVDPAGEDPVR
EECCCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCCCHHHHHHHHCCEEECCCCCCCCC
ADRDYTVLLSDWTDEDPMRVLSKLKVQSDYYNYNQPTAVDFFRDVSNDGLKAALDKRRMW
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
NQMRMNPTDLADMSGATLTYLTNGLTPAGNWTGLFRPGERVRLRFINGAGNTFFDVRIPG
HHHCCCCCHHHHCCCCEEEEEECCCCCCCCCCEECCCCCEEEEEEEECCCCEEEEEEECC
LKLRVVQVDGVNIEPVTVDEFRFGPGETCDVVVEPRDDAYTIFSQSMDRTGYARGTLSVR
EEEEEEEECCCEECEEEECCEECCCCCCEEEEECCCCCEEEHHHHCCCCCCCCEEEEEEC
DGLPAPVPALDKAEWLTMGDMMGDMAGMHGADHGGMAMDHSQHAMDHSQHATHGAAADNP
CCCCCCCCCCCCCHHEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHCCCCCCCCCCC
LKVPGKAVRHARTEYGASTDMRVDTPRTNLDDPGIGLRNNGRRVLTLADMHTLGGPPDPR
CCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCC
GPGREIELHLTGNMERYTWSFDGVEFGKSTPVHFRHGERLRVILHNDTMMTHPMHMHGMW
CCCCEEEEEEECCCEEEEEEECCEECCCCCCEEEECCCEEEEEEECCEEEECCCHHCCCC
SDLEAPDGTFQARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVS
CCCCCCCCCCHHHCCCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEEECCCHHHHHHCC
>Mature Secondary Structure
MRRDPTTGLLLPNLSRRRFVQGLAAGGVLAGLPVWQGSAHAQPAATAFGTAPVLRGTEFD
CCCCCCCEEECCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHCCCCCCCCCCCEE
LVVAESMVNFTGKPALATTINGMLPGPTLRWREGDTVTIRVTNRLREHTSIHWHGIILPY
EEEEHHHHCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECHHHHCCCEEEEEEEEEE
QMDGVPGISFGGIAPGETFTYRFKVAQSGSYWYHSHSGFQEMIGLYGGIIVDPAGEDPVR
EECCCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCCCHHHHHHHHCCEEECCCCCCCCC
ADRDYTVLLSDWTDEDPMRVLSKLKVQSDYYNYNQPTAVDFFRDVSNDGLKAALDKRRMW
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
NQMRMNPTDLADMSGATLTYLTNGLTPAGNWTGLFRPGERVRLRFINGAGNTFFDVRIPG
HHHCCCCCHHHHCCCCEEEEEECCCCCCCCCCEECCCCCEEEEEEEECCCCEEEEEEECC
LKLRVVQVDGVNIEPVTVDEFRFGPGETCDVVVEPRDDAYTIFSQSMDRTGYARGTLSVR
EEEEEEEECCCEECEEEECCEECCCCCCEEEEECCCCCEEEHHHHCCCCCCCCEEEEEEC
DGLPAPVPALDKAEWLTMGDMMGDMAGMHGADHGGMAMDHSQHAMDHSQHATHGAAADNP
CCCCCCCCCCCCCHHEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHCCCCCCCCCCC
LKVPGKAVRHARTEYGASTDMRVDTPRTNLDDPGIGLRNNGRRVLTLADMHTLGGPPDPR
CCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCC
GPGREIELHLTGNMERYTWSFDGVEFGKSTPVHFRHGERLRVILHNDTMMTHPMHMHGMW
CCCCEEEEEEECCCEEEEEEECCEECCCCCCEEEECCCEEEEEEECCEEEECCCHHCCCC
SDLEAPDGTFQARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVS
CCCCCCCCCCHHHCCCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]