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The map label for this gene is ilvD1 [H]

Identifier: 73542118

GI number: 73542118

Start: 2666226

End: 2668085

Strand: Direct

Name: ilvD1 [H]

Synonym: Reut_A2432

Alternate gene names: 73542118

Gene position: 2666226-2668085 (Clockwise)

Preceding gene: 73542117

Following gene: 73542121

Centisome position: 70.04

GC content: 65.48

Gene sequence:

>1860_bases
ATGCCCGCATACCGTTCCAAGACCTCCACCGCCGGCCGCAACATGGCTGGGGCCCGCTCGCTGTGGCGCGCCACCGGCAT
GAAAGACGACGATTTCAACAAGCCGATCATCGCGGTGGTGAACTCGTTCACCCAGTTCGTGCCCGGCCACGTCCACCTGA
AGGACCTGGGCCAGCTCGTCGCGCGCGAAATCGAAGCCGCTGGCGGCGTGGCCAAGGAGTTCAACACGATTGCGGTCGAT
GACGGCATCGCCATGGGCCACGACGGCATGCTGTATTCGCTGCCGAGCCGCGACATCATCGCCGACTCGGTCGAGTACAT
GGTCAACGCGCACTGCGCCGACGCCATGGTGTGCATCTCGAACTGCGACAAGATCACCCCGGGCATGCTGATGGCCGCCA
TGCGCCTGAACATCCCCGTGATCTTCGTCTCGGGCGGCCCGATGGAAGCCGGCAAGACGCGCCTGGCCAACCCGGTCACC
AAGGCCGTCGAATTCAAGAAGCTCGACCTGGTTGACGCCATGGTGATCGCGGCCGACCCGGCCTATTCCGACGCCGACGT
GGCCGAGGTCGAGCGCTCCGCCTGCCCCACCTGCGGCTCGTGCTCGGGCATGTTCACGGCCAATTCGATGAACTGCCTGA
CCGAAGCACTGGGCCTGTCGCTGCCCGGCAATGGCACCGTCGTCGCCACGCACGCGGACCGCGAGCAGCTGTTCAAGCGC
GCGGGCAGCCGTATCGTCGAACTGGCCCGCCAGTACTACGAGCAGGAAGACGCGCGCGTGCTGCCGCGTTCGGTCGGCTT
CAAGGCGTTCGAGAACGCGATGACGCTGGACATCGCCATGGGCGGTTCCACGAATACCATCCTGCACCTGCTGGCAATCG
CGCAGGAAGCGGGCATCGATTTCTCCATGAATGACATCGACCGCCTGTCGCGCGTCGTGCCACAGCTGTGCAAGGTGGCG
CCCAACACCAACAAGTACCACATCGAAGACGTGCACCGCGCGGGCGGCATCATGGCCATCCTGGGCGAGCTCGAGCGTGC
CGGCAAGCTGCATACCGACGTGCCGACCGTACATGCCCCGTCGCTCGGCGACGCGCTGAATCAGTGGGACATCGTCCGCA
CGAAGGACGAGGCCGTCCGTCATTTCTACATGGCTGGCCCGGCCGGCATCCCGACGCAGGTGGCGTTCAGCCAGAACACG
CGCTGGCCGAGCCTAGACCTGGACCGCGCCGAGGGCTGCATCCGCTCGTACGAGCACGCCTTCTCCAAGGAAGGTGGCCT
GGCAGTGCTGCGCGGCAATATCGCGCTGGACGGCTGCGTGGTGAAGACTGCCGGCGTGGACGAAAGCATCCTCGTGTTCG
AGGGTTCGGCTCACGTGACCGAATCGCAGGACGAGGCGGTCGAGAACATCCTCAACGACAAGGTCAAGGCCGGGGATGTC
GTGATCGTGCGCTACGAAGGTCCCAAGGGCGGCCCCGGCATGCAGGAAATGCTCTACCCGACGAGCTACATCAAGTCGAA
GGGCCTGGGCAAGGCTTGCGCGCTACTCACGGATGGCCGCTTCTCGGGCGGCACGTCCGGGCTGTCGATCGGCCACTGCT
CGCCGGAAGCAGCCGCCGGCGGCGCCATCGGCCTCGTGCGCGACGGCGACAAGATCCGCATCGACATTCCGAACCGGACG
ATCGATGTGCTCGTGTCGGACGAAGAACTGGCGCGCCGCCGCGAAGAGCAGAACGCCAAGGGCTGGAAGCCGGCGAAGGC
ACGTCCGCGTAAAGTGTCGGCCGCACTGAAGGCGTATGCCAAGCTCGTCATGTCGGCGGACAAGGGCGCAGTGCGCGATC
TGTCGTTGCTGGACGATTGA

Upstream 100 bases:

>100_bases
CCCAGGGCGCAGCTCAAGAGGTTGTTCGCACGGGCGCATGAGGGGCCCCTATTCCCGTGGCCCCGCATCCTTTCCGCGAT
ACTGATTTCACAACCCCACA

Downstream 100 bases:

>100_bases
TATCGCGGCGGTCTTCGTGCCCGGCTGCGAACAAAGGCCGCTCTTCGGAGCGGCTTTTTTTTGTTTGTTGAGCCCGCGAG
AACTTAAAAAAAACGGAGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDDDFNKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVT
KAVEFKKLDLVDAMVIAADPAYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGSRIVELARQYYEQEDARVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFSMNDIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPSLGDALNQWDIVRTKDEAVRHFYMAGPAGIPTQVAFSQNT
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLRGNIALDGCVVKTAGVDESILVFEGSAHVTESQDEAVENILNDKVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRT
IDVLVSDEELARRREEQNAKGWKPAKARPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Sequences:

>Translated_619_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDDDFNKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVT
KAVEFKKLDLVDAMVIAADPAYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGSRIVELARQYYEQEDARVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFSMNDIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPSLGDALNQWDIVRTKDEAVRHFYMAGPAGIPTQVAFSQNT
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLRGNIALDGCVVKTAGVDESILVFEGSAHVTESQDEAVENILNDKVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRT
IDVLVSDEELARRREEQNAKGWKPAKARPRKVSAALKAYAKLVMSADKGAVRDLSLLDD
>Mature_618_residues
PAYRSKTSTAGRNMAGARSLWRATGMKDDDFNKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTK
AVEFKKLDLVDAMVIAADPAYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKRA
GSRIVELARQYYEQEDARVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFSMNDIDRLSRVVPQLCKVAP
NTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPSLGDALNQWDIVRTKDEAVRHFYMAGPAGIPTQVAFSQNTR
WPSLDLDRAEGCIRSYEHAFSKEGGLAVLRGNIALDGCVVKTAGVDESILVFEGSAHVTESQDEAVENILNDKVKAGDVV
IVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRTI
DVLVSDEELARRREEQNAKGWKPAKARPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=621, Percent_Identity=73.9130434782609, Blast_Score=934, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=553, Percent_Identity=30.0180831826401, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI2367371, Length=521, Percent_Identity=30.3262955854127, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1786464, Length=557, Percent_Identity=30.3411131059246, Blast_Score=178, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=611, Percent_Identity=37.4795417348609, Blast_Score=350, Evalue=4e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66305; Mature: 66174

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSKTSTAGRNMAGARSLWRATGMKDDDFNKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTKAVEFKKLDLVDAMVIAADP
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHEEEEECCC
AYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGSRIVELARQYYEQEDARVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGID
HHHHHHHHHHHHHHCHHHHHCHHHHCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCC
FSMNDIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
SLGDALNQWDIVRTKDEAVRHFYMAGPAGIPTQVAFSQNTRWPSLDLDRAEGCIRSYEHA
CHHHHHCCCCEEECHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLRGNIALDGCVVKTAGVDESILVFEGSAHVTESQDEAVENILNDKVKAGDV
HCCCCCEEEEECCEEECCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDKIRIDIPNRTIDVLVSDEELARRREEQNAKGWKPAKARPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure 
PAYRSKTSTAGRNMAGARSLWRATGMKDDDFNKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTKAVEFKKLDLVDAMVIAADP
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHEEEEECCC
AYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGSRIVELARQYYEQEDARVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGID
HHHHHHHHHHHHHHCHHHHHCHHHHCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCC
FSMNDIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
SLGDALNQWDIVRTKDEAVRHFYMAGPAGIPTQVAFSQNTRWPSLDLDRAEGCIRSYEHA
CHHHHHCCCCEEECHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLRGNIALDGCVVKTAGVDESILVFEGSAHVTESQDEAVENILNDKVKAGDV
HCCCCCEEEEECCEEECCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDKIRIDIPNRTIDVLVSDEELARRREEQNAKGWKPAKARPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA