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The map label for this gene is lysN [H]

Identifier: 73542036

GI number: 73542036

Start: 2589808

End: 2590992

Strand: Direct

Name: lysN [H]

Synonym: Reut_A2350

Alternate gene names: 73542036

Gene position: 2589808-2590992 (Clockwise)

Preceding gene: 73542035

Following gene: 73542037

Centisome position: 68.04

GC content: 66.16

Gene sequence:

>1185_bases
ATGACATGGGCCATCTCCCGCCGGGCGCAGCAACTGACCAGCTCGGCCATCCGCGAAATCCTGAAGGTCACCGAGCGTCC
GGAAGTCATTTCGTTCGCCGGCGGCCTCCCCTCGCCGGCGTCGTTCCCGGTCGCGGCCATGGAGGCGGCGACGGCCCGTG
TATTTGCCGACAATCCGGCCGCCGCGTTGCAGTACGCCGCCACCGAAGGCTACCTGCCGCTGCGCGAGTTCATCGCCAAG
CGCCATAACGTTGGCGTGGAGCGCGTGCTGATCACCACCGGTTCGCAGCAGGCGCTGGACCTGATCGCCAAGGTGCTGAT
CGATCCGGGCAGCAAGGTGCTCGTGGAAACGCCGAGCTACCTTGGCGCGCTGCAGGCGTTCTCGCTGTTCGAGCCGGAGT
TCACGTCGGTGCCCACGGACGAGAAAGGCCTGCAGCCGGAAGCCCTGACCGCCGCGCTGACCGCTGGCGCACGCTTCCTG
TACGCGCTGCCCAACTTCCAGAACCCGACCGGCCGCCGCCTGCCGCTGGAGCGCCGCCAGGCGCTGGTGGCGCGCGCCAA
GGAACTGGGCGTGTTGATCGTGGAAGACGATCCCTACGGCGAACTGAGCTACACCGGCGACCAGCTGCCGACGCTGCTGT
CGATGAACCCCGACGGCGTGATCTACATGGGCTCGTTCTCGAAGATCCTGGCACCGGGCCTGCGGCTCGGCTTCGTGATT
GCGCCGCCGGAACTGCATTTCAAGCTGTGCCAGGCCAAGCAGGCTTCTGACCTGCACACCCCTACCTTTACGCAGCGCGT
GGCCTACGAGACCGTGCGGGATGGGCTCCTCGAGCGCCACATACCGACCATCCGCGAGCTGTACGGAAAGCAATGCAAAG
TCATGCTCGACGCGCTGGCGCGCCACATGCCCGAAGGCGTAAGCTGGAATGCACCCGAAGGCGGCATGTTCATCTGGGTG
CAGCTGCCGCAGGGCCTGGACAGCATGGCTATCCTGGAAGAAGCGGTGAAACGCAATGTGGCCTATGTGCCGGGCGCGCC
GTTCTATGCCAGCAACCCGCAACGCAATACGCTGCGCCTGGCGTTTGTCACGGTGCCGCCGGAACGCATCGAGCAGGGTG
TGGCAATCCTCGGCACGCTGTTCCGCGAAGCCATCACTGCGGCATCGCAGGCCCGCGCTGCCTGA

Upstream 100 bases:

>100_bases
GCGGAACCGCACCGATCGTCCACGCCGACTGGTGCGAGACTATTTATCGTTGACTGAGCCGCCCGCCAGGCGGCTCTCCC
CCAGAGAAAAGAGAAACATC

Downstream 100 bases:

>100_bases
AATACCACACTGAGATGCCACACTGAGGTGTAACACTGCAGTGCAACAATGAGGCGAAACAGCCAACGCAAAAGATCAGG
GGAGAGTCTTCATGCTGCGG

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTWAISRRAQQLTSSAIREILKVTERPEVISFAGGLPSPASFPVAAMEAATARVFADNPAAALQYAATEGYLPLREFIAK
RHNVGVERVLITTGSQQALDLIAKVLIDPGSKVLVETPSYLGALQAFSLFEPEFTSVPTDEKGLQPEALTAALTAGARFL
YALPNFQNPTGRRLPLERRQALVARAKELGVLIVEDDPYGELSYTGDQLPTLLSMNPDGVIYMGSFSKILAPGLRLGFVI
APPELHFKLCQAKQASDLHTPTFTQRVAYETVRDGLLERHIPTIRELYGKQCKVMLDALARHMPEGVSWNAPEGGMFIWV
QLPQGLDSMAILEEAVKRNVAYVPGAPFYASNPQRNTLRLAFVTVPPERIEQGVAILGTLFREAITAASQARAA

Sequences:

>Translated_394_residues
MTWAISRRAQQLTSSAIREILKVTERPEVISFAGGLPSPASFPVAAMEAATARVFADNPAAALQYAATEGYLPLREFIAK
RHNVGVERVLITTGSQQALDLIAKVLIDPGSKVLVETPSYLGALQAFSLFEPEFTSVPTDEKGLQPEALTAALTAGARFL
YALPNFQNPTGRRLPLERRQALVARAKELGVLIVEDDPYGELSYTGDQLPTLLSMNPDGVIYMGSFSKILAPGLRLGFVI
APPELHFKLCQAKQASDLHTPTFTQRVAYETVRDGLLERHIPTIRELYGKQCKVMLDALARHMPEGVSWNAPEGGMFIWV
QLPQGLDSMAILEEAVKRNVAYVPGAPFYASNPQRNTLRLAFVTVPPERIEQGVAILGTLFREAITAASQARAA
>Mature_393_residues
TWAISRRAQQLTSSAIREILKVTERPEVISFAGGLPSPASFPVAAMEAATARVFADNPAAALQYAATEGYLPLREFIAKR
HNVGVERVLITTGSQQALDLIAKVLIDPGSKVLVETPSYLGALQAFSLFEPEFTSVPTDEKGLQPEALTAALTAGARFLY
ALPNFQNPTGRRLPLERRQALVARAKELGVLIVEDDPYGELSYTGDQLPTLLSMNPDGVIYMGSFSKILAPGLRLGFVIA
PPELHFKLCQAKQASDLHTPTFTQRVAYETVRDGLLERHIPTIRELYGKQCKVMLDALARHMPEGVSWNAPEGGMFIWVQ
LPQGLDSMAILEEAVKRNVAYVPGAPFYASNPQRNTLRLAFVTVPPERIEQGVAILGTLFREAITAASQARAA

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=412, Percent_Identity=32.2815533980583, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI33469970, Length=412, Percent_Identity=32.2815533980583, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI95147551, Length=403, Percent_Identity=23.8213399503722, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169881279, Length=403, Percent_Identity=23.8213399503722, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787710, Length=380, Percent_Identity=29.2105263157895, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1790797, Length=369, Percent_Identity=29.2682926829268, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1788722, Length=376, Percent_Identity=25.7978723404255, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321236, Length=488, Percent_Identity=25, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321000, Length=434, Percent_Identity=25.3456221198157, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321929, Length=420, Percent_Identity=24.2857142857143, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356535, Length=397, Percent_Identity=25.9445843828715, Blast_Score=108, Evalue=9e-24,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 42965; Mature: 42834

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWAISRRAQQLTSSAIREILKVTERPEVISFAGGLPSPASFPVAAMEAATARVFADNPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHEEECCCCH
AALQYAATEGYLPLREFIAKRHNVGVERVLITTGSQQALDLIAKVLIDPGSKVLVETPSY
HHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHH
LGALQAFSLFEPEFTSVPTDEKGLQPEALTAALTAGARFLYALPNFQNPTGRRLPLERRQ
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHH
ALVARAKELGVLIVEDDPYGELSYTGDQLPTLLSMNPDGVIYMGSFSKILAPGLRLGFVI
HHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHCCCCCEEEEE
APPELHFKLCQAKQASDLHTPTFTQRVAYETVRDGLLERHIPTIRELYGKQCKVMLDALA
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RHMPEGVSWNAPEGGMFIWVQLPQGLDSMAILEEAVKRNVAYVPGAPFYASNPQRNTLRL
HHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEEE
AFVTVPPERIEQGVAILGTLFREAITAASQARAA
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TWAISRRAQQLTSSAIREILKVTERPEVISFAGGLPSPASFPVAAMEAATARVFADNPA
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHEEECCCCH
AALQYAATEGYLPLREFIAKRHNVGVERVLITTGSQQALDLIAKVLIDPGSKVLVETPSY
HHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHH
LGALQAFSLFEPEFTSVPTDEKGLQPEALTAALTAGARFLYALPNFQNPTGRRLPLERRQ
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHH
ALVARAKELGVLIVEDDPYGELSYTGDQLPTLLSMNPDGVIYMGSFSKILAPGLRLGFVI
HHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHCCCCCEEEEE
APPELHFKLCQAKQASDLHTPTFTQRVAYETVRDGLLERHIPTIRELYGKQCKVMLDALA
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RHMPEGVSWNAPEGGMFIWVQLPQGLDSMAILEEAVKRNVAYVPGAPFYASNPQRNTLRL
HHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEEE
AFVTVPPERIEQGVAILGTLFREAITAASQARAA
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA