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The map label for this gene is lysN [H]

Identifier: 73542029

GI number: 73542029

Start: 2584232

End: 2585770

Strand: Reverse

Name: lysN [H]

Synonym: Reut_A2343

Alternate gene names: 73542029

Gene position: 2585770-2584232 (Counterclockwise)

Preceding gene: 73542038

Following gene: 73542028

Centisome position: 67.93

GC content: 68.62

Gene sequence:

>1539_bases
ATGGACGGCAGCCAGCAGCAAGATTCATCGGCCACGCCAGAGCGCAAGGATAGCGGAGGCGGCTTGCAGGATGCCCCGGC
GCGTGGCCTGCGGCTGGTCGTGCCGCCAGGCGCGACGGGCAGCACGGAACGCATGCCAGACCCGGTGCCGTCGGCGCAGA
TGACGCTGGTGGAGCAACTGACCGAATGGGCCCGCATGCGCATCGACGAACGCGTGTTCCGCGCGGGCATGCGCATGCCG
TCGATCCGGCAATTGGCGCAGGAGAAGGGGATTTCCCGCTTCACCGTGGTGGAGGCGTACGAACGCCTGGTGGCGCTCGG
CTATCTGGAATCGCGTCGCGGCTCGGGCTTTTACGTGCGCGAGCGCGTGGCGCAGGCGTCGGCGGTCCCGGTGGCGCCGG
TGGCGGTGGCCGCGCGCAATATCGACGTGACCTGGCTGCTGCGCAGCATGTTCCATACCGCGGAGACCCACAAGGCGCCC
GGCCTCGGCTTCCTGCCCAACGAATGGCTCGATGGCGAACTGATTGCCAGTGCGCTGCGCGGGCTCGGCCGCCAGCCCGG
CAACCATTTCCTCGCCAGCGGCACGCCACAGGGCTTCCTGCCGCTGCGCCAGCAACTGCGCACGCGGCTCGAGGAACTGG
AGATCGGCGCCACGGCGGAACAGATCGTGCTGACGTCGGGCATCACGCAGGCGCTGGACCTGATCGCGCGGCTCTACCTG
CGCCCCGGCGACACCGTGCTGGTCGGGGACCCTGCCTGGTTCGTGATGTTCGGCCGCTTTGCCGCGCAGGGTGCGCAGGT
GATCGGTGTGCCTTATACGGCCGAGGGCCCCGATCTTGAAGCGCTCGAACGCATCGTCCAGGCGCACCGGCCGCGGCTCT
TCGTCATCAACTCGGTGCTGCATAACCCGACAGGTACGTCGCTGTCGGCCGCCAAGGCGTTCCGGCTGCTGCAGATGGCC
GAGCAGTACGACTTTCTGATCGTCGAGGACGATATCTACTGCGACCTGTGCCCGCCGGGCCATGCCGCGACGCGGCTTGC
CAGCCTCGACCAGCTTCGCCGCGTGATCTACCTGGGCAGCTTCTCCAAGACGCTCGCTGCGAACTTGCGCGTCGGCTTCG
TCGCCGCCCATCCGGAGCTGGCTGCGACGCTGACCGACAGCAAACTGCTGGCCGGGCTGGCCACGCCCGAGATCAACGAA
CGCGTGCTGTACAAGGTGCTGACCGAAGGCCACTACCGCAAGCACGTCGAGCGCGTGCGCGGGCGGCTGGACCGGGCCCG
CGACGAGACCCGTCGCGAGCTGGAGCGCCGTGGCCTGCGCCTGTTCCCGGGGCAGCACGCCGGCATGTACCTGTGGGCCG
ACACCGGTCGTGACACCAACGCCATCGCCACGTCCGGGCACGAGGAAGGCTACCTGTTCGCGCCCGGCAGCCTGTTCTCG
CCGTCGCAGATGCCGTCCGGATGGATGCGCTTCAACGTCGCCAGCAGCGGCGATCCGGACATGCTCGATTTCCTGTCCCG
GCAGCTCGAACGCCTCTGA

Upstream 100 bases:

>100_bases
CGAGAGCGAGCTTCATCGTGGCTTGATGGTAGACAAGGTAGTCGGTACAGTACCGGTACAGTTATGCGGATCGTATTCAG
TACAGTTGCAGGAGCACCAC

Downstream 100 bases:

>100_bases
CAAGCCACTGATTCGGCTCTTACAGGAAAGCGGGGTCTTGAAATCCGCCGGTGCCGGCCCTATTTCGGGAGGCATTGGCG
ACGCGCCAGACCCCATTCCC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MDGSQQQDSSATPERKDSGGGLQDAPARGLRLVVPPGATGSTERMPDPVPSAQMTLVEQLTEWARMRIDERVFRAGMRMP
SIRQLAQEKGISRFTVVEAYERLVALGYLESRRGSGFYVRERVAQASAVPVAPVAVAARNIDVTWLLRSMFHTAETHKAP
GLGFLPNEWLDGELIASALRGLGRQPGNHFLASGTPQGFLPLRQQLRTRLEELEIGATAEQIVLTSGITQALDLIARLYL
RPGDTVLVGDPAWFVMFGRFAAQGAQVIGVPYTAEGPDLEALERIVQAHRPRLFVINSVLHNPTGTSLSAAKAFRLLQMA
EQYDFLIVEDDIYCDLCPPGHAATRLASLDQLRRVIYLGSFSKTLAANLRVGFVAAHPELAATLTDSKLLAGLATPEINE
RVLYKVLTEGHYRKHVERVRGRLDRARDETRRELERRGLRLFPGQHAGMYLWADTGRDTNAIATSGHEEGYLFAPGSLFS
PSQMPSGWMRFNVASSGDPDMLDFLSRQLERL

Sequences:

>Translated_512_residues
MDGSQQQDSSATPERKDSGGGLQDAPARGLRLVVPPGATGSTERMPDPVPSAQMTLVEQLTEWARMRIDERVFRAGMRMP
SIRQLAQEKGISRFTVVEAYERLVALGYLESRRGSGFYVRERVAQASAVPVAPVAVAARNIDVTWLLRSMFHTAETHKAP
GLGFLPNEWLDGELIASALRGLGRQPGNHFLASGTPQGFLPLRQQLRTRLEELEIGATAEQIVLTSGITQALDLIARLYL
RPGDTVLVGDPAWFVMFGRFAAQGAQVIGVPYTAEGPDLEALERIVQAHRPRLFVINSVLHNPTGTSLSAAKAFRLLQMA
EQYDFLIVEDDIYCDLCPPGHAATRLASLDQLRRVIYLGSFSKTLAANLRVGFVAAHPELAATLTDSKLLAGLATPEINE
RVLYKVLTEGHYRKHVERVRGRLDRARDETRRELERRGLRLFPGQHAGMYLWADTGRDTNAIATSGHEEGYLFAPGSLFS
PSQMPSGWMRFNVASSGDPDMLDFLSRQLERL
>Mature_512_residues
MDGSQQQDSSATPERKDSGGGLQDAPARGLRLVVPPGATGSTERMPDPVPSAQMTLVEQLTEWARMRIDERVFRAGMRMP
SIRQLAQEKGISRFTVVEAYERLVALGYLESRRGSGFYVRERVAQASAVPVAPVAVAARNIDVTWLLRSMFHTAETHKAP
GLGFLPNEWLDGELIASALRGLGRQPGNHFLASGTPQGFLPLRQQLRTRLEELEIGATAEQIVLTSGITQALDLIARLYL
RPGDTVLVGDPAWFVMFGRFAAQGAQVIGVPYTAEGPDLEALERIVQAHRPRLFVINSVLHNPTGTSLSAAKAFRLLQMA
EQYDFLIVEDDIYCDLCPPGHAATRLASLDQLRRVIYLGSFSKTLAANLRVGFVAAHPELAATLTDSKLLAGLATPEINE
RVLYKVLTEGHYRKHVERVRGRLDRARDETRRELERRGLRLFPGQHAGMYLWADTGRDTNAIATSGHEEGYLFAPGSLFS
PSQMPSGWMRFNVASSGDPDMLDFLSRQLERL

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=311, Percent_Identity=26.6881028938907, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI33469970, Length=311, Percent_Identity=26.6881028938907, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1787710, Length=457, Percent_Identity=26.4770240700219, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790797, Length=467, Percent_Identity=27.1948608137045, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 56520; Mature: 56520

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSQQQDSSATPERKDSGGGLQDAPARGLRLVVPPGATGSTERMPDPVPSAQMTLVEQL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
TEWARMRIDERVFRAGMRMPSIRQLAQEKGISRFTVVEAYERLVALGYLESRRGSGFYVR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ERVAQASAVPVAPVAVAARNIDVTWLLRSMFHTAETHKAPGLGFLPNEWLDGELIASALR
HHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
GLGRQPGNHFLASGTPQGFLPLRQQLRTRLEELEIGATAEQIVLTSGITQALDLIARLYL
HCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
RPGDTVLVGDPAWFVMFGRFAAQGAQVIGVPYTAEGPDLEALERIVQAHRPRLFVINSVL
CCCCEEEECCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEHHHH
HNPTGTSLSAAKAFRLLQMAEQYDFLIVEDDIYCDLCPPGHAATRLASLDQLRRVIYLGS
CCCCCCCHHHHHHHHHHHHHHHCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHCC
FSKTLAANLRVGFVAAHPELAATLTDSKLLAGLATPEINERVLYKVLTEGHYRKHVERVR
CHHHHHHCCEEEEEEECCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
GRLDRARDETRRELERRGLRLFPGQHAGMYLWADTGRDTNAIATSGHEEGYLFAPGSLFS
HHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCCCCEEECCCCCCEEECCCCCCC
PSQMPSGWMRFNVASSGDPDMLDFLSRQLERL
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDGSQQQDSSATPERKDSGGGLQDAPARGLRLVVPPGATGSTERMPDPVPSAQMTLVEQL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
TEWARMRIDERVFRAGMRMPSIRQLAQEKGISRFTVVEAYERLVALGYLESRRGSGFYVR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ERVAQASAVPVAPVAVAARNIDVTWLLRSMFHTAETHKAPGLGFLPNEWLDGELIASALR
HHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
GLGRQPGNHFLASGTPQGFLPLRQQLRTRLEELEIGATAEQIVLTSGITQALDLIARLYL
HCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
RPGDTVLVGDPAWFVMFGRFAAQGAQVIGVPYTAEGPDLEALERIVQAHRPRLFVINSVL
CCCCEEEECCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEHHHH
HNPTGTSLSAAKAFRLLQMAEQYDFLIVEDDIYCDLCPPGHAATRLASLDQLRRVIYLGS
CCCCCCCHHHHHHHHHHHHHHHCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHCC
FSKTLAANLRVGFVAAHPELAATLTDSKLLAGLATPEINERVLYKVLTEGHYRKHVERVR
CHHHHHHCCEEEEEEECCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
GRLDRARDETRRELERRGLRLFPGQHAGMYLWADTGRDTNAIATSGHEEGYLFAPGSLFS
HHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCCCCEEECCCCCCEEECCCCCCC
PSQMPSGWMRFNVASSGDPDMLDFLSRQLERL
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA