Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 73542009

GI number: 73542009

Start: 2561877

End: 2563655

Strand: Reverse

Name: sdhA [H]

Synonym: Reut_A2323

Alternate gene names: 73542009

Gene position: 2563655-2561877 (Counterclockwise)

Preceding gene: 73542010

Following gene: 73542008

Centisome position: 67.35

GC content: 64.08

Gene sequence:

>1779_bases
ATGGTCGCAGTCAAGACTGGATTGCCGCGTCGCCGCTTTGACGTGGTCATCGTCGGTGCTGGCGGCGCCGGGATGCGCGC
ATCCCTCCAGCTCGCGGAAGCCGGCCTGAACGTGGCCGTGCTGTCCAAGGTGTTCCCGACCCGCTCGCACACCGTGGCGG
CGCAGGGCGGCATCGGTGCTTCGCTCGGCAACATGAGCGAAGACAACTGGCACTATCACTTCTACGACACCATCAAGGGC
TCCGACTGGCTGGGCGACCAGGACGCCATCGAGTTCATGTGCCGTGAAGCCCCGAAGGTCGTGTACGAGCTCGAACACTT
CGGCATGCCATTCGACCGTAACCCGGACGGCACGATCTACCAGCGTCCGTTCGGCGGCCATACGGCCAATTACGGTGAAA
AGCCCGTGCAGCGCGCCTGCGCCGCGGCTGACCGTACCGGCCACGCACTGCTGCACACGCTGTACCAGCGCAATGTGCGC
GCCAAGACCCACTTCTTCGTCGAATGGATGGCGCTGGACCTGATCCGCGACCAGGACGGCGACGTGCTGGGCGTGACCGC
GCTGGAAATGGAAACCGGCGAGGTCTACATCCTCGAAGCCAAGACCACGCTGTTCGCCACGGGCGGTGCCGGCCGTATCT
ACGCTGCGTCGACCAACGCCTTCATCAATACCGGTGACGGTCTGGGCATGGCCGCTCGCGCTGGCGTGCCGCTGGAAGAC
ATGGAGTTCTGGCAGTTCCACCCGACCGGCGTGGCCGGCGCGGGCGTGCTGATCACCGAAGGCGTGCGCGGCGAAGGCGG
TATCCTGCGCAACAAGGACGGCGAGCGCTTCATGGAGCGCTATGCCCCGACGCTGAAGGATCTGGCGCCGCGTGACTTCG
TGTCGCGCTCGATGGACCAGGAAATCAAGGAAGGCCGCGGCTGCGGCCCGAACGGCGACTACGTGCTGCTCGACCTGACC
CACGTCGGTGCCGAGACCATCATGAAGCGCCTGCCGTCGATCCGCGAAATCGGCATGAAGTTCGCCAACGTCGACGCGAT
CAAGGAACCGATTCCCGTCGTCCCGACCATCCACTATCAGATGGGTGGCATTCCGACGAACTTCCACGGCCAGGTCGTGG
TGCCGAAGAACGGTAACCCGAACGAGGTGCTGAACGGTTTCTACGCGATCGGCGAATGCTCGTGCGTGTCGGTCCACGGC
GCGAACCGCCTGGGCACCAACTCGCTGCTGGACCTGGTGGTGTTCGGCCGTGCCGCCGGCAACCACATCATCGCCCAGAA
CCTGAAGCAGAAGGAACACAAGCCGCTGCCGGCCGATGCCGCGGACCTCGCGATGTCGCGCCTGGCCAAGCTGCAGGCCA
CGTCGTCGGGCGAATACACGCAGGACGTCGCCAACGACATCCGCAAGAACATGCAGTCGCATGCCGGCGTGTTCCGTACG
CAAAAGCTGATGGACGAAGGCGTTGAGCGCATCCTGGAAGTGTCGGAGCGCGCCAACAACATCCACCTGAAGGACAAGTC
CAAGGTCTTCAACACCGCGCTGGTTGAAGCCCTGGAAGTGGCCAACCTGGTGGAAGTGGCCAAGGCAACGATGATTTCGG
CCGCTGCCCGCAAGGAATCGCGCGGTGCGCACGCCCACAGCGATTTCCCGAACCGCGACGACCAGAACTGGCTCAAGCAC
ACGCTGTTCTACAGCGAAGGCAACCGCCTCGACTACAAGCCGGTGAAGATGGAGCCGCTGACGGTGGAAAGCGTTCCGCC
GAAGGCCCGTACTTTCTGA

Upstream 100 bases:

>100_bases
GAAGCCGATGGCCGTGCGCCTCGTGCTGCAAGTTCTTACGATTCTGTGGCTCGTCGGTTGTGCGGGCTACGCTGCTCAGA
TTCTCTGGAGGGTGTAATAA

Downstream 100 bases:

>100_bases
GCACCGCATCGTAGAGAAAACAGGACCTACAGAAATGAAGCGTATTTTCGAAGTCTACCGCTACGATCCGGACAAGGACG
CGGCACCGCGCATGCAGACC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MVAVKTGLPRRRFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDQDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQMGGIPTNFHGQVVVPKNGNPNEVLNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRAAGNHIIAQNLKQKEHKPLPADAADLAMSRLAKLQATSSGEYTQDVANDIRKNMQSHAGVFRT
QKLMDEGVERILEVSERANNIHLKDKSKVFNTALVEALEVANLVEVAKATMISAAARKESRGAHAHSDFPNRDDQNWLKH
TLFYSEGNRLDYKPVKMEPLTVESVPPKARTF

Sequences:

>Translated_592_residues
MVAVKTGLPRRRFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDQDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQMGGIPTNFHGQVVVPKNGNPNEVLNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRAAGNHIIAQNLKQKEHKPLPADAADLAMSRLAKLQATSSGEYTQDVANDIRKNMQSHAGVFRT
QKLMDEGVERILEVSERANNIHLKDKSKVFNTALVEALEVANLVEVAKATMISAAARKESRGAHAHSDFPNRDDQNWLKH
TLFYSEGNRLDYKPVKMEPLTVESVPPKARTF
>Mature_592_residues
MVAVKTGLPRRRFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDQDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQMGGIPTNFHGQVVVPKNGNPNEVLNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRAAGNHIIAQNLKQKEHKPLPADAADLAMSRLAKLQATSSGEYTQDVANDIRKNMQSHAGVFRT
QKLMDEGVERILEVSERANNIHLKDKSKVFNTALVEALEVANLVEVAKATMISAAARKESRGAHAHSDFPNRDDQNWLKH
TLFYSEGNRLDYKPVKMEPLTVESVPPKARTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=51.2776831345826, Blast_Score=588, Evalue=1e-168,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=56.1433447098976, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=576, Percent_Identity=41.1458333333333, Blast_Score=414, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=557, Percent_Identity=33.0341113105925, Blast_Score=240, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17550100, Length=589, Percent_Identity=49.9151103565365, Blast_Score=576, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17505833, Length=590, Percent_Identity=48.9830508474576, Blast_Score=567, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=52.5423728813559, Blast_Score=614, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6322416, Length=589, Percent_Identity=52.4617996604414, Blast_Score=605, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=26.3803680981595, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=50.4966887417219, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=50.4966887417219, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=50.4966887417219, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24663005, Length=607, Percent_Identity=47.9406919275124, Blast_Score=564, Evalue=1e-161,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64769; Mature: 64769

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVKTGLPRRRFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGA
CEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVRAKTHFFVEWMALDLIRDQDG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
CEEEEEEEEECCCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNGDYVLLDLTHVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCCCHHHHHHHHHCHHHHHCCCCCCCEEEEE
MGGIPTNFHGQVVVPKNGNPNEVLNGFYAIGECSCVSVHGANRLGTNSLLDLVVFGRAAG
ECCCCCCCCCEEEECCCCCHHHHHHHHHEECCEEEEEECCCCCCCHHHHHHHHHHHCCCC
NHIIAQNLKQKEHKPLPADAADLAMSRLAKLQATSSGEYTQDVANDIRKNMQSHAGVFRT
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QKLMDEGVERILEVSERANNIHLKDKSKVFNTALVEALEVANLVEVAKATMISAAARKES
HHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHAHSDFPNRDDQNWLKHTLFYSEGNRLDYKPVKMEPLTVESVPPKARTF
CCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCEECCEEECCCCCCCCCC
>Mature Secondary Structure
MVAVKTGLPRRRFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGA
CEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVRAKTHFFVEWMALDLIRDQDG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
CEEEEEEEEECCCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNGDYVLLDLTHVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCCCHHHHHHHHHCHHHHHCCCCCCCEEEEE
MGGIPTNFHGQVVVPKNGNPNEVLNGFYAIGECSCVSVHGANRLGTNSLLDLVVFGRAAG
ECCCCCCCCCEEEECCCCCHHHHHHHHHEECCEEEEEECCCCCCCHHHHHHHHHHHCCCC
NHIIAQNLKQKEHKPLPADAADLAMSRLAKLQATSSGEYTQDVANDIRKNMQSHAGVFRT
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QKLMDEGVERILEVSERANNIHLKDKSKVFNTALVEALEVANLVEVAKATMISAAARKES
HHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHAHSDFPNRDDQNWLKHTLFYSEGNRLDYKPVKMEPLTVESVPPKARTF
CCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCEECCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]