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The map label for this gene is trpF [H]

Identifier: 73541993

GI number: 73541993

Start: 2544079

End: 2544795

Strand: Reverse

Name: trpF [H]

Synonym: Reut_A2307

Alternate gene names: 73541993

Gene position: 2544795-2544079 (Counterclockwise)

Preceding gene: 73541994

Following gene: 73541992

Centisome position: 66.85

GC content: 67.5

Gene sequence:

>717_bases
ATGACGCAGCCTGAGCGTGCCGACGCCGCGGCACCGGCCCGCACCCGCATCAAGATCTGCGGCCTCACGCGCGAGGACGA
CGTCCGCGCCGCGGTTGACGCGGGTGCTGACGCAATCGGGCTGGTGTTCTATCCGCCCAGTCCGCGCTATGTGGATCTGG
CCCGCGCAGCGGAACTTGCCGAGGTCGCGGGGCCGTTCGTGTCCGTGGTCGGCCTGTTCGTCAATGCCGAGATGGAAGAC
GTGGCTCACGTCGCCGAGCGTGTGCCCCTTACGATGCTCCAGTTCCACGGCGACGAGACCCCGCAGTCCTGCACCCAGAC
CGCCCAGCGCTGCCGCCTGCCTTTTCTGCGCGCGGCGCGTGTGCGGCCAGGGCTCGATTTGGTAGAATTCGCCGGTCAAT
ACCGCGATGCCGCTGGCTTGCTGCTCGACGCTTTCGTCGAGGGCTATGGCGGCGGCGGCCACGTCTTCGACTGGACCCTG
ATCCCTCCGGCATGGCTTGCTTCCAACCATCCGTCTCCCGGCAACCCGAACGCAAACGGCGCTCCTCGCATCGTTTTGAG
TGGTGGGTTGAACGCGCAAAACGTCGCTGGCGCGATTGAACGCGTGCGGCCCTACGCTGTGGATGTCAGCAGCGGAGTCG
AGGCCGCCAAGGGCGTGAAGGACCACGCCCGCATCGCCGCGTTCGTGCGCGCAGTCCGCAGTGCCGAGGCAGGATGA

Upstream 100 bases:

>100_bases
ATGCCGGACGGTCTCTACCTCGCGGACGTGAAGTATCCTGAGGCTTACAAGATTCCGGCGGCGGACCCATCCGCCAGCCT
GTTCCACGGAGTATTCCGCC

Downstream 100 bases:

>100_bases
AGCGGTCGCAAGATCGGCCCCTTCACCATGGCCCCGGCGAATTGCAGTAGCGCCGCTCGCATCGCAGTCAAAATTTGCGC
CCTTGCCCGTGAGGCAAGGC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTQPERADAAAPARTRIKICGLTREDDVRAAVDAGADAIGLVFYPPSPRYVDLARAAELAEVAGPFVSVVGLFVNAEMED
VAHVAERVPLTMLQFHGDETPQSCTQTAQRCRLPFLRAARVRPGLDLVEFAGQYRDAAGLLLDAFVEGYGGGGHVFDWTL
IPPAWLASNHPSPGNPNANGAPRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEAAKGVKDHARIAAFVRAVRSAEAG

Sequences:

>Translated_238_residues
MTQPERADAAAPARTRIKICGLTREDDVRAAVDAGADAIGLVFYPPSPRYVDLARAAELAEVAGPFVSVVGLFVNAEMED
VAHVAERVPLTMLQFHGDETPQSCTQTAQRCRLPFLRAARVRPGLDLVEFAGQYRDAAGLLLDAFVEGYGGGGHVFDWTL
IPPAWLASNHPSPGNPNANGAPRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEAAKGVKDHARIAAFVRAVRSAEAG
>Mature_237_residues
TQPERADAAAPARTRIKICGLTREDDVRAAVDAGADAIGLVFYPPSPRYVDLARAAELAEVAGPFVSVVGLFVNAEMEDV
AHVAERVPLTMLQFHGDETPQSCTQTAQRCRLPFLRAARVRPGLDLVEFAGQYRDAAGLLLDAFVEGYGGGGHVFDWTLI
PPAWLASNHPSPGNPNANGAPRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEAAKGVKDHARIAAFVRAVRSAEAG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=219, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320210, Length=224, Percent_Identity=27.2321428571429, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 25134; Mature: 25002

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPERADAAAPARTRIKICGLTREDDVRAAVDAGADAIGLVFYPPSPRYVDLARAAELA
CCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHH
EVAGPFVSVVGLFVNAEMEDVAHVAERVPLTMLQFHGDETPQSCTQTAQRCRLPFLRAAR
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHCCHHHHHHH
VRPGLDLVEFAGQYRDAAGLLLDAFVEGYGGGGHVFDWTLIPPAWLASNHPSPGNPNANG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCC
APRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEAAKGVKDHARIAAFVRAVRSAEAG
CCEEEEECCCCHHHHHHHHHHHCCEEEEHHHCHHHHHCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQPERADAAAPARTRIKICGLTREDDVRAAVDAGADAIGLVFYPPSPRYVDLARAAELA
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHH
EVAGPFVSVVGLFVNAEMEDVAHVAERVPLTMLQFHGDETPQSCTQTAQRCRLPFLRAAR
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHCCHHHHHHH
VRPGLDLVEFAGQYRDAAGLLLDAFVEGYGGGGHVFDWTLIPPAWLASNHPSPGNPNANG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCC
APRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEAAKGVKDHARIAAFVRAVRSAEAG
CCEEEEECCCCHHHHHHHHHHHCCEEEEHHHCHHHHHCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA