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The map label for this gene is moeA [H]

Identifier: 73541965

GI number: 73541965

Start: 2511209

End: 2512498

Strand: Direct

Name: moeA [H]

Synonym: Reut_A2278

Alternate gene names: 73541965

Gene position: 2511209-2512498 (Clockwise)

Preceding gene: 73541964

Following gene: 73541966

Centisome position: 65.97

GC content: 68.29

Gene sequence:

>1290_bases
ATGCCATCCCTGCAATCCGTCATTTCCTGCCTGTCCGACTACGATCCCACCGCCCTGCCCGTGGACCAGGCCAACCGCAT
CATCGGCGAAGTGGTCGAACCCGTGCGCGGCATCGAGCAAGTGCCGATCCGCAGCGCGCTGGACCGCGTGCTGGCCGAGG
ACATCATCTCGCCGATCGATGTCCCCGCTCACGACAACTCGGCAATGGACGGCTACGCGTTCGCCAGCAGTGCACTGCTG
GCCGCCGATGCAGGACAAGTGGAACTCGAAGTCGTCAGTACCGCATTCGCGGGCGGCGGCTTGAGCAGCCAGCCGGGCGC
GAGCCAGGCCGTGCGGATCATGACCGGCGCCGTCATGCCGGATAGCTGCGATACCGTCGTGCCGCAGGAATTCGTCGACG
TGTTGGCAGACGGCAGCCGGATCCGCTTTGCCGCGGACACTGTGCGTGCCGGCGACAACCGCCGCCTGCGCGGCGAAGAC
CTCGCGCGCGGCCAGTCCGCGCTGCAGGCCGGCCGTATCATCCAGCCTGCCGACCTGGGCCTGCTCGCCTCGCTCGGCTT
CGCCGAGGTACGCGTGCGCCGTCGTTTGCGCGTGGCGTTTTTCTCGACCGGCGACGAGCTGCGCTCGATCGGCGAGCCGC
TGGACGCCGGTTGCGTCTACGACTCGAATCGCTACACGCTGCACGGCATGCTGCGGCGCCTGAATGTCGATCTGATCGAC
ATGGGCGTAGTGCGCGACGACCCCGCGGCGCTGGAAGCCGCGTTCCGCACGGCCTGCGAGACGGCCGATGCGGTGATCAC
CTCGGGCGGCGTCTCGGTCGGCGAAGCCGACTATACCAAGCAGATCATGGCCAGCCTCGGCGATGTCACGTTCTGGAAGA
TTGCGATGCGCCCCGGGCGGCCGATGGCGTTCGGGCGGATCGCTTCGGGCGGGCGCGACGCGCTGCTCTTCGGCCTGCCG
GGCAACCCGGTCGCCGTCATGGTGACCTTTTACCATTTCGTGCGCGCCGCGCTGCATCGACAGATGGGCGCCAACGTGCC
GCCGCTGCCGCTGATGCGCGTGCGCAGCGCCCAAGCCATCCGCAAGAAGCCCGGCCGCACCGAATACCAGCGCGGCATAC
TTGCGCGCGCCGATGGCGGAGAGTGGGAGGTGCGCATCACCGGGCAACAGGGCTCCGGCGTGCTGCGCTCGATGAGCGAG
GCCAACTGCTTCATCGTGCTGGCCCATGAACAGGGTGCGGTCCGGGCCGGCGACATGGTCGACGTGATGCTGTTCGACGG
GCTGGTCTGA

Upstream 100 bases:

>100_bases
GCTGGCGGAAGTCCTGTTCGATGACGCTGGCGCCTTTGCCAATATCAACACTCTCGACGAGCTGCGCACGCACGAAGCCG
GCTGAACGCCCGTTCCCACC

Downstream 100 bases:

>100_bases
AGGACGCACGCCCACCCCGATCTGTCGTTTTTGCGCCGCATATTGATGCCTGCCGCCGAGCCGCGGCAGGTGAAATGCAC
GCCACCTCTCTGCCGGACTA

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MPSLQSVISCLSDYDPTALPVDQANRIIGEVVEPVRGIEQVPIRSALDRVLAEDIISPIDVPAHDNSAMDGYAFASSALL
AADAGQVELEVVSTAFAGGGLSSQPGASQAVRIMTGAVMPDSCDTVVPQEFVDVLADGSRIRFAADTVRAGDNRRLRGED
LARGQSALQAGRIIQPADLGLLASLGFAEVRVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLRRLNVDLID
MGVVRDDPAALEAAFRTACETADAVITSGGVSVGEADYTKQIMASLGDVTFWKIAMRPGRPMAFGRIASGGRDALLFGLP
GNPVAVMVTFYHFVRAALHRQMGANVPPLPLMRVRSAQAIRKKPGRTEYQRGILARADGGEWEVRITGQQGSGVLRSMSE
ANCFIVLAHEQGAVRAGDMVDVMLFDGLV

Sequences:

>Translated_429_residues
MPSLQSVISCLSDYDPTALPVDQANRIIGEVVEPVRGIEQVPIRSALDRVLAEDIISPIDVPAHDNSAMDGYAFASSALL
AADAGQVELEVVSTAFAGGGLSSQPGASQAVRIMTGAVMPDSCDTVVPQEFVDVLADGSRIRFAADTVRAGDNRRLRGED
LARGQSALQAGRIIQPADLGLLASLGFAEVRVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLRRLNVDLID
MGVVRDDPAALEAAFRTACETADAVITSGGVSVGEADYTKQIMASLGDVTFWKIAMRPGRPMAFGRIASGGRDALLFGLP
GNPVAVMVTFYHFVRAALHRQMGANVPPLPLMRVRSAQAIRKKPGRTEYQRGILARADGGEWEVRITGQQGSGVLRSMSE
ANCFIVLAHEQGAVRAGDMVDVMLFDGLV
>Mature_428_residues
PSLQSVISCLSDYDPTALPVDQANRIIGEVVEPVRGIEQVPIRSALDRVLAEDIISPIDVPAHDNSAMDGYAFASSALLA
ADAGQVELEVVSTAFAGGGLSSQPGASQAVRIMTGAVMPDSCDTVVPQEFVDVLADGSRIRFAADTVRAGDNRRLRGEDL
ARGQSALQAGRIIQPADLGLLASLGFAEVRVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLRRLNVDLIDM
GVVRDDPAALEAAFRTACETADAVITSGGVSVGEADYTKQIMASLGDVTFWKIAMRPGRPMAFGRIASGGRDALLFGLPG
NPVAVMVTFYHFVRAALHRQMGANVPPLPLMRVRSAQAIRKKPGRTEYQRGILARADGGEWEVRITGQQGSGVLRSMSEA
NCFIVLAHEQGAVRAGDMVDVMLFDGLV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=426, Percent_Identity=33.0985915492958, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI66932975, Length=426, Percent_Identity=33.0985915492958, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1787049, Length=382, Percent_Identity=47.1204188481675, Blast_Score=335, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI25147659, Length=427, Percent_Identity=28.1030444964871, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=226, Percent_Identity=30.9734513274336, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136978, Length=424, Percent_Identity=27.8301886792453, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24638841, Length=424, Percent_Identity=27.8301886792453, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45810; Mature: 45679

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSLQSVISCLSDYDPTALPVDQANRIIGEVVEPVRGIEQVPIRSALDRVLAEDIISPID
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
VPAHDNSAMDGYAFASSALLAADAGQVELEVVSTAFAGGGLSSQPGASQAVRIMTGAVMP
CCCCCCCCCCCHHHHHCHHEECCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHCCCCCC
DSCDTVVPQEFVDVLADGSRIRFAADTVRAGDNRRLRGEDLARGQSALQAGRIIQPADLG
CCCCCCCHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCH
LLASLGFAEVRVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLRRLNVDLID
HHHHCCHHHHHHHHHHHEEEECCCHHHHHHCCCCCCCEEECCCCEEHHHHHHHCCCCEEE
MGVVRDDPAALEAAFRTACETADAVITSGGVSVGEADYTKQIMASLGDVTFWKIAMRPGR
ECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PMAFGRIASGGRDALLFGLPGNPVAVMVTFYHFVRAALHRQMGANVPPLPLMRVRSAQAI
CCEEHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
RKKPGRTEYQRGILARADGGEWEVRITGQQGSGVLRSMSEANCFIVLAHEQGAVRAGDMV
HCCCCCCHHHCCEEEECCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCEE
DVMLFDGLV
EEHHHCCCC
>Mature Secondary Structure 
PSLQSVISCLSDYDPTALPVDQANRIIGEVVEPVRGIEQVPIRSALDRVLAEDIISPID
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
VPAHDNSAMDGYAFASSALLAADAGQVELEVVSTAFAGGGLSSQPGASQAVRIMTGAVMP
CCCCCCCCCCCHHHHHCHHEECCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHCCCCCC
DSCDTVVPQEFVDVLADGSRIRFAADTVRAGDNRRLRGEDLARGQSALQAGRIIQPADLG
CCCCCCCHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCH
LLASLGFAEVRVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLRRLNVDLID
HHHHCCHHHHHHHHHHHEEEECCCHHHHHHCCCCCCCEEECCCCEEHHHHHHHCCCCEEE
MGVVRDDPAALEAAFRTACETADAVITSGGVSVGEADYTKQIMASLGDVTFWKIAMRPGR
ECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PMAFGRIASGGRDALLFGLPGNPVAVMVTFYHFVRAALHRQMGANVPPLPLMRVRSAQAI
CCEEHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
RKKPGRTEYQRGILARADGGEWEVRITGQQGSGVLRSMSEANCFIVLAHEQGAVRAGDMV
HCCCCCCHHHCCEEEECCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCEE
DVMLFDGLV
EEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]