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The map label for this gene is fabF [H]

Identifier: 73541948

GI number: 73541948

Start: 2493696

End: 2494928

Strand: Reverse

Name: fabF [H]

Synonym: Reut_A2261

Alternate gene names: 73541948

Gene position: 2494928-2493696 (Counterclockwise)

Preceding gene: 73541949

Following gene: 73541947

Centisome position: 65.54

GC content: 63.67

Gene sequence:

>1233_bases
GTGAGCCGTCGTCGCGTCGTTGTCACTGGGCTTGGCCTTGTGTCTCCGGTCGGAAACACGGTTGCCGAAGGCTGGGCCAA
CCTGGTTGCCGGCAAGTCCGGTATCGCCACCGTCACCAAATTCGATCATTCCGCGCTTTCCGTGCACTTTGCCGGTGAAG
TGAAGGGCTTCAATGCCGAGGATTACATCCCGGCCAAGGAAGCCCGCAATATGGATACGTTCATCCACTATGGCATTGCT
GCCGGCGCCCAGGCGCTCAAGGACAGCGGCTATGAGGTGACCGATGCCAATGCGGAGCGCATCGGCGTGCTGGTCGGCTC
GGGCATTGGCGGCTTGCCGATGATCGAGGACACGCATGCCACGCTGACCGAGCGTGGTCCACGCCGTATTTCGCCGTTCT
TCGTGCCGGGATCGATCATCAACATGATCTCTGGCCACCTGTCGATCATGCACGGCCTGAAGGGCCCGAACCTCGCCGCG
GTGACCGCCTGCACGACCGGCCTGCACAGCATTGGCCTGGCTGCTCGCCTGATTCAGGCCGGCGACGCCGACGCCATGCT
GGCGGGCGGTGCCGAGTCGACCGTGTCGCCGCTGGGCATCGGCGGTTTCGCGGCCGCGCGCGCCTTGTCGACGCGCAATG
ACGATCCCGCAGCCGCTTCGCGCCCGTGGGACAAGGACCGCGACGGCTTCGTGCTGGGCGAGGGTGCCGGCGTCATGATG
CTGGAAGAGTACGAATCTGCGAAGGCGCGCGGTGCGCGCATCTATGCGGAGCTCGTGGGCTTCGGCATGAGTGGAGACGC
ATTCCACATGACTGCGCCGAACATGGACGGCCCGCGCCGCTGCATGGTCAACGCGCTGCGGGACGCCGGCATCAACGCGG
ACGAGGTGCAGTACCTGAACGCGCACGGCACGTCGACGCCGCTCGGCGACAAGAACGAAACCGATGCTATCAAAGCAGCC
TTCGGTGACCATGCCTACAAGATGGTGGTGAATTCGACCAAGTCGATGACCGGCCACTTGCTGGGCGGCGCAGGTGGCCT
GGAATCGGTGTTCACCGTGCTCGCACTGCATAACCAGGTGTCGCCGCCGACCATCAACATCGATAACCAGGATCCGGAAT
GTGACCTGGACTACGTGGCCAACACGGCGCGTGAAATGAAAATCGATGTGGCCGTGAAGAACAACTTCGGCTTCGGCGGT
ACCAACGGCACGCTGGTCTTCCGTCGCGCCTGA

Upstream 100 bases:

>100_bases
CGCAGAATCAAAGCACGTACCGCGCGCCGCTGACCCTCGGGTCCGCGATCTTGGCGGCACGTGTCCCTGATCCTGCATCA
CGCACCCGTAGGAAATCATA

Downstream 100 bases:

>100_bases
TTCGGTGTCACGGACACGCCTCGCCGGCTCCCGACTCGGCGGGCTTCATCGCTTGCGGTGGGCCCTGCTCGTGCTCTGGG
CGGGCGAGGCAATTGCCTTC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATVTKFDHSALSVHFAGEVKGFNAEDYIPAKEARNMDTFIHYGIA
AGAQALKDSGYEVTDANAERIGVLVGSGIGGLPMIEDTHATLTERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
LEEYESAKARGARIYAELVGFGMSGDAFHMTAPNMDGPRRCMVNALRDAGINADEVQYLNAHGTSTPLGDKNETDAIKAA
FGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNQVSPPTINIDNQDPECDLDYVANTAREMKIDVAVKNNFGFGG
TNGTLVFRRA

Sequences:

>Translated_410_residues
MSRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATVTKFDHSALSVHFAGEVKGFNAEDYIPAKEARNMDTFIHYGIA
AGAQALKDSGYEVTDANAERIGVLVGSGIGGLPMIEDTHATLTERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
LEEYESAKARGARIYAELVGFGMSGDAFHMTAPNMDGPRRCMVNALRDAGINADEVQYLNAHGTSTPLGDKNETDAIKAA
FGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNQVSPPTINIDNQDPECDLDYVANTAREMKIDVAVKNNFGFGG
TNGTLVFRRA
>Mature_409_residues
SRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATVTKFDHSALSVHFAGEVKGFNAEDYIPAKEARNMDTFIHYGIAA
GAQALKDSGYEVTDANAERIGVLVGSGIGGLPMIEDTHATLTERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAAV
TACTTGLHSIGLAARLIQAGDADAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMML
EEYESAKARGARIYAELVGFGMSGDAFHMTAPNMDGPRRCMVNALRDAGINADEVQYLNAHGTSTPLGDKNETDAIKAAF
GDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNQVSPPTINIDNQDPECDLDYVANTAREMKIDVAVKNNFGFGGT
NGTLVFRRA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=46.875, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=49.7005988023952, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=24.2009132420091, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=62.1359223300971, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1788663, Length=410, Percent_Identity=38.0487804878049, Blast_Score=244, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=35.1941747572816, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=38.4313725490196, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=380, Percent_Identity=25.7894736842105, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=411, Percent_Identity=25.3041362530414, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=35.2017937219731, Blast_Score=256, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=44.4976076555024, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI221330659, Length=375, Percent_Identity=23.4666666666667, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19920632, Length=375, Percent_Identity=23.4666666666667, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24581345, Length=387, Percent_Identity=23.2558139534884, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42846; Mature: 42715

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATVTKFDHSALSVHFAGEVKGFNAE
CCCCEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCC
DYIPAKEARNMDTFIHYGIAAGAQALKDSGYEVTDANAERIGVLVGSGIGGLPMIEDTHA
CCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCH
TLTERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGARIYAELVGFGMSGDAFHMTAPNMDGPRRCMVNALRDAGINADEVQYLN
EECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEE
AHGTSTPLGDKNETDAIKAAFGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNQV
CCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCHHHCEEEECCCCCHHHHHHHHHHHCCC
SPPTINIDNQDPECDLDYVANTAREMKIDVAVKNNFGFGGTNGTLVFRRA
CCCEEEECCCCCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATVTKFDHSALSVHFAGEVKGFNAE
CCCEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCC
DYIPAKEARNMDTFIHYGIAAGAQALKDSGYEVTDANAERIGVLVGSGIGGLPMIEDTHA
CCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCH
TLTERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGARIYAELVGFGMSGDAFHMTAPNMDGPRRCMVNALRDAGINADEVQYLN
EECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEE
AHGTSTPLGDKNETDAIKAAFGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNQV
CCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCHHHCEEEECCCCCHHHHHHHHHHHCCC
SPPTINIDNQDPECDLDYVANTAREMKIDVAVKNNFGFGGTNGTLVFRRA
CCCEEEECCCCCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]