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The map label for this gene is yngG [H]

Identifier: 73541795

GI number: 73541795

Start: 2315793

End: 2316773

Strand: Reverse

Name: yngG [H]

Synonym: Reut_A2107

Alternate gene names: 73541795

Gene position: 2316773-2315793 (Counterclockwise)

Preceding gene: 73541796

Following gene: 73541794

Centisome position: 60.86

GC content: 66.77

Gene sequence:

>981_bases
ATGAGCGCCGCCGAATTCAACTCCCCGGCCTTGCGCGGCCCAGCCCGTATCGAGATCAACGAAGTGTCGCCTCGCGACGG
CCTGCAGATCGAGCCGGTCGTGGTGCCTACCGATGCCAAGGTCGCCTTTGTCGATGCGCTGTCCGCCTGTGGCTTCGCGC
GCATCGAAGCCACATCGTTCACATCGGCCAAGGCCATCCCGGCGCTTGCGGATGCCGAAGCGCTGATGCACCGCATGCAT
CGCCGGCCCGGCGTGCGCTATACCGCGCTGGTGCCGAACCTCCGTGGCCTGGAGCGCGCGCTTTCGTGCCGGCCCGATGA
GGTCAACCTGGTGATGTCGGTCAGCGAAACCCACAACCGCGCGAACCTGCGCATGACGCGTGCGCAATCGGAGGCGCAGT
TGCTCGCGATGATCGCTGAGGCCCGCGCGGCCGGTGTGCCGGTCAACGTGTCGCTGTCGACGGTGTTCGGTTGTCCGTTC
GAGGGCGAGGTGAGCACTGACGCCGTGATGGCATTGGCTCACAGCTTTGCGGAGGCCGGCGCGCAAGGCATCACGCTGTG
CGATACCACCGGCATGGCTTTTCCGAACCAGGTCGCGCAGATGTGCGAGCAGTTCCAGCAACGCCTGCCGGATACGGGCC
TGACCATTCATCTTCACAACACGCGCGGCATGGGTTTGGCGAATGCCGTGGCAGCCTGGGAAACCGGCGTCACACGCTTC
GATGCCGCGGCCGGCGGCCTTGGTGGCTGCCCCTATGCGCCCGGTGCGAGCGGCAATGTCAGTACTGAGGAGCTCGTGCA
CATGTTTGCCTGCATGGGCGTGCAGACCGGCGTGGACCTGCCTGCGCTGCTCGATGTCGTCGCCGGCATTCCCGCGCTGG
TGGAACGCGACATCGGCAGCCAACTGCTGCGCGCCGGCCCGCGCCTGCGCACGCATCAGCCGCCAGCCTGGCTGGCAGAG
CATTTCGCCGGACAGGACTAG

Upstream 100 bases:

>100_bases
ACCGCGCGCCGACACTGGGCGAGCACACCGACACGGTGCTGGAACAGGCAGGGTTTGACGCAGCAGCCATCGCCGATCTG
CGCGCACGCAAGGTAATCGC

Downstream 100 bases:

>100_bases
GTTCCTGAGGCATGCGCGCGCCGGGGCAAGCGGCGCGACGACAAAAAAAGACTTTTACCGATACCGGAGACATTCCATGA
AGCAAGCCTTTTCCCTACGG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSAAEFNSPALRGPARIEINEVSPRDGLQIEPVVVPTDAKVAFVDALSACGFARIEATSFTSAKAIPALADAEALMHRMH
RRPGVRYTALVPNLRGLERALSCRPDEVNLVMSVSETHNRANLRMTRAQSEAQLLAMIAEARAAGVPVNVSLSTVFGCPF
EGEVSTDAVMALAHSFAEAGAQGITLCDTTGMAFPNQVAQMCEQFQQRLPDTGLTIHLHNTRGMGLANAVAAWETGVTRF
DAAAGGLGGCPYAPGASGNVSTEELVHMFACMGVQTGVDLPALLDVVAGIPALVERDIGSQLLRAGPRLRTHQPPAWLAE
HFAGQD

Sequences:

>Translated_326_residues
MSAAEFNSPALRGPARIEINEVSPRDGLQIEPVVVPTDAKVAFVDALSACGFARIEATSFTSAKAIPALADAEALMHRMH
RRPGVRYTALVPNLRGLERALSCRPDEVNLVMSVSETHNRANLRMTRAQSEAQLLAMIAEARAAGVPVNVSLSTVFGCPF
EGEVSTDAVMALAHSFAEAGAQGITLCDTTGMAFPNQVAQMCEQFQQRLPDTGLTIHLHNTRGMGLANAVAAWETGVTRF
DAAAGGLGGCPYAPGASGNVSTEELVHMFACMGVQTGVDLPALLDVVAGIPALVERDIGSQLLRAGPRLRTHQPPAWLAE
HFAGQD
>Mature_325_residues
SAAEFNSPALRGPARIEINEVSPRDGLQIEPVVVPTDAKVAFVDALSACGFARIEATSFTSAKAIPALADAEALMHRMHR
RPGVRYTALVPNLRGLERALSCRPDEVNLVMSVSETHNRANLRMTRAQSEAQLLAMIAEARAAGVPVNVSLSTVFGCPFE
GEVSTDAVMALAHSFAEAGAQGITLCDTTGMAFPNQVAQMCEQFQQRLPDTGLTIHLHNTRGMGLANAVAAWETGVTRFD
AAAGGLGGCPYAPGASGNVSTEELVHMFACMGVQTGVDLPALLDVVAGIPALVERDIGSQLLRAGPRLRTHQPPAWLAEH
FAGQD

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=292, Percent_Identity=36.6438356164384, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI109150427, Length=292, Percent_Identity=36.6438356164384, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=36.8243243243243, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI260654708, Length=139, Percent_Identity=38.8489208633094, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17510563, Length=271, Percent_Identity=36.1623616236162, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24582381, Length=299, Percent_Identity=36.1204013377926, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34418; Mature: 34286

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAEFNSPALRGPARIEINEVSPRDGLQIEPVVVPTDAKVAFVDALSACGFARIEATSF
CCCCCCCCCCCCCCCEEEEECCCCCCCCEECEEEECCCCCHHHHHHHHHCCCEEEEECCC
TSAKAIPALADAEALMHRMHRRPGVRYTALVPNLRGLERALSCRPDEVNLVMSVSETHNR
CCHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCC
ANLRMTRAQSEAQLLAMIAEARAAGVPVNVSLSTVFGCPFEGEVSTDAVMALAHSFAEAG
CCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEHHHEECCCCCCCCCHHHHHHHHHHHHHCC
AQGITLCDTTGMAFPNQVAQMCEQFQQRLPDTGLTIHLHNTRGMGLANAVAAWETGVTRF
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHH
DAAAGGLGGCPYAPGASGNVSTEELVHMFACMGVQTGVDLPALLDVVAGIPALVERDIGS
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHH
QLLRAGPRLRTHQPPAWLAEHFAGQD
HHHHCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SAAEFNSPALRGPARIEINEVSPRDGLQIEPVVVPTDAKVAFVDALSACGFARIEATSF
CCCCCCCCCCCCCCEEEEECCCCCCCCEECEEEECCCCCHHHHHHHHHCCCEEEEECCC
TSAKAIPALADAEALMHRMHRRPGVRYTALVPNLRGLERALSCRPDEVNLVMSVSETHNR
CCHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCC
ANLRMTRAQSEAQLLAMIAEARAAGVPVNVSLSTVFGCPFEGEVSTDAVMALAHSFAEAG
CCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEHHHEECCCCCCCCCHHHHHHHHHHHHHCC
AQGITLCDTTGMAFPNQVAQMCEQFQQRLPDTGLTIHLHNTRGMGLANAVAAWETGVTRF
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHH
DAAAGGLGGCPYAPGASGNVSTEELVHMFACMGVQTGVDLPALLDVVAGIPALVERDIGS
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHH
QLLRAGPRLRTHQPPAWLAEHFAGQD
HHHHCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]