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The map label for this gene is argH [H]

Identifier: 73541464

GI number: 73541464

Start: 1936900

End: 1938429

Strand: Direct

Name: argH [H]

Synonym: Reut_A1775

Alternate gene names: 73541464

Gene position: 1936900-1938429 (Clockwise)

Preceding gene: 73541463

Following gene: 73541467

Centisome position: 50.88

GC content: 64.51

Gene sequence:

>1530_bases
ATGCCCCTCACGCGGTGGAAGCGCAATACCTCGCGCATCCTCGGATCGTCAGCCCTCGTCCTGGTTGCCGCCTCGGCAGC
ACCCTTTCCCGCTTTCGCGGCGGATACCGTCCACCACGACGCCTTCTACTGGCTTGGCGAGATCAACAAGGCATCGGCCG
TCATCAACACCGACGAAGGCCTGCTGGACAAGTCACTGGCACCGAAAGTTGCCGGGGGCATTGCCACCGTGCTCGCGAAC
GGCGACAAGCCCGGCGGCAAACGCCCGTCGACCGTCATTACGTTCGAGCCGCTGATGATCCAGGCCGCAGGCCAGGAAGT
CACGCTGCTGCACGCCGGCCGCTCCAGCCAGGACATGCTGGCCACGGTCCGCGCGGCGATGCTGCGCGAGAAGGTCCTGG
CACTGGCCGACCAGCTCAACAAGACCTCCGCCACGATCGTCGGACTGGCCAGGCAGCATGCCGGCACCGTCGTGCCCAAC
TACACCAACGGCGTAGCCGCGCAGCCGAACAGCTACGGGCATTACCTGCTCGGCATTACCGCCGGGCTCGACCGCGATGC
CGAGCGGCTGCGCGAAGCCTATCGCCGCATCGACCGCTCGCCGATGGGCACGACTGTGCTCAATGGCACCGGCTGGCCGC
TGAACCGTACGCGGATGGCGAGCTACCTTGGTTTCTCCGCGCTCGTCGACAACGCTTATGACGCGTCGCAGATCAGCGCC
GTGGACCTGCCGGTCGAGGTGGCGTCGATCGTAACCAGCATCGGCCTGCACGCCGGCAGCTTCATCGAAGATGTGATGAC
GCAGTATGCCCAGCCGCGTCCGTGGATTCTCCTGCGCGAAGGCGGCGGCAATACCTATGTATCGAGCGCGATGCCGCAGA
AGCAAAACCCCGGACTGCTGAATTCCACGCGGGAGCGCGCGTCGACCGCACTGACGCTGGCGATGGGGCCGGTGATGCGG
GCCCACAACCTGCCGCCGGGCATGTCGGACGCCAAGGATGCCGTCGTCAACGGCGAGATGGTCGATAGCGCGATCCGCGT
ACTGCAGGGCTGGGACAAGATCATGCAAGCGCTCGTCATCGATCCGAAGCGGGCATTGGAGGAGCTGGACAGCGACTGGA
CTGCATCGCAGGAACTGGCCGATGAACTGATGCGCAAGTACAAGCTGCCGTTCCGCGTCGGCCATCATTTCGCGTCGGAG
CTGGTCGAGTACGCGAAGGCGCATGACATCCGCCCTAGCGCATTTCCCTACGCCGAGGCGCGGCGCATCTATGCCGAATC
GGTACGCAGCTACAGCAGCACCACGGATTTCCCGATGAGCGAGGCCGAATTCCGTGCGGCGCTGGATCCGGTGGCGATCG
TCAACCACCGTGTCACGAGCGGCGGCCCTCAGCCCGCAGAGATGGCGCGCATGCTGAAAGAGGAGGACCAGAAAATCGCG
CAACAGGAGGCCTGGATCAAGGCAACGCGCGGTTCTATCGATGCGTCATTGGCCAGGCTCGATCGGGACTTCAGCAAACT
GTTGAAGTAA

Upstream 100 bases:

>100_bases
CGAATGGGCATCCGGCAACAATCCTGACTGGACCGGTCGACGAACGCGCAATGATGCGCGAACATTGCCGACAATAAACG
CCCCAGATACAGGAGATGCC

Downstream 100 bases:

>100_bases
GGTGTGGCGGCCTCGGCAGTAAGGCCCTGGGCCGCCCTCTTCCCCGCTCATTTCCTTATGGCTCCTGCATCGTTACCCCG
TGGCTGGCAAAGATGCGGGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MPLTRWKRNTSRILGSSALVLVAASAAPFPAFAADTVHHDAFYWLGEINKASAVINTDEGLLDKSLAPKVAGGIATVLAN
GDKPGGKRPSTVITFEPLMIQAAGQEVTLLHAGRSSQDMLATVRAAMLREKVLALADQLNKTSATIVGLARQHAGTVVPN
YTNGVAAQPNSYGHYLLGITAGLDRDAERLREAYRRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
VDLPVEVASIVTSIGLHAGSFIEDVMTQYAQPRPWILLREGGGNTYVSSAMPQKQNPGLLNSTRERASTALTLAMGPVMR
AHNLPPGMSDAKDAVVNGEMVDSAIRVLQGWDKIMQALVIDPKRALEELDSDWTASQELADELMRKYKLPFRVGHHFASE
LVEYAKAHDIRPSAFPYAEARRIYAESVRSYSSTTDFPMSEAEFRAALDPVAIVNHRVTSGGPQPAEMARMLKEEDQKIA
QQEAWIKATRGSIDASLARLDRDFSKLLK

Sequences:

>Translated_509_residues
MPLTRWKRNTSRILGSSALVLVAASAAPFPAFAADTVHHDAFYWLGEINKASAVINTDEGLLDKSLAPKVAGGIATVLAN
GDKPGGKRPSTVITFEPLMIQAAGQEVTLLHAGRSSQDMLATVRAAMLREKVLALADQLNKTSATIVGLARQHAGTVVPN
YTNGVAAQPNSYGHYLLGITAGLDRDAERLREAYRRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
VDLPVEVASIVTSIGLHAGSFIEDVMTQYAQPRPWILLREGGGNTYVSSAMPQKQNPGLLNSTRERASTALTLAMGPVMR
AHNLPPGMSDAKDAVVNGEMVDSAIRVLQGWDKIMQALVIDPKRALEELDSDWTASQELADELMRKYKLPFRVGHHFASE
LVEYAKAHDIRPSAFPYAEARRIYAESVRSYSSTTDFPMSEAEFRAALDPVAIVNHRVTSGGPQPAEMARMLKEEDQKIA
QQEAWIKATRGSIDASLARLDRDFSKLLK
>Mature_508_residues
PLTRWKRNTSRILGSSALVLVAASAAPFPAFAADTVHHDAFYWLGEINKASAVINTDEGLLDKSLAPKVAGGIATVLANG
DKPGGKRPSTVITFEPLMIQAAGQEVTLLHAGRSSQDMLATVRAAMLREKVLALADQLNKTSATIVGLARQHAGTVVPNY
TNGVAAQPNSYGHYLLGITAGLDRDAERLREAYRRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISAV
DLPVEVASIVTSIGLHAGSFIEDVMTQYAQPRPWILLREGGGNTYVSSAMPQKQNPGLLNSTRERASTALTLAMGPVMRA
HNLPPGMSDAKDAVVNGEMVDSAIRVLQGWDKIMQALVIDPKRALEELDSDWTASQELADELMRKYKLPFRVGHHFASEL
VEYAKAHDIRPSAFPYAEARRIYAESVRSYSSTTDFPMSEAEFRAALDPVAIVNHRVTSGGPQPAEMARMLKEEDQKIAQ
QEAWIKATRGSIDASLARLDRDFSKLLK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=318, Percent_Identity=27.6729559748428, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI68303542, Length=318, Percent_Identity=27.6729559748428, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI68303547, Length=314, Percent_Identity=27.3885350318471, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790398, Length=390, Percent_Identity=26.4102564102564, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321806, Length=303, Percent_Identity=26.4026402640264, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221473854, Length=407, Percent_Identity=25.7985257985258, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI78706858, Length=407, Percent_Identity=25.7985257985258, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 55308; Mature: 55176

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTRWKRNTSRILGSSALVLVAASAAPFPAFAADTVHHDAFYWLGEINKASAVINTDEG
CCCCHHCCHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCC
LLDKSLAPKVAGGIATVLANGDKPGGKRPSTVITFEPLMIQAAGQEVTLLHAGRSSQDML
HHHHHCCHHHHCCCEEEEECCCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCCCHHHH
ATVRAAMLREKVLALADQLNKTSATIVGLARQHAGTVVPNYTNGVAAQPNSYGHYLLGIT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE
AGLDRDAERLREAYRRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCC
VDLPVEVASIVTSIGLHAGSFIEDVMTQYAQPRPWILLREGGGNTYVSSAMPQKQNPGLL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCC
NSTRERASTALTLAMGPVMRAHNLPPGMSDAKDAVVNGEMVDSAIRVLQGWDKIMQALVI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHC
DPKRALEELDSDWTASQELADELMRKYKLPFRVGHHFASELVEYAKAHDIRPSAFPYAEA
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RRIYAESVRSYSSTTDFPMSEAEFRAALDPVAIVNHRVTSGGPQPAEMARMLKEEDQKIA
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
QQEAWIKATRGSIDASLARLDRDFSKLLK
HHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLTRWKRNTSRILGSSALVLVAASAAPFPAFAADTVHHDAFYWLGEINKASAVINTDEG
CCCHHCCHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCC
LLDKSLAPKVAGGIATVLANGDKPGGKRPSTVITFEPLMIQAAGQEVTLLHAGRSSQDML
HHHHHCCHHHHCCCEEEEECCCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCCCHHHH
ATVRAAMLREKVLALADQLNKTSATIVGLARQHAGTVVPNYTNGVAAQPNSYGHYLLGIT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE
AGLDRDAERLREAYRRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCC
VDLPVEVASIVTSIGLHAGSFIEDVMTQYAQPRPWILLREGGGNTYVSSAMPQKQNPGLL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCC
NSTRERASTALTLAMGPVMRAHNLPPGMSDAKDAVVNGEMVDSAIRVLQGWDKIMQALVI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHC
DPKRALEELDSDWTASQELADELMRKYKLPFRVGHHFASELVEYAKAHDIRPSAFPYAEA
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RRIYAESVRSYSSTTDFPMSEAEFRAALDPVAIVNHRVTSGGPQPAEMARMLKEEDQKIA
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
QQEAWIKATRGSIDASLARLDRDFSKLLK
HHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA