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The map label for this gene is envZ [H]

Identifier: 73541061

GI number: 73541061

Start: 1471067

End: 1472416

Strand: Reverse

Name: envZ [H]

Synonym: Reut_A1367

Alternate gene names: 73541061

Gene position: 1472416-1471067 (Counterclockwise)

Preceding gene: 73541062

Following gene: 73541060

Centisome position: 38.68

GC content: 65.7

Gene sequence:

>1350_bases
GTGGCGACCGCCCTCGGCCGTACGGCCACGCGTTTCTTTGGTTCGCTGTTCTGGCGAACCTTCATGCTGATCGCGCTTCT
GCTGGCTATTTCTCTGGGCATCTGGTTTCAGAGCTACCGGCTGTTCGAACGCGCCCCGCGGGCGCAGCAGATCGCCATGC
AGGTGGTCAGCGTGGTCAAGCTGACGCGCGCGGCCCTGCTCTATTCGGACCCGGCACGGCGCCGGTTCCTGCTGCTCGAC
CTGGTCCAGAACGAAGGCATCAAGGTTTATCCGCGCGAGAAGGACGACGATTTTGCCGCGCCGACCGCCAACCCGTTCCT
GACCCAGCTTGTGCAGCAGGAAATCCGCAGCCGGCTTGGCGAGGACACGGTGCTGGCCACCACCGTCAACGATATTCCCG
GCGTATGGGTCAGCTTCGAGATCGAGGGTGACGATTACTGGGTCGCGATCAGCCCGGAGCGTTTCGAGCGCGTGTCAGGC
ATCCAGTGGCTGTGGTGGAGTATCGCGGCGTTGCTGCTGTCAATCATCGGCGCCGCGTTCATTACCGCACGCGTCAACTA
CCCGCTCAAGCGGCTGGCCACTGCGGCGCGCGAGATTGGCGCGGGCGGCGATCCGCCGCCACTGCCCGAGCATGGCGCCA
GCGAAGTCGCGCTGGCCAACCACAGCTTCAACCAGATGGTGCGTGACCTGCGCCAGCTCGATGACGACCGGGCGGTGATG
CTGGCCGGCATCTCGCATGACCTGCGCACGCCGCTTACGCGCCTGCGGCTGGAAACCGAGATGTCGCCGGCCGACAATGC
CACGCGTGAAGCGATGATCACCGACATCGAGCAGATGGATGCCATCATCGGCCAGTTCCTGAACTACGCGCGGCCGCCGC
TCGAAATGGTCGAGCCGGTGGACCTGTCGGCGCTCGTCCAGGATGCCGTGGGAGTCTATGCCGCACATGACGACGTGCGC
GTGCAGGTCCGCGCCAACGAGCCGGTCATGGCCGTGGCCAACCGCATGGAAGTCCAACGCATTCTCGACAACCTGGTCGA
AAACGCGCGCCGCTATGCCAAGAACGACGACACCGGCATTGCCGAGGTCGAGATCACCACGAAGCTCGACGACAAGGACG
CCGTGCTCACCGTGGCCGACAACGGCAAGGGCGTGCCGGACGCCCAGCTTTCGTTGCTGACCCGGCCGTTCTATCGGCTC
GACAGCGCGCGCAGCGAAGCCAAGGGCGCGGGGCTGGGCATGTCGATCGTCAACCGCATCCTGCAGCGCAACGGCGGCCG
GCTGGTGCTGTCGAACCGCTCGGCGCCCCACTCCGGCCTTGTCGTCAGCGCCTGTTTCCGCCGCGCCTGA

Upstream 100 bases:

>100_bases
GCCCGATCCGAGCAACCCGCGCTTTATCCAGACAGTCTGGGGTCTGGGCTACGTGTTCATTCCCGATGGCGTGAAGTAAC
CCGGTCGGCCGCTCAACATC

Downstream 100 bases:

>100_bases
CGAAAACGGCGCCCGCCGCACATTGCCGGCGCACATCCCGGCGACTGACAGGTTTTCGACAGCTACTGATAGGGATCTGT
AAGGTCTTTGACAGGGCAAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MATALGRTATRFFGSLFWRTFMLIALLLAISLGIWFQSYRLFERAPRAQQIAMQVVSVVKLTRAALLYSDPARRRFLLLD
LVQNEGIKVYPREKDDDFAAPTANPFLTQLVQQEIRSRLGEDTVLATTVNDIPGVWVSFEIEGDDYWVAISPERFERVSG
IQWLWWSIAALLLSIIGAAFITARVNYPLKRLATAAREIGAGGDPPPLPEHGASEVALANHSFNQMVRDLRQLDDDRAVM
LAGISHDLRTPLTRLRLETEMSPADNATREAMITDIEQMDAIIGQFLNYARPPLEMVEPVDLSALVQDAVGVYAAHDDVR
VQVRANEPVMAVANRMEVQRILDNLVENARRYAKNDDTGIAEVEITTKLDDKDAVLTVADNGKGVPDAQLSLLTRPFYRL
DSARSEAKGAGLGMSIVNRILQRNGGRLVLSNRSAPHSGLVVSACFRRA

Sequences:

>Translated_449_residues
MATALGRTATRFFGSLFWRTFMLIALLLAISLGIWFQSYRLFERAPRAQQIAMQVVSVVKLTRAALLYSDPARRRFLLLD
LVQNEGIKVYPREKDDDFAAPTANPFLTQLVQQEIRSRLGEDTVLATTVNDIPGVWVSFEIEGDDYWVAISPERFERVSG
IQWLWWSIAALLLSIIGAAFITARVNYPLKRLATAAREIGAGGDPPPLPEHGASEVALANHSFNQMVRDLRQLDDDRAVM
LAGISHDLRTPLTRLRLETEMSPADNATREAMITDIEQMDAIIGQFLNYARPPLEMVEPVDLSALVQDAVGVYAAHDDVR
VQVRANEPVMAVANRMEVQRILDNLVENARRYAKNDDTGIAEVEITTKLDDKDAVLTVADNGKGVPDAQLSLLTRPFYRL
DSARSEAKGAGLGMSIVNRILQRNGGRLVLSNRSAPHSGLVVSACFRRA
>Mature_448_residues
ATALGRTATRFFGSLFWRTFMLIALLLAISLGIWFQSYRLFERAPRAQQIAMQVVSVVKLTRAALLYSDPARRRFLLLDL
VQNEGIKVYPREKDDDFAAPTANPFLTQLVQQEIRSRLGEDTVLATTVNDIPGVWVSFEIEGDDYWVAISPERFERVSGI
QWLWWSIAALLLSIIGAAFITARVNYPLKRLATAAREIGAGGDPPPLPEHGASEVALANHSFNQMVRDLRQLDDDRAVML
AGISHDLRTPLTRLRLETEMSPADNATREAMITDIEQMDAIIGQFLNYARPPLEMVEPVDLSALVQDAVGVYAAHDDVRV
QVRANEPVMAVANRMEVQRILDNLVENARRYAKNDDTGIAEVEITTKLDDKDAVLTVADNGKGVPDAQLSLLTRPFYRLD
SARSEAKGAGLGMSIVNRILQRNGGRLVLSNRSAPHSGLVVSACFRRA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=441, Percent_Identity=31.9727891156463, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787894, Length=292, Percent_Identity=31.1643835616438, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=29.8892988929889, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=28.3636363636364, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790551, Length=272, Percent_Identity=28.6764705882353, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=306, Percent_Identity=24.1830065359477, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790861, Length=283, Percent_Identity=26.1484098939929, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=26.3888888888889, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=27.1493212669683, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=30.6034482758621, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=208, Percent_Identity=22.1153846153846, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49865; Mature: 49734

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATALGRTATRFFGSLFWRTFMLIALLLAISLGIWFQSYRLFERAPRAQQIAMQVVSVVK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LTRAALLYSDPARRRFLLLDLVQNEGIKVYPREKDDDFAAPTANPFLTQLVQQEIRSRLG
HHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
EDTVLATTVNDIPGVWVSFEIEGDDYWVAISPERFERVSGIQWLWWSIAALLLSIIGAAF
CCEEEEEECCCCCCEEEEEEEECCEEEEEECHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ITARVNYPLKRLATAAREIGAGGDPPPLPEHGASEVALANHSFNQMVRDLRQLDDDRAVM
HHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCEEE
LAGISHDLRTPLTRLRLETEMSPADNATREAMITDIEQMDAIIGQFLNYARPPLEMVEPV
EECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
DLSALVQDAVGVYAAHDDVRVQVRANEPVMAVANRMEVQRILDNLVENARRYAKNDDTGI
CHHHHHHHHHHHEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
AEVEITTKLDDKDAVLTVADNGKGVPDAQLSLLTRPFYRLDSARSEAKGAGLGMSIVNRI
EEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LQRNGGRLVLSNRSAPHSGLVVSACFRRA
HHCCCCEEEEECCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
ATALGRTATRFFGSLFWRTFMLIALLLAISLGIWFQSYRLFERAPRAQQIAMQVVSVVK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LTRAALLYSDPARRRFLLLDLVQNEGIKVYPREKDDDFAAPTANPFLTQLVQQEIRSRLG
HHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
EDTVLATTVNDIPGVWVSFEIEGDDYWVAISPERFERVSGIQWLWWSIAALLLSIIGAAF
CCEEEEEECCCCCCEEEEEEEECCEEEEEECHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ITARVNYPLKRLATAAREIGAGGDPPPLPEHGASEVALANHSFNQMVRDLRQLDDDRAVM
HHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCEEE
LAGISHDLRTPLTRLRLETEMSPADNATREAMITDIEQMDAIIGQFLNYARPPLEMVEPV
EECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
DLSALVQDAVGVYAAHDDVRVQVRANEPVMAVANRMEVQRILDNLVENARRYAKNDDTGI
CHHHHHHHHHHHEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
AEVEITTKLDDKDAVLTVADNGKGVPDAQLSLLTRPFYRLDSARSEAKGAGLGMSIVNRI
EEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LQRNGGRLVLSNRSAPHSGLVVSACFRRA
HHCCCCEEEEECCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]