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The map label for this gene is pyrD [H]

Identifier: 73541011

GI number: 73541011

Start: 1412325

End: 1413359

Strand: Reverse

Name: pyrD [H]

Synonym: Reut_A1317

Alternate gene names: 73541011

Gene position: 1413359-1412325 (Counterclockwise)

Preceding gene: 73541012

Following gene: 73541010

Centisome position: 37.13

GC content: 67.44

Gene sequence:

>1035_bases
GTGCTCAACGCGCTCTACCCCCTGTTCCGCCCCGCCCTGTTTTCGATGGATGCGGAGGACGCCCACCACTTCACCCTGAA
CAACCTGCTGCGCGCCCAGCGCCTGGGCCTCGGCGGCTGCATCGGCAACCGTATCGCCGAGGATCCGCGCACCGTGATGG
GCGTGCGTTTTCCGAACCCCGTGGGCCTTGCCGCCGGGCTGGACAAGGATGGCGCGTATATCGACGGGCTCGCGTCGTTC
GGCTTCGGCTTCATCGAGGTGGGCACGGTCACGCCACGCGCGCAGCCCGGCAACCCGCGCCCGCGCATGTTCCGCCTGCC
GCAGGCCGACGCGCTGATCAACCGCATGGGCTTCAACAACGGCGGCGTCGACGCGTTCATCGCCAACGTCAAGGCATCTC
GCTGGAAGGCGGAAGGCGGCGTGCTGGGCCTGAACATCGGCAAGAACGCCGATACGCCGATCGAACGCGCAGCCGACGAC
TACCTATATTGCCTCGAGCGCGTCTATCCGCATGCGAGCTACGTGACGGTCAACATCTCGTCGCCGAACACCAAGAACCT
GCGCCAGCTCCAGGGCGCCAGCGAACTCGACAGCCTGCTGTCGACGCTCAAGGCCGCCCAGCAGCGCCTGGCCGACCAGC
ACAAGCGTTACGTGCCGGTGGCCCTGAAGATCGCGCCCGATCTCGATGCCGACCAGATCGGCAATATCGGCGACGCGCTG
GTACGCCACAAGATCGACGGCGTGATCGCGACCAACACCACGATCTCCCGCGATGCCGTGAAGGGCCTGCCGCACGCGGA
AGAAGCCGGCGGACTGTCCGGCCGGCCGGTGTTCGAGCAGTCGACGCACGTGGTGCGCGCGCTGCGCCAGGTCGTTGGCG
ATGCGGTGCCCATCATTGGCGTGGGCGGCATTTTCAGCGGCGCGGACGCCCGCGCGAAAATCGATGCCGGGGCAAAGCTC
GTCCAGGTCTACAGCGGCCTGATCTACCGAGGGCCGACACTCGTACGCGATTGCGCCGCCGCGCTGCGTGCCTGA

Upstream 100 bases:

>100_bases
CGGGCCTGCAAGGCCCATCCCGGCGCGCGAGCAAGCGCCCCAGCCGCTACAATGCCGGCTTGGTTTTCACTCTGCGCCGG
CTTCCCGGTCGCCCCTCCCC

Downstream 100 bases:

>100_bases
ATCCGTTCTGCTAGCCAGCAAGGAGAACAACATGGAAACCGTCCGCCTCGGCCGCAGCGACCTGGAGGTCTCCCGCATCT
GCCTGGGCACCATGACCTTC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLNALYPLFRPALFSMDAEDAHHFTLNNLLRAQRLGLGGCIGNRIAEDPRTVMGVRFPNPVGLAAGLDKDGAYIDGLASF
GFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNNGGVDAFIANVKASRWKAEGGVLGLNIGKNADTPIERAADD
YLYCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAPDLDADQIGNIGDAL
VRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEQSTHVVRALRQVVGDAVPIIGVGGIFSGADARAKIDAGAKL
VQVYSGLIYRGPTLVRDCAAALRA

Sequences:

>Translated_344_residues
MLNALYPLFRPALFSMDAEDAHHFTLNNLLRAQRLGLGGCIGNRIAEDPRTVMGVRFPNPVGLAAGLDKDGAYIDGLASF
GFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNNGGVDAFIANVKASRWKAEGGVLGLNIGKNADTPIERAADD
YLYCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAPDLDADQIGNIGDAL
VRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEQSTHVVRALRQVVGDAVPIIGVGGIFSGADARAKIDAGAKL
VQVYSGLIYRGPTLVRDCAAALRA
>Mature_344_residues
MLNALYPLFRPALFSMDAEDAHHFTLNNLLRAQRLGLGGCIGNRIAEDPRTVMGVRFPNPVGLAAGLDKDGAYIDGLASF
GFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNNGGVDAFIANVKASRWKAEGGVLGLNIGKNADTPIERAADD
YLYCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAPDLDADQIGNIGDAL
VRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEQSTHVVRALRQVVGDAVPIIGVGGIFSGADARAKIDAGAKL
VQVYSGLIYRGPTLVRDCAAALRA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=300, Percent_Identity=46.3333333333333, Blast_Score=235, Evalue=5e-62,
Organism=Escherichia coli, GI1787177, Length=337, Percent_Identity=51.9287833827893, Blast_Score=360, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17509475, Length=327, Percent_Identity=43.7308868501529, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI281361352, Length=349, Percent_Identity=42.4068767908309, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI17137316, Length=349, Percent_Identity=42.4068767908309, Blast_Score=247, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36740; Mature: 36740

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNALYPLFRPALFSMDAEDAHHFTLNNLLRAQRLGLGGCIGNRIAEDPRTVMGVRFPNP
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCC
VGLAAGLDKDGAYIDGLASFGFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNN
CCHHCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCC
GGVDAFIANVKASRWKAEGGVLGLNIGKNADTPIERAADDYLYCLERVYPHASYVTVNIS
CCHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEC
SPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAPDLDADQIGNIGDAL
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHH
VRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEQSTHVVRALRQVVGDAVPIIG
HHHHHCCEEECCCEECHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VGGIFSGADARAKIDAGAKLVQVYSGLIYRGPTLVRDCAAALRA
ECCCCCCCCCCEEHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLNALYPLFRPALFSMDAEDAHHFTLNNLLRAQRLGLGGCIGNRIAEDPRTVMGVRFPNP
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCC
VGLAAGLDKDGAYIDGLASFGFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNN
CCHHCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCC
GGVDAFIANVKASRWKAEGGVLGLNIGKNADTPIERAADDYLYCLERVYPHASYVTVNIS
CCHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEC
SPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAPDLDADQIGNIGDAL
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHH
VRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEQSTHVVRALRQVVGDAVPIIG
HHHHHCCEEECCCEECHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VGGIFSGADARAKIDAGAKLVQVYSGLIYRGPTLVRDCAAALRA
ECCCCCCCCCCEEHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA