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The map label for this gene is appC [H]

Identifier: 73540937

GI number: 73540937

Start: 1326999

End: 1327949

Strand: Direct

Name: appC [H]

Synonym: Reut_A1242

Alternate gene names: 73540937

Gene position: 1326999-1327949 (Clockwise)

Preceding gene: 73540936

Following gene: 73540938

Centisome position: 34.86

GC content: 66.35

Gene sequence:

>951_bases
ATGTCCATCCCTGCAACTGAACCCGGTACGACGGGTGCGCCGCTGGCGTCTGCCAGCGCGCCGGGCACAGCGTCCGCGCG
GCCGCATCGGCCGTCTTTTCTCTCACGCTTCCTGCGCAACCGCGTGGCGGCGGCAGCGCTGGCGCTCTTGCTCGCGTTGA
TGCTGGTCGCCGTGTTCGCCGGCGTGATCAGCCCGCAGAATCCATATGACCTGGCCACCGTGTCAGTCATCGATTCCGAA
CTGCCGCCCGGCGCGGTCGGCTATGACGGCCAGATGCGCTACTGGCTCGGCACCGACGGTGCTGGGCGCGACCTGGTCAG
TGCCATCTTCTATGGCATCCGCATCAGTGTCGGTGTCGGCGTGATCAGCGCCGTGGTGGCGCTCGTGCTCGGTGCCGCGA
TTGGCCTGATCGCGGCCTACTGCGGCGGCGTGGTCGACGCCGTGATCATGCGCATCGTAGACCTCCAGCTGAGCTTGCCG
GCGATTCTTGTCGCGCTGATTCTGCTCGCAGTGCTTGGGCAGGGCGTGGACAAGACGCTGATGGCGCTGGTGATCGTGCA
ATGGGCCTACTTCGCGCGGACCGTGCGCGCATCGGCACAGGTCGAACGGCGCAAGGACTACGTCGAAGCGGCGCTCGGAC
AGGGGCTGCCTGCCTGGCGCGTGATGTTCCGCCACATCCTGCCAAACTGCATGGCACCGCTGGTGGTGACCGCGACGCTG
CAGATCGCGCATGCGATCACGCTGGAAGCGACCATGAGCTTCCTCGGCATCGGCCTGCCGCGCACGCAGCCGTCGCTGGG
CATGCTGATCGCCAATGGCTTCGAATACATGCTGTCGAACAAGTACTGGATCAGCATTTTCCCGGGCGTGGCCCTGGTGC
TGCTGATCGGCGCCATCAACCTGGTGGGCGACCGGCTGCGCCGCGTGCTCAATCCCCGCAACGAGGGCTGA

Upstream 100 bases:

>100_bases
AACCTGATCGTCGACCTGCTTTACGTATTGCTCGATCCGCGCCTGCGCCACAAGGCAGCCTGAACCCCTTTTTTGAACCT
GTCATTCGCCAAGTTTTACG

Downstream 100 bases:

>100_bases
GGAGAGAAATCATGGCACTGCTGGAAGTCAACGGTCTGACCACGCGCTTCGCCCTGGAGCACGGCGCGGTCACTGCGGTC
GACAATGTTTCTTTCTCGCT

Product: binding-protein dependent transport system inner membrane protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSIPATEPGTTGAPLASASAPGTASARPHRPSFLSRFLRNRVAAAALALLLALMLVAVFAGVISPQNPYDLATVSVIDSE
LPPGAVGYDGQMRYWLGTDGAGRDLVSAIFYGIRISVGVGVISAVVALVLGAAIGLIAAYCGGVVDAVIMRIVDLQLSLP
AILVALILLAVLGQGVDKTLMALVIVQWAYFARTVRASAQVERRKDYVEAALGQGLPAWRVMFRHILPNCMAPLVVTATL
QIAHAITLEATMSFLGIGLPRTQPSLGMLIANGFEYMLSNKYWISIFPGVALVLLIGAINLVGDRLRRVLNPRNEG

Sequences:

>Translated_316_residues
MSIPATEPGTTGAPLASASAPGTASARPHRPSFLSRFLRNRVAAAALALLLALMLVAVFAGVISPQNPYDLATVSVIDSE
LPPGAVGYDGQMRYWLGTDGAGRDLVSAIFYGIRISVGVGVISAVVALVLGAAIGLIAAYCGGVVDAVIMRIVDLQLSLP
AILVALILLAVLGQGVDKTLMALVIVQWAYFARTVRASAQVERRKDYVEAALGQGLPAWRVMFRHILPNCMAPLVVTATL
QIAHAITLEATMSFLGIGLPRTQPSLGMLIANGFEYMLSNKYWISIFPGVALVLLIGAINLVGDRLRRVLNPRNEG
>Mature_315_residues
SIPATEPGTTGAPLASASAPGTASARPHRPSFLSRFLRNRVAAAALALLLALMLVAVFAGVISPQNPYDLATVSVIDSEL
PPGAVGYDGQMRYWLGTDGAGRDLVSAIFYGIRISVGVGVISAVVALVLGAAIGLIAAYCGGVVDAVIMRIVDLQLSLPA
ILVALILLAVLGQGVDKTLMALVIVQWAYFARTVRASAQVERRKDYVEAALGQGLPAWRVMFRHILPNCMAPLVVTATLQ
IAHAITLEATMSFLGIGLPRTQPSLGMLIANGFEYMLSNKYWISIFPGVALVLLIGAINLVGDRLRRVLNPRNEG

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789964, Length=282, Percent_Identity=39.3617021276596, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1787760, Length=275, Percent_Identity=33.8181818181818, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787054, Length=285, Percent_Identity=32.9824561403509, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787498, Length=279, Percent_Identity=34.0501792114695, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789889, Length=246, Percent_Identity=32.9268292682927, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788505, Length=220, Percent_Identity=29.5454545454545, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787549, Length=275, Percent_Identity=26.9090909090909, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33338; Mature: 33207

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPATEPGTTGAPLASASAPGTASARPHRPSFLSRFLRNRVAAAALALLLALMLVAVFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVISPQNPYDLATVSVIDSELPPGAVGYDGQMRYWLGTDGAGRDLVSAIFYGIRISVGVG
HHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VISAVVALVLGAAIGLIAAYCGGVVDAVIMRIVDLQLSLPAILVALILLAVLGQGVDKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MALVIVQWAYFARTVRASAQVERRKDYVEAALGQGLPAWRVMFRHILPNCMAPLVVTATL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
QIAHAITLEATMSFLGIGLPRTQPSLGMLIANGFEYMLSNKYWISIFPGVALVLLIGAIN
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
LVGDRLRRVLNPRNEG
HHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIPATEPGTTGAPLASASAPGTASARPHRPSFLSRFLRNRVAAAALALLLALMLVAVFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVISPQNPYDLATVSVIDSELPPGAVGYDGQMRYWLGTDGAGRDLVSAIFYGIRISVGVG
HHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VISAVVALVLGAAIGLIAAYCGGVVDAVIMRIVDLQLSLPAILVALILLAVLGQGVDKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MALVIVQWAYFARTVRASAQVERRKDYVEAALGQGLPAWRVMFRHILPNCMAPLVVTATL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
QIAHAITLEATMSFLGIGLPRTQPSLGMLIANGFEYMLSNKYWISIFPGVALVLLIGAIN
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
LVGDRLRRVLNPRNEG
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]